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Effects of Nigella sativa on outcome of hepatitis C in Egypt

World Journal of Gastroenterology 2013年第16期19卷 2529-2536页

作者： eman mahmoud fathy barakat Lamia Mohamed El Wakeel Radwa Samir Hagag Department of Tropical Medicine Faculty of Medicine Ain Shams University Department of Clinical Pharmacy Faculty of Pharmacy Ain Shams University Department of Clinical Pharmacy Faculty of Pharmacy Egyptian Russian University

AIM: To evaluate the safety, efficacy and tolerability of Nigella sativa (N. sativa ) in patients with hepatitis C not eligible for interferon (IFN)-α. METHODS: Thirty patients with hepatitis C virus (HCV) infection, who were not eligible for IFN/ribavirin therapy, were included in the present study. Inclusion criteria included: patients with HCV with or without cirrhosis, who had a contraindication to IFN-α therapy, or had refused or had a financial constraint to IFN-α therapy. Exclusion criteria included: patients on IFN-α therapy, infection with hepatitis B or hepatitis Ⅰ virus, hepatocellular carcinoma, other malignancies, major severe illness, or treatment non-compliance. Various parameters, including clinical parameters, complete blood count, liver function, renal function, plasma glucose, total antioxidant capacity (TAC), and polymerase chain reaction, were all assessed at baseline and at the end of the study. Clinical assessment included: hepato and/ or splenomegaly, jaundice, palmar erythema, flapping tremors, spider naevi, lower-limb edema, and ascites. N. sativa was administered for three successive months at a dose of (450 mg three times daily). Clinical response and incidence of adverse drug reactions were assessed initially, periodically, and at the end of the study. RESULTS: N. sativa administration significantly improved HCV viral load (380808.7 ± 610937 vs 147028.2 ± 475225.6, P = 0.001) and TAC (1.35 ± 0.5 vs 1.612 ± 0.56, P = 0.001). After N. sativa administration, the following laboratory parameters improved: total protein (7.1 ± 0.7 vs 7.5 ± 0.8, P = 0.001), albumin (3.5 ± 0.87 vs 3.69 ± 0.91, P = 0.008), red blood cell count (4.13 ± 0.9 vs 4.3 ± 0.9, P = 0.001), and platelet count (167.7 ± 91.2 vs 198.5 ± 103, P = 0.004). Fasting blood glucose (104.03 ± 43.42 vs 92.1 ± 31.34, P = 0.001) and postprandial blood glucose (143.67 ± 72.56 vs 112.1 ± 42.9, P = 0.001) were significantly decreased in both diabetic and non-diabetic HCV patients. Patients

关键词： Hepatitis C virus Nigella sativa Oxidative stress Viral load

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Combined radiofrequency and chemoembolization *** in management of hepatocellular carcinoma

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Hepatoma Research 2015年第1期1卷 19-23页

作者： Ahmed Kamal El Dorry eman mahmoud fathy barakat Amal Tohamy Abd ElMoez Mervat Abd Fatah Mawad Nevien Fouad El-Fouly Mohamed Kamal Shaker Department of Radiology Medicine Faculty of MedicineAin Shams UniversityCairo 11566Egypt Department of Tropical Medicine Faculty of MedicineAin Shams UniversityCairo 11566Egypt Atomic Energy Authority Cairo 13759Egypt

Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the *** left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of *** aim of this study is to assess the value of combined radiofrequency ablation(RFA),followed by trans-arterial chemoembolization(TACE)in the management of ***:Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment:25 HCC patients treated with RFA followed by TACE within 5 days and 25 HCC patients treated with TACE ***:Complete response was achieved in 100%and 84%of the HCC patients after 1 month from combined RFA-TACE therapy and TACE only *** rate of objective response after 7 months was 84%and 44%in the RFA-TACE and TACE groups *** year disease free survival rate was 56%and 24%in RFA-TACE and TACE groups respectively,and overall survival rate was 88%in the RFA-TACE group and 80%in the TACE only ***:Combined RFA-TACE appears to be an effective modality and superior to TACE only for the treatment of HCC.

关键词： Hepatocellular carcinoma radiofrequency trans-arterial chemoembolization

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World Journal of Gastroenterology 2016年第30期22卷 6800-6816页

作者： mahmoud fathy Dondeti eman Anwar El-Maadawy Roba Mohamed Talaat Genetic Engineering and Biotechnology Research Division National Research Centre Molecular Biology Department Genetic Engineering and Biotechnology Research Institute University of Sadat City

Hepatocellular carcinoma(HCC) is a primary liver cancer, which is one of the most prevalent cancers among humans. Many factors are involved in the liver carcinogenesis as lifestyle and environmental factors. Hepatitis virus infections are now recognized as the chief etiology of HCC; however, the precise mechanism is still enigmatic till now. The inflammation triggered by the cytokine-mediated immune response, was reported to be the closest factor of HCC development. Cytokines are immunoregulatory proteins produced by immune cells, functioning as orchestrators of the immune response. Genes of cytokines and their receptors are known to be polymorphic, which give rise to variations in their genes. These variations have a great impact on the expression levels of the secreted cytokines. Therefore, cytokine gene polymorphisms are involved in the molecular mechanisms of several diseases. This piece of work aims to shed much light on the role of cytokine gene polymorphisms as genetic host factor in hepatitis related HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus Hepatitis B virus Cytokines Polymorphism

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