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Colla.en crosslinking with.ph.toa.tiva.ed ribofla.in in a.va.ced infectious kera.itis with.cornea. melting: Electroph.siologica. Study

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Interna.iona. Journa. of Oph.h.0}mology(English.edition) 2020年第4期13卷 574-579页

作者： eman a.a.a. Mona.a.delka.er a.eera.G.a.delh.1}eed Wa.id M.Ga.fa. Th.1}wa. h.Mokbel Oph.h.0}mology Center Faculty of MedicineMansoura UniversityMansoura PO.35516Egypt

a.M: To a.sess th. effect of ph.toa.tiva.ed ch.omoph.re for kera.itis crosslinking(Pa.K-CXL) in ca.e of severe kera.itis with.melting on th. electroph.siologica. function of th. retina.a.d th. optic ***: Th. study included 32 eyes of 32 pa.ients with.smea. positive severe infectious kera.itis with.cornea. melting. Th. pa.ients were ra.domly divided into two groups. Group I(control group) included 16 eyes received systemic a.d topica. a.timicrobia. drugs gua.ded by culture a.d sensitivity test. Group II underwent CXL a.d th.n continued th.ir a.timicrobia. trea.ment. Full field electroretinogra.(ERG) a.d fla.h.visua. evoked potentia.(VEP) were done for ea.h.pa.ient in both.groups ba.ica.ly a.d th.n 1 wk, 1 a.d 3 mo post-trea.ment to a.sess th. ch.0}ges in th. electroph.siologica. function of th. retina.a.d optic ***: h.a.ing of 10 eyes in group I in compa.ison to 14 eyes in group II wa. recorded. Th. mea. dura.ion of h.a.ing wa. 36.56±5.21 d in group I vs 20.2±4.4 d in group II(Ph.wed a. insignifica.t reduction of a.l pa.a.eters of ERG a.d VEP a.ter CXL. Th. a.plitude of scotopic rod response, oscilla.ory potentia. a.plitude, flicker a.plitude a.d ph.topic cone response were insignifica.tly decrea.ed(P=0.4, 0.8, 0.1, a.d 0.3 respectively). Th.re were insignifica.t prolonga.ion of la.encies of scotopic rod, oscilla.ory potentia., flicker a.d ph.topic cone response(P=0.2, 0.7, 0.5 a.d 0.1). Th.re wa. sligh. dela. in la.ency of VEP with.ut a.significa.t reduction in ***: CXL is a. effective tech.ique in trea.ment of severe infectious kera.itis with.melting a. it h.0}ts th. melting process with.a.cepta.le sa.ety on th. retina. a.d optic nerve function.

关键词： ph.toa.tiva.ed ch.omoph.re for kera.itis crosslinking infectious kera.itis cornea. melting electroretinogra. fla.h visua. evoked potentia.

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Development of Generic Drug Products by Ph.0}ma.eutica. Industries Considering Regula.ory a.pects: a.Review

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Journa. of Biosciences a.d Medicines 2021年第10期9卷 23-39页

作者： Md. Imtia. hasan Sh.0}na. a.ter Sh.mu a.h. a.th.r Ish.a. Ja.a. Md. h.0}iduzza.a. a. h. M. Na.mul hasan Depa.tment of Ph.0}ma.y University of Asia Pacific Dhaka Bangladesh Rena.a.Limited Dhaka Bangladesh

Development of generic drug product by ph.0}ma.eutica. industry is a.scientific a.d tech.ica. a.proa.h.wh.ch.is tota.ly different from developing a.reference or innova.or product. Most of th. developing countries focus on developing th. generic drug products beca.se h.ge a.ount of investment is required for innova.ion a.d to develop reference product. Th. generic medicine h.0} to be bioequiva.ent to th. innova.or drug a.d ensure th. sa.e biologica. effect with.proper sa.ety a.d effica.y. Nowa.a.s, th. ph.0}ma.eutica. industries focus on th. development of generic product a. th.s does not require th.0} much.time a.d cost compa.ed to th. innova.or compa.y. But development of generic product is a.so difficult a. it conta.ns th. sa.e th.ra.eutic effica.y a. innova.or. Th. development a.proa.h.is ba.ed on th. ta.get ma.ket, i.e. US ma.ket, EU ma.ket. If a.ma.ufa.turer ta.gets th. US ma.ket, th.n a.l excipients sh.uld be USP gra.e, a.a.ysis sh.uld be conducted by USP meth.d or in-h.use meth.d a.d sta.ility studies a. well. Prior a.d during th. development of generic drug product a.I selection, dosa.e form selection, reference product selection a.d ch.0}a.teriza.ion, formula.ion development, a.a.ytica. meth.d development, tech.tra.sfer or submission ba.ch.a.e prime concern. Th.n a.a.n, bioequiva.ence study, drug registra.ion procedure a.d commercia.iza.ion of th. generic product considering regula.ory guida.ce of respective regula.ory a.encies a.d th. a.proa.h.s ta.en by th. regula.ory a.encies for th. development of registra.ion of generic medicines a.e a.so crucia. a. well for th. development of generic drug product. Th. a.m of th.s study wa. to review th. entire sta.e of a.generic drug development by a.generic ph.0}ma.eutica. compa.y.

关键词： Generic Drug Reference Product Pre-Formula.ion NDA

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a.socia.ion between th. Presence of Seruma.ti-Ca.diolipin a.tibodies a.d Infertility

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Journa. of Biosciences a.d Medicines 2016年第1期4卷 95-100页

作者： a.dul-Ra.a. Sh. hasan a.ma. h. h.a.d Za.na. h. Ma.dy Depa.tment of Microbiology College of Medicine Diyala University Diyala Iraq Depa.tment of Biology College of Education for Pure Science Diyala University Diyala Iraq

Ba.kground: Infertility is a.common problem a.fecting 15% - 20% of couples. Th. increa.ed incidence of a.tica.diolipin (a.L) a.tibodies in infertile women supports th. contention th.0} th.se a.toa.tibodies contribute to th. infertility. Objectives: To investiga.e wh.th.r th.re is a. a.socia.ion between th. presence of serum a.L a.tibodies a.d infertility in both.men a.d women in Diya.a.province. Subjects a.d meth.ds: Th. present study wa. conducted in Ba.uba.city for th. period from October 2013 to November 2014. Subjects included in th.s study were ch.sen from th.se a.tending Ba.uba.Tea.h.ng h.spita., a.-Ba.ool Tea.h.ng h.spita. for Ma.ernity a.d Ch.ldren a.d some Prima.y h.a.th.Ca.e Centers in Ba.uba. Th. subjects were ca.egorized a. follows: 30 a.pa.ently h.a.th. ma.es with.a.e ra.ged between (18 - 45) yea.s;30 a.pa.ently h.a.th. women (a.e ra.ge: 18 - 47 yea.s) h.0} a. lea.t two live birth. with.ut a.y misca.ria.es;25 women (a.e ra.ge: 18 - 43 yea.s) h.0} reproductive fa.lure for a. lea.t one yea. of ma.ria.e;30 women (a.e ra.ge: 24 - 44 yea.s) with.a. lea.t one live birth.h.0} no pregna.cy for a. lea.t two yea.s a.ter la.t ch.ld;40 ma.es with.prima.y infertility (no ch.ldren a.ter a. lea.t five yea.s of ma.ria.e a.d th.ir a.tive sperm count wa. zero). Detection of a.ti-a.L IgG a.d IgM wa. done using enzyme-linked immunosorba.t a.sa. (ELISa. commercia. kits (Wendell/Sh.lm/Germa.y). a.l da.a.were sta.istica.ly a.a.yzed. Results: Th. results revea.ed th.0} th. a.ti-a.L IgM positivity ra.e wa. significa.tly h.gh.r a.ong women with.prima.y fertility compa.ed to h.a.th. women (p = 0.006). Simila.ly, th. a.ti-a.L IgM a.d a.ti-a.L IgG were significa.tly a.ong women with.seconda.y infertility compa.ed to h.a.th. women (p = 0.012) a.d (p = 0.038) respectively. a.th.ugh.th. a.ti-a.L IgG a.d IgM positivity ra.e a.ong men with.prima.y infertility wa. h.gh.r th.0} th.0} of h.a.th. control. h.wever, th. differences were fa.led to rea.h.th. sta.istica. significa.ce (p = 0.07) a.d (p

关键词： a.tica.diolipin a.tibodies Prima.y Infertility Seconda.y Infertility

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a.Netnogra.h.c-Ba.ed Semantic a.a.ysis of Tweet Contents for Stress Ma.a.ement

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Computers, Ma.eria.s & Continua 2022年第1期70卷 1845-1856页

作者： Ja.i Jussila.eman a.kh.0}ma.h.Nora. Sa.eh.a.gh.0}di Pra.h.0}th.Ma.h.0}a.Moh.0}ma. a.oub Kh.0} h.0}K Sma.t Resea.ch.Unit Häme University of Applied SciencesHämeenlinna13100Finland Depa.tment of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia College of Computer a.d Informa.ion Sciences Princess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Fa.ulty of Ma.a.ement a.d Business Tampere UniversityTampere33720Finland College of Computing a.d Informa.ion Tech.ologies University of BishaBisha67714Saudi Arabia

Socia. media.pla.forms provide new va.ue for ma.kets a.d resea.ch.*** a.ticle explores th. use of socia. media.da.a.to enh.0}ce customer va.ue *** ca.e study involves a.compa.y th.0} develops wea.a.le Internet of Th.ngs(IoT)devices a.d services for stress *** a.d semantic a.nota.ion for recognizing a.d ca.egorizing th. context of tweets a.e conducted to ga.n a.better understa.ding of users’stress ma.a.ement *** a.m is to a.a.yze th. tweets a.out stress ma.a.ement pra.tices a.d to identify th. context from th. ***,we ma. th. tweets on plea.ure a.d a.ousa. to elicit customer *** a.a.yzed a.ca.e study of a.ma.keting stra.egy on th. Twitter *** in th. ma.keting ca.pa.gn sh.0}ed ph.tos a.d texts a.out th.ir stress ma.a.ement *** lea.ning tech.iques were used to eva.ua.e a.d estima.e th. emotions a.d contexts of th. tweets posted by th. ca.pa.gn *** computa.iona. semantic a.a.ysis of th. tweets wa. compa.ed to th. text a.a.ysis of th. *** content a.a.ysis of only tweet ima.es resulted in 96%a.cura.y in detecting tweet context,wh.le th.0} of th. textua. content of tweets yielded a. a.cura.y of 91%.Semantic ta.ging by Ontotext wa. a.le to detect correct tweet context with.a. a.cura.y of 50%.

关键词： Socia. media stress semantic a.a.ysis Twitter context recognition

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a.Va.ida.ed h.gh.Performa.ce Th.n-La.er Ch.oma.ogra.h. (h.tlc) Meth.d for th. Qua.tita.ive Determina.ion of Tricin in Two <i>Spergula.ia.lt;/i>Species

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a.erica. Journa. of a.a.ytica. Ch.mistry 2013年第11期4卷 668-673页

作者： Omnia.Ga.a. El-Dien eman Sh.0}ky a.a. h. a.y Rokia.M. a.da.la. Na.il a. a.del-Sa.a. Ph.0}ma.ognosy Depa.tment Faculty of Pharmacy University of Alexandria Alexandria Egypt

a.simple, sensitive, precise a.d robust h.gh.performa.ce th.n-la.er ch.oma.ogra.h.c (h.TLC) meth.d for a.a.ysis of tricin h.0} been developed a.d va.ida.ed for th. determina.ion of tricin in genus Spergula.ia. a.a.ysis of tricin wa. performed on pre-coa.ed TLC a.uminum pla.es with.silica.gel a. th. sta.iona.y ph.0}e. Linea. a.cending development wa. ca.ried out in double twin trough.gla.s ch.0}ber sa.ura.ed with.a.mobile ph.0}e consisting of ch.oroform: meth.0}ol (37:3 v/v). Spectro-densitometric sca.ning wa. performed by TLC sca.ner III (Ca.a.) in a.sorba.ce mode a. th. wa.elength.of 270 nm. Th. system wa. found to give compa.t spots for tricin (Rf va.ue of 0.34 ± 0.04). Th. linea. regression a.a.ysis da.a.for th. ca.ibra.ion plots sh.wed a.good linea. rela.ionsh.p with.r2 = 0.9981 in th. concentra.ion ra.ge 2-15 μl with.respect to pea. a.ea. a.cording to th. Interna.iona. Conference on h.0}moniza.ion (ICh. guidelines, th. meth.d wa. va.ida.ed for precision, recovery, a.d robustness. Th. tricin content qua.tified from Spergula.ia.ma.ina.a.d S. da.a.dra.wa. found to be 0.398 mg/100g a.d 1.642 mg/100g fresh.weigh., respectively. Sta.istica. a.a.ysis of th. da.a.sh.wed th.0} th. meth.d is reproducible a.d selective for th. estima.ion of tricin.

关键词： Spergula.ia ma.ina Spergula.ia dia.dra h.TLC Qua.tita.ive Tricin

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Insulin Resista.ce, Viscera. a.iposity Index a.d TyG Index in Genotype-4 Ch.onic h.V Pa.ients a.d Th.ir Rela.ion to h.pa.ic h.stopa.h.logy

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Open Journa. of Ga.troenterology 2016年第10期6卷 249-264页

作者： eman a. Sa.et a.ma. N. Moh.1}ma. La.la.M. Yousef a.med R. h. a.med a.eer Sh.neef Depa.tment of Interna. Medicine Faculty of Medicine Sohag University Sohag Egypt Depa.tment of Tropica. Medicine a.d Ga.troenterology Faculty of Medicine Sohag University Sohag Egypt Depa.tment of Clinica. Pa.h.logy Faculty of Medicine Sohag University Sohag Egypt Depa.tment of Pa.h.logy Faculty of Medicine Sohag University Sohag Egypt Depa.tment of Medica. Microbiology a.d Immunology Faculty of Medicine Sohag University Sohag Egypt

Introduction: h.pa.itis C virus (h.V) genotype 4 is th. most preva.ent in Egypt. Vis-cera. a.iposity index (Va.) a.d (TyG) index a.e newly developed indices for a.sess-ment of meta.olic syndrome (MS) a.d insulin resista.ce (IR). We a.med a. compa.ing th.ir levels in h.V-pa.ients with.h.a.th. controls a.d va.ida.e th.ir use for prediction of h.pa.ic h.stopa.h.logica. ch.0}ges. Pa.ient a.d Meth.ds: 78 ch.onic h.V-infected pa.ients proven by PCR, vira. genotyping a.d h.pa.ic h.stopa.h.logy, a.d 67 h.a.th. controls were enrolled. Presence of MS, h.meosta.is Model a.sessment for IR esti-ma.ion (h.Ma.IR), TyG index, a.d Va. were a.sessed. Results: h.Ma.IR, TyG a.d frequency of MS were significa.tly h.gh.r in pa.ients’ group (p p p = 0.002). Conclusion: h.V genotype 4 is significa.tly a.socia.ed with.MS a.d increa.ed va.ues of h.Ma.IR a.d TyG index. TyG index a.d Va. a.e va.ua.le simple indices th.0} could predict th. h.stopa.h.logica. ch.0}ges in Egyptia. Ch. pa.tients.

关键词： h.V IR TyG Va. Stea.osis Genotype 4

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Eva.ua.ion of th. h.pa.oprotective a.d a.tioxida.t effects of Tegilla.ca.gra.osa.flesh.body extra.t a.a.nst pota.sium bromide toxicity via.ta.geting th. h.stomorph.metry,ch.omosoma. a.d expressions of TGF-β1,VEGF a.d COX-2 genes in ra.s

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BIOCELL 2022年第1期46卷 219-234页

作者： a.I h.a.U a.Ma.TY Ba.Ma.M.h.NDa. Fa.EZ a.Th.Ba.TI eman Fa.a. Ya.MIN M.a.D EL-a.IZ Depa.tment of Zoology Faculty of SciencePort Said UniversityPort Said42526Egypt Depa.tment of h.sba.dry a.d Development of a.ima. Wea.th Faculty of Veterinary MedicineMansoura UniversityMansoura35516Egypt Depa.tment of Biotech.ology Faculty of ScienceTaif UniversityTaif21944Saudi Arabia

Th. h.pa.otoxic effect of pota.sium bromide(KBr)on ra. liver tissues were determined,a. well a. th. potentia. protective effect of Tegilla.a.a.gra.osa.***)flesh.body *** a.ult ma.e a.bino ra.s were equa.ly distributed into four groups;Group(I)trea.ed with.ph.siologica. sa.ine(control group),Group(II)wa. ora.ly ga.a.ed by 200 mg/kg of *** body extra.t da. a.ter da.,Group(III)wa. intoxica.ed by KBr(150 mg/kg bwt da. a.ter da. ora.ly)a.d fina.ly,Group(IV)wa. given a.combina.ion of *** flesh.body extra.t plus KBr with.simila. doses in th. second a.d th.rd *** th. end of one month.blood,liver tissue a.d bone ma.row sa.ples were collected to be used for th. required la.ora.ory *** response to KBr toxicity,th.re wa. a.significa.t increa.e in serum a.tioxida.t bioma.kers,wh.ch.wa. a.compa.ied by a.significa.t ch.0}ge in h.pa.ocyte ultra.tructure a.d a.significa.t ch.0}ge in ca.boh.dra.e a.d protein levels with.n th. liver *** a.dition,KBr intoxica.ion resulted in a.substa.tia. increa.e in th. incidence of ch.omosoma. a.erra.ions such.a. h.les,splits,deletions,fra.ments,ploidy,a.d ring ch.omosomes,a. well a. significa.t upregula.ion of TGF-1,VEGF,a.d COX-2 gene *** h.pa.otoxic effect of KBr wa. countera.ted by trea.ment with.*** flesh.body *** flesh.body extra.t h.0} a.cura.ive a.tioxida.t a.d numerous protective effects a.a.nst KBr h.pa.otoxicity.

关键词： Pota.sium bromide Tegilla.ca.gra.osa h.pa.ic toxicity a.tioxida.t bioma.ker h.stomorph.metry Ch.omosoma. a.erra.ions Gene expression

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Protection Coordina.ion Optimiza.ion for FREEDM （Future Renewa.le Electric Energy Delivery a.d Ma.a.ement） System

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Journa. of Electrica. Engineering 2018年第3期6卷 161-176页

作者： Moh.0}ed F. Kotb Ma.di El-Sa.da.i eman h. El-Desouky Depa.tment of Electrica. Engineering Faculty of Engineering Mansoura University Mansoura 35516 Egypt North.Delta.Electricity Distribution Co. Mansoura 35511 Egypt

Th. FREEDM （future renewa.le electric energy delivery a.d ma.a.ement） system is a.sma.t distribution system th.0} fa.ilita.es sea.less integra.ion of h.gh.penetra.ion DRER （distributed renewa.le energy resources） a.d DESD （distributed energy stora.e devices） with.th. existing distribution system. Protection sch.mes h.0}e been proposed to detect th. overcurrent fa.lts th.ough.ut th. FREEDM system, a.cording to its requirements. In th.s pa.er th. time inverse directiona. over current protection coordina.ion sch.me is developed a. a.ba.kup protection wh.n th. prima.y protection communica.ion fa.led. Th. proposed sch.me is a.plied to FREEDM network using conventiona. ma.h.ma.ica. model. To speed up th. fa.lt clea.ing time with.ut coordina.ion loss, th. settings of th. proposed rela.s in th. two directions a.e minimized using genetic a.gorith.. Th. developed meth.ds a.e va.ida.ed using ETa. softwa.e. Th. results ensure th.0} th. fa.lts th.ough.ut th. FREEDM system sections a.e detected a.d th. rela.s tripping time a.e minimized.

关键词： FREEDM protection coordina.ion genetic a.gorith. ETa. softwa.e.

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Qua.tita.ive Gene Expression of Peroxida.e, Polyph.noloxida.e a.d Ca.a.a.e a. Molecula. Ma.kers for Resista.ce a.a.nst Ra.stonia.sola.a.ea.um

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a.erica. Journa. of Molecula. Biology 2016年第2期6卷 88-100页

作者： eman El-a.ga.y Ibra.im a. a.ss Pla.t Pa.h.logy Depa.tment Faculty of Agriculture Damanhour University Damanhour Egypt Division of Genetics Faculty of Agriculture Damanhour University Damanhour Egypt

Brown rot or ba.teria. wilt of pota.o ca.sed by Ra.stonia.sola.a.ea.um, is a. economica.ly importa.t disea.e. Pota.o, cv. Nicola. wa. found to be rela.ively h.gh.y resista.t to th. infection with.R. sola.a.ea.um a.d sh.wed 15.12% wilt disea.e index, mea.time, cv. Ka.a.sh.wed intermedia.e resista.ce with.37.40% disea.e index wh.le, cv. Spunta.wa. susceptible a.d sh.wed 80.33% disea.e index. Th. role of defense-rela.ed enzymes in impa.ting resista.ce in pota.o a.a.nst R. sola.a.ea.um wa. investiga.ed by qua.tifying enzymes a.tivity a.d gene expression of th.ee defense- rela.ed enzymes, peroxida.e, polyph.nol oxida.e a.d ca.a.a.e. Peroxida.e sh.wed ma.imum a.tivity 0.488 min-1·g-1 ea.ly a. 12 h.a.ter pa.h.gen inocula.ion in th. cv. Nicola. wh.rea. in susceptible cultiva. Spunta.sh.wed lower a.tivity of ma.imum 0.226 min-1·g-1 la.er a. 48 h.a.ter inocula.ion. Wh.le, th. modera.ely resista.t cultiva. Ka.a.sh.wed intermedia.e a.tivity for th. pea. a.d its time. Mea.wh.le, polyph.nol oxida.e sh.wed simila. trends to th.0} of peroxida.e. On th. contra.y, ca.a.a.e sh.wed th. h.gh.st a.tivity va.ues in th. susceptible, cv. Spunta. wh.le, in rela.ively h.gh.y resista.t (cv. Nicola. a.d th. modera.ely resista.t (cv. Ka.a. sh.wed lower va.ues of a.tivity a.d up to 96 h.a.ter inocula.ion. Mea.wh.le, gene expression of rela.ed enzymes th. RT-PCR wa. used. a. zero time, th. rela.ively h.gh.y resista.t pota.o cultiva., Nicola. sh.wed th. h.gh.st va.ues of gene expression for both.Peroxida.e (POD) a.d Poly Ph.nol Oxida.e (PPO). Wh.le, th. susceptible pota.o cultiva., Spunta.sh.wed th. lowest va.ues. On th. contra.y, Ca.a.a.e (Ca.) gene expression wa. th. h.gh.st in th. susceptible, cv. Spunta. a.d wa. th. lowest in th. rela.ively h.gh.y resista.t, cv. Nicola. wh.le, wa. of intermedia.e va.ues in th. intermedia.e resista.ce, cv. Ka.a. Results sh.w th.0} peroxida.e a.d polyph.nol oxida.e a.tivities ca. be used a. bioch.mica. ma.kers

关键词： RT-PCR Defense Rela.ed Enzymes Gene Expression Pota.o Brown Rot Ra.stonia.sola.a.ea.um

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Wind Energy a.sessment of th. Za.iya.Region, in North.est Libya

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Energy a.d Power Engineering 2017年第6期9卷 325-331页

作者： Sa.h.0} h. a.wa. hasan a.dulmunim Guwa.der Wenzh.ng Ga. Electrica. a.d Computer Engineering University of Denver Colorado USA Electrica. a.d Computer Engineering Oklahoma State University Oklahoma USA

Th. objective of th.s pa.er is to eva.ua.e th. a.nua., month.y a.d th. sea.ona. performa.ce of th. wind resource a. th. Za.iya.region in north.est of Libya. In th.s study, th. wind da.a.a.e obta.ned from th. coa.ta. site loca.ed in th. north.est of Libya.a. h.igh. of 50 meters a.ove th. ground level. Th. results sh.w th.0} th. a.nua. a.era.e speed is 6.14 m/s, a.d th. a.nua. Weibull pa.a.eters a.e sh.0}e fa.tor K = 3.2, sca.e fa.tor C = 6.9 m/s, a.d th. a.nua. energy production of 750 kw wind turbine is 2.70 Gwh.yea..

关键词： Za.iya Region Libya Weibull La.itude

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