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第十二届中国体视学与图像分析学术会议

作者： SEN Han (Veeco Instruments,Inc.,2650 E.elvira road,Tucson,AZ 85756,USA)

Interferometric profilers have been widely employed in semiconductor,data storage, MEMS and research fields for more than two decades. These systems are known to produce rapid,accurate, and repeatable characterization of surface roughness, form,film thickness,and more recently dynamic be- havior of MEMS and other moving ***, however,optical profiling has been playing a more and more important role in biosensor,living biological sys- tem and biomedical applications. The measurement of living cells presents technical challenges for standard interferometric *** system must be able to measure objects in fluid,where the index of the cell and fluid is sometimes very simi- ***,the timescales of change for different experi- ments involving living cells can vary greatly,requiring a variety of measurement methodologies to maximize data,including strobed interferometry and video-rate deformation *** addition,the responses of individual cells can differ significantly from one another in a given experiment,making measurement of large numbers of cells in parallel very important to achieve proper statistical sampling of the *** pres- ents challenges both in how to best trade field-of-view for lateral resolution and for how each surface image is analyzed,as the software intelligently track and log in- formation from each of many different ceils simultane- ously. Measurement of inorganic parts,such as cantile- ver arrays,removes some of the challenges associated with ***,the need for varying temporal range,parallelism of measurement across parts,and intelligent analyses that allow the researcher to easily connect theory with the implemented part are still pres- *** paper describes how multiple interferometric techniques,implemented on a single system,can be combined to provide viable measurements of both bio- sensors and cells,enabling collection of data in envi- ronments and with timescales not previously achieva- b

关键词： interferometer optical profiler biosensor cellular measurement

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Nanosecond Pulse Treatment on Water and Water Solutions

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Journal of Chemistry and Chemical Engineering 2013年第6期7卷 529-532页

作者： Valeriy V. Krymski Vladimir F. Balakirev Ekaterina V. Litvinova elvira A. Ibragimova Maria Y.Kuzmina Energy Department South Ural State University Chelyabinsk 454080 Russia Institute of Metallurgy of the Ural Division of the russia Academy of Sciences Ekaterinburg 620016 Russia

The experiment results of the nanosecond electromagnetic pulses action on water and water solutions containing radionuclides are described. An activity decrease of radionuclides solution is observed in many experiment... 详细信息

关键词： Pulse electromagnetic treatment water purification water solution radionuclide hydrated electron.

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TET2 Mutations in Ph-Negative-Myeloproliferative Neoplasms: Identification of Three Novel Mutations and relationship with Clinical and Laboratory Findings

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Open Journal of Blood Diseases 2013年第3期3卷 79-84页

作者： Andrea Patriarca Donatella Colaizzo Gianluca Tiscia raffaele Spadano Silvia Di Zacomo Antonio Spadano Ida Villanova Maurizio Margaglione elvira Grandone Alfredo Dragani Atherosclerosis and Thrombosis Unit IRCCS Casa Sollievo Della Sofferenza San Giovanni Rotondo Italy Bleeding and Thrombotic Disorders Unit Department of Hematology Ospedale Civile Dello “Spirito Santo” Pescara Italy Department of Medical Genetics Foggia University Foggia Italy. Laboratory of Molecular Biology Department of Hematology Ospedale Civile Dello “Spirito Santo” Pescara Italy

High-throughput DNA sequence analysis was used to screen for TET2 mutations in peripheral blood derived DNA from 97 patients with BCr-ABL-negative-myeloproliferative neoplasms (MPNs). Overall six mutations in the coding region of the gene were identified in 7 patients with an overall mutational frequency of 7.2%. In polycythemia vera patients (n = 25) were identified 2 mutations (8%);in those with essential thrombocythemia (n = 55) 2 mutations (3.6%);in those with unclassifiable MPN (n = 8) 3 mutations (37.5%). No primary myelofibrosis patiens (n = 6) harboured TET2 mutations. Three unreported mutations were identified (p.P177fs, p.C1298del, p.P411del) the first two in patients with unclassifiable MPN, the last in a patient with essential thrombocythemia. On multivariate analysis the diagnosis of an unclassifiable MPN was significantly related to the presence of TET2 mutations (p = 0.02;Or: 2.81;95% CI 1.11 - 7.06). We conclude that TET2 mutations occur in both JAK2V617F-positive and -negative MPN and are more frequent in MPN-U patients. This could represent the biological link between the different classes of myeloid malignancies.

关键词： MPN Methylation TET2 Molecular Biology

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加工降低大豆中的致敏蛋白P34的致敏性

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营养健康新观察 2004年第3期 77-85页

作者： Shannon Wilson Kristen Blaschek elvira Gonzalez de Mejia 王劲

大豆位于大多数过敏食品的"大8"中,并且随着豆制品消费量的增加,预计大豆过敏的发病率会上升。大豆及其衍生物普遍存在于素食者和以肉为基础的食物制品中,因此,难以做到膳食戒除。然而,可以通过多种方法处理大豆来改变其致敏性。已有一... 详细信息

大豆位于大多数过敏食品的"大8"中,并且随着豆制品消费量的增加,预计大豆过敏的发病率会上升。大豆及其衍生物普遍存在于素食者和以肉为基础的食物制品中,因此,难以做到膳食戒除。然而,可以通过多种方法处理大豆来改变其致敏性。已有一些研究用食品加工、农艺或基因调控技术来改变免疫显性过敏原 P34的结构,从而着重降低大豆的致敏性。本文对这些相关研究文献加以综述。

关键词：致敏性大豆种子 P34 免疫显性豆球蛋白胰蛋白酶抑制剂食品加工亚单位抗原决定簇蛋白水解

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人卵透明带蛋白ZP3a和ZP3b肽段的免疫原性及其抗血清体外抑制人精子-半透明带结合

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生理学报 2005年第6期57卷 682-688页

作者：宋力雯汪玉宝倪崖何亚萍洪爱真 elvira Hinsch Klaus-Dieter Hinsch 周思畅袁玉英石其贤徐万祥复旦大学上海医学院上海200032 上海市计划生育科学研究所上海200032 浙江省医学科学院杭州310013 皮肤与男科学中心Juetus Liebig 大学支薪雇员公共机构联邦保险riff康复门诊部

分析大肠杆菌表达的重组人卵透明带-3(r-huZP3)蛋白两个肽段(r-huZP3a22-176及r-huZP3b177-348)的免疫原性,比较两者抗血清体外抑制人精子-半透明带结合的能力。以制备性聚丙烯酰胺凝胶电泳(PAGE)纯化的大肠杆菌表达蛋白为抗原, 主动免... 详细信息

分析大肠杆菌表达的重组人卵透明带-3(r-huZP3)蛋白两个肽段(r-huZP3a22-176及r-huZP3b177-348)的免疫原性,比较两者抗血清体外抑制人精子-半透明带结合的能力。以制备性聚丙烯酰胺凝胶电泳(PAGE)纯化的大肠杆菌表达蛋白为抗原, 主动免疫新西兰兔产生抗huZP3a22-176及huZP3b177-348抗血清;通过ELISA测定比较两者的抗体应答水平:以蛋白印迹和免疫组化方法测定两者抗血清同重组表达蛋白、天然人卵ZP以及卵巢组织的反应性;通过竞争性半透明带结合试验 (hemizona assay,HZA)观察两者抗血清体外抑制人精子-ZP结合能力。结果显示:未与大分子蛋白载体耦联的r-huZP3a22-176 和r-huZP3b177-348抗原都在免疫兔中产生了较高的抗体滴度,而且它们的抗血清可识别大肠杆菌表达的各自重组ZP3肽以及人卵细胞表面天然ZP,两者抗血清也都能在体外抑制人精子-ZP结合。由此可见,r-huZP3a22-176及r-huZP3b177-348蛋白具有良好免疫原性,所产生抗血清也都显示出细胞和组织特异性。因此,单一或合并两个huZP3肽段均可作为抗原研制检测不明原因性不孕妇女中是否存在抗自身ZP抗体的诊断试剂盒,另外它们的抗血清也能用于鉴定已知huZP3表位肽段的最小B-细胞表位基序。

关键词：人卵透明带重组ZP3肽抗血清卯母细胞:半透明带结合试验

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应用丙酮研究聚氯乙烯加工形态和制品形态

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聚氯乙烯 1982年第3期 78-81页

作者： James W.Summers ,elvira B.rabinovitch ,韩松锦西化工研究院

有文献综述指出聚氯乙烯形态有许多重要特点。聚氯乙烯颗粒(150μm)切片,呈现出一次粒子(1μm)和一次粒子的聚集体(3—10μm)。如果微观范围更小,当密度变化大约为0.01μm的间距时,用X—射线小角散射来揭示。密度变化稍小于0.01μm时,X... 详细信息

有文献综述指出聚氯乙烯形态有许多重要特点。聚氯乙烯颗粒(150μm)切片,呈现出一次粒子(1μm)和一次粒子的聚集体(3—10μm)。如果微观范围更小,当密度变化大约为0.01μm的间距时,用X—射线小角散射来揭示。密度变化稍小于0.01μm时,X—射线广角散射的实验结果证明了微晶的存在。有文献提出聚氯乙烯微观领域的问题与微晶有关系。

关键词：聚氯乙烯溶胀丙酮脂肪族酮制品

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Evaluation Preliminary of a Dry Emulsion System as a <i>Pasteurella multocida</i>Oral Carrier for Pigs

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Journal of Biosciences and Medicines 2020年第9期8卷 114-124页

作者： David Quintanar-Guerrero Edgar Aguilera Cerón María Elena Trujillo Ortega Sofia González Gallardo Alejandro Vargas Sánchez Abel Ciprián Carrasco Susana Mendoza elvira Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Mexico City México Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Mexico City México

Background: This work evaluated the capacity of a dry emulsion as a carrier of viable microorganisms with potential use as prophylaxis of infectious diseases. Methods: The aqueous phase containing P. multocida not via... 详细信息

rong>Background:rong> This work evaluated the capacity of a dry emulsion as a carrier of viable microorganisms with potential use as prophylaxis of infectious diseases. rong>Methods:rong> The aqueous phase containing P. multocida not viable in PBS was emulsified in mineral oil to obtain a w/o emulsion. The microorganisms remained stable and only in two cases (n = 6) did the bacterial concentration decrease. Scanning Electron Microscopy (SEM) revealed a structure of a system with the organized association of particles with cubic symmetry. Using two ex vivo bioadhesion systems, it was demonstrated that the disperse-adsorbed system is capable of adhering to the intestinal mucosa and remains adhered for long periods of time. rong>results: rong>The no viability of the bacteria in the dry emulsion and the possibility of controlled release were confirmed. In vivo trial was conducted in pigs. It was possible to locate the emulsion and the bacteria attached to the gut of the living animal. An ELISA kit was used to monitor the mean antibody titer of treated pigs over a 2-week period, and a classic primary response curve occurred when the titer was plotted against time. rong>Conclusion: rong>We propose the disperse-adsorbed system as an alternative to commonly used vehicles for immunogens in the oral vaccines.

关键词： Dry Emulsion Oral Carrier Pasteurella multocida Pigs Bioadhesion

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Changes of liver fat content and transaminases in obese children after 12-mo nutritional intervention

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World Journal of Hepatology 2013年第9期5卷 505-512页

作者： elvira Verduci Carlo Pozzato Giuseppe Banderali Giovanni radaelli Chiara Arrizza Antonio rovere Enrica riva Marcello Giovannini Department of Pediatrics San Paolo HospitalUniversity of Milan20142MilanItaly Unit of Medical Statistics San Paolo HospitalUniversity of Milan20142 MilanItaly Department of radiology San Paolo Hospital20142 MilanItaly

AIM:To assess a relationship between longitudinal changes in liver fat content and biochemical parameters in obese children after 1-year nutritional ***:Forty-six obese children, 21 males and 25females, aged 6-14 years, underwent metabolic measurements, liver ultrasonography(US) and chemicalshift magnetic resonance imaging(MrI) examinations at baseline and after 1-year nutritional intervention. A child was defined obese if her/his body mass index(BMI)was above the age- and sex-adjusted BMI Cole's curve passing through the cut-off of 30 kg/m2 at 18 *** Z scores were calculated and adjusted for age and gender by using the Cole's LMS-method and Italian reference data. Biochemistry included serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST). Abdominal US and chemical-shift MrI were performed according to a randomized *** same radiologist performed US by a GE Logiq 9(General Electric Healthcare Medical Systems, Milwaukee, WI, United States) using a 3.5-MHz convex array transducer. Liver echogenicity was evaluated independently on videotape by 3 radiologists unaware of the child and MrI outcomes, and a consensus was established. Another experienced radiologist, unaware of the child and US data, performed the abdominal chemicalshift MrI with a 1-t system NT-Intera(Philips Medical Systems, Best, The Netherlands) and a phased-array coil. Liver fat fraction(FF) on MrI was judged elevated when greater than 9%. A FF>18% was considered expressing more severe cases of fatty liver according to Fishbein. A nutritional-behavioral intervention was recommended to promote a normocaloric balanced diet and active lifestyle based on the Italian guidelines for treatment of childhood ***:Compared to baseline, at the end of intervention children showed lower intakes of energy(mean± SD:2549±1238 Kcal vs 1770±622 Kcal, Prbohydrates(356±174g vs 241±111 g, P=0.001),and protein(99±

关键词： Nonalcoholic fatty liver disease Childhood obesity Serum transaminases Magnetic resonance imaging Nutritional intervention

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Effect Found in the Combination of Kitasamycin with Other Antibiotics Used against <i>Actinobacillus pleuropneumoniae</i>

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Journal of Biosciences and Medicines 2020年第7期8卷 63-75页

作者： Elsa Patricia Flores-Castellanos Sofía González Gallardo Jose Ivan Sanchez-Betancourt Maria Elena Trujillo Ortega David Quintanar Guerrero Abel Ciprian Carrasco Susana E. Mendoza elvira Facultad de Estudios Superiores Cuautitlán (FESC) Universidad Nacional Autónoma de México México City México Facultad de Medicina Veterinaria y Zootecnia (FMVZ) Universidad Nacional Autónoma de México México City México

Background: Combinations of antibiotics are used to increase the therapeutic options via the simultaneous activities of two compounds. The goals of combination therapy are to resolve the bacterial infection while redu... 详细信息

rong>Background:rong> Combinations of antibiotics are used to increase the therapeutic options via the simultaneous activities of two compounds. The goals of combination therapy are to resolve the bacterial infection while reducing the treatment cost. The use of kitasamycin is used frequently and in addition to other antibiotics, the desired combinations were not found. rong>Methods:rong> Fields strains: we use serotypes 1, 3, 5 y 7. Microbial culturing: The serotypes 1, 3, 5 y 7 was identified. Antibiotics and reagents: The antibiotics used were kitasamycin;enrofloxacin and oxolinic acid. The following combinations were tested: a) kitasamycin with enrofloxacin;b) kitasamycin with norfloxacin;and c) kitasamycin with oxolinic acid. Preparation of bacterial suspensions: The cultures were adjusted to a concentration of 5 colony-forming units per ml (CFU/ml) using the same sterile culture medium as the diluent. Determination of the fractional inhibitory concentrations (FICs): To test each combination and their interactions and to calculate the fractional inhibitory concentration (FIC) of each antibiotic. Calculation of the index of the fractional minimum inhibitory concentration (FMIC): The FMIC index was calculated by applying the following formula: FIC index = FIC of antibiotic A/FIC of antibiotic B. rong>results:rong> What was found showed that: A combination of kitasamycin and norfloxacin has been shown to have an indifferent effect. A combination of kitasamycin and enrofloxacin had antagonistic effects against all of the Actinobacillus pleuropneumoniae serotypes studied. Finally, a combination of kitasamycin and oxolinic acid had antagonist effects against serotypes 1, 3 and 5 and a synergistic effect against serotype 7. rong>Conclusion:rong> The “in vitro” combination Kitasamycin-Norfloxacin showed an indifferent effect, and combination Kitasamycin and Enrofloxacin demonstrated an antagonistic interaction between these two anti

关键词： Antibiotics Combination A. pleuropneumoniae

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为俄罗斯经济转型提供金融支持

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中国金融 2023年第1期 27-30页

作者：埃尔维拉·纳比乌琳娜张林(编译) 俄罗斯中央银行《中国金融》杂志编辑部

俄罗斯央行将继续推出一系列旨在确保低通胀、维护金融基础设施稳定和金融市场强劲运行的政策,为经济尽快实现结构性转型创造条件危机凸显经济转型的紧迫性在过去的一年,俄罗斯经济的外部条件发生了巨变。前所未有的制裁正在改变俄罗斯... 详细信息

俄罗斯央行将继续推出一系列旨在确保低通胀、维护金融基础设施稳定和金融市场强劲运行的政策,为经济尽快实现结构性转型创造条件危机凸显经济转型的紧迫性在过去的一年,俄罗斯经济的外部条件发生了巨变。前所未有的制裁正在改变俄罗斯进出口商品的地缘格局,以前的许多对外经济关系已经破裂,这就迫使我们必须建立新的经济关系。

关键词：对外经济关系进出口商品金融基础设施经济转型金融市场结构性转型地缘格局低通胀

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