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Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?

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World Journal of Gastroenterology 2014年第5期20卷 1192-1210页

作者： Georgina L Hold megan Smith Charlie Grange Euan Robert Watt emad m el-omar Indrani mukhopadhya Gastro-intestinal Research Group Division of Applied Medicine University of Aberdeen Foresterhill

Our understanding of the microbial involvement in inflammatory bowel disease (IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn’s disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or “dysbiosis” is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity (including polymorphisms in genes involved in autophagy: ATG16L1 and IGRm), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Gut microbiota, Innate immune response, Probiotics, Prebiotics, Faecal transplant

Depositional Environment,Petrophysical Evaluation and electrical Properties of Zeit Formation,Northwestern Shore of Gulf of Suez,Egypt

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Journal of Earth Science 2024年第5期35卷 1720-1737页

作者： mohamed m.Gomaa emad A.Abd el Aziz Geophysical Sciences Department National Research CentreEl-Behoos St.DokkiCairo 12622Egypt

The Zeit sand reservoir is one of the most prolific formations at Northwestern side of the Gulf of *** this research we will try to coordinate between electrical,petrophysical properties,depositional environment and facies discrimination in order to evaluate the hydrocarbon potentiality of studied Zeit *** statistical parameters for potassium(K),thorium(Th)and Th/U ratio contents have a general increase towards northwestern parts,whereas uranium(U)content has a general increase towards southeastern *** sandstone facies is distinguished from the other facies by its thorium content>4 ppm.U has high carbonate content(U≥1 ppm).Rocks'electrical properties vary greatly depending on a number of *** measurements were taken at frequencies range of(5×10^(-4)Hz-100 kHz)for fully saturated samples(clayey sandstone)with NaCl(20 gm/L).As salinity,clay content,and frequency increase,consequently does the electrical *** continental condition are present in northwestern part(back-sea)which is distinguished by high K percent,high Th,high Th/U ratio,and low U *** K,Th,and Th/U ratio contents,with high U contents,characterize the marine depositional environment that existed around the east and southeastern parts(foresea coincide with the dipping of strata).Furthermore,the studied Zeit Formation has good petrophysical properties that coincide with marine *** middle and eastern parts(around ISS-94 and CSS-288)is a good reservoir(porosity 36%-39%,shale content<15%,hydrocarbon saturation 71%-92%,and net pay thickness 17-63 feet).

关键词： Zeit Formation petrophysical evaluation depositional environment Spectral Gamma Ray electrical properties gulf of Suez sedimentology

Critical assessment of R410A alternatives for mini-split air conditioners in the Egyptian market

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Energy and Built Environment 2024年第3期5卷 426-445页

作者： omar m.Zaki omar Abdelaziz mechanical Power Engineering Department Faculty of EngineeringCairo UniversityGiza 12613Egypt Department of mechanical Engineering The American University in CairoAUC AvenueNew Cairo 11835Egypt

In this study,the potential implementation of three different low-GWP refrigerants(R32,R452B,and R454B)as replacements for R410A was *** study was performed using a simulation tool developed by the authors called RACHP-Lab,which is a vapor compression system simulation tool developed based on physics-based simulation for typical mini-split air *** simulation study was carried out and validated using experimental performance data of 10 different air conditioning units available in the Egyptian *** units included fixed-speed or variable-speed compressors and operated in cooling or heating ***-in replace-ment with the new refrigerants was carried *** R32,the capacity increased between 4.9%and 13%for cooling cases,and 6.3%and 12.4%for heating ***,COP did not improve in all *** R452B and R454B with direct replacement,the capacity nearly remained the same,with an increase of COP between 1.6%and 8.0%.Soft optimization was also conducted on cooling cases where compressor suction superheat,condenser subcooling,and compressor volumetric speed were optimized to maximize COP while maintaining the original capacity of R410A.R32 showed an improvement of COP over R410A between 4.6%and 15.5%,while for R452B and R454B between 2.2%and 13.2%.

关键词： Air conditioner Heat pump Alternative refrigerants Vapor compression cycle modeling

Large magnetocaloric effect and magnetic properties of EuRhO3

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Journal of Rare Earths 2024年第9期42卷 1724-1729页

作者： m.Lassri m.Sajieddine A.elouafi A.el Hachmi S.el Ouahbi R.moubah Laboratory of Energy and materials Engineering (LGEm) University of Sultan Moulay SlimaneFaculty of Science and Technology (FST) Institute of Applied Physics (IAP)-School of Industrial management (EmINES) Mohammed Ⅵ Polytechnic University National School of Applied Sciences (ENSA) University of Sultan Moulay Slimane Laboratory of mechanics Production and Industrial Engineering (LMPGI)Higher School of Technology of Casablanca (ESTC)University of Hassan Ⅱ Casablanca Laboratory of Radiation on matter and Instrumentation (LRmI) Faculty of Science and Technology (FST) SettatHassan Ⅰ University Laboatory of Physics of Advanced materials and Thermic (LPmAT) Faculty of Science Ain Chock (FSAC)University of Hassan Ⅱ Casablanca

We report on the structural,magnetic,and magnetocaloric properties of *** oxidation states of Eu and Rh ions were studied using X-ray photoelectron spectroscopy（XPS）.It is found that the Eu ions are mainly in the divalent oxidation state while the Rh ions have+4 ***3powders are found to be antiferromagnetic with a second order magnetic transition at Neel temperature（TN=2.9 K）.Analysis of the magnetic susceptibility versus temperature data in terms of the Curie=Weiss law:(χ=C/（T-θW）) for T>TN,yields θW=-3.1 K and effective magne tic moment ■,which is close to the theoretical value ■.The magnetic entropy change(-ΔSm),was determined by em ploying the thermodynam ic maxwell's *** μ0H=5 T and near TN,■ and relative cooling power（RCP） exhibit large values of 33.7 J/（kg·K） and 238 J/kg,*** large magnitude of-ΔSmand RCP show that the EuRhO3compound could be a potential candidate to be used in cryogenic magnetic refrigeration.

关键词： Cryogenic magnetic refrigeration magnetic properties magnetocaloric effect Rare earths X-ray photoelectron spectroscopy

Existence results and behavior analysis for nonlinear age-dependent population dynamics problems with conformable fractional operator

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International Journal of Biomathematics 2024年第5期17卷 229-256页

作者： Hiba el Asraoui m'hamed el omari Ali el mfadel Khalid Hilal Laboratory of Applied mathematics Scientific Computing Sultan moulay Slimane University BP 523 Beni MellalMorocco

In this paper,we investigate the existence of solutions and analyze the large-time behavior for Gurtin-maccamy population model involving conformable fractional *** a preliminary step,we construct a generic structure of the solution associated with our proposed model by utilizing some basic properties and tools of conformable fractional *** establish the existence of a unique solution of the given model with the given initial *** last,by using the upper and lower solutions for the characteristic equation,we define the upper and lower boundaries for the obtained solution and describe the large-time behavior of the total population.

关键词： Age-dependent population conformable fractional operator upper and lower boundary of the solution dynamics of populations

Stability analysis and soliton solutions of the(1+1)-dimensional nonlinear chiral Schrodinger equation in nuclear physics

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Communications in Theoretical Physics 2024年第9期76卷 1-15页

作者： Fazal Badshah Kalim U Tariq Ahmet Bekir S m Raza Kazmi emad Az-Zo'bi School of electrical and Information Engineering Hubei University of Automotive TechnologyShiyan 442002China Department of mathematics Mirpur University of Science and TechnologyMirpur-10250(AJK)Pakistan Neighbourhood of Akcaglan Imarli StreetNumber:28/426030EskisehirTurkey Department of mathematics and Statistics Faculty of ScienceMutah UniversityAlKarak 61710Jordan

The nonlinear Schrodinger equation equation is one of the most important physical models used in optical fiber theory to explain the transmission of an optical *** field of chiral soliton propagation in nuclear physics is very interesting because of its numerous applications in communications and ultra-fast signal routing ***(1+1)-dimensional chiral dynamical structure that describes the soliton behaviour in data transmission is dealt with in this work using a variety of in-depth analytical *** work has applications in particle physics,ionised science,nuclear physics,optics,and other applied mathematical *** are able to develop a variety of solutions to demonstrate the behaviour of solitary wave structures,periodic soliton solutions,chiral soliton solutions,and bell-shaped soliton solutions with the use of applied ***,in order to verify the scientific calculations,the stability analysis for the observed solutions of the governing model is taken into *** addition,the3-dimensional,contour,and 2-dimensional visuals are supplied for a better understanding of the behaviour of the *** employed strategies are dependable,uncomplicated,and effective;yet have not been utilised with the governing model in the literature that is now *** resulting outcomes have impressive applications across a large number of study areas and computational physics phenomena representing real-world *** methods applied in this model are not utilized on the given models in previous literature so we can say that these describe the novelty of the work.

关键词： solitons the nonlinear Schrodinger equation stability analysis chiral solitons exact solutions

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： David Ahmad Haidar David mintz Brandon m Wubben omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

The Upper Jurassic sediments,marib-Shabwa Basin,Yemen:Lithofacies aspects and sequence stratigraphic analysis

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Energy Geoscience 2024年第1期5卷 342-357页

作者： mohammed Albaroot mohamed m.elhossainy Nabil m.Al-Areeq emad A.Abdullah Abdelhamid m.Salman Department of Applied Geology Faculty of Science and EducationUniversity of Saba RegionMaribYemen Department of Geology Faculty of ScienceKafrelsheikh UniversityKafrelsheikh33516Egypt Department of Geology and Environment Faculty of Applied SciencesThamar UniversityYemen Department of mineral Developing and Oil&Gas Engineering Academy of EngineeringPeoples’Friendship University of Russia(RUDN University)Moscow117198Russia Department of Geology Faculty of ScienceAssiut UniversityAssiut71516Egypt

The present study is devoted to understanding the evolution of the Upper Jurassic Sab'atayn Formation in the marib-Shabwa Basin,Yemen,through a sequence stratigraphic analysis based on integrating datasets of sedimentology,seismic sections,and well *** Sab'atayn Formation(Tithonian age)is represented by a series of clastic and evaporites that were deposited under fluvio-deltaic to prodeltaic *** is divided into four members including Yah(at the base),upwards to Seen,Alif,and Safir at the *** third-order depositional sequences were determined for the Tithonian succession which were separated by three sequence *** sequences were classified into their systems tracts signifying several sedimentation patterns of progradational,aggradational,and retrogradational parasequence *** first depositional sequence corresponds to the early-middle Tithonian Yah and Seen units that can be classified into lowstand,transgressive,and highstand systems *** second sequence comprises the late Tithonian Alif unit that can be subdivided into transgressive and highstand systems *** sandy deposits of the Alif member(highstand deposits)represent the most productive hydrocarbon reservoir in the *** Upper Jurassic sediments in the study area were resulted from a combination of eustatic and tectonic effects.

关键词： Sequence stratigraphy Sandstone reservoir Well logs Upper Jurassic marib-Shabwa Basin Yemen

Exact solutions for magnetohydrodynamic nanofluids flow and heat transfer over a permeable axisymmetric radially stretching/shrinking sheet

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Chinese Physics B 2024年第2期33卷 108-114页

作者： U.S.mahabaleshwar G.P.Vanitha L.m.Pérez emad H.Aly I.Pop Department of Studies in mathematics Davangere UniversityShivagangothriDavangereIndia Departamento de F´ısica FACIUniversidad de Tarapac´aCasilla 7DAricaChile Department of mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt Department of mathematics Babes-Bolyai University400084 Cluj-NapocaRomania

We report on the magnetohydrodynamic impact on the axisymmetric flow of Al_(2)O_(3)/Cu nanoparticles suspended in H_(2)O past a stretched/shrinked *** the use of partial differential equations and the corresponding thermophysical characteristics of nanoparticles,the physical flow process is *** resultant nonlinear system of partial differential equations is converted into a system of ordinary differential equations using the suitable similarity *** transformed differential equations are solved *** of the magnetic parameter,solid volume fraction and stretching/shrinking parameter on momentum and temperature distribution have been analyzed and interpreted *** skin friction and Nusselt number were also *** addition,existence of dual solution was deduced for the shrinking sheet and unique solution for the stretching ***,Al_(2)O_(3)/H_(2)O nanofluid flow has better thermal conductivity on comparing with Cu/H_(2)O ***,it was found that the first solutions of the stream are stable and physically realizable,whereas those of the second ones are unstable.

关键词： magnetohydrodynamic nanofluid stretching/shrinking sheet axisymmetric flow analytical solution suction/injection