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Institutional analysis of intra-and post-operative tracheostomy management for risk reduction

World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第4期8卷 370-377页

作者： Laura E.Henry ellen a.paul Joshua H.Atkins Niels D.Martin Ara A.Chalian Christopher H.Rassekh Department of Otorhinolaryngology-Head and Neck Surgery University of PennsylvaniaPhiladelphia19104PAUSA Department of Anesthesiology and Critical Care University of PennsylvaniaPhiladelphia19104PAUSA Department of Traumatology Surgical Critical Careand Emergency SurgeryUniversity of PennsylvaniaPhiladelphia19104PAUSA

Objectives:Determine variability in intra-and post-operative management of tracheostomies(trachs)at our institution as existing literature suggests that trachs are a frequent trigger for airway-related *** the development of an institution-wide protocols for trach ***:A 39-question online survey was sent to 55 providers who perform open and percutaneous trachs at three of the hospitals within our large,urban,academic medical *** providers were identified by surveillance of the operating room schedules for 1 ***:The survey was completed by 40 of the 53 eligible providers(75.5%).Response rate by question *** included members of all departments that perform trachs at our institution(Otorhinolaryngology,Trauma Surgery,Thoracic Surgery,General Surgery,Cardiovascular Surgery and Interventional Pulmonology).While most responses demonstrated uniformity in practice,notable variations included the following:80%of percutaneous trach providers stated that morbid obesity was not a contraindication to performing a trach outside of the operating room(n=20)while 58%of open trach providers stated that morbid obesity was a contraindication;only 35%of open trach providers perform a Bjork flap(n=350).The survey also identified significant variability in practice with regards to timing of trach suture ***:Lack of uniformity was identified in several practices related to intra-and post-operative tracheostomy *** did,however,trend toward consensus in many *** results are being used to establish a more consistent approach to tracheostomy management across our institution to ensure standardization of practice amidst the rapidly evolving practices of trach *** for practice:With ongoing evolution in the methods of trach placement and its management,the concepts put forth here will be a resource for health care providers at other institutions to consider intra-institutional analysis and

关键词： Open tracheostomy Percutaneous tracheostomy Quality improvement Risk reduction Standardization

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Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle

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Regenerative Biomaterials 2023年第1期10卷 261-270页

作者： ellen Ngarande Emma Doubell Ousman Tamgue Manuel Mano paul Human Mauro Giacca Neil Hamer Davies Cardiovascular Research Unit Department of SurgeryFaculty of Health SciencesUniversity of Cape TownObservatory 7925South Africa International Centre for Genetic Engineering and Biotechnology(ICGEB) Cape Town ComponentObservatory 7925South Africa Institute of Infectious Diseases and Molecular Medicine(IDM) Department of PathologyDivision of Immunology and South African Medical Research Council(SAMRC)Immunology of Infectious DiseasesFaculty of Health SciencesUniversity of Cape TownObservatory 7925South Africa King’s College London British Heart Foundation Centre of Research ExcellenceSchool of Cardiovascular Medicine&SciencesWC2R 2LSLondonUK Present address:Department of Biochemistry Faculty of SciencesUniversity of DoualaDoualaCameroon

RNA interference is a promising therapeutical approach presently hindered by delivery concerns such as rapid RNA degradation and targeting of individual *** hydrogels are one potentially simple and direct route towards overcoming these *** we report on the utility of a combination of a mildly modified form of the clinically utilised fibrin hydrogel with Invivofectamine^(■)3.0,a lipid nonviral transfection vector,for local and sustained *** of fibrin allowed for controlled release of small interfering RNA(siRNA)-lipopolyplexes for at least 10 days and greatly increased the stability of fibrin in vitro and in vivo.A 3D cell culture model and a release study showed transfection efficacy of siRNA-lipopolyplexes was retained for a minimum of 7 *** in conjunction with PEGylated-fibrinogen significantly increased retention of siRNA-lipopolyplexes in mouse skeletal muscle and enhanced knockdown of myostatin mRNA that correlated with muscle ***,the increased efficacy observed here for the combination of a lipid nanoparticle,the only type of nonviral vector approved for the clinic,with fibrin,might allow for more rapid translation of injectable hydrogel-based RNA interference.

关键词： RNA interference controlled release fibrin lipopolyplex

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Disaster Risk Management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-paul Pinelli Maria Esteva ellen M.Rathje David Roueche Scott J.Brandenberg Gilberto Mosqueda Jamie Padgett Frederick Haan Department of Mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

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Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment

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Bone Research 2022年第1期10卷 107-121页

作者： Anke Baranowsky Denise Jahn Shan Jiang Timur Yorgan Peter Ludewig Jessika Appelt Kai K.Albrecht ellen Otto paul Knapstein Antonia Donat Jack Winneberger Lana Rosenthal paul Köhli Cordula Erdmann Melanie Fuchs Karl-Heinz Frosch Serafeim Tsitsilonis Michael Amling Thorsten Schinke Johannes Keller Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-EppendorfHamburg 20246Germany Department of Osteology and Biomechanics University Medical Center Hamburg-EppendorfHamburg 20246Germany Center for Musculoskeletal Surgery Charité-Universitätsmedizin BerlinBerlin 13353Germany Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration Charité-Universitätsmedizin BerlinBerlin 13353Germany Department of Neurology University Medical Center Hamburg-EppendorfHamburg 20251Germany Berlin Institute of Health Berlin 10178Germany

Intermittent injections of parathyroid hormone(iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone(PTH) primarily results in increased bone resorption. Here, we identified Calca,encoding the sepsis biomarker procalcitonin(ProCT), as a novel target gene of PTH in murine osteoblasts that inhibits osteoclast formation. During iPTH treatment, mice lacking ProCT develop increased bone resorption with excessive osteoclast formation in both the long bones and axial skeleton. Mechanistically, ProCT inhibits the expression of key mediators involved in the recruitment of macrophages, representing osteoclast precursors. Accordingly, ProCT arrests macrophage migration and causes inhibition of early but not late osteoclastogenesis. In conclusion, our results reveal a potential role of osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH.

关键词： treatment representing skeleton

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Feeding Biochar to Cows:An Innovative Solution for Improving Soil Fertility and Farm Productivity

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Pedosphere 2015年第5期25卷 666-679页

作者： Stephen JOSEPH Doug POW Kathy DAWSON David R.G.MITCHELL Aditya RAWAL James HOOK Sarasadat TAHERYMOOSAVI Lukas VAN ZWIETEN Joshua RUST Scott DONNE paul MUNROE Ben PACE ellen GRABER Torsten THOMAS Shaun NIELSEN Jun YE Yun LIN PAN Genxing LI Lianqing Zakaria M.SOLAIMAN Discipline of Chemistry University of Newcastle School of Materials Science and Engineering University of New South Wales Electron Microscopy Center AIIMUniversity of Wollongong Institute of Resources Ecosystem and Environment of AgricultureNanjing Agricultural University Marron Brook Farm Warren Catchments Council 52 Bath StManjimup 6258 (Australia) Mark Wainwright Analytical Centre University of New South Wales Wollongbar Primary Industries Institute NSW Department of Primary Industries Institute of Soil Water and Environmental SciencesThe Volcani CenterAgricultural Research Organization Centre for Marine Bio-Innovation School of Biotechnology and Biomolecular SciencesThe University of New South Wales Soil Biology and Molecular Ecology Group School of Earth and Environment (M087)The University of Western Australia

Addition of biochar produced through thermal decomposition of biomass has been seen as a strategy to improve soils and to sequester carbon （C）, but wide scale implementation of the technology requires to devise innovative profitable solutions. To develop biochar utilisation with an integrated system approach, an innovative program was implemented in 2012 on a 53-ha farm in Western Australia to determine the costs and benefits of integrating biochar with animal husbandry and improvement of pastures. Biochar was mixed with molasses and fed directly to cows. The dung-biochar mixture was incorporated into the soft profile by dung beetles. We studied the changes in soil properties over 3 years. Biochar extracted from fresh dung and from the soil to a depth of 40 cm was characterised. A preliminary financial analysis of the costs and benefits of this integrated approach was also undertaken. The preliminary investigation results suggested that this strategy was effective in improving soil properties and increasing returns to the farmer. It was also concluded that the biochar adsorbed nutrients from the cow＇s gut and from the dung. Dung beetles could transport this nutrient-rich biochar into the soil profile. There was little evidence that the recalcitrant component of the biochar was reduced through reactions inside the gut or on/in the soil. Further research is required to quantify the long-term impact of integrating biochar and dung beetles into the rearing of cows.

关键词： animal husbandry biochar C sequestration dung beetles financial benefit pasture

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Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep

Localizing Effects of Leptin on Upper Airway and Respiratory...

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第二届中国西部睡眠医学大会

作者： Qiaoling Yao Huy Pho Jason Kirkness ellen E.Ladenheim Sheng Bi Timothy H.Moran David D.Fuller paul J.Reiter David C.Bloom Alan R.Schwartz Vsevolod Y.Polotsky

Objectives Obesity hypoventilation syndrome and obstructive sleep apnea are common complications of obesity linked to defects in respiratory pump and upper airway neural *** deficient ob/ob mice have impaired hypercapnic ventilatory response and inspiratory flow limitation during sleep,which are both reversed with *** study is to localize CNS site（s） of leptin action on respiratory and upper airway neuro-ventilatory *** We localized the effect of leptin to medulla *** by administering intracerbroventricular leptin（10μg/2ul）vs vehicle to the lateral（n=14）vs fourth ventricle（n=11）of ob/ob mice followed by a 6 h polysomnographic *** were stratified for effects on respiratory（non-flow limited breaths） and upper airway（inspiratory flow limitation） *** loci were identified by（a） leptin-induced STAT3 phosphorylation and（b）projections of respiratory and upper airway motoneurons with a retrograde tracer pseudorabies *** Both routes of leptin administration increased minute ventilation during non-flow limited breathing in *** motoneurons projected to the nucleus of the solitary tract,which showed STAT3 phosphorylation,but not to the *** flow limitation and obstructive hypopneas were attenuated by leptin administration to the lateral,but not to the fourth cerebral *** airway motoneurons projected to the dorsomedial hypothalamus,which exhibited STAT3 *** Leptin relieves upper airway obstruction in sleep apnea by activating the forebrain,possibly in the dorsomedial *** contrast,leptin up-regulates ventilatory control through hindbrain sites of action,possibly in the nucleus of the solitary tract.

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语言、对话与想象:辩证诠释学的应用

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安徽师范大学学报（社会科学版） 2008年第3期36卷 284-288页

作者：艾伦·赫达美国旧金山大学教育学院 San Francisco CA94118

保罗·利科倡导的叙述的变革力量通过语言、对话和想象被极大地扩展了,尤其在一群西方的发展者和泰国北部的马来布族人之间。持续的对话和对社会全景的展望给新的生活方式带来了充分的想象空间,对我们生活的热情叙述和学习也给建立新的... 详细信息

保罗·利科倡导的叙述的变革力量通过语言、对话和想象被极大地扩展了,尤其在一群西方的发展者和泰国北部的马来布族人之间。持续的对话和对社会全景的展望给新的生活方式带来了充分的想象空间,对我们生活的热情叙述和学习也给建立新的关系网络带来了可能,并成为可持续性国际发展的基石。这里讨论的以批判诠释学为基础的方法尝试区别于传统的市场经济论,希望能给社会的发展以指导性的启示。

关键词：叙述一致性国际发展利科社会全景

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Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.Jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger paul M.Kirk A.Martyn Ainsworth Jean-Marc Moncalvo Rytas Vilgalys ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori Center for Forest Mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly Mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario Museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest Mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National Mycological Herbarium(DAOM) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia CBS Fungal Biodiversity Centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology

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青光眼视网膜神经纤维层厚度的光学相干断层扫描纵向评估

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美国医学会眼科杂志（中文版） 2005年第4期17卷 214-220页

作者： Gadi Wollstein Joel S. Schuman Lori L. Price Ali Aydin paul C. Stark ellen Hertzmark Edward Lai Hiroshi Ishikawa Cynthia Mattox James G. Fujimoto Lelia A. Paunescu 刘春（译）朱志忠（校） New England Eye Center Biostatistics Research Center Division of Clinical Care Research Department of Epidemiology Harvard School of Public Health Boston Department of Electrical Engineering and Research laboratory of Electranics Massachusetts Institute of Technology Cambridge Tufts-New England Medical Center Tufts University School of Medicine Boston Mass UPMC Eye Center Department of Ophthahnology University of Pittsburgh School of Medicine Pittsburgh Pa 不详

目的：纵向评估光学相干断层扫描（OCT）视盘周围神经纤维层厚度测量，并将这些检查与临床状态和自动视野计检查作横向比较。方法：对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼（37例）作回顾性评估。所有参与者每6个月作一次... 详细信息

目的：纵向评估光学相干断层扫描（OCT）视盘周围神经纤维层厚度测量，并将这些检查与临床状态和自动视野计检查作横向比较。方法：对参与前瞻性纵向研究的青光眼或疑似青光眼患者64只眼（37例）作回顾性评估。所有参与者每6个月作一次全面的临床评估、视野检查和OCT。视野进展按可重复性测量的视野平均偏差至少比基线降低2dB，OCT进展按可重复性测量视网膜神经纤维层平均厚度至少变薄20pro。结果：每个患者在中位值为4．7年的随访中有5个可使用的OCT扫描。青光眼和疑似青光眼患者之间视网膜神经纤维层厚度线性回归斜度的差异对所有变量均不显著；然而，Kaplan-Meier生存曲线分析显示视野比OCT测量有较高的进展率。在随访期间66％的眼是稳定的。22％只有OCT进展，9％单有视野平均偏差进展。3％视野和OCT都有进展。结论：OCT比全自动视野计对辨别青光眼进展有更大的可能性。这可能反映OCT的敏感性或在常规方法发现之前其真实损害就能被OCT发现。

关键词：视网膜神经纤维层厚度光学相干断层扫描青光眼患者全自动视野计前瞻性纵向研究重复性测量视野检查平均偏差随访期间 OCT

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南澳卡恩曼托群贱金属成矿作用的构造和变质环境

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国外前寒武纪地质 1989年第2期 45-53页

作者： paul G. pry Jeffrey C. Schiller Ross A. Both 高坪仙

引言贱金属矿化出现在阿德雷得南50公里卡恩曼托(Kanmantoo)和斯特拉斯奥尔比(Strathalbyn)之间罗弗特(Lofty)山区东南侧,区域变质的卡恩曼托群内的几处地方。硫化物成矿作用有三种主要类型(Seccombe等,1985):1.铜矿床,有卡恩曼托矿山... 详细信息

引言贱金属矿化出现在阿德雷得南50公里卡恩曼托(Kanmantoo)和斯特拉斯奥尔比(Strathalbyn)之间罗弗特(Lofty)山区东南侧,区域变质的卡恩曼托群内的几处地方。硫化物成矿作用有三种主要类型(Seccombe等,1985):1.铜矿床,有卡恩曼托矿山和布雷默(Bremer)矿山、南希尔(South Hill)勘探区和数处次要产地。2.铅-锌矿床,有阿克拉雷(Aclare)、惠阿尔埃列(Wheal ellen)、斯特拉斯奥尔比、圣艾夫斯、

关键词：贱金属矿卡恩曼托群成矿作用

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