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Effect of treating chronic hepatitis C with direct-acting antivirals on extrahepatic cutaneous manifestations

World Journal of Hepatology 2020年第10期12卷 841-849页

作者： mohamed El Kassas Osama mO Hegazy eman m salah Department of Endemic medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineHelwan UniversityCairo 11795Egypt

BACKGROUND Hepatitis C virus(HCV)is a disease with a significant global impact,affecting approximately 2%-2.5%of the world’s *** direct-acting antivirals(DAAs)have been introduced over the past few years with great success in viral *** association of chronic HCV infection with a wide spectrum of cutaneous manifestations has been widely reported in the *** To assess the effect of treating HCV with DAAs on the extrahepatic cutaneous manifestations of *** This prospective observational study included 1039 HCV positive Egyptian patients who were eligible to receive DAAs.A total of 30 patients were diagnosed with extrahepatic cutaneous manifestations and fulfilled the inclusion criteria of the *** these patients,6 had classic lichen planus,8 were diagnosed with psoriasis vulgaris and 16 had *** patients received DAAs from October 2018 to July 2019 in the form of a three-month course of sofosbuvir/daclatasvir *** with lichen planus or psoriasis were dermoscopically evaluated before treatment and 6 mo after treatment,while patients with hepatic pruritus were assessed using the 12-Item Pruritus Severity Scale over the same *** All patients with psoriasis showed significant improvement in all psoriatic plaques,and all patients with hepatic pruritus scored 0 on the 12-Item Pruritus Severity Scale indicating total improvement of *** addition,four of six patients with lichen planus showed complete *** Treatment of HCV with DAAs was significantly effective in improving virusrelated extrahepatic cutaneous manifestations.

关键词： Directly acting antivirals Extrahepatic manifestations Hepatitis C virus Lichen planus Pruritus Cutaneous manifestations

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Chemically mediated Interactions between Grapevine, Aphid, Ladybird, and Ant in the Context of Insect Chemical Ecology

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1523-1542页

作者： Taghreed Alsufyani Noura J.Alotaibi Nour Houda m’sakni mona A.Almalki eman m.Alghamdi Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Chemistry Department Faculty of ScienceKing AbdulAziz UniversityP.O.Box 80200Jeddah21589Saudi Arabia

This study simpliﬁes the complex relationship among grapevine plants,aphids,ladybirds,and ants,which is essential for effective pest management and ecological *** study investigated the impact of aphid attacks and the presence of ants and ladybirds on the volatile compounds proﬁle released into the chemosphere of the community consisting of the common vine Vitis vinifera,the aphid Aphis illinoisensis,the ladybird Cocci-nella undecimpunctata-and the ant Tapinoma *** study aims to analyze the volatile compounds emitted by the grapevine and surrounding insects in response to these intricate *** extraction of volatile organic compounds(VOCs)was carried out using closed-loop stripping(CLS)and then analyzed via gas chromatography-mass spectrometry(GC-mS)and principles coordinated analysis(PCA)was *** grapevine was exposed to different types and order of treatments,including non-infested,aphid-infested,aphid-infested with ant,aphid-infested with ladybird,and various combinations of ant and *** the aphid attack,the outcomes uncovered massive alterations in the volatile compound proﬁ*** grapevine displayed distinct emissions of germacrene D,an alcohol,and an alkene compared to non-infested *** characteristic VOC proﬁle was the share of infested grapes in the presence of ants,with benzene derivatives and sesquiterpenes dominating the *** coexistence of ladybirds with ants and aphids resulted in a dif-ferent volatile proﬁle characterized by elevated levels of aldehydes,ketones,α-farnesene,and its hydroxy *** was concluded that the emission of VOCs into the chemosphere of the grapevine communities varied qualitatively and quantitatively depending on the level of the relationship complexity within each community in response to the infestation of grapevines by aphids,the presence of ladybirds as natural predators,and the presence of ant as *** grapevine’s status-dependent compounds

关键词： Aphids Aphis illinoisensis volatile organic compounds chemosphere pest management gas chromatography-mass spectrometry closed-loop stripping

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Exploring the impact of tacrolimus on kidney transplant recipients: insights into immunological outcomes

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Journal of Chinese Pharmaceutical Sciences 2024年第8期 737-750页

作者： Zainab A Abbood Ahmed Hamza AL-Shammari eman m.Jasim Amjad I.Oraibi Department of Pharmacy Kut University College AL-manara College For medical Science/Department of Pharmacy

To minimize graft rejection, it is crucial to reduce immunosuppression. In the present study, we investigated immunological markers in the blood of transplant patients who did not receive tacrolimus. We also assessed alloreactive CD4+CD25+Fox P3+ Tregs both before transplantation and after tacrolimus reduction. The comparative analysis included 50 individuals experiencing early rejection after tacrolimus discontinuation and 100 non-rejectors. Before reducing tacrolimus, rejectors exhibited elevated levels of memory CD8+ T cells compared to Tregs, while non-rejectors displayed a lower ratio of memory CD4+ T cells to Tregs. Following tacrolimus removal, rejectors showed an increase in na?ve T cells and a decrease in effector T cells. After transplantation, CD4+ Treg levels declined, but their anti-donor regulatory function remained consistent in both rejectors and non-rejectors. Immunological correlation revealed an association between acute rejection after tacrolimus discontinuation and the pre-reduction ratio of memory T cells to regulatory T cells. These indicators identified individuals whose immunosuppression could be safely reduced.

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Non-alcoholic fatty liver disease: The diagnosis and management

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World Journal of Hepatology 2015年第6期7卷 846-858页

作者： Shehab m Abd El-Kader eman m salah El-Den Ashmawy Department of Physical Therapy Faculty of Applied Medical Sciences King Abdulaziz University Department of Physical Therapy for Cardiopulmonary Disorders and Geriatrics Faculty of Physical Therapy Cairo University

Non-alcoholic fatty liver disease(NAFLD) is now the most frequent chronic liver disease that occurs across all age groups and is recognized to occur in 14%-30% of the general population, representing a serious and growing clinical problem due to the growing prevalence of obesity and overweight. Histologically, it resembles alcoholic liver injury but occurs in patients who deny significant alcohol consumption. NAFLD encompasses a spectrum of conditions, ranging from benign hepatocellular steatosisto inflammatory nonalcoholic steatohepatitis, fibrosis, and cirrhosis. The majority of hepatocellular lipids are stored as triglycerides, but other lipid metabolites, such as free fatty acids, cholesterol, and phospholipids, may also be present and play a role in disease progression. NAFLD is associated with obesity and insulin resistance and is considered the hepatic manifestation of the metabolic syndrome, a combination of medical conditions including type 2 diabetes mellitus, hypertension, hyperlipidemia, and visceral adiposity. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies; however, staging the disease requires a liver biopsy. Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and medications appear promising. The aim of this review is to highlight the current information regarding epidemiology, diagnosis, and management of NAFLD as well as new information about pathogenesis, diagnosis and management of this disease.

关键词：非酒精的脂肪肝疾病非酒精的 steatohepatitis 肝疾病

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Optimization of Cooperative Relayingmolecular Communications for Nanomedical Applications

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1259-1275页

作者： eman S.Attia Ashraf A.m.Khalaf Fathi E.Abd El-Samie Saied m.Abd El-atty Konstantinos A.Lizos Osama Alfarraj Heba m.El-Hoseny Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of Electronics and Electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(mCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDS)***,because the mCvD is unreliable and there exists molecular noise and inter symbol interference(ISI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by themodified Central Force Optimization(mCFO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression

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Neural Regeneration Research 2024年第12期19卷 2750-2759页

作者： Fahaid H.A.L-Hashem salah O.Bashir Amal F.Dawood moutasem S.Aboonq Ismaeel Bin-Jaliah Abdulaiziz m.Al-Garni mohamed D.morsy Department of Physiology College of MedicineKing Khalid UniversityAbhaSaudi Arabia Department of Basic medical Sciences College of MedicinePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Physiology College of MedicineTaibah UniversityAl-Madinah Al-MunawwarahSaudi Arabia Department of medicine College of MedicineKing Khalid UniversityAbhaSaudi Arabia

memory loss and dementia are major public health concerns with a substantial economic *** stress has been shown to play a crucial role in the pathophysiology of hippocampal damage-induced memory *** investigate whether the antioxidant and anti-inflammatory compound vanillyla cetone(zingerone) can protect against hippocampal damage and memory loss induced by cadmium chloride(CdCl_(2)) administration in rats,we explo red the potential involvement of the nuclear factor erythroid 2-related factor 2(Nrf2) signaling pathway,which is known to modulate oxidative stress and *** healt hy male Wistar rats were divided into five groups:vehicle-treated(control),vanillylacetone,CdCl_(2),vanillylacetone+ CdCl_(2),vanillylacetone+ CdCl_(2)+ brusatol(a selective pharmacological N rf2inhibitor) *** effectively attenuated CdCl_(2)-induced damage in the dental gyrus of the hippocampus and improved the memory function assessed by the morris Water maze ***,vanillylacetone markedly decreased the hippocampal tissue levels of inflammatory biomarkers(interleukin-6,tumor necrosis factor-α,intracellular cell adhesive molecules) and apoptosis biomarkers(Bax and cleaved caspase-3).The control and CdCl_(2)-treated groups treated with va nillylacetone showed reduced generation of reactive oxygen species,decreased malondialdehyde levels,and increased superoxide dismutase and glutathione activities,along with significant elevation of nuclear Nrf2 mRNA and protein expression in hippocampal *** the protective effects of vanillylacetone we re substantially blocked by the co-administration of brusatol(a selective N rf2 inhibitor).Va nillylacetone mitigated hippocampal damage and memory loss induced by CdCl_(2),at least in part, by activating the nuclear transcription factor ***,vanillylacetone exerted its potent antioxidant and antiinflammatory actions.

关键词： hippocampus neuroprotective Nrf2 gene oxidative stress vanillylacetone

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Responses of Annual Variability of Vegetation NPP to Climate Variables Using Satellite Techniques in Gadarif State, Sudan

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Journal of Geographic Information System 2024年第2期16卷 136-147页

作者： Anwar mohamedelhassan Bo Zhang Abdelrahim E. Jahelnabi eman m. Elhassan Faculty of Geography and Environmental Sciences Northwest Normal University Lanzhou China Faculty of Agriculture University of Khartoum Khartoum Sudan Faculty of Agriculture Omdurman Islamic University Omdurman Sudan

Plants play an essential role in matter and energy transformations and are key messengers in the carbon and energy cycle. Net primary productivity (NPP) reflects the capability of plants to transform solar energy into photosynthesis. It is very sensible for factors affecting on vegetation variability such as climate, soils, plant characteristics and human activities. So, it can be used as an indicator of actual and potential trend of vegetation. In this study we used the actual NPP which was derived from mODIS to assess the response of NPP to climate variables in Gadarif State, from 2000 to 2010. The correlations between NPP and climate variables (temperature and precipitation) are calculated using Pearson’s Correlation Coefficient and ordinary least squares regression. The main results show the following 1) the correlation Coefficient between NPP and mean annual temperature is Somewhat negative for Feshaga, Rahd, Gadarif and Galabat areas and weakly negative in Faw area;2) the correlation Coefficient between NPP and annual total precipitation is weakly negative in Faw, Rahd and Galabat areas and somewhat negative in Galabat and Rahd areas. This study demonstrated that the correlation analysis between NPP and climate variables (precipitation and temperature) gives reliably result of NPP responses to climate variables that is clearly in a very large scale of study area.

关键词： Climate Variables mODIS NPP Climate Change Correlation Coefficient Gadarif State Remote Sensing GIS Applications

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mXene@c-mWCNT Adhesive Silica Nanofiber membranes Enhancing Electromagnetic Interference Shielding and Thermal Insulation Performance in Extreme Environments

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Nano-micro Letters 2024年第10期16卷 82-98页

作者： Ziyuan Han Yutao Niu Xuetao Shi Duo Pan Hu Liu Hua Qiu Weihua Chen Ben Bin Xu Zeinhom mEl-Bahy Hua Hou eman Ramadan Elsharkawy mohammed AAmin Chuntai Liu Zhanhu Guo Key Laboratory of materials Processing and mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002People's Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026People's Republic of China Key Laboratory of multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123People's Republic of China Shaanxi Key Laboratory of macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072People's Republic of China College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001People's Republic of China mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18UK Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt Department of Chemistry Faculty of ScienceNorthern Border UniversityArarSaudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia

A lightweight flexible thermally stable composite is fabricated by com-bining silica nanofiber membranes(SNm)with mXene@c-mWCNT hybrid *** flexible SNm with outstanding thermal insulation are prepared from tetraethyl orthosilicate hydrolysis and condensation by electrospinning and high-temperature calcination;the mXene@c-mWCNT_(x:y)films are prepared by vacuum filtration *** particular,the SNm and mXene@c-mWCNT_(6:4)as one unit layer(SmC_(1))are bonded together with 5 wt%polyvinyl alcohol(PVA)solution,which exhibits low thermal conductivity(0.066 W m^(-1)K^(-1))and good electromagnetic interference(EmI)shielding performance(average EmI SE_(T),37.8 dB).With the increase in func-tional unit layer,the overall thermal insulation performance of the whole composite film(SmC_(x))remains stable,and EmI shielding performance is greatly improved,especially for SmC_(3)with three unit layers,the average EmI SET is as high as 55.4 *** addition,the organic combination of rigid SNm and tough mXene@c-mWCNT_(6:4)makes SmC_(x)exhibit good mechanical tensile ***,SmC_(x)exhibit stable EmI shielding and excellent thermal insulation even in extreme heat and cold ***,this work provides a novel design idea and important reference value for EmI shielding and thermal insulation components used in extreme environmental protection equipment in the future.

关键词： SiO_(2)nanofiber membranes mXene@c-mWCNT Composite film Thermal insulation Electromagnetic interference shielding

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Utilization of Logistical Regression to the modified Sine-Gordon model in the mST Experiment

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Open Journal of modelling and Simulation 2024年第2期12卷 43-58页

作者： Nizar J. Alkhateeb Hameed K. Ebraheem eman m. Al-Otaibi Department of Electronic Engineering Technology College of Technological Studies (CTS) The Public Authority of Applied Education and Training (PAAET) Kuwait City Kuwait

In this paper, a logistical regression statistical analysis (LR) is presented for a set of variables used in experimental measurements in reversed field pinch (RFP) machines, commonly known as “slinky mode” (Sm), observed to travel around the torus in madison Symmetric Torus (mST). The LR analysis is used to utilize the modified Sine-Gordon dynamic equation model to predict with high confidence whether the slinky mode will lock or not lock when compared to the experimentally measured motion of the slinky mode. It is observed that under certain conditions, the slinky mode “locks” at or near the intersection of poloidal and/or toroidal gaps in mST. However, locked mode cease to travel around the torus;while unlocked mode keeps traveling without a change in the energy, making it hard to determine an exact set of conditions to predict locking/unlocking behaviour. The significant key model parameters determined by LR analysis are shown to improve the Sine-Gordon model’s ability to determine the locking/unlocking of magnetohydrodyamic (mHD) modes. The LR analysis of measured variables provides high confidence in anticipating locking versus unlocking of slinky mode proven by relational comparisons between simulations and the experimentally measured motion of the slinky mode in mST.

关键词： madison Symmetric Torus (mST) magnetohydrodyamic (mHD) Sine-Gordon Toroidal Dynamic modelling Reversed Field Pinch (RFP) Logistical Regression

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Prevalence and associated factors of clubfoot in the eastern province of Saudi Arabia: A hospital-based study

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World Journal of Orthopedics 2024年第7期15卷 635-641页

作者： Ammar K Alomran Bandar A Alzahrani Bader S Alanazi mohammed A Alharbi Loay m Bojubara eman m Alyaseen Department of Orthopedic College of MedicineImam Abdulrahman bin Faisal UniversityDammam 34212Saudi Arabia College of medicine Imam Abdulrahman bin Faisal UniversityDammam 34212Saudi Arabia College of medicine Arabian Gulf UniversityManama 329Bahrain

BACKGROUND Clubfoot,or congenital talipes equinovarus,is a widely recognized cause of disability and congenital deformity worldwide,which significantly impacts the quality of *** management of clubfoot requires long-term,multidiscip-linary *** is important to understand how common this condition is in order to assess its impact on the ***,few studies have investigated the prevalence of clubfoot in Saudi *** To determine the prevalence of clubfoot in Saudi Arabia via the patient population at King Fahad University Hospital(KFUH).mETHODS This was a retrospective study conducted at one of the largest hospitals in the country and located in one of the most densely populated of the administrative *** Of the 7792 births between 2015 to 2023 that were included in the analysis,42 patients were diagnosed with clubfoot,resulting in a prevalence of 5.3 per 1000 live births at *** The observed prevalence of clubfoot was significantly higher than both global and local estimates,indicating a substantial burden in the study population.

关键词： Clubfoot Talipes equinovarus Congenital talipes equinovarus Prevalence Saudi Arabia

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