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P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers

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World Journal of Gastroenterology 2017年第9期23卷 1513-1520页

作者： elke Cario Experimental Gastroenterology Department of Gastroenterology and HepatologyUniversity Hospital EssenMedical SchoolUniversity of Duisburg-Essen45147 EssenGermany

The gastrointestinal barrier is constantly exposed to numerous environmental substrates that are foreign and potentially harmful. These xenobiotics can cause shifts in the intestinal microbiota composition, affect mucosal immune responses, disturb tissue integrity and impair regeneration. The multidrug transporter ABCB1/MDR1 p-glycoprotein (p-gp) plays a key role at the front line of host defence by efficiently protecting the gastrointestinal barrier from xenobiotic accumulation. This Editorial discusses how altered expression and function of ABCB1/MDR1 p-gp may contribute to the development and persistence of chronic intestinal inflammation in inflammatory bowel diseases (IBD). Recent evidence implies multiple interactions between intestinal microbiota, innate immunity and xenobiotic metabolism via p-gp. While decreased efflux activity may promote disease susceptibility and drug toxicity, increased efflux activity may confer resistance to therapeutic drugs in IBD. Mice deficient in MDR1 A develop spontaneously chronic colitis, providing a highly valuable murine IBD model for the study of intestinal epithelial barrier function, immunoregulation, infectious co-triggers and novel therapeutic approaches. Possible associations of human ABCB1 gene polymorphisms with IBD susceptibility have been evaluated, but results are inconsistent. Future studies must focus on further elucidation of the pathophysiological relevance and immunological functions of p-gp and how its ambiguous effects could be therapeutically targeted in IBD.

关键词： Inflammatory bowel diseases Multidrug resistance Innate immunity Microbiota Xenobiotics

Prospects and limitations of soil amendment and irrigation techniques for the water-saving public urban greenery and ephemeral weed management in the sandy soils of the United Arab Emirates

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Journal of Arid Land 2024年第9期16卷 1288-1302页

作者： Ayesha ALAM elke GABRIEL-NEUMANN Department of Integrative Agriculture College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates ASPIRE Research Institute of Food Security in Drylands College of Agriculture and Veterinary MedicineUnited Arab Emirates UniversityAl Ain 15551the United Arab Emirates

Public urban greenery greatly contributes to the residential and tourist value of cities in the Gulf Region,but due to the hyper-arid climatic conditions,the cost of irrigation and plant maintenance is very *** strategies to reduce the monetary and ecological costs involve the cultivation of native xerophytic plantations,and/or the use of soil improvers to increase water-and nutrient-holding capacity of the sandy *** soil improvers based on mineral,organic,or synthetic materials have entered the United Arab Emirates(UAE)market in recent years,but there is considerable uncertainty about how they should best be used in combination with ornamental plant stands involving xerophytic native *** present study investigated the effect of soil amendment and deep pipe irrigation on perennial ornamental plant stands involving native plants(Tephrosia appolinea(Gel.)Link in combination with Aerva javanica(Burm.f.)*** Schult.)and native-exotic plants(*** in combination with Ruelia simplex ***)either or not topsoil and subsoil amendment with bentonite and hydrophobic sand under the irrigation water supply of less than 50%of reference evapotranspiration(ET0).After one year of cultivation,*** and ***(native ***)produced high biomass and exhibited high water use efficiency(WUE)as compared with *** and ***(native ***)combination given that no significant differences were found under the soil amendment *** stands thrived under irrigation water supply far below what is usually supplied to exotic ornamental stands in public parks of the Al Ain City,the ***,subsoil amendment in combination with deep pipe irrigation reduced the occurrence of weeds and increased the overall plant rooting *** results suggest that subsoil amendment and irrigation up to 60-80 cm depth can potentially control ephemeral weed infestation,which is a great challenge in various plant production systems of the

关键词： native and exotic plant communities competitive strength soil improvers urban plantation subsoil amendment weed management

A journey of a thousand miles begins with one small step

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 112-114页

作者： elke Roeb Department of Gastroenterology Medical Clinic IIJustus Liebig UniversityGiessenGermany

Liver disease associated with metabolic dysfunction now affects more than 30%of the world’s population(1).Historically known as non-alcoholic fatty liver disease(NAFLD)is caused by obesity,lack of exercise,and a westernised lifestyle(2).To date,numerous attempts have been made to influence the steatohepatitis and liver fibrosis associated with metabolism-associated fatty liver disease(MAFLD)with *** to date,no substance has been authorised for the indication NAFLD/MAFLD/metabolism-associated steatosis liver disease(MASLD)(3).It has long been known that a consistent change in lifestyle with a reduced diet and physical exercise is able to improve fatty liver disease,steatohepatitis.

关键词： Metabolism-associated steatosis liver disease(MASLD) metabolism-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) exercise fatty liver

Correlation of Lopingian to Middle Triassic Palynozones

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Journal of Earth Science 2018年第4期29卷 755-777页

作者： Hendrik Nowak elke Schneebeli-Hermann Evelyn Kustatscher Museum of Nature South Tyrol Bindergasse/Via Bottai 1 Bozen/Bolzano 39100 Italy Palaiontologisehes Institut und Museum Karl-Schmid-Strasse 4 Zurich 8006 Switzerland Department for Geo- und Umweltwissenschafien Pala'ontologie und Geobiologie Ludwig-Maximilians-Universitait and Bayerische Staatssammlung Jur P alaiontologie und Geob iologie Richard-Wagner-Strafle 10 Munchen 80333 Germany

Terrestrial floras underwent important changes during the Lopingian （Late Permian）, Early Triassic, and Middle Triassic, i.e., before, during, and after the end-Permian mass extinction. An accurate account of these developments requires reliable correlation. Macrofossils of land plants can only provide a low-resolution biostratigraphy, while detailed zonation schemes based on palynomorphs are available for many regions. Their applicability is still limited due to several factors, such as （micro-）floral provincialism, a lack of suitable marker taxa commonly occurring at important boundaries, and in many cases a lack of independent age control. Nevertheless, these palynostratigraphic schemes are regularly used for dating and correlation of successions between different regions. To support such efforts, the biozonation schemes based on palynomorphs from the Lopingian up to and including the Middle Triassic from across the world are summarized and revised. Thus, a consistent correlation of palynozones with the currently recognized international stages is established.

关键词： Permian Triassic land plants palynomorpbs biostratigraphy.

Second-Kind Boundary Integral Equations for Scattering at Composite Partly Impenetrable Objects

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Communications in Computational Physics 2018年第1期23卷 264-295页

作者： Xavier Claeys Ralf Hiptmair elke Spindler Sorbonne Universites UPMC Univ Paris 06CNRSINRIAUMR 7598Laboratoire Jacques-Louis Lionsequipe AlpinesF-75005ParisFrance Seminar for Applied Mathematics Swiss Federal Institute of TechnologyCH-8092 ZurichSwitzerland

We consider acoustic scattering of time-harmonic waves at objects composed of several homogeneous *** of those may be impenetrable,giving rise to Dirichlet boundary conditions on their *** start from the recent secondkind boundary integral approach of[***,and ***,and ***.A second-kind Galerkin boundary element method for scattering at composite *** Numerical Mathematics,55(1):33-57,2015]for pure transmission problems and extend it to settings with essential boundary *** on so-called global multipotentials,we derive variational second-kind boundary integral equations posed in L^(2)(S),where S denotes the union of material *** suppress spurious resonances,we introduce a combined-field version(CFIE)of our new *** numerical tests highlight the low andmesh-independent condition numbers of Galerkin matrices obtained with discontinuous piecewise polynomial boundary element *** also confirm competitive accuracy of the numerical solution in comparison with the widely used first-kind single-trace approach.

关键词： Acoustic scattering second-kind boundary integral equations Galerkin boundary element methods

Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis

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Journal of Genetics and Genomics 2015年第5期42卷 207-219页

作者： Monika L?ffler Elizabeth A.Carrey elke Zameitat Institute of Physiological Chemistry Faculty of Medicine Philipps University Marburg UCL Institute of Child Health University College London

It is timely to consider the many facets of the small molecule orotic acid （OA）, which is well-known as an essential intermediate of pyrimidine de novo synthesis. In addition, it can be taken up by erythrocytes and hepatocytes for conversion into uridine and for use in the pyrimidine recycling pathway. We discuss the link between dietary orotate and fatty liver in rats, and the potential for the alleviation of neonatal hyperbilirubinaemia. We address the development of orotate derivatives for application as anti-pyrimidine drugs, and of com- plexes with metal ions and organic cations to assist therapies of metabolic syndromes. Recent genetic data link human Miller syndrome to defects in the dihydroorotate dehydrogenase （DHODH） gene, hence to depleted orotate production. Another defect in pyrimidine biosynthesis, the orotic aciduria arising in humans and cattle with a deficiency of UMP synthase （UMPS）, has different symptoms. More recent work leads us to conclude that OA may have a role in regulating gene transcription.

关键词： Orotic acid Pyrimidines Orotic aciduria Miller syndrome Gene defects

Histological examination of carotid artery tissue in cases of ligature strangulation and hanging

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Forensic Sciences Research 2022年第2期7卷 247-254页

作者： Julia Ulbricht Burkhard Madea elke Doberentz Institute of Legal Medicine University Hospital BonnBonnGermany

Violence against the neck can result in a range of macromorphological and micromorphological ***,the forensic relevance of the carotid sinus in cases of violence against the neck remains *** this follow-up study of 22 cases of suicidal and accidental strangulations,carotid bifurcations were examined histologically for morphological changes implying direct trauma,including haemorrhage and immunohistochemical expression of heat-shock proteins 27,60,and 70 and *** cases were compared with a control group(82 cases)without neck compression or head trauma and with variable causes of *** relevant histopathological findings implying direct trauma of the carotid bifurcation were *** cases showed positive aquaporin-3 staining and only five cases showed positive heat-shock protein-27 staining,all of which were *** massive trauma of the carotid bifurcation,histological alterations cannot be *** signs of rapid death,findings of acute circulatory failure,macromorphological and micromorphological findings of neck compression,and reliable markers indicating relevant impact on the carotid bifurcation the diagnosis of a lethal reflex cannot be verified.

关键词： Forensic sciences carotid bifurcation carotid body carotid sinus haemorrhage hanging ligature strangulation aquaporin-3(AQP-3) heat-shock protein(Hsp)

Microscopic examination of pituitary glands in cases of fatal accidental hypothermia

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Forensic Sciences Research 2017年第3期2卷 132-138页

作者： elke Doberentz Burkhard Madea Institute of Forensic Medicine University of BonnBonnGermany

In cases of death caused by hypothermia,histological analysis can be used to determine the cause of *** histological alterations of the pituitary glands in hypothermia have been reported in the literature,including haemorrhage,hyperaemia and cellular vacuolization of cells in the anterior *** the present study,the validity of these morphological alterations as markers for fatal accidental hypothermia was investigated in autopsy material.A total of 34 pituitary glands in cases of verified fatal accidental hypothermia were examined histologically(haematoxylin and eosin,ferric,azan)and immunohistochemically(LCA,ACTH,C5b-9).The findings were compared with 61 cases in a control *** was found in 50.0%of the study group cases and 59.0% of the control group *** vacuolization was observed in one case(2.9%)in the study group and one case(1.6%)in the control *** or recent haemorrhage in the glandular tissue was never *** our study,the histopathological characteristics described in the literature as pathognomonic for hypothermia could not be ***,histological differences in the pituitary glands between fatal hypothermia cases and control group cases were not observed.

关键词： Forensic pathology adenohypophysis haemorrhage hypothermia hyperaemia pituitary gland vacuolization post-mortem examination

Modifier-concept of colorectal carcinogenesis: Lipidomics as a technical tool in pathway analysis

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World Journal of Gastroenterology 2010年第15期16卷 1820-1827页

作者： Nikolaus Gassler Christina Klaus elke Kaemmerer Andrea Reinartz Institute of Pathology RWTH Aachen University Department of Pediatrics RWTH Aachen University School of Biology Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology

In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids. Increased consumption of long-chain fatty acids is in discussion to modify the development of colorectal carcinoma in humans. Saturated long-chain fatty acids, in particular, are assumed to promote carcinogenesis, whereas poly-unsaturated forms are likely to act in the opposite way. At present, the molecular mechanisms behind these effects are not well understood. Recently, it has been demonstrated by lipidomics and associated molecular techniques, that activation and metabolic channeling of long-chain fatty acids are important mechanisms to modify colorectal carcinogenesis. In this Editorial, an overview about the present concept of long-chain fatty acids and its derivatives in colorectal carcinogenesis as well as technical algorithms in lipid analysis is given.

关键词： Colorectal neoplasms Carcinogenesis Long-chain fatty acids Acyl-CoA Lipidomics