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中国护理管理 2016年第2期16卷 202-206页

作者：李智刘均娥陈双琴 Frances Marcus Lewis ellen h.zahlis 首都医科大学护理学院北京市100069 华盛顿大学护理学院

不良的沟通方式会影响乳腺癌夫妻关系的调适。本文详细介绍了乳腺癌患者配偶夫妻沟通干预方案的本土化修订过程、内容、实施方法及效果的初步评价,旨在帮助配偶学会良好的夫妻沟通方法,为乳腺癌家庭支持研究提供参考。

关键词：乳腺肿瘤配偶夫妻沟通干预

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit ellen Schrama hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda heinz Jacobs Sjoerd h.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MhC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week:An analysis with 707,616 adolescents

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Journal of Sport and health Science 2024年第5期13卷 709-716页

作者： Raphael h.O.Araujo AndrúO.Werneck Clarice L.Martins Luciana L.Barboza Rafael M.Tassitano Nicolas Aguilar-Farias Gilmar M.Jesus Robinson Ramírez-Véelez Riki Tesler Adewale L.Oyeyemi ellen C.M.Silva Robert G.Weaver Mark S.Tremblay Javier Brazo-Sayavera Grégore I.Mielke Danilo R.P.Silva Graduation Program in health Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidemiological Research in Nutrition and health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Physical Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of Physical Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Postgraduate Program in Physical Education University of BrasıliaBrasılia 70910-900Brazil Department of Kinesiology and Community health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA Department of Physical Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile Department of health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia health Management Department Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of health Solutions Arizona State UniversityPhoenixAZ 85004USA Arnold School of Public health University of South CarolinaColumbiaSC 29208USA healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Department of health Sciences Carleton UniversityOttawaON K1S 5B6Canada Department of Sports and Computer Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional Noreste Universidad de la RepublicaRivera 40000Uruguay School of Public health The University of QueenslandBrisbaneQLD 4006Australia Department of Physical Education

Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).however,using only this cut-off could hide important *** instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate ***,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity ***,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender ***:We used representative datasets from 146 countries/territories collected between 2003 and *** was *** were grouped into younger(≤14 years old)and older(>14 years old)*** Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled *** were stratified by country and ***:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per *** prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions werehe prevalence of≥60 min of MVPA≥1 days per week was higher among boys than girls,with the largest differences occurring among the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)*** ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between *** differences were observed in several countries,especially among the oldest *** fo

关键词： Global School-based Student health Survey health Behaviour Among School-aged Children survey Inequality Surveillance Youth

Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis

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World Journal of Gastroenterology 2022年第32期28卷 4725-4739页

作者： ellen S Wagner hussien Ahmed h Abdelgawad Meghan Landry Belal Asfour Mark B Slidell Ruba Azzam Pediatric Gastroenterology Hepatologyand NutritionThe University of Chicago MedicineComer Children’s HospitalChicagoIL 60637United States Department of Medicine Zagazig UniversityZagazig 44511EgyptEgypt Department of Pediatrics The University of Chicago MedicineComer Children’s HospitalChicagoIL 60637United States Graduate School of Professional Education-Biomedical Informatics University of ChicagoChicagoIL 60637United States Department of Surgery The University of Chicago MedicineComer Children’s HospitalChicagoIL 60637United States

BACKGROUND Timely differentiation of biliary atresia(BA)from other infantile cholestatic diseases can impact patient ***,non-invasive staging of fibrosis after Kasai hepatoportoenterostomy has not been widely *** wave elastography is an ultrasound modality that detects changes in tissue *** authors propose that the utility of elastography in BA can be elucidated through meta-analysis of existing *** To assess the utility of elastography in:(1)BA diagnosis,and(2)post-Kasai fibrosis *** A literature search identified articles that evaluated elastography for BA diagnosis and for post-Kasai *** studies met criteria for meta-analysis:Eleven for diagnosis and nine for follow-up *** diagnostic odds ratio(DOR),sensitivity,and specificity of elastography were calculated through a random-effects model using Meta-DiSc *** Mean liver stiffness in BA infants at diagnosis was significantly higher than in non-BA,with overall DOR 24.61,sensitivity 83%,and specificity 79%.Post-Kasai,mean liver stiffness was significantly higher in BA patients with varices than in patients without,with DOR 16.36,sensitivity 85%,and specificity 76%.Elastography differentiated stage F4 fibrosis from F0-F3 with DOR of 70.03,sensitivity 96%,and specificity 89%.Elastography also differentiated F3-F4 fibrosis from F0-F2 with DOR of 24.68,sensitivity 85%,and specificity 81%.CONCLUSION Elastography has potential as a non-invasive modality for BA diagnosis and surveillance *** paper’s limitations include inter-study method heterogeneity and small sample ***,standardized,multi-center studies are recommended.

关键词： Biliary atresia Cholestasis hepatic portoenterostomy Fibrosis Esophageal and gastric varices Elasticity imaging techniques

Institutional analysis of intra-and post-operative tracheostomy management for risk reduction

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World Journal of Otorhinolaryngology-head and Neck Surgery 2022年第4期8卷 370-377页

作者： Laura E.henry ellen A.Paul Joshua h.Atkins Niels D.Martin Ara A.Chalian Christopher h.Rassekh Department of Otorhinolaryngology-head and Neck Surgery University of PennsylvaniaPhiladelphia19104PAUSA Department of Anesthesiology and Critical Care University of PennsylvaniaPhiladelphia19104PAUSA Department of Traumatology Surgical Critical Careand Emergency SurgeryUniversity of PennsylvaniaPhiladelphia19104PAUSA

Objectives:Determine variability in intra-and post-operative management of tracheostomies(trachs)at our institution as existing literature suggests that trachs are a frequent trigger for airway-related *** the development of an institution-wide protocols for trach ***:A 39-question online survey was sent to 55 providers who perform open and percutaneous trachs at three of the hospitals within our large,urban,academic medical *** providers were identified by surveillance of the operating room schedules for 1 ***:The survey was completed by 40 of the 53 eligible providers(75.5%).Response rate by question *** included members of all departments that perform trachs at our institution(Otorhinolaryngology,Trauma Surgery,Thoracic Surgery,General Surgery,Cardiovascular Surgery and Interventional Pulmonology).While most responses demonstrated uniformity in practice,notable variations included the following:80%of percutaneous trach providers stated that morbid obesity was not a contraindication to performing a trach outside of the operating room(n=20)while 58%of open trach providers stated that morbid obesity was a contraindication;only 35%of open trach providers perform a Bjork flap(n=350).The survey also identified significant variability in practice with regards to timing of trach suture ***:Lack of uniformity was identified in several practices related to intra-and post-operative tracheostomy *** did,however,trend toward consensus in many *** results are being used to establish a more consistent approach to tracheostomy management across our institution to ensure standardization of practice amidst the rapidly evolving practices of trach *** for practice:With ongoing evolution in the methods of trach placement and its management,the concepts put forth here will be a resource for health care providers at other institutions to consider intra-institutional analysis and

关键词： Open tracheostomy Percutaneous tracheostomy Quality improvement Risk reduction Standardization

Taking Care of her: A Pilot Feasibility Study of a Caregiver Intervention for Women with Advanced Stage Ovarian Cancer

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Journal of Cancer Therapy 2017年第5期8卷 472-489页

作者： Frances Marcus Lewis Zainab Alzawad Kristin Griffith hebah Almulla Pei-Chin Wu Nai-Ching Chi ellen h. zahlis Mary ellen Shands Public health Sciences Division & Clinical Research Division Fred Hutchinson Cancer Research Center Seattle USA Department of Family and Child Nursing University of Washington Seattle USA

The purpose of this study is to examine the feasibility and short-term impact of a fully manualized, telephone-delivered intervention for spouse caregivers, Taking Care of her (TCh). A total of 12 study participants from the Pacific NW were enrolled whose wife was diagnosed with Stage III ovarian cancer within 8 months. Feasibility was confirmed by rates of recruitment and retention;the quality of delivery of the intervention by telephone;and through data obtained on program acceptability during follow up exit interviews. Outcomes from the within-group analysis revealed improvements on standardized measures of spouses’ and patients’ depressed mood and anxiety;marital communication about the cancer;caregivers’ skills and confidence to manage the emotional toll of the illness on themselves and wives;and wives’ positive appraisal of spousal support. Study results suggest that the TCh Program has the potential to positively affect both spouse caregiver and patients’ adjustment to recently diagnosed advanced ovarian cancer. Telephone delivery holds promise for sustainability. A future clinical trial with a larger study sample is warranted.

关键词： Advanced Ovarian Cancer Couple Adjustment Spouse Caregiver Intervention

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流体-固体相互作用、碰撞和起飞的建模

Acta Mechanica Sinica 2023年第5期39卷 1-12页

作者： Frank T.Smith ellen M.Jolley Ryan A.Palmer Department of Mathematics University College LondonLondonUK School of Biological Sciences University of BristolBristolEngland School of Mathematics University of BristolBristolEngland

本文是流体-固体相互作用机制方面的最新进展综述,主要研究固体物体自身的运动与其周围流体运动之间的相互影响.非稳态相互作用的数学模型是对两个空间维度和时间尺度的内部通道和外部近壁流的描述.本文重点描述伴随计算量减少的分析发... 详细信息

本文是流体-固体相互作用机制方面的最新进展综述,主要研究固体物体自身的运动与其周围流体运动之间的相互影响.非稳态相互作用的数学模型是对两个空间维度和时间尺度的内部通道和外部近壁流的描述.本文重点描述伴随计算量减少的分析发展过程.文章讨论无黏性流中掠过和下沉、物体的起飞、飞离或弹跳,以及黏性效应,特别是黏性和无黏性之间的相互作用和影响.主要研究结果涉及撞击时间、起飞条件、撞击和飞离之间的边界、主要参数及其范围以及物体形状和质量对物理及力学机制的影响.

关键词： Fluid-body interactions Skimming Impacts Analysis

CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract

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World Journal of Gastroenterology 2009年第23期15卷 2855-2861页

作者： ellen J Beswick Victor E Reyes Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Pediatrics and Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, helicobacter pylori (h pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or h pylori, NF-κB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

关键词：抗原提呈胃肠道炎症癌症幽门螺旋杆菌炎性细胞因子抑制因子幽门螺杆菌

Doping 25-Atom and 38-Atom Gold Nanoclusters with Palladium

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物理化学学报 2011年第3期27卷 513-519页

作者： QIAN huifeng BARRY ellen ZhU Yan JIN Rongchao Department of Chemistry Carnegie Mellon University Pittsburgh Pennsylvania 15213 USA Department of Chemistry University of Pittsburgh Pittsburgh Pennsylvania 15260 USA）

In this work,we describe two synthetic procedures for preparing palladium doped 25-atom nanoclusters(referred to as Pd_1Au_(24)(SR)_(18), where―SR represents thiolate,R=C_2h_4Ph). Pure Pd_1Au_(24)(SC_2h_4Ph)_(18)nanoclusters are isolated by solvent extraction and size exclusion chromatography. Mass spectrometry and optical spectroscopy analyses demonstrate that the Pd_1Au_(24)(SC_2h_4Ph)_(18)nanocluster adopts the same core-shell structure as that of the homogold Au_(25)(SC_2h_4Ph)_(18)nanocluster, that is,a Pd-or Au-centered icosahedron surrounded by six Au_2(SR)_3"staple"-like motifs. Similar doping behavior has also been observed in 38-atom M_(38)(SR)_(24)(M:metal)nanoclusters, indicating the unique behavior of Pd dopant being preferentially located in the icosahedral center. The catalytic activity of Pd_1Au_(24)(SC_2h_4Ph)_(18)has also been evaluated for the selective hydrogenation of α,β-unsaturated ketone(e.g., benzalacetone)toα,β-unsaturated alcohol, and a 42%conversion of benzalacetone is attained

关键词：物理化学 DFT hPLC SC2h4Ph

Effectiveness of an early operating room start time in managing pediatric trauma

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World Journal of Orthopedics 2023年第7期14卷 516-525页

作者： Dan Kym Japsimran Kaur Nicole Segovia Pham Eric Klein Joanna Lind Langner ellen Wang John Schoeneman Vorhies Department of Orthopaedic Surgery Stanford University School of MedicinePalo AltoCA 94304United States Lucile Packard Children’s hospital Palo AltoCA 94304United States Department of Anesthesiology Pain and Perioperative MedicineStanford University School of MedicinePalo AltoCA 94304United States

BACKGROUND The timing of operative treatment for pediatric supracondylar humerus fractures(SChF)and femoral shaft fractures(FSF)remains *** fractures previously considered to be surgical emergencies,such as SChF and open fractures,are now commonly being treated the following *** presented with an urgent fracture overnight needing operative treatment,the on-call surgeon must choose whether to mobilize resources for a late-night case or to add the case to an elective schedule of the following *** To describe the effect of a program allowing an early operating room(OR)start for uncomplicated trauma prior to an elective day of surgery to decrease wait times for surgery for urgent fractures admitted *** Starting in October 2017,patients were eligible for the early slot in the OR at the discretion of the surgeon if they were admitted after 21:00 the previous night and before 05:*** compared demographics and timing of treatment of SChF and FSF treated one year before and after implementation as well as the survey responses from the surgical *** Of the 44 SChF meeting inclusion criteria,16 received treatment before imple mentation while 28 were treated *** implementation,the mean wait time for surgery decreased by 4.8 h or 35.4%(13.4 h vs 8.7 h;P=0.001).There were no significant differences in the operative duration,time in the post anesthesia care unit,and wait time for *** results demonstrated decreased popularity of the program among nurses and anesthesiologists relative to *** 57%of the surgeons believed that the program was effective,only 9%of anesthesiologists and 16%of nurses *** program was ultimately discontinued given the *** Our findings demonstrate significantly reduced wait times for surgery for uncomplicated SChF presenting overnight while discussing the importance of shared decision-making with the *** the program produced promisi

关键词： Pediatrics Trauma Supracondylar humerus fractures Operating room