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Dopamine regulation of striatal inhibitory transmission and plasticity： dopamine, low or high？

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Neural Regeneration Research 2016年第2期11卷 214-214页

作者： elizabeth Hernandez-Echeagaray Laboratorio de Neurofisiologia del Desarrollo y la Neurodegeneracion Unidad de Biomedicina FES-I Universidad Nacional Autonoma de Mexico Los Reyes Iztacala C.P. Tlalnepanfla Mexico

Basal ganglia are known for their involvement in motor *** function is accomplished via the modulatory actions of different signalling molecules;one of these is dopamine（DA）,which,besides regulating cognition and reward mechanisms,participates in the organization of motor programmes by filtering and selecting cortical commands on striatal synapses （Bromberg-Martin et al., 2010）.

关键词： striatal regulation Dopamine

cardiac Sarcoidosis:Sorting Fact from Fiction in This Rare cardiomyopathy

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cardiovascular Innovations and Applications 2015年第B10期1卷 37-45页

作者： Indranee Rajapreyar elizabeth Langlois center for Advanced Heart Failure UTHealth Medical SchoolHoustonTXUSA

Sarcoidosis is a rare condition of granulomatous infi ltration of many tissues of the body,including the *** sarcoidosis has been challenging to study,as it is often asymptomatic,although the initial presentation can be sudden cardiac *** incidence and prevalence rates have been diffi cult to establish and no expert agreed upon guidelines for diagnosis and management of cardiac sarcoidosis exist,and clinical manifestations are *** pathophysiology of granuloma formation in the myocardium as well as other tissues is governed by immune response to some environmental *** is also thought to play a role,although gene alterations have not been extensively studied,and no specifi c set of genetic mutations has been identifi ed to aid in identifi cation of individuals at risk of developing *** factors likely play a signifi cant role in modulation of gene expression with respect to immune *** is no standardized screening tool for the identifi cation of cardiac *** presence of systemic sarcoidosis and new-onset third-degree heart block or ventricular arrhythmias warrants further investigation for cardiac *** and PET are useful in helping to identify cardiac sarcoidosis but are not stand-alone *** biopsy is the gold standard but has a low yield owing to the patchy nature of granuloma formation in the *** should be instituted early and involves immunosuppressive therapy with predominant use of ***,either ventricular or high-grade heart blocks,are managed with device *** presentation may warrant use of antiarrhythmic agents and/or catheter *** and disease prognosis are dependent on early diagnosis and *** review details the current understanding of cardiac sarcoidosis and highlights diagnostic strategies and treatment with the aim of guiding the clinician to early identifi cation of patients and implemen

关键词： cardiac sarcoid cardiomyopathy sarcoidosis heart failure

Attachment of <i>Escherichia coli</i>to fine sediment particles within construction sediment basins

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Advances in Bioscience and Biotechnology 2013年第3期4卷 407-414页

作者： elizabeth A. Kunkel charles V. Privette calvin B. Sawyer John c. Hayes Biosystems Engineering Clemson University Clemson USA

The conventional best management practice of sediment basins may create a reservoir for pathogenic bacteria. The fine particles that enter these basins have been shown to provide protection for bacteria;the small pores of clays and silts minimize predators and block sunlight. Therefore, while these basins decrease sediment loadings to water bodies downstream, they may introduce harmful levels of pathogenic bacteria into surface waters. In addition to causing human health risks, high bacteria levels alter natural biological makeup of downstream ecosystems. This paper describes the attachment of Escherichia coli to various particle sizes in construction site sediment basins. Five sediment basins, located in Anderson, South carolina were sampled after rain events to explore trends that exist between various particle sizes and E. coli densities. Results provide evidence to suggest that sediment basins are a reservoir for pathogenic bacteria. Data showed that most E. coli attached to smaller particles with diameters less than 0.004 mm. These particles do not settle out of the water column quickly and are often passed through the basin during intense storms. consequently, high levels of bacteria are passed to downstream waters. This research provides considerable evidence that the clays and silts within man-made construction basins can cause detrimental effects to South carolina surface waters. With this knowledge, better stormwater management practices may be developed with the goal of remediating impaired surface waters of South carolina.

关键词： E. coli Sediment Sediment Basins Erosion Stormwater Runoff construction

Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis

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World Journal of Gastroenterology 2017年第40期23卷 7321-7331页

作者： Kelly L Hayward Patricia c Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine elizabeth E Powell W Neil cottrell Pharmacy Department Princess Al-exandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland cancer and chronic Disease Research Group QIMR Berghofer Medical Research Institute School of Medicine and Public Health The University of Newcastle The centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital The Centre for Liver Disease Research Translational Research Institute The University of Queensland Department of Gastroenterology and Hepatology Princess Alexandra Hospital Statistics Unit QIMR Berghofer Medical Research Institute School of Pharmacy The University of Queensland

AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated *** One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(chronic Liver Disease Questionnaire) were examined. clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = *** Medication adherence was " High " in 42 % o f participants, "Medium" in 37%, and "Low" in 21%. compared to patients with "High" adherence, those with "Medium" or "Low" adherence were more likely to report difficulty affording their medications(P ception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with "Low" adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-concerns Differential ≤ 5, OR = 3.66, 95%cI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%cI: 1.22-12.25) as independent predictors of "Low"*** The association between "Low" adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explor

关键词： Medication adherence Medication beliefs Illness perceptions Quality of life Liver cirrhosis

Assessment of Mg(OH)_(2)/TiO_(2) coating in the Mg-ca-Zn alloy for improved corrosion resistance and antibacterial performance

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Journal of Magnesium and Alloys 2023年第1期11卷 361-378页

作者： Leonardo Hernández Jesús Ramón-Sierra Montserrat Soria-castro Ángel Bacelis Geonel Rodríguez-Gattorno elizabeth Ortiz-Vázquez Gloria Acosta Applied Physics Department Center for Research and Advanced Studies of the National Polytechnic Institute(CINVESTAV-IPN)Carr.Ant.a Progreso km.6C.P.97310MeridaYucatanMexico Tecnológico Nacional de México/Instituto Tecnológico de Mérida.Av.Tecnológico s/n Km.4.5 ant.carr.Mérida-Progreso C.P.97118MéridaYucatánMéxico Facultad de Química Universidad Nacional Autónoma de México(UNAM)Av.Universidad 3000C.P.04510CoyoacánCDMXMéxico

The high activity of metallic magnesium and alloys limits its potential in biomedical applications;in recent years,extensive efforts have been devoted to modulating this *** this work,we present Mg(OH)_(2) and TiO_(2)barrier coatings to reduce the degradation of magnesium alloy(Mg-ca-Zn)*** coatings were deposited by the anodization method and the spin-coating technique,*** anodized layer was coated with TiO_(2)generated from the hydrolysis of 3%weight of TTIP(Ti[OcH(cH_(3))_(2)]_(4),Titanium(IV)isopropoxide)in 2-Propanol deposited by the spin-coating *** the degradation in Ringer’s solution by electrochemical impedance spectroscopy and OcP revealed a 98%reduction in pittings in uncoated samples after 14 days of *** p H measurements revealed that the TiO_(2)coating reduced the alkalization of the physiological environment,keeping the pH at 6.0 *** vitro studies of two types of bacteria(*** and ***)exhibited zones of inhibition in the agar and activity bactericidal(kill time test).The mechanisms behind the improved degradation resistance and enhanced antibacterial activity are presented and discussed *** modification with Mg(OH)_(2)/TiO_(2)coatings is a promising strategy to control the biodegradation of magnesium implants for bone regeneration.

关键词： Magnesium alloy EIS Mg(OH)_(2) TiO_(2) Antibacterial coatings

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

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Protein & cell 2010年第1期1卷 82-95页

作者： Isaac M.Westwood Sanjib Bhakta Angela J.Russell elizabeth Fullam Matthew c.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim Department of Pharmacology University of OxfordOxford OX13QTUnited Kingdom chemistry Research Laboratory Department of Organic ChemistryUniversity of OxfordOxford OX13QLUnited Kingdom School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Tuberculosis Immunology Group Department of Respiratory MedicineNational Heart and Lung InstituteWright Fleming Institute of Infection and ImmunityImperial College LondonNorfolk PlaceLondon W21PGUnited Kingdom Structure-Based Drug Design Team Sections of Structural Biology and Cancer TherapeuticsInstitute of Cancer ResearchChester Beatty LaboratoriesLondon SW36JBUnited Kingdom Institute of Structural and Molecular Biology Department of Biological ScienceBirkbeckUniversity of LondonLondon WC1E 7HXUnited Kingdom

New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting *** have a unique cell *** of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis *** nat gene and its associated gene cluster are almost identical in sequence in *** BcG and *** gene cluster is essential for intracellular survival of *** have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT ***,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both *** BcG and *** most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular *** also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity *** conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved.

关键词： N-acetyltransferase Mycobacterium tuberculosis triazoles screening

Synthesis and evaluation as cO2 chemisorbent of the Li5(Al1-xFex)O4 solid solution materials:Effect of oxygen addition

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Journal of Energy chemistry 2017年第5期26卷 948-955页

作者： Paulina Olavarría elizabeth Vera Enrique J.Lima Heriberto Pfeiffer Laboratorio de Fisicoquímica y Reactividad de Superficies(LaFReS) Instituto de Investigaciones en MaterialesUniversidad Nacional Autońoma de MexicoCircuito exterior s/nCd.UniversitariaDel.Coyoacan C.P.04510Ciudad de MéxicoMexico

Pentalithium aluminate（β-LiAlO） and the corresponding iron-containing solid solution(Li(AlFe)O)were synthetized by solid-state reaction. All the samples were characterized structural and microstructurally by X-ray diffraction, solid-state nuclear magnetic resonance, scanning electron microscopy, Nadsorption-desorption and temperature-programmed desorption of cO. Results showed that 30 mol% of iron can be incorporated into the β-LiAlOcrystalline structure at aluminum positions. Moreover, iron addition induced morphological and superficial reactivity variations. Li(AlFe)Osamples chemisorbed cObetween 200 and 700 °c, where the superficial chemisorption presented the highest enhancement,in comparison to β-LiAlO. Additionally, Li(AlFe)Osamples sintered at higher temperatures thanβ-LiAlO. Isothermal cOchemisorption experiments of β-LiAlOand Li(AlFe)Owere fitted to a first order reaction model, corroborating that iron enhances the cOchemisorption, kinetically. When oxygen was added to the gas flow, cOchemisorption process was mainly enhanced between 400 and 600 °c for the Li(AlFe)Osample in comparison to β-LiAlO. Hence, Li(AlFe)Osolid solution presented an enhanced cOchemisorption process, in the presence and absence of oxygen, in comparison to β-LiAlO.

关键词： Lithium aluminate cO2 chemisorption Solid solution Thermogravimetry

Intensivist-based deep sedation using propofol for pediatric outpatient flexible bronchoscopy

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World Journal of critical care Medicine 2017年第4期6卷 179-184页

作者： Kamal Abulebda Samer Abu-Sultaneh Sheikh Sohail Ahmed elizabeth A S Moser Renee c McKinney Riad Lutfi Department of Pediatrics Section of Critical CareIndiana University School of MedicineRiley Hospital for Children at Indiana University Health Department of Biostatistics Indiana University School of Medicine and Richard M Fairbanks School of Public Health

AIM To evaluate the safety and efficacy of sedating pediatric patients for outpatient flexible *** A retrospective chart review was conducted for all children, age 17 years or under who underwent flexible bronchoscopy under deep sedation in an outpatient hospital-based setting. Two sedation regimens were used; propofol only or ketamine prior to propofol. Patients were divided into three age groups; infants(less than 12 mo), toddlers(1-3 years) and children(4-17 years). Demographics, indication for bronchoscopy, sedative dosing, sedation and recovery time and adverse events were *** Of the total 458 bronchoscopies performed, propofol only regimen was used in 337(74%) while propofol and ketamine was used in 121(26%). About 99% of the procedures were successfully completed. children in the propofol + ketamine group tend to be youngerand have lower weight compared to the propofol only group. Adverse events including transient hypoxemia and hypotension occurred in 8% and 24% respectively. Median procedure time was 10 min while the median discharge time was 35 min. There were no differences in the indication of the procedure, propofol dose, procedure or recovery time in either sedative regimen. When compared to other age groups, infants had a higher incidence of *** children can be effectively sedated for outpatient flexible bronchoscopy with high rate of success. This procedure should be performed under vigilance of highly trained providers.

关键词： Pediatric flexible bronchoscopy Propofol Deep sedation Procedural sedation Sedation time Hypoxemia

Nat Immunol:科学家阐明如何有效抑制自身免疫疾病的发生

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现代生物医学进展 2017年第8期17卷 I0002-I0003页

作者： Thomas H auml ggl #x000F6 f, Saikiran K Sedimbi Mikael c I Karlsson Jennifer L Yates elizabeth A Leadbetter Roham Parsa Robert A Harris Briana Hauff Salas elizabeth A Leadbetter Department of Microbiology Tumor and Cell Biology Karolinska Institutet Solna Sweden. Trudeau Institute Saranac Lake New York USA. Department of clinical Neuroscience Karolinska Institutet Centre for Molecular Medicine Karolinska University Hospital at Solna Solna Sweden. Department of Microbiology Immunology and Molecular Genetics University of Texas Health Science Center at San Antonio San Antonio Texas USA.

机体免疫系统中一种未知的安全机制能够保持机体免于自身免疫疾病，日前一项刊登于国际杂志Nature Immunology上的研究报告中，来自瑞典卡罗琳学院的研究人员通过研究发现。机体先天性免疫系统中的细胞能够阻止后天性的免疫系统对机体... 详细信息

机体免疫系统中一种未知的安全机制能够保持机体免于自身免疫疾病，日前一项刊登于国际杂志Nature Immunology上的研究报告中，来自瑞典卡罗琳学院的研究人员通过研究发现。机体先天性免疫系统中的细胞能够阻止后天性的免疫系统对机体固有的细胞产生反应，否则就会引发诸如系统性红斑狼疮等自身免疫疾病的发生。

关键词：自身免疫疾病机体免疫系统 Nat 科学家系统性红斑狼疮安全机制研究人员后天性