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Severe dengue associated with aseptic meningitis, acute kidney injury, and sudden sensorineural hearing loss: A case report

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 187-190页

作者： Renan GM Diniz Elaine c dos Santos Gabriel cL chagas elizabeth F Daher Department of Internal Medicine Faculty of MedicineFederal University of CearaCearaBrazil Department of Intensive care Unit Fortaleza General HospitalFortalezaCearaBrazil Post-Graduation Program in Medical Sciences Department of Internal MedicineFederal University of CearaFortalezaCearaBrazil

Rationale:Dengue is the most important human arboviral *** manifestations occur rarely in *** the best of our knowledge,there is only one reported case of dengue-associated sudden sensorineural hearing loss(SSNHL)in Brazil untill *** concerns:A 42-year-old man was presented to the emergency department with unconsciousness and generalized tonicclonic ***:Dengue-associated aseptic meningitis,acute kidney injury,and ***:The patient was treated with anticonvulsants and thiamine and underwent mechanical *** received combined ceftriaxone and acyclovir,which were later switched to meropenem,acyclovir and ampicillin empirically until culture results became *** also required hemodialysis and plasmapheresis sessions and fresh frozen plasma and buffy coat transfusions until definitive ***:The patient was discharged after improvement of his general condition and of his blood test results,but hearing loss remained.A six-month follow-up visit showed persistent ***:Dengue should be included in the differential diagnosis of patients from dengue-endemic areas presenting an acute febrile disease with neurological *** the best of our knowledge,this is the second reported case of dengueassociated SSNHL,suggesting an association between dengue and development of SSNHL.

关键词： Dengue Aseptic meningitis Acute kidney injury Sensorineural hearing loss Deafness

Associations between aerobic and muscle-strengthening physical activity,sleep duration,and risk of all-cause mortality:A prospective cohort study of 282,473 ***

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Journal of Sport and Health Science 2023年第1期12卷 65-72页

作者： Mitch J.Duncan Stina Oftedal christopher E Kline Ronald c.Plotnikoff elizabeth G.Holliday School of Medicine&Public Health College of HealthMedicineand WellbeingThe University of NewcastleCallaghanNSW 2308Australia Priority Research centre for Physical Activity and Nutrition The University of NewcastleCallaghanNSW 2308Australia Department of Health&Human Development The University of PittsburghPittsburghPA 15261USA School of Education University of NewcastleCallaghanNSW 2308Australia

Purpose:To examine the joint associations between meeting guidelines for physical activity(PA)and sleep duration and all-cause mortality risk among ***:Participants were adults(n=282,473)aged 18-84 years who participated in the 2004-2014 *** Health Interview *** status was ascertained using the National Death Index through December ***-reported PA(Active:meeting both aerobic(AER)and muscle-strengthening(MSA)guidelines,AER only(AER),MSA only(MSA),or not meeting either AER or MSA(Inactive))and sleep duration(Short,recommended(Rec),or Long)were classified according to guidelines,and 12 PA-sleep categories were *** hazard ratios and 95%confidence intervals(95%cIs)for all-cause mortality risk were estimated using cox proportional hazards regression ***:A total of 282,473 participants(55%females)were included;18,793 deaths(6.7%)occurred over an average follow-up of 5.4 *** to the Active-Rec group,all other PA-sleep groups were associated with increased mortality risk except for the Active-Short group(hazard ratio=1.08;95%cI:0.92-1.26).The combination of long sleep with either MSA or Inactive appeared to be *** a given sleep duration,mortality risk progressively increased among participants classified as AER,MSA,and *** each activity level,the mortality risk was greatest among adults with long ***:Relative to adults meeting guidelines for both PA and sleep duration,adults who failed to meet guidelines for both AER and muscle strengthening PA and who also failed to meet sleep duration guidelines had elevated all-cause mortality *** results support interventions targeting both PA and sleep duration to reduce mortality risk.

关键词： Activity-sleep patterns All-cause mortality Prospective Resistance training

Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome

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Neural Regeneration Research 2015年第11期10卷 1856-1859页

作者： Michael Alexander Malahias elizabeth O.Johnson George c.Babis Vasileios S.Nikolaou Second Department of Orthopedics Athens University Department of Anatomy School of Medicine Athens University

Both in vitro and in vivo experiments have confirmed that platelet-rich plasma has therapeutic effects on many neuropathies, but its effects on carpal tunnel syndrome remain poorly understood. We aimed to investigate whether single injection of platelet-rich plasma can improve the clinical symptoms of carpal tunnel syndrome. Fourteen patients presenting with median nerve injury who had suffered from mild carpal tunnel syndrome for over 3 months were included in this study. Under ultrasound guidance, 1-2 m L of platelet-rich plasma was injected into the region around the median nerve at the proximal edge of the carpal tunnel. At 1 month after single injection of platelet-rich plasma, Visual Analogue Scale results showed that pain almost disappeared in eight patients and it was obviously alleviated in three patients. Simultaneously, the disabilities of the arm, shoulder and hand questionnaire showed that upper limb function was obviously improved. In addition, no ultrasonographic manifestation of the carpal tunnel syndrome was found in five patients during ultrasonographic measurement of the width of the median nerve. During 3-month follow-up, the pain was not greatly alleviated in three patients. These findings show very encouraging mid-term outcomes regarding use of platelet-rich plasma for the treatment of carpal tunnel syndrome.

关键词： nerve regeneration carpal tunnel syndrome platelet-rich plasma ultrasound guidance pilot study neural regeneration

cD8+T cell metabolic flexibility elicited by cD28-ARS2 axisdriven alternative splicing of PKM supports antitumor immunity

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cellular & Molecular Immunology 2024年第3期21卷 260-274页

作者： G.Aaron Holling colin A.chavel Anand P.Sharda Mackenzie M.Lieberman caitlin M.James Shivana M.Lightman Jason H.Tong Guanxi Qiao Tiffany R.Emmons Thejaswini Giridharan Shengqi Hou Andrew M.Intlekofer Richard M.Higashi Teresa W.M.Fan Andrew N.Lane Kevin H.Eng Brahm H.Segal elizabeth A.Repasky Kelvin P.Lee Scott H.Olejniczak Department of Immunology Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Department of Medicine Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA center for Environmental Systems Biochemistry Department of Toxicology and Cancer Biology and Markey Cancer CenterLexingtonKY 40536USA Department of cancer Genetics and Genomics Roswell Park Comprehensive Cancer CenterBuffaloNY 14263USA Present address:University of colorado Boulder BoulderCO 80309USA Present address:Dana Farber cancer Institute BostonMA 02215USA Present address:Massachusetts Institute of Technology BostonMA 02139USA Present address:Melvin and Bren Simon comprehensive cancer center Indiana University School of MedicineIndianapolisIN 46202USA

Metabolic flexibility has emerged as a critical determinant of cD8+T-cell antitumor activity,yet the mechanisms driving the metabolic flexibility of T cells have not been *** this study,we investigated the influence of the nuclear cap-binding complex(cBc)adaptor protein ARS2 on mature T *** doing so,we discovered a novel signaling axis that endows activated cD8+T cells with flexibility of glucose ***2 upregulation driven by cD28 signaling reinforced splicing factor recruitment to pre-mRNAs and affected approximately one-third of T-cell activation-induced alternative splicing *** these effects,the cD28-ARS2 axis suppressed the expression of the M1 isoform of pyruvate kinase in favor of PKM2,a key determinant of cD8+T-cell glucose utilization,interferon gamma production,and antitumor effector ***,PKM alternative splicing occurred independently of cD28-driven PI3K pathway activation,revealing a novel means by which costimulation reprograms glucose metabolism in cD8+T cells.

关键词： Immunometabolism mRNA splicing cD8 T cells ARS2 PKM2

Pesticide food safety standards as companions to tolerances and maximum residue limits

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Journal of Integrative Agriculture 2015年第11期14卷 2358-2364页

作者： carl K Winter elizabeth A Jara Department of Food Science and Technology University of California

Allowable levels for pesticide residues in foods, known as tolerances in the US and as maximum residue limits （MRLs） in much of the world, are widely yet inappropriately perceived as levels of safety concern. A novel approach to develop scientifically defensible levels of safety concern is presented and an example to determine acute and chronic pesticide food safety standard （PFSS） levels for the fungicide captan on strawberries is provided. Using this approach, the chronic PFSS level for captan on strawberries was determined to be 2 000 mg kg-1 and the acute PFSS level was determined to be 250 mg kg-1. Both levels are far above the existing tolerance and MRLs that commonly range from 3 to 20 mg kg-~, and provide evidence that captan residues detected at levels greater than the tolerance or MRLs are not of acute or chronic health concern even though they represent violative residues. The benefits of developing the PFSS approach to serve as a companion to existing tolerances/MRLs include a greater understanding concerning the health significance, if any, from exposure to violative pesticide residues. In addition, the PFSS approach can be universally applied to all potential pesticide residues on all food commodities, can be modified by specific jurisdictions to take into account differences in food consumption practices, and can help prioritize food residue monitoring by identifying the pesticide/commodity combinations of the greatest potential food safety concern and guiding development of field level analytical methods to detect pesticide residues on prioritized pesticide/commodity combinations.

关键词： pesticide residues food safety tolerances maximum residue limits (MRLs) regulation reference dose captan strawberries

Investigation of factors influencing roof stability at a Western *** coal mine

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International Journal of Mining Science and Technology 2019年第1期29卷 139-143页

作者： Meriel Young Gabriel Walton elizabeth Holley Department.Geology&Geol.Engineering Colorado School of Mines Department Mining Engineering Colorado School of Mines

The coal mine roof rating(cMRR) was developed to bridge the gap between geological variation in underground coal mines and engineering design. The cMRR accounts for the compressive strength of the immediate roof, the shear strength and intensity of any discontinuities present, and the moisture sensitivity of the immediate roof. The cMRR has been widely used and validated in Eastern US coal mines, but it has seen limited application in the Western US. This study focuses on roof behavior at a Western coal mine(Mine A). Mine A shows significant lateral geological variation, along with localized faulting and a laterally extensive sandstone channel network. The cMRR is not used to predict roof instability at the mine. It is, therefore, hypothesized that there are other factors that are correlated with roof instability in underground coal mines that could potentially also be considered in conjunction with the *** hypothesis was tested by collecting 30 cMRR measurements at Mine A. At each measurement location, a binary record of the roof condition(stable or unstable) was made, and other parameters such as depth of cover, presence of faulting, and sandstone channels were also recorded. ANOVA tests showed that the cMRR values and the roof conditions were not strongly correlated, indicating that the cMRR input criteria are not fully predictive of roof stability at this mine. The cMRR values showed statistically significant correlations(p less than 0.05) with faulting as well as with location at an intersection. For areas that had previously experienced roof fall but were currently stable, faulting was correlated with roof condition(p less than 0.05) only when the condition was classified as unstable.

关键词： coal mine roof stability cMRR Western U.S.coal case study

The role of phase impurities and lattice defects on the electron dynamics and photochemistry of cuFeO2 solar photocathodes

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Nano Research 2019年第9期12卷 2390-2399页

作者： elizabeth A. Fugate Somnath Biswas Mathew c. clement Minkyu Kim Dongjoon Kim Aravind Asthagiri L. Robert Baker Department of chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA

cuFeO2 is a promising photocathode for H2 evolution and cO2 reduction *** better understand the complex defect chemistry and role of impurity phases in this material and their effect on the photochemical performance,we employ visible light transient absorption spectroscopy and density functional theory(DFT)calculations to investigate the electron dynamics in electrochemically deposited cu-Fe oxide thin *** analysis of carrier lifetime shows a fast,sub-ps contribution to relaxation followed by persistence of a Iong-lived state to time delays greater than 2 *** amplitude of the Iong-lived state is shown to correlate with the rate of fast initial relaxation,and this is explained in terms of a competition between charge carrier trapping and charge *** separation in cuFeO2 occurs via hole thermalizati on from O 2p to cu 3d vale nee band states leadi ng to segregatio n of electr ons and holes across layers in the cuFeO2 *** between transient absorption measurements and DFT calculations suggest that cu vacancies enhanee photochemical performance by facilitating charge separation *** contrast,O interstitials are predicted to switch the relative positions of O 2p and cu 3d vale nee band states,which would in hibit charge separatio n by in ter-band hole thermal izatio *** ally,we find no evide nee for electron in jecti on from cuFeO2 to cuO suggest!ng that charge separati on at this heterostructure in terface does not play a role in the carrier lifetime or photochemical performance of the catalysts studied here.

关键词： delafossite cuFeO2 charge-carrier dynamics transient absorption spectroscopy cu vacancy O interstitial

Investigating bee dietary preferences along a gradient of floral resources:how does resource use align with resource availability?

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Insect Science 2021年第2期28卷 555-565页

作者： Tyler T.Kelly elizabeth Elle Evolutionary and Behavioural Ecology Research Group Department of Biological SciencesSimon Fraser UniversityBurnabyCanada

Bee dietary preferences,or the floral resources that they consistently collect,likely impact where a species can *** this reason it is likely that bee dietary preferences are dependent upon the composition of the plant *** this study,we evaluated floral visits and pollen loads of the mining bee,Andrena angustitarsata Viereck,across a 630 km north-south range to understand dietary preferences along a floral resource *** research,in a more geographically limited area,suggested this species was an eclectic oligolege on predominantly Apiaceae and in part *** the present study we found the species predominately visited and collected pollen from Apiaceae and Rosaceae,but visited 12 flower families and collected pollen from 32,distinguishing them as generalist *** frequency of Apiaceae pollen on the bees and the species-level specialization index(a measure of visit specialization)were higher in regions with higher Apiaceae *** addition Apiaceae and Rosaceae were the only plant families significantly preferred for pollen collection,regardless of floral *** conclude that across our study region *** has a generalist dietary breadth,but also has dietary preference for Apiaceae and *** study indicates that while bees may overall make generalist foraging decisions they may still prefer and likely benefit from selecting fewer flower taxa.

关键词： andrenidae dietary breadth ecoregions oak-savanna pollen specialization

Towards a Policy that Supports People-centered Housing Recovery——Learning from Housing Reconstruction after the Hanshin-Awaji Earthquake in Kobe,Japan

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International Journal of Disaster Risk Science 2012年第1期3卷 56-65页

作者： elizabeth Maly Yoshimitsu Shiozaki Department of Engineering Kobe UniversityKobe 657-8501Japan

The goal of disaster recovery is for survivors to regain stability in their lives,livelihoods,and housing. A people-centered housing recovery requires that residents are empowered to make decisions about their housing reconstruction,and that policies create housing options that support the ability of all residents to reconstruct their homes and lives. The 1995 Hanshin-Awaji Earthquake caused the largest amount of damage in Japan since World War II,and the subsequent recovery is a starting point for understanding contemporary post-disaster housing reconstruction policies in Japan. Beyond an overview of housing reconstruction programs,we can understand the impact these policies had on Kobe residents’ housing and community recovery. In many cases,housing policies implemented after the Kobe earthquake fragmented communities and caused further damage and disruption in the lives of the survivors. A single-track approach failed to support the entire population of the disaster-stricken area. In subsequent years,Japanese disaster reconstruction laws and policies have seen modifications and improvements. Some of these changes can be seen in cases of recovery after more recent disasters,notably after the 2004 chuetsu Earthquake in Niigata Prefecture. In the context of these past examples,we can consider what is needed for a people-centered recovery in the Tohoku area after the 2011 Great East Japan Earthquake and Tsunami.

关键词： disaster Earthquake subsequent