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World Journal of Critical Care Medicine 2024年第3期13卷 17-24页

作者： Mutaz I Othman emad M Mustafa Moayad alfayoumi Mohamad Y Khatib Abdulqadir J Nashwan Department of Nursing Hamad Medical CorporationDoha 3050Qatar Department of Pharmacy Hamad Medical CorporationDoha 3050Qatar Department of Critical Care Hamad Medical CorporationDoha 3050Qatar

The effect of intravenous bolus rates on patient outcomes is a complex and crucial aspect of critical *** challenges are commonly used in critically ill patients to manage their hemodynamic status,but there is limited information available on the specifics of when,how much,and at what rate fluids should be administered during these *** aim of this review is to thoroughly examine the relationship between intravenous bolus rates,fluid-electrolyte balance,and mortality and to analyze key research findings and methodologies to understand these complex dynamics *** challenges are commonly employed in managing hemodynamic status in this population,yet there is limited information on the optimal timing,volume,and rate of fluid *** a narrative review approach,the analysis identified nine relevant studies that investigate these *** findings underscore the importance of a precise and individualized approach in clinical settings,highlighting the need to tailor intravenous bolus rates to each patient's specific needs to maximize *** review provides valuable insights that can inform and optimize clinical practices in critical care,emphasizing the necessity of meticulous and exact strategies in fluid administration.

关键词： Fluid balance Fluid resuscitation Intensive care unit Precision medicine Mortality

Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed ali Jerah Manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam Mohamed ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(Pal applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

Biochemical Liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected Rat Model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil emad B. Ata Margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha M. F. Hassan Soad M. Nasr Mohamed A. Helal Ebtesam M. al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and alT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum alT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis Molecular Characterization

Effect of heterogeneity on engineered water injection in carbonates using five-spot sector model:A numerical study

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Petroleum 2022年第3期8卷 375-390页

作者： Jamiu Oyekan Adegbite emad Walid al-Shalabi Petroleum Engineering Department Khalifa University of Science and TechnologySas Al Nakhl CampusAbu DhabiUnited Arab Emirates

One of the promising and emerging enhanced oil recovery techniques in both sandstones and carbonates is engineered water injection(EWI).However,few studies discussed the field-scale applications of this technique in heterogeneous carbonate *** paper is an extension of our previous work of the EWI technology at *** research numerically investigates heterogeneity effect on EWI technique in carbonates at field-scale using five-spot *** synthetic five-spot sector models were considered including homogeneous,heterogeneous with permeability channeling,and heterogeneous with gravity *** results showed that EWI improves both volumetric and displacement sweep efficiencies compared to conventional formation water injection(FWI)for all models ***,tracer method is recommended for better estimation of volumetric sweep efficiency as opposed to fractional flow ***,secondary EWI outperforms other techniques including secondary FW and tertiary *** addition,the observed delay in tertiary EWI can be reduced by increasing well injection pressure and sulfate concentration in the engineered *** optimum sulfate concentration of 25,000 ppm is recommended for achieving the highest oil recovery by *** study gives more insight into understanding the performance of the EWI technique at *** for boosting the performance of this technique have been discussed,which assure more certainty and lower risk.

关键词： Engineered water injection(EWI) Low salinity water injection(LSWI) Field application Permeability channeling Gravity underride

Extraction of cobalt(Ⅱ) from aqueous solution by N,N'-carbonyl difatty amides

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Chinese Chemical Letters 2011年第4期22卷 469-472页

作者： emad A.Jaffar al-Mulla Khalid Waleed S.al-Janabi Department of Chemistry College of ScienceUniversity of KufaAnNajafIraq Department of Chemistry College of EducationBaghdad UniversityBaghdadIraq

The development of economic and environmentally friendly extractants to recover cobalt metal is required due to the increasing demand for this *** this study,solvent extraction of Co（Ⅱ） from aqueous solution using a mixture of N,N＇-carbonyl difatty amides（CDFAs） synthesised from palm oil as the extractant was carried *** effects of various parameters such as acid,contact time,extractant concentration,metal ion concentration and stripping agent and the separation of Co（Ⅱ） from other metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ） were *** was found that the extraction of Co（Ⅱ） into the organic phase involved the formation of 1：1 ***（Ⅱ） was successfully separated from commonly associated metal ions such as Fe（Ⅱ）,Ni（Ⅱ）,Zn（Ⅲ） and Cd（Ⅱ）.Co（Ⅱ） stripping from the loaded organic phase was studied in aqueous *** results are useful to recover Co（Ⅱ） from aqueous solution utilising（CDFAs） as an extractant.

关键词： N N'-Carbonyl difatty amides Solvent extraction Co(Ⅱ)

Sodium-Glucose Cotransporter-2 Inhibitors: Who, When & How? Guidance for Use from a Multidisciplinary Practical Approach

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International Journal of Clinical Medicine 2024年第9期15卷 413-435页

作者： Khalifa Abdullah Magdy ElSharkawy emad R. Issak Ahmed Shawky ElSerafy Samah Idris Ahmed Bendary Haytham Reda Badr May Shehata Ashraf Reda Internal Medicine Department Diabetes & Metabolism Unit Faculty of Medicine Alexandria University Alexandria Egypt Nephrology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine Department Faculty of Medicine Ain Shams University Cairo Egypt Cardiology Department Faculty of Medicine Ain Shams University Cairo Egypt Internal Medicine and Nephrology Department Faculty of Medicine Alexandria University Alexandria Egypt Cardiology Department Faculty of Medicine Benha University Benha Egypt Internal Medicine Department Diabetes and Endocrinology Unit Faculty of Medicine Menoufia University Menoufia Egypt Product Manager Al-Esraa Pharma Cairo Egypt Cardiology Department Faculty of Medicine Menoufia University Menoufia Egypt

Sodium-glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) have transformed diabetes management by targeting renal glucose reabsorption. Designed initially as antidiabetic agents, their ability to lower blood glucose levels independently of insulin is well-documented. Beyond glycemic control, emerging research has unveiled their profound cardiorenal benefits. By inhibiting SGLT-2 protein, these drugs enhance glucose excretion in urine, reducing blood glucose levels. This mechanism has translated into significant cardiovascular and renal protection, establishing SGLT-2 inhibitors as pivotal in managing not only diabetes but also cardiovascular and renal diseases. Recent studies have illuminated the broader therapeutic potential of SGLT-2 inhibitors beyond diabetes. Evidence indicates their efficacy in managing heart failure, chronic kidney disease (CKD), and cardiovascular complications in individuals with or without diabetes. This expanded therapeutic landscape has catalyzed a paradigm shift in SGLT-2 inhibitor use, positioning them as key agents in the cardiorenal metabolic continuum. Moreover, their role in the secondary prevention of cardiovascular events and slowing CKD progression in T2DM patients has garnered considerable attention. This consensus-based review aims to offer practical guidance in an algorithmic approach to primary care healthcare professionals to optimize SGLT-2 inhibitors utilization and maximize their benefits. The review seeks to empower clinicians to effectively manage patients who may benefit from SGLT-2 inhibitor therapy by addressing common initiation barriers and optimizing treatment strategies. Additionally, it aims to raise awareness among primary care physicians regarding the multifaceted benefits of these medications and overcome clinical inertia in their adoption into routine clinical practice.

关键词： Sodium-Glucose Cotransporter-2 Inhibitors Cardiorenal Benefits Therapeutic Potential Cardiovascular Protection Primary Care Optimization

Effect of elevation on floristic diversity,life forms and chorotypes in the alHada mountain escarpment,Saudi Arabia

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Journal of Mountain Science 2022年第10期19卷 2806-2816页

作者： Mohamed A.FADL Hatim M.al-YASI emad A.alSHERIF Department of Biology College of ScienceTaif UniversityTaif 21944Saudi Arabia Department of Biology College of Science and ArtsUniversity of JeddahJeddah 21921Saudi Arabia Department of Botany and Microbiology Faculty of ScienceBeni-Suef UniversityBeni Suef 62521Egypt

Mountains are biodiversity hotspots,and due to their unique microclimatic circumstances,they host a vast range of endemic *** are two main hypotheses,the Rapoport and the mid-domain effect hypotheses,which explain how elevation and species richness are *** current study was conducted in the al-Hada escarpment,which is a unique area in the *** is located on the border of Eurasia and Africa,where there are a lot of plant species from both *** study aimed to detect the effect of elevation on the floristic composition of the study *** obtained results showed that the al-Hada escarpment flora consists of 297 species belonging to 194 genera and fifty-seven distinct *** two families,Poaceae and Asteracae,had 22%of the whole recorded *** obtained results showed that with increasing elevation,the numbers of species,genera,and families increased,in accordance with the Rapoport *** numbers of families increased by 62%from the lowest elevation to the highest one,while the numbers of both species and genera increased by more than *** exhibited the maximum number,which was 44%,and Chamaephytes came in second with 25%.Phanerophytes and hemicryptophytes made up 13%and 11%of all life forms,respectively,while geophytes made up just 7%.Monoregional elements represented 33.2%of the total recorded species,where Saharo-Sindian species had the most monoregional species,accounting for around 13%of the total *** the highest elevation,succulents accounted for 7.6%of the research area,whereas Nfixing plants accounted for 6.2%.At the highest elevation,they had the lowest value,and at the middle elevation,they had the highest *** the rise in elevation,the neotropical,endemic,and Mediterranean elements *** and Nfixing species did not show a clear relationship with the elevation but exhibited the lowest value at the highest elevation,and vice *** and geophytes increased while th

关键词： Rapoport hypothesis Mid-domain effect Arid land Mountain altitude al-Hada escarpment

Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa M. Hamed Khaled M. EL-Shahat aliaa Mahmoud Mahmoud Abdallah Ibraheem Haggag emad Moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of Medical Physics Al Azhar University Cairo Egypt Department of Medical Physics International Medical Center (IMC) Cairo Egypt Department of Medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain Metastases PTV

Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and Fisheries 2024年第1期9卷 57-65页

作者： Mohammed F.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-Hais Mohamed G.Elhanafy emad H.El-Bilawy Amr I.Zaineldin Mohamed F.A.Abdel-Aziz Ibrahim A.Abouelsaad Ibrahim TEl-Ratel Kumbukani Mzengereza Ronick S.Shadrack Islam I.Teiba Faculty of Agriculture Tanta UniversityTanta31527Egypt King Salman International University South Sinai46618Egypt Faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt Fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and Fisheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi Faculty of Aquaculture and Marine Fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).Fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(SOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

捕集数对碳酸盐岩油藏生物聚合物驱采收率的影响

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石油勘探与开发 2022年第4期49卷 778-786页

作者： al-SHalABI emad W 阿联酋哈利法科技大学石油工程学院阿布扎比127788阿联酋

基于储集层岩石和流体数据,采用一维数值模拟方法,研究捕集数对碳酸盐岩油藏裂褶菌多糖生物聚合物驱提高采收率的影响。对不可及孔隙体积、生物聚合物吸附量、渗透率降低系数、剪切速率系数、注入水硬度以及捕集数进行敏感性分析,与岩... 详细信息

基于储集层岩石和流体数据,采用一维数值模拟方法,研究捕集数对碳酸盐岩油藏裂褶菌多糖生物聚合物驱提高采收率的影响。对不可及孔隙体积、生物聚合物吸附量、渗透率降低系数、剪切速率系数、注入水硬度以及捕集数进行敏感性分析,与岩心驱替实验采收率数据进行历史拟合。结果表明,不可及孔隙体积、生物聚合物吸附量、渗透率降低系数、剪切速率系数和注入水硬度对生物聚合物驱提高采收率的影响可以忽略不计,且在其典型值范围内无法与采收率数据实现历史拟合。当通过毛细管去饱和曲线模型考虑捕集数影响时,残余油饱和度从不考虑捕集数影响或低捕集数条件下的25.1%降低到10.0%,采收率拟合效果较好。因此,为了更好地对碳酸盐岩油藏生物聚合物驱进行模拟研究,不能忽略捕集数影响。

关键词：碳酸盐岩油藏生物聚合物驱裂褶菌多糖生物聚合物捕集数提高采收率