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Role of liver biopsy in nonalcoholic fatty liver disease

World Journal of Gastroenterology 2014年第27期20卷 9026-9037页

作者： ILKe Nalbantoglu elizabeth M Brunt Department of Pathology and Immunology Washington University School of MedicineSaint Louis MO 63110 United States

Nonalcoholic fatty liver disease (NAFLD), defined as abnormal accumulation (> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis (NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the “gold standard” for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Liver biopsy Histopathology Grading and staging

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Consequences of fractal grade distribution for bulk sorting of a copper porphyry deposit

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Geoscience Frontiers 2015年第4期6卷 477-480页

作者： Peter Coghill David Miljak elizabeth Williams CSIRO Mineral Resources Flagship

We show the presence of fractal ordering of copper grade in bore core data at short range in the Cadia Ridgeway porphyry deposit and measure its persistence after mining by monitoring the output of the mine every 20 s for a month using a large scale, zero field magnetic resonance sensor. A simple model is used to investigate this connection and its consequences for sorting of the ore. Fractal distributions, and their associated power laws, have two features highly favourable for segregating ore： a large proportion of low-grade pods and the large scale spatial clustering of grade.

关键词： FractalMagnetic resonanceCopperPorphyry

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Hyporheic Zone Flow Disruption from Channel Linings： Implications for the Hydrology and Geochemistry of an Urban Stream, St. Louis, Missouri, USA

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Journal of Earth Science 2016年第1期27卷 98-109页

作者： elizabeth a.hasenmueller heather k.robinson Department of Earth and Atmospheric Sciences Saint Louis University St. Louis MO 63108 USA

Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales due to disruption of hyporheic flowpaths. Detailed analyses of water isotopes, major and trace elements, and in situ water quality data for an individual flood event reveal that baseflow contributions rise by 8% only 320 m downstream of the point where this particular channel changes from cement-lined to unlined. However, additional hydrograph separations indicate baseflow contributions are variable and can be much higher（average baseflow increase is 16%）. Stream electrical conductivity（EC） and solute concentrations in the lined reach were up to 25% lower during peak flow than in the unlined channel, indicating a greater event flow fraction. In contrast, during low flow, stream EC and solute concentrations in the lined reach were up to 30% higher due to the restricted inflow of more dilute groundwater. Over longer timescales, EC, solute concentrations, turbidity, and bacterial loads decrease downstream signifying increasing contributions of dilute baseflow. The decreased connectivity of surface waters and groundwaters along the hyporheic zone in lined channels increases the hydrologic and geochemical variability of urban streams.

关键词： stream channel linings hyporheic zone groundwater-surface water interactions,flood hydrograph urban geochemistry urban streams.

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Oxidative stress battles neuronal Bcl-xL in a fight to the death

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Neural Regeneration Research 2021年第1期16卷 12-15页

作者： Han-A Park Katheryn Broman elizabeth A.Jonas Department of Human Nutrition and Hospitality Management College of Human Environmental SciencesThe University of AlabamaTuscaloosaALUSA Department of Internal Medicine Section of EndocrinologyYale UniversityNew HavenCTUSA

Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial ***-xL supports growth,development,and maturation of neurons,and it also prevents neuronal death during neurotoxic *** article reviews the mechanisms and upstream signaling that regulate the activity and abundance of *** team and others have reported that oxidative stress is a key regulator of intracellular Bcl-xL balance in *** stress regulates synthesis,degradation,and activity of Bcl-xL and therefore neuronal *** apoptosis,pro-apoptotic Bcl2 proteins such as Bax and Bak translocate to and oligomerize in the mitochondrial *** of oligomers causes release of cytochrome c and activation of caspases that lead to neuronal ***-xL binds directly to pro-apoptotic Bcl2 proteins to block apoptotic *** anti-apoptotic roles of Bcl-xL have been well documented,an increasing number of studies in recent decades show that protein binding partners of Bcl-xL are not limited to Bcl2 ***-xL forms a complex with F1Fo ATP synthase,DJ-1,DRP1,IP3R,and the ryanodine *** proteins support physiological processes in neurons such as growth and development and prevent neuronal damage by regulating mitochondrial ATP production,synapse formation,synaptic vesicle recycling,neurotransmission,and calcium ***,under conditions of oxidative stress,Bcl-xL undergoes proteolytic cleavage thus lowering the abundance of functional Bcl-xL in ***,oxidative stress alters formation of Bcl-xL-mediated multiprotein complexes by regulating post-translational ***,oxidative stress regulates transcription factors that target the Bcl-x gene and alter accessibility of microRNA to mRNA influencing mRNA levels of *** this review,we discussed how Bcl-xL supports the normal physiology of neurons,and how oxidative stress contributes to pathology by manipulating the dynamics of Bcl

关键词： ATP Bcl-xL F1Fo ATP synthase mitochondria neuroprotection oxidative stress

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Effect of organic acids—essential oils blend and oat fiber combination on broiler chicken growth performance, blood parameters, and intestinal health

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Animal Nutrition 2021年第4期7卷 1039-1051页

作者： Deborah I.Adewole Samson Oladokun elizabeth Santin Department of Animal Science and Aquaculture Faculty of AgricultureDalhousie UniversityTruroNSB2N 5E3Canada b JEFO Nutrition Inc.Saint-HyacintheQC J2R 2E7Canada

This study evaluated the effect of organic acids-essential oils blend with or without oat hulls(OH)on growth performance,organ weights,blood parameters,gut morphology,microbiota,and short-chain fatty acids(SC FA)in ***-old broiler chickens were randomly allocated to 4 dieta ry treatments consisting of 1)a corn-soybean meal-wheat based diet(BAS),2)BAS+0.05%bacitracin methylene disalicylate(BMD),3)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed(OE),and 4)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed+3%OH(OEOH),in 8 replicate *** was in starter(d0 to 14),grower(d 14 to 24),and finisher(d 24 to 36)*** weight(BW),feed intake(FI),feed conversion ratio(FCR),and mortality were determined *** d 36,8 chickens per treatment were sampled for blood biochemistry,organ weights,cecal SCFA production,and *** had no effect on FI and FCR at all *** OE and OEOH treatments reduced(P<0.001)the body weight gain of birds at the starter *** fed the OEOH treatment had higher(P<0.001)gizzard weight,while those offered the BMD diet showed a tendency(P=0.08)to have higher cecal *** in the OEOH treatment recorded increased ileal villus height and villus height-to-crypt depth ratio,as well as reduced duodenal crypt depth,while birds in the OE treatment had increased j ej unal villus height and villus height-to-crypt depth *** OEOH and OE treatments increased the number of goblet cells produced in the duodenum and *** had no effecton SCFA *** in the OE treatment recorded the lowest concentration of blood urea(P=0.05)and cholesterol(P<0.05).Both OE and OEOH treatments increased(P<0.05)the relative abundance of potentially beneficial bacteria in the genus Firmicutesunclassified,Ruminococcus,Turicibacter,and Erysipelotrichaceaeunclassified,while reducing(P<0.001)the relative abundance of potentially harmful ***,bo

关键词： Organic acid Essential oil Oat hull Broiler chicken Ceca microbiota

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The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples

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Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie E. Curiel Cid Alexandra Ortega Ubbo Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie Kirsten Horne Crenshaw Ashleigh Beaulieu Brooke Bosworth Liz Gallardo Emory Neer Sofia Ramirez elizabeth A. Crocco Mike Georgiou Efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PET. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

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On the potential of iPhone significant location data to characterize individual mobility for air pollution health studies

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Frontiers of Environmental Science & Engineering 2022年第5期16卷 109-113页

作者： Eastman elizabeth A.Stevens Kelly Ivey Cesunica Haofei Yu Department of Civil Environmentaland Construction EngineeringUniversity of Central FloridaOrlandoFL 32816USA School of Public Administration University of Central FloridaOrlandoFL 32801USA Department of Civil and Environmental Engineering University of California-BerkeleyBerkeleyCA 94720USA

In many air pollution health studies,the time-activity pattern of individuals is often ignored largely due to lack of ***,a better understanding of this location-based information is expected to decrease uncertainties in exposure ***,we showcase the potential of iPhone’s Significant Location(iSL)data in capturing the user’s historical time-activity patterns in order to estimate exposure to ambient air *** this study,one subject carried an iPhone in tandem with a reference GPS tracking device for one *** GPS device recorded locations in 10 second intervals while the iSL recorded the time spent in locations the subject visited *** GPS data as a reference,we then evaluated the accuracy of iSL data in capturing the subject’s time-activity patterns and time-weighted air pollution concentration within the study time *** found the iSL data accurately captured the time the subject spent in 16 microenvironments(*** the subject visited more than once),which was 93%of the time during the study *** average error of time-weighted aerosol optical depth value,a surrogate of particle pollution,is only 0.012%.To explore the availability of iSL data among iPhone users,an online survey was *** the 349 surveyed participants,72%of them have iSL data *** the popularity of iPhones,iSL data may be available for a significant portion of the general *** results suggest iSL data have great potential for characterizing historical time-activity patterns to improve air pollution exposure estimation.

关键词： Air pollution exposure Human mobility iPhone Significant Location Smartphone data

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Current and near-term advances in Earth observation for ecological applications

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Ecological Processes 2021年第1期10卷 1-57页

作者： Susan L.Ustin elizabeth M.Middleton John Muir Institute of the Environment University of CaliforniaDavisCA 95616USA NASA/Goddard Space Flight Center(Emerita) GreenbeltMD 20771USA.

There is an unprecedented array of new satellite technologies with capabilities for advancing our understanding of ecological processes and the changing composition of the Earth’s biosphere at scales from local plots to the whole *** identified 48 instruments and 13 platforms with multiple instruments that are of broad interest to the environmental sciences that either collected data in the 2000s,were recently launched,or are planned for launch in this *** have restricted our review to instruments that primarily observe terrestrial landscapes or coastal margins and are available under free and open data *** focused on imagers that passively measure wavelengths in the reflected solar and emitted thermal *** suite of instruments we describe measure land surface characteristics,including land cover,but provide a more detailed monitoring of ecosystems,plant communities,and even some species then possible from historic *** newer instruments have potential to greatly improve our understanding of ecosystem functional relationships among plant traits like leaf mass area(LMA),total nitrogen content,and leaf area index(LAI).They provide new information on physiological processes related to photosynthesis,transpiration and respiration,and stress detection,including capabilities to measure key plant and soil biophysical *** include canopy and soil temperature and emissivity,chlorophyll fluorescence,and biogeochemical contents like photosynthetic pigments(e.g.,chlorophylls,carotenoids,and phycobiliproteins from cyanobacteria),water,cellulose,lignin,and nitrogen in foliar *** data will enable us to quantify and characterize various soil properties such as iron content,several types of soil clays,organic matter,and other *** of these satellites are in low Earth orbit(LEO),but we include a few in geostationary orbit(GEO)because of their potential to measure plant physiological traits over diurnal periods,impro

关键词： Terrestrial ecosystems Earth Observing Satellites Ecosystem processes Physiological functions Multispectral Hyperspectral Thermal LiDAR Radar imagers Biochemistry Soil properties Species mapping Change detection 3D canopy structure Topography

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疗愈花园类型的概念界定

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风景园林 2024年第5期31卷 75-90页

作者：伊丽莎白·R·M·黛尔姜博(译) 程宇(译) 佛罗里达大学环境园艺学院哈尔滨工业大学建筑与设计学院哈尔滨工业大学寒地城乡人居环境科学与技术工业和信息化部重点实验室

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项... 详细信息

【目的】随着疗愈花园研究的不断深入,相关描述性术语也越来越多,很难区分不同类型的疗愈花园。通过明确疗愈花园类型,设计师和其他相关专业人员能更好地为客户和其他利益相关者提供信息,创造出更具针对性和响应性的设计,有效促进新项目的开发。【方法】建立疗愈花园类型层次框架,并以现有花园为例,分析每种类型疗愈花园的设计目的、设计重点和潜在用户。【结果】将疗愈花园类型层次框架的基本结构分为主动型(使能型)和被动型(恢复型)的双轨结构,明确了不同类型疗愈花园的区别和联系。【结论】“疗愈花园”一词常被用于描述医疗机构中的花园,而不同类型的疗愈花园之间存在一些重要区别。这些区别为疗愈花园的设计提供了依据,有助于在花园空间中开展高质量的活动,同时兼顾使用者的需求。疗愈花园的设计必须满足使用人群的特定需求,包括居民/患者、员工和家庭成员。

关键词：疗愈花园恢复花园使能花园治疗花园感官花园

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Characterization of the D" beneath the Galapagos Islands using SKKS and SKS waveforms

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Earthquake Science 2011年第1期24卷 87-99页

作者： elizabeth Vanacore Fenglin Niu Department of Earth Science Rice University Houston TX 77005 USA Research School of Earth Sciences The Australian National University Canberra ACT 0200 Australia

SKS and SKKS waveforms from 16 events occurring between 2003 and 2005 in the Tonga Trench that were recorded by the BOLIVAR array are analyzed to determine the structure of the D＂ layer beneath the Galapagos Islands. 248 differential travel-time residuals of SKKS-SKS are measured and reveal a region of positive residuals of differential travel times in the northeast portion of the sampled region. Analyzing correlation statistics between the measured SKKS-SKS residuals and the observed absolute travel time delay of the individual SKS and SKKS phases for two events with high data quality, we determine that the residual differential travel time is due to excess low velocity along the SKKS raypaths. First order modeling of three potential low velocity structures, ultra-low velocity zones （ULVZ）, plume conduit, D＂ structure, indicates that the observed SKKS-SKS residuals can be best explained by a low velocity anomaly within the D＂ layer. To determine the presence of lower mantle anisotropy, amplitude ratios of the radial and transverse component of SKS and SKKS waveform are calculated and compared. Regions with significant presence of seismic anisotropy are interpreted as the edge of the flow field associated with a hypothetical mantle upwelling.

关键词： SKKS-SKS D" structure plume formation anisotropy differential travel-time residuals

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