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肾包膜下种植建立人前列腺癌异种移植动物模型

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中华医学杂志 2010年第30期90卷 2136-2139页

作者：孙宏斌 WANG Hong Renea A taylor Gall P Risbridger 南京医科大学附属南京第一医院泌尿外科 210006 3168 Victoria Australia M h Institute of Medical Research Monash University Melbourne

目的采用肾包膜下种植方案建立人前列腺癌异种移植动物模型.方法 15只SCID雄鼠按随机表分组法随机分为3组,每组5只.应用组织重组技术,将人前列腺癌新鲜组织和新出生BALB/c雄鼠精囊间质（SVm）在体外重组,显微外科条件下种植于SCID鼠肾... 详细信息

目的采用肾包膜下种植方案建立人前列腺癌异种移植动物模型.方法 15只SCID雄鼠按随机表分组法随机分为3组,每组5只.应用组织重组技术,将人前列腺癌新鲜组织和新出生BALB/c雄鼠精囊间质（SVm）在体外重组,显微外科条件下种植于SCID鼠肾包膜下,4周后观察肿瘤种植率并称重、计算体积.检测血清前列腺特异性抗原（PSA）值.用细胞角蛋白（CK）8/18、波形蛋白（vimentin）单克隆抗体特异标记人前列腺上皮和基质成纤维细胞,用P63单克隆抗体标记上皮基底膜证实其是否为前列腺癌组织.另将人前列腺癌新鲜组织单独种植于SCID鼠肾包膜下作为对照.结果 15只SCID鼠78只次组织种植中无一只死亡.4周后,重组种植组成瘤率为100%（39/39）,单独种植组为94.1%（37/39）,差异无统计学意义（P＞0.05）.新生瘤体为实体状、不规则、黄/白色,隆出肾脏表面和（或）嵌入肾实质.重组种植组瘤体生长旺盛,单独种植组瘤体较为平坦,肿瘤大小及重量在两组间差异有统计学意义[（9.7±3.1）mm^3比（6.8±2.0）mm^3;（12.1±3.6）μg比（8.2±2.2）μg,均P＜0.01].重组种植组血清PSA值高于单独种植组,但两组间差异无统计学意义（P＞0.05）.CK8/18、vimentin单抗标记证实新生瘤体为人源性前列腺组织,P63单抗标记显示上皮基底膜消失证实为前列腺癌.结论肾包膜下种植可高效率建立人前列腺癌异种移植动物模型.本模型含有肿瘤基质成分,可为体内研究前列腺癌发病和病程演变中间质-上皮细胞相互作用提供技术平台.

关键词：前列腺肿瘤移植异种肾包膜下测定组织重组

Atmosphere-ionosphere response to the m9 Tohoku earthquake revealed by multiinstrument space-borne and ground observations:Preliminary results

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Earthquake Science 2011年第6期24卷 557-564页

作者： Dimitar Ouzounov Sergey Pulinets Alexey Romanov Alexander Romanov Konstantin Tsybulya Dmitri Davidenko menas Kafatos Patrick taylor Department of Physics Chapman UniversityOrangeCA 92866USA NASA Goddard Space Flight Center GreenbeltMD 20771USA Institute of Applied Geophysics Moscow 129128Russia Space Research Institute RAS Moscow 117997Russia Russian Space Systems Moscow 111250Russia

We retrospectively analyzed the temporal and spatial variations of four different physical parameters characterizing the state of the atmosphere and ionosphere several days before the m9 Tohoku, Japan earthquake of march 11, 2011. The data include outgoing long wave radiation （OLR）, GPS/TEC, lower Earth orbit ionospheric tomography and critical frequency foF2. Our first results show that on march 7th a rapid increase of emitted infrared radiation was observed from the satellite data and an anomaly developed near the epicenter. The GPS/TEC data indicate an increase and variation in electron density reaching a maximum value on march 8. Starting from this day in the lower ionosphere also there was confirmed an abnormal TEC variation over the epicenter. From march 3 to 11 a large increase in electron concentration was recorded at all four Japanese ground-based ionosondes, which returned to normal after the main earthquake. The joint preliminary analysis of atmospheric and ionospheric parameters during the m9 Tohoku, Japan earthquake has revealed the presence of related variations of these parameters implying their connection with the earthquake process. This study may lead to a better understanding of the response of the atmosphere/ionosphere to the great Tohoku earthquake.

关键词： Tohoku earthquake thermal anomaly GPS/TEC earthquake precursor early warning

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肾上腺髓质素的内分泌和代谢作用

世界医学杂志 2002年第15期6卷 36-39页

作者： m.m.taylor T.Shimosawa

肾上腺髓质素(adrenomedullin,Am)是一种有效的降压激素,可以对心血管、肾脏、内分泌和神经系统产生许多直接的作用。这种肽对正常生殖组织的功能和维持妊娠有作用。在脑垂体Am抑制ACTH的分泌,在体液缺失的情况下,控制血管加压素(抗利... 详细信息

肾上腺髓质素(adrenomedullin,Am)是一种有效的降压激素,可以对心血管、肾脏、内分泌和神经系统产生许多直接的作用。这种肽对正常生殖组织的功能和维持妊娠有作用。在脑垂体Am抑制ACTH的分泌,在体液缺失的情况下,控制血管加压素(抗利尿激素)的分泌释放。这种肽作用于肾上腺调控醛固酮的分泌,可以导致儿茶酚胺的释放。Am抑制胰岛分泌胰岛素。Am不仅参与了各个系统的正常功能,在许多疾病状态下,包括癌症、先兆子痫、糖尿病、充血性心衰与感染性休克中也可以发现这种肽表达水平的变化。最近新研制的Am基因敲除小鼠与Am基因过度表达的转基因小鼠提供了用以研究在正常和疾病状态下这种肽的作用模型,同时也可以用来评价Am类似物或者Am拮抗剂潜在的治疗作用。学习目的:阐述循环与胎盘中肾上腺髓质素(Am)的变化,对维持妊娠的意义,以及先兆子痫时发生的变化。明确Am可能影响垂体、肾上腺与胰腺的功能或与之相互作用的方式。认识Am在疾病状态下,包括癌症、血管损伤与败血症等有哪些可能的作用。

关键词：肾上腺髓质素内分泌肽类临床意义降压激素

Resveratrol decreases oxidative stress in the cardiovascular system by modifying redox genes

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Resveratrol decreases oxidative stress in the cardiovascular...

第14届国际自由基学术大会

作者： Andreas Daiber Alice Habermeier Gerrit Spanier matthias Oelze ellen I. Closs Thomas münzel Ulrich Frstermann II. medizinische Klinik Johannes Gutenberg University Mainz Germany Department of Pharmacology

＜正＞Resveratrol, a naturally occurring phytoalexin found in grapes and wine, is likely to contribute to the potential of red wine in preventing human cardiovascular disease. In addition to its （moderate） direct antioxidant effect, we have found that resveratrol also regulates pro- oxidative and anti-oxidative enzymes in cardiovascular system

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新年新计划

空中英语教室（初级版．大家说英语） 2016年第12期 43-45,56页

作者： ellen Lie

读读看!新年假期是一段令人振奋的时间，大家都会为明年设定新目标。你对于新年新计划有什么有趣的主意吗？琳达热爱阅读，她计划看更多书；泰乐想要学一种新语言,她可以在网上订购一本教科书。罗柏和亚力克斯说不定也可以帮她的忙。

关键词：英语学习学习方法阅读知识阅读材料

Calcium signaling and T-type calcium channels in cancer cell cycling

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World Journal of Gastroenterology 2008年第32期14卷 4984-4991页

作者： James T taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka ming Li Department of Pharmacology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Urology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Physiology Tulane University Health Sciences Center New Orleans LA 70112 United States Department of Pathology Tulane University Health Sciences Center New Orleans LA 70112 United States

Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the m phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers.

关键词： T-type calcium channels Cancer Cellcycle Calcium

Effects of Weight Loss on Pericardial Fat and Left Ventricular mass Assessed with Cardiac magnetic Resonance Imaging in morbid Obesity

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International Journal of Clinical medicine 2011年第4期2卷 360-366页

作者： Stephan m. Schneiter Ranjana Warrier Lisa Lefkovits Cheryl Laurie Paul E. O’Brien Andrew J. taylor 不详

Background: Obesity is a risk factor for cardiovascular disease and mortality. Significant weight loss has beneficial effects on left ventricular structure, in particular on regression of left ventricular hypertrophy (LVH). We therefore evaluated the consequences of significant weight loss on left ventricular morphology, hemodynamics and pericardial fat. methods: We performed volumetric cardiac magnetic resonance (CmR) imaging before and after significant weight loss due to laparoscopic adjustable gastric banding (LAGB). CmR was used to measure cardiac mass, volume and function, as well as to quantify pericardial fat. Results: Eleven patients (age 40.5 ± 10 yrs, body mass index 42.5 ± 3.9 kg/m2) underwent CmR imaging before and a median 15.4 months after gastric banding. The BmI declined by 9.3 ± 3.3 kg/m2 (p Discussion: Significant weight loss in obesity is accompanied by a marked regression of LVH, with no apparent change in cardiac volume or function. The local effect of a diminished amount of pericardiac fat tissue may be more important than absolute weight loss with respect to the regression of LVH in obesity.

关键词： Cardiac magnetic Resonance Imaging morbid Obesity Left Ventricular mass Pericardial Fat

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学做菜!

空中英语教室（初级版．大家说英语） 2016年第11期 15-17,51页

作者： ellen Lie

读读看!班恩不会做菜，可是他下星期要上奥斯卡主厨的料理节目现在他才看食谱？别担心，班恩，泰乐可以帮忙。班恩可以学一些厨房用语，汤锅和平底锅是不一样的，班恩有很多东西要学!琳达和班恩可以烤饼干班恩．别忘了穿上围裙!

关键词：做菜奥斯卡平底锅

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一起赛龙舟吧!

空中英语教室（初级版．大家说英语） 2017年第5期 41-43,55页

作者： ellen Lie

端午节到了。泰乐喜欢看龙舟比赛。她会划船吗？不对．“划”龙舟不是用“row”，而是用“paddle”!不过，泰乐不会划船，她只是观赏。今天天气很好。亚力克斯和苏希在龙舟比赛现场。龙舟比赛不容易，每个队伍成员都很强壮。

关键词：龙舟比赛比赛现场端午节划船