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Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt

World Journal of Gastroenterology 2013年第37期19卷 6214-6220页

作者： Abeer Elkady Sahar Aboulfotuh elsayed mostafa ali Douaa Sayed Nashwa M Abdel-Aziz Amany M ali Shuko Murakami Sayuki Iijima Yasuhito Tanaka Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences Department of Clinical and Chemical Pathology Medical School of South Valley University Department of Clinical and Chemical Pathol-ogy Medical School of Sohag University Department of Medical Oncology Medical School of Sohag University Department of Clinical and Chemical Pathology South Egypt Cancer Institute Department of Medical Oncology South Egypt Cancer Institue

AIM:To investigate characteristics of hepatitis B virus(HBV)implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive ***:Serum samples were collected from 53 patients with hematological malignancies negative for hepatitis B surface antigen(HBsAg)before the start of and throughout the chemotherapy *** reactivation was diagnosed when the HBsAg status changed from negative to positive after the initiation of chemotherapy and/or when HBV DNA was detected by realtime detection polymerase chain reaction(RTD-PCR).For detecting the serological markers of HBV infection,HBsAg as well as antibodies to the core antigen(antiHBc)and to the surface antigen were measured in the sera by *** acids were extracted from sera,and HBV DNA sequences spanning the S gene were amplified by *** extracted DNA was further subjected to PCR to amplify the complete genome as well as the specific genomic sequences bearing the enhancerⅡ/core promoter/pre-core/core regions(nt1628-2364).Amplicons were sequenced ***:Thirty-five(66%)of the 53 HBsAg-negative patients were found to be negative serologically for antiHBc,and the remaining 18(34%)patients were positive for *** of the 53(9.4%)patients with hematologic malignancies experienced HBV *** D1 was detected in all five *** types of mutant strains were detected in the S gene product of HBV strains and were isolated from 3 patients with HBV reactivation:T/S120,L143,and *** DNA was detected in the pretreatment HBsAg-negative samples in one of the five patients with HBV *** this patient,sequences encompassing the HBV full genome obtained from sera before the start of chemotherapy and at the time of de novo HBV hepatitis were detected and it showed 100%***,in the phylogenetic tree,the sequences were clustered together,thereby indicating that this patient developed reactivation from an occult

关键词： Hepatitis B virus Occult infection Reactivation Hepatitis B surface antigen

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Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt

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World Journal of Hepatology 2017年第9期9卷 477-486页

作者： Abeer Elkady Sayuki Iijima Sahar Aboulfotuh elsayed mostafa ali Douaa Sayed Nashwa M Abdel-Aziz Amany M ali Shuko Murakami Masanori Isogawa Yasuhito Tanaka Department of Clinical and Chemical Pathology Medical School of South Valley University Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences Department of Clinical and Chemica Pathology Medical School of Sohag University Department of Medical Oncology Medical School of Sohag University Department of Clinical and Chemical Pathology South Egypt Cancer Institute Department of Medical Oncology South Egypt Cancer Institue

AIM To investigate the prevalence and virological characteristics of occult hepatitis B virus(HBV) infections in patients with hematological malignancies in South *** Serum samples were collected from 165 patients with hematological malignancies to monitor titers of HBV DNA, hepatitis B surface antigen(HBs Ag), and antibodies to HBV core(anti-HBc) and surface antigens. Serum samples negative for HBs Ag and positive for anti-HBc were subjected to nucleic acid extraction and HBV DNA detection by real-time polymerase chain reaction. DNA sequences spanning the S region were analyzed in cases with occult HBV infection. In vitro comparative study of constructed 1.24-fold wild type and S protein mutant HBV genotype D clones was further performed. RESULTS HBV DNA was detected in 23(42.6%) of 54 patients with hematological malignancies who were HBsA g negative, but anti-HBc positive, suggesting the presence of occult HBV infection. The complete HBV genome was retrieved from 6 occult HBV patients, and P120 T and S143 L were detected in 3 and 2 cases, respectively. Site directed mutagenesis was done to produce 1.24-fold genotype D clones with amino acid mutations T120 and L143. The in vitro analyses revealed that a lower level of extracellular HBsA g was detected by chemiluminescence enzyme immunoassay(CLEIA) with the clone containing T120 mutation, compared with the wild type or the clone with S143 L mutation despite the similar levels of extracellular and intracellular HBs Ag detected by Western blot. Southern blot experiments showed that the levels of intracellular HBV DNA were not different between these clones. CONCLUSION Occult HBV infection is common in patients with hematological malignancies and associated with P120 T and S143 L mutations. 120 T mutation impairs the detection of HBsA g by CLEIA.

关键词： Occult hepatitis B infection Hematological malignancies Escape mutation

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Prolonged Infusion of Low Dose Gemcitabine in Advanced Pancreatic Carcinoma

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Journal of Cancer Therapy 2020年第7期11卷 401-409页

作者： elsayed mostafa ali Ahmed M. Maklad Salah M. Khallaf Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Sohag Egypt Medical Oncology Department South Egypt Cancer Institute Assiut Egypt

Background: Gemcitabine was established as a monotherapy or in combination for locally advanced or metastatic pancreatic carcinoma. Aim: This study aimed to evaluate the efficacy of the low-dose gemcitabine over 6-hour infusion in patients with advanced pancreatic adenocarcinoma. Methods: 26 patients with locally advanced or metastatic pancreatic carcinoma were recruited into the study from December 2013 to October 2014. Patients received the treatment in Clinical Oncology Department, Sohag University, and Medical Oncology Department, Assiut University. Patients received low-dose gemcitabine (250 mg/m2) over 6-hour infusion, weekly for seven weeks and then on days 1 and 8 every 3 weeks till unacceptable toxicity or progression of the disease. Results: Twenty-six patients were enrolled in this study. After starting 7 weeks of treatment, the disease control rate was 38.5% in the form of complete response in 3.8% of patients, partial response in 26.9%, and stationary response in 7.7%. However, disease progression occurred in 61.5%. Progression-free survivals were

关键词： Gemcitabine Pancreatic Cancer Intravenous Infusion Low-Dose

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Cardiac Safety with High Cumulative Dose of Pegylated Liposomal Doxorubicin in Patients with Metastatic Breast Cancer Previously Treated with Conventional Anthracyclines

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Advances in Breast Cancer Research 2020年第3期9卷 55-65页

作者： Ahmed Refaat Dalia O. Mohamed elsayed mostafa ali Salah Mabrouk Khallaf Medical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Radiation Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Sohag Egypt

Introduction: The treatment of metastatic breast cancer (MBC) is still challenging. Many studies documented the efficacy of pegylated liposomal doxorubicin (PLD) in patients with MBC, but there is a limited data about the cardiac safety with high cumulative dose (HCD) of PLD. Aim of the work: We conducted this trial to outline the cardiac safety of HCD of PLD in patients with MBC who previously received conventional anthracyclines. Methods: During the period of nine years (January 2011 to December 2019). We extracted the data of the patients with MBC receiving PLD at Medical Oncology Department, South Egypt Cancer Institute, Assiut University. These included patients’ demographics and therapeutic data including the full data of PLD, prior conventional anthracyclines, prior trastuzumab, and prior radiotherapy. Also, data about comorbidities as well as cardiac and other toxicities of PLD were obtained. The data was analysed using SPSS v. 21. Results: For all

关键词： Metastatic Breast Cancer Pegylated Liposomal Doxorubicin High Cumulative Dose Cardiac Toxicity

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Surrogate Role of CD85k on Monocytic Lineage Involved Leukemogenesis Biology and Clinical Aspect

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Open Journal of Blood Diseases 2018年第4期8卷 61-73页

作者： Hasnaa A. Abo-Elwafa Shereen P. Aziz Heba A. Ahmed elsayed mostafa ali Doaa S. Elsaied Clinical Pathology Department Sohag Faculty of Medicine Sohag University Sohag Egypt Clinical Oncology Department Sohag Faculty of Medicine Sohag University Sohag Egypt

Background: Unique receptor involved in leukemogenesis is CD85k;an immuneglobulin receptor for immune tolerance, CD36 is glycoprotein mediates cellular adhesion and metastatic spread, CD14, CD15 considered common monocytic markers. Aims: to investigate CD85k with monocytic lineage involved leukemia (MLIL) markers in leukemia pathogenesis and clinical presentation. Patients and Methods: 47 patients (32 diagnosed acute myeloid leukemia (AML);15 non-malignant hematological disease as a control), were included, aged from 2 to 80 years, all subjected to peripheral blood (***) and bone marrow (B.M) examination, immunophenotyping (IPT) using FASC Canto four color flow cytometer (FCM) Becton Dickenson (BD) USA, for CD13, CD33, MPO, HLA-DR, CD34, CD38, CD117, CD14, CD15 and CD36 the Mo Abs supplied by B.D Bioscience, and anti CD85k Mo Abs by Aveda de Coimbra Flamenco, reference No. 1399990130. Results: Frequency of CD85k is 19/32 (59.37%) of AML;14/14 (M4/M5) 100% positive CD85k, insignificant correlations of CD85k to sex, lymphadenopathy or organomegaly, platelets count and *** blast (P > 0.05), significant to age 50,000 × 109/l, Hb 0.05). Conclusion: Although CD85k is MLIL associated marker, it is not correlated with other MLIL markers with frequency 100% in MLIL and 59.37% in AML, age predisposition is <35 years with no sex variation, significant correlation to progenitor and myeloid markers, it’s a crucial role in leukemogenesis biology, not in clinical presentations, considered good follow up predictor MLIL marker.

关键词： CD85k Monocytic Lineage Leukemia

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In Frail Elderly Patients, Low-Dose Gemcitabine over 6-Hour Infusion Is Equally Effective and Less Toxic Than the Standard Gemcitabine Protocol for Advanced Pancreatic Adenocarcinoma: A Randomized Phase II Trial

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Journal of Cancer Therapy 2020年第3期11卷 124-141页

作者： Salah Mabrouk Khallaf elsayed mostafa ali Ahmed MMaklad Mohamed Medhat Samir Anwar Tawfik Amin Muhammad Abbas El-masry Mona MSayed Dalia Osama Medical Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt Clinical Oncology and Nuclear Medicine Department Sohag UniversitySohagEgypt Surgical Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt Division of gastroenterology-Department of internal medicine Assiut UniversityAssiutEgypt Radiation Oncology Department South Egypt Cancer InstituteAssiut UniversityAssiutEgypt

Background:?Treatment of frail elderly patients with pancreatic cancer is still a major problem due to intolerance to standard chemotherapy doses. Aim:?This study aims to compare the low-dose gemcitabine over 6 hours (LD6H) to the standard gemcitabine protocol in terms of clinical benefit, survival, and safety in the frail elderly patients with advanced pancreatic adenocarcinoma. Methods:?Patients enrolled in this trial were randomly assigned by in a 1:1 fashion via closed envelope method to either receive gemcitabine of 1000 mg/m2?over 30-minute infusion on days 1, 8, and 15 of every 4-week cycle (standard protocol arm) or gemcitabine as a weekly low-dose (250 mg/m2) over 6-hour infusion (LD6H arm). Results:?We enrolled eighty-two eligible frail elderly patients with advanced pancreatic cancer. The patients were randomly assigned to receive either standard gemcitabine protocol (40 patients) or low-dose (250 mg/m2) gemcitabine over 6-hour infusion, given weekly (42 patients). There was no significant difference between the standard group and low-dose group as regard of the overall response rate (p = 0.654), the disease control rate (DCR) (p = 0.845), the median progression-free survival (PFS) (p = 0.908) and the overall survival (OS) (p = 0.331). The low-dose regimen had a significantly lower incidence of adverse effects grades 3 or 4 when compared to the standard regimen: (p = 0.024 for fatigue, p = 0.027 for hypotension, p = 0.012 for each anemia as well as thrombocytopenia, and p = 0.006 for neutropenia). Conclusion:?Low-dose gemcitabine over 6-hour infusion is equally effective and less toxic when compared to standard gemcitabine protocol in frail elderly patients with advanced pancreatic adenocarcinoma. So, we recommend the low-dose gemcitabine for frail elderly patients with advanced pancreatic cancer.

关键词： Continuous Infusion Elderly Frail Low Dose Gemcitabine Pancreatic Cancer

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MARIE:One-Stage Object Detection Mechanism for Real-Time Identifying of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader Hassan Harb ali Jaber ali Mansour Christophe Osswald Nour mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security and safety remain paramount concerns for both governments and individuals *** today’s context,the frequency of crimes and terrorist attacks is alarmingly increasing,becoming increasingly intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively alert law enforcement and security forces,thereby preventing potential attacks or violent *** advancements in big data analytics and deep learning have significantly enhanced the capabilities of computer vision in object detection,particularly in identifying *** paper introduces a novel automatic firearm detection surveillance system,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically optimized to balance the speed-accuracy trade-off critical in firearm detection *** SSD model was further refined by integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly satisfactory performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy *** these innovations,MARIE sets a new standard in surveillance technology,offering a robust solution to enhance public safety effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network

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A Multi-Factor Authentication-Based Framework for Identity Management in Cloud Applications

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Computers, Materials & Continua 2022年第5期71卷 3193-3209页

作者： Wael Said elsayed mostafa M.M.Hassan Ayman Mohamed mostafa Faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt College of Computer and Information Sciences Jouf UniversitySakaka72314Saudi Arabia

User’s data is considered as a vital asset of several *** data to the cloud computing is not an easy decision for any organization due to the privacy and security *** providers must ensure that both data and applications that will be stored on the cloud should be protected in a secure *** data stored on the public cloud will be vulnerable to outside and inside *** paper provides interactive multi-layer authentication frameworks for securing user identities on the *** access control policies are applied for verifying users on the cloud.A security mechanism is applied to the cloud application that includes user registration,granting user privileges,and generating user authentication *** intrusion detection system is embedded to the security mechanism to detect malicious *** multi factor authentication,intrusion detection,and access control techniques can be used for ensuring the identity of the ***,encryption techniques are used for protecting the data from being *** results are carried out to verify the accuracy and efficiency of the proposed frameworks and *** results recorded high detection rate with low false positive alarms.

关键词： Cloud computing service providers multi-layer authentication frameworks and access control

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Catalytic behaviors of Co-Mn/TiO_2 catalysts for Fischer-Tropsch synthesis

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燃料化学学报 2012年第12期40卷 1435-1443页

作者： mostafa Feyzi Faculty of Chemistry Razi UniversityKermanshahIran

The 15%(Co-Mn)/TiO2,(Co/Mn=1/6) catalyst was prepared using fusion procedure and studied for the conversion of synthesis gas to C2 ～ 4 *** effects of calcination conditions and operation conditions such as the H 2 / CO molar feed ratio at different temperatures,gas hourly space velocity(GHSV) and total reaction pressure on the catalytic performance of catalyst were *** stability of the catalyst during 150 h at optimal operation conditions(t = 250℃ H2 /CO= 2/1,GHSV=1 500 h-1 and p =0.3 MPa) has been *** is found that this catalyst is high stable for production C2 ～ 4 *** of both precursors and calcined catalysts by powder X-ray diffraction,scanning electron microscopy(SEM),Brunauer-Emmett-Teller(BET) specific surface area measurement and thermal analysis methods such as thermal gravimetric analysis(TGA) and differential scanning calorimetry(DSC) show that the different preparation method influences the catalyst precursor structure and morphology.

关键词：气化理论燃料化学研究发展

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Physical properties of three short period close binaries:KIC 2715417,KIC 6050116 and KIC 6287172

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Research in Astronomy and Astrophysics 2019年第2期19卷 111-124页

作者： Mahmoud AbdelFattah NegmEldin Ahmed Essam elsayed Shahinaz mostafa Yousef Astronomy Space Science and Meteorology Department Faculty of Science Cairo University Department of Astronomy National Research Institute of Astronomy and Geophysics(Egypt)

We present the physical parameters of three short period close binaries using data observed from the Kepler Space Telescope. All of these observations were taken in a single bandpass(which approximates the Johnson V-band). Our three systems are KIC 2715417, KIC 6050116 and KIC 6287172. The first system, KIC 2715417, is considered a semi-detached system with the secondary component filling its Roche lobe. The second system, KIC 6050116, is an overcontact system, while the third system, KIC 6287172, belongs to ellipsoidal variables as deduced from the Roche lobe geometry. For photometric analysis, we used the PHOEBE software package, which is based on the Wilson-Devinney code. Due to lack of spectroscopic data, the photometric mass ratios are determined from the analyses of light curves using the q-search method. The absolute parameters are determined using three different methods(Harmanec, Maceroni &Van'tVeer and Gazeas & Niarchos).

关键词： stars:binaries:eclipsing stars:fundamental parameters stars:luminosity function,mass function stars:individual(KIC 2715417,KIC 6050116 and KIC 6287172)

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