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Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients

World Journal of Hepatology 2017年第9期9卷 469-476页

作者： Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam eman el hadidy Rehab Yousry Ahmed K el Dorry Department of Tropical Medicine Faculty of MedicineAin Shams University Department of Clinical Pathology Faculty of MedicineAin Shams University Department of Radiodiagnosis and Inter-ventional Radiology Faculty of MedicineAin Shams University

AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 *** In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, *** Serum ANXA2 may serve as a biomarker for the early detection of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus Annexin A2 Alpha-fetoprotein Tumor markers

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Optimization of Cooperative RelayingMolecular Communications for Nanomedical Applications

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1259-1275页

作者： eman S.Attia Ashraf A.M.Khalaf Fathi E.Abd el-Samie Saied M.Abd el-atty Konstantinos A.Lizos Osama Alfarraj Heba M.el-Hoseny Department of electrical Engineering Faculty of EngineeringMinia UniversityMinia61111Egypt Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Department of Computer science The Higher Future Institute for Specialized Technological StudiesEl ShoroukEgypt

Recently,nano-systems based on molecular communications via diffusion(MCvD)have been implemented in a variety of nanomedical applications,most notably in targeted drug delivery system(TDDS)***,because the MCvD is unreliable and there exists molecular noise and inter symbol interference(ISI),cooperative nano-relays can acquire the reliability for drug delivery to targeted diseased cells,especially if the separation distance between the nano transmitter and nano receiver is *** this work,we propose an approach for optimizing the performance of the nano system using cooperative molecular communications with a nano relay scheme,while accounting for blood flow effects in terms of drift *** fractions of the molecular drug that should be allocated to the nano transmitter and nano relay positioning are computed using a collaborative optimization problem solved by theModified Central Force Optimization(MCFO)*** the previous work,the probability of bit error is expressed in a closed-form *** is used as an objective function to determine the optimal velocity of the drug molecules and the detection threshold at the nano *** simulation results show that the probability of bit error can be dramatically reduced by optimizing the drift velocity,detection threshold,location of the nano-relay in the proposed nano system,and molecular drug budget.

关键词： Nanomedical system molecular communication cooperative relay optimization

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MXene@c-MWCNT Adhesive Silica Nanofiber Membranes Enhancing electromagnetic Interference Shielding and Thermal Insulation Performance in Extreme Environments

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Nano-Micro Letters 2024年第10期16卷 82-98页

作者： Ziyuan Han Yutao Niu Xuetao Shi Duo Pan Hu Liu Hua Qiu Weihua Chen Ben Bin Xu Zeinhom Mel-Bahy Hua Hou eman Ramadan elsharkawy Mohammed AAmin Chuntai Liu Zhanhu Guo Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002People's Republic of China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026People's Republic of China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123People's Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi'an 710072People's Republic of China College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001People's Republic of China Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18UK Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt Department of Chemistry Faculty of ScienceNorthern Border UniversityArarSaudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia

A lightweight flexible thermally stable composite is fabricated by com-bining silica nanofiber membranes(SNM)with MXene@c-MWCNT hybrid *** flexible SNM with outstanding thermal insulation are prepared from tetraethyl orthosilicate hydrolysis and condensation by electrospinning and high-temperature calcination;the MXene@c-MWCNT_(x:y)films are prepared by vacuum filtration *** particular,the SNM and MXene@c-MWCNT_(6:4)as one unit layer(SMC_(1))are bonded together with 5 wt%polyvinyl alcohol(PVA)solution,which exhibits low thermal conductivity(0.066 W m^(-1)K^(-1))and good electromagnetic interference(EMI)shielding performance(average EMI SE_(T),37.8 dB).With the increase in func-tional unit layer,the overall thermal insulation performance of the whole composite film(SMC_(x))remains stable,and EMI shielding performance is greatly improved,especially for SMC_(3)with three unit layers,the average EMI SET is as high as 55.4 *** addition,the organic combination of rigid SNM and tough MXene@c-MWCNT_(6:4)makes SMC_(x)exhibit good mechanical tensile ***,SMC_(x)exhibit stable EMI shielding and excellent thermal insulation even in extreme heat and cold ***,this work provides a novel design idea and important reference value for EMI shielding and thermal insulation components used in extreme environmental protection equipment in the future.

关键词： SiO_(2)nanofiber membranes MXene@c-MWCNT Composite film Thermal insulation electromagnetic interference shielding

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Erratum to “Plant Defense against Necrotrophic Pathogens” [American Journal of Plant Sciences 11(12) (2020) 2122-2138]

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American Journal of Plant Sciences 2024年第2期15卷 122-138页

作者： Mahmoud H. Ghozlan Nikita Gambhir eman el-Argawy Serkan Tokgöz Dilip K. Lakshman Amitava Mitra University of Nebraska Lincoln NE USA USDA-ARS Beltsville MD USA

The original online version of this article (Ghozlan, M.H., el-Argawy, E., Tokgöz, S., Lakshman, D.K. and Mitra, A. (2020) Plant Defense against Necrotrophic Pathogens. American Journal of Plant Sciences, 11, 2122-2138. https://***/10.4236/ajps.2020.1112149) was published mistakenly without another co-author, Nikita Gambhir. In this regard, we revise authors and “how to cite” sections by adding her name.

关键词： Effectors Host Immunity Signaling P/MAMP ETI Disease Resistance

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Optimal searching for a Helix target motion

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Science China Mathematics 2015年第4期58卷 749-762页

作者： MOHAMED Abd Allah el-hadidy Department of Mathematics Faculty of Science Tanta University

This paper discusses a search problem for a Helix target motion in which any information of the target position is not available to the searchers. There exist three searchers start searching for the target from the origin. The purpose of this paper is to formulate a search model and finds the conditions under which the expected value of the first meeting time between one of the searchers and the target is finite. Also, the existence of the optimal search plan that minimizes the expected value of the first meeting time is shown. Furthermore,this optimal search plan is found. The effectiveness of this method is illustrated by using an example with numerical results.

关键词： Helix motion optimal search plan first meeting time probability measure multiobjective nonlinear programming problem

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Searching for the Random Walking microorganism cells

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International Journal of Biomathematics 2019年第6期12卷 43-54页

作者： Mohamed Abd Allah el-hadidy Hamdy MAbou-Gabalt Mathematics Statistics DepartmentCollege of ScienceTaibah UniversityYanbuKingdom of Saudi Arabia Mathematics Department Faculty of ScienceTanta UniversityTaniaEgypt

In this paper,we present a complex cooperative search technique for finding the Random Walking microorganism cells on one of n-intersect real lines at the *** have 2n unit speed searchers starting together from the ***,proving the existence of a finite search plan,we are discussing the existence of optimality for this search plan which minimizes the expected value of the first meeting time between one of the searchers and the microorganism cells.

关键词： Cooperative search technique one-dimensional Random Walking microor ganism cells optimal search plan.

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Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

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World Journal of Gastroenterology 2012年第18期18卷 2188-2196页

作者： Abeer A Al Masri eman el Eter Department of Physiology College of Medicine and King Khalid University HospitalKing Saud UniversityRiyadh 11461Saudi Arabia

AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) ***:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,*** 15 min prior to gastric ischemia) were *** injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 *** tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and *** endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue *** assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and *** set of experiments was run to study vascular permeability of the stomach using Evan's blue ***:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P el(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced ***-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated *** administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were ***:AGM protects the stomach against I/R injury by reducing vascular permeability and *** protection is possibly mediated by Akt/PI3K.

关键词： Ischemia reperfusion injury Agmatine Wortmannin Vascular permeability Monocyte chemoattractant protein-1 Stomach Vascular endothelial growth factor

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Assessment and management of immature facial scars by non-surgical methods

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Chinese Journal of Plastic and Reconstructive Surgery 2022年第2期4卷 67-73页

作者： Riwina Adel el-Orabi Mohamed Radwan el-hadidy Ahmed Hassan el-Sabbagh Plastic Surgery Center Faculty of MedicineMansoura UniversityMansoura 35516Egypt

Background:Scar quality is affected by patients’wound healing conditions,trauma type,and skin features that differ due to *** tremendous improvements in scar remodeling techniques,conspicuous scars can still remain ***-surgical methods used for handling scars include the use of topical corticosteroids,pressure therapy,lasers,and platelet-rich plasma(PRP).This study aimed to assess and evaluate different non-surgical modalities for treating immature facial ***:Fifteen patients with scars were included for non-surgical *** received one or more of 5 treatments:corticosteroid injection,topical silicone gel application with or without bandage,pressure therapy,lasers,or PRP *** were assessed using the Patient and Observer Scar Assessment Scale(POSAS)and serial ***:There were no significant differences in the results obtained using *** of the patients required a secondary intervention or sought a second *** rate of complications associated with the treatments were very ***:Good assessment of patient characteristics,proper planning,and appropriate treatment lead to favorable outcomes.

关键词： Facial scar Immature scar Non-surgical methods

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Toxoplasma gondii infection can induce retinal DNA damage: an experimental study

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 431-436页

作者： Nagwa Mostafa el-Sayed eman Mohamed Aly Department of Medical Parasitology Research Institute of Ophthalmology Department of Basic Science Biophysics and Laser Science Unit Research Institute of Ophthalmology

AIM:To detect whether Toxoplasma gondii(***)infection of mice can induce retinal DNA ***:A total of 20 laboratory-bred male Swiss albino mice were used and divided into four groups:control group(non-infected animals);*** infected group;immunosuppressed infected group;and infected group treated with sulfadiazine and *** eyes were collected 6wk post infection and retinas were *** retina was immediately processed for comet assay and the frequency of tailed nuclei(DNA damage)was *** addition,retinal DNA damage was revealed by various comet assay parameters that were provided by the image analysis software including tail length,percentage of DNA in the tail,percentage of tailed cells and tail ***:The obtained results showed that *** infection induced a statistically significant increase in the frequency of tailed nuclei,tail length,percentage of DNA in the tail,and tail moment in mice retinal cells compared to the control group(which showed some degree of DNA damage).In immunosuppressed infected group,retinal DNA damage was severing and there was significant increase in various comet assay parameters compared to both control and infected *** treatment with sulfadiazine and pyrimethamine,retinal DNA damage decreased and all comet assay parameters showed a statistical significant decrease compared to infected ***:*** infection can induce DNA damage in mice retinal cells.

关键词： Toxoplasma gondii retinochoroiditis DNA damage comet assay

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Mesenchymal stem cells transplantation attenuates experimentally induced brain injury after neonatal hypoxia by different two routes of administrations

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BIOCelL 2019年第1期43卷 21-28页

作者： Nesrine EBRAHIM eman EHSAN eman Abd el GHANY Dina SABRY Ashraf SHAMAA Histology and Cell Biology Department Faculty of MedicineBenha UniversityBenhaEgypt Pediatrics Department Faculty of MedicineCairo UniversityGizaEgypt Medical Biochemistry and molecular biology Department Faculty of MedicineCairo UniversityGizaEgypt Surgical and Radiology Department Faculty of Veterinary MedicineCairo UniversityGizaEgypt

The neonatal hypoxic-ischemic encephalopathy(HIE)is an important cause of neurological morbidity and mortality in *** therapy is considered a promising method for treating severe neurological disorders such as this *** cells have the capacity for self-renewal and differentiation into certain cell *** present study was aimed to find out the most beneficial route of bone marrow-derived mesenchymal stem cells(BMSCs)administration for the attenuation of experimentally induced HIE in neonatal *** neonatal rats were divided randomly into four *** 1:control *** 2:rats were exposed to bilateral ligation of cephalic *** 3:rats were exposed to bilateral ligation of cephalic arteries and then underwent intravenous(IV)BMSC *** 4:rats were exposed to bilateral ligation of cephalic arteries and then underwent intracerebroventricular(ICV)BMSC *** animals were evaluated by(a)neurobehavioral tests;(b)histopathology,i.e.,histological and immuno-histochemical studies;and(3)gene expression *** BMSC treated groups(3 and 4)showed improvement in neurobehavioral tests,histopathological studies,and gene expression,as compared to non-injected lesioned rats(Group 2)with better improvement in Group 4(ICV injections)than in Group 3(IV injections).

关键词： Cerebral cortex Neonatal hypoxic ischemia Stem cells

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