检索结果-南通市图书馆

High-dose infliximab for treatment of pediatric ulcerative colitis:A survey of clinical practice

World Journal of Gastroenterology 2012年第11期18卷 1229-1234页

作者： Roy Nattiv Janet M Wojcicki elizabeth A Garnett Neera Gupta Melvin B Heyman Department of Pediatrics UCSF Benioff Children's HospitalUniversity of CaliforniaSan FranciscoCA 94143-0136United States

AIM:To assess attitudes and trends regarding the use of high-dose infliximab among pediatric gastroenterologists for treatment of pediatric ulcerative colitis(UC).METHODS:A 19-item survey was distributed to subscribers of the pediatric gastroenterology(PEDSGI) *** were submitted anonymously and results compiled in a secure ***:A total of 113 subscribers(88% based in the United States) responded(101 pediatric gastroenterology attendings and 12 pediatric gastroenterology fellows).There were 46% in academic medical institutions and 39% in hospital-based *** majority(91%) were treating >10 patients with UC;13% were treating >100 patients with UC;91% had prescribed infliximab(IFX) 5 mg/kg for UC;72% had prescribed IFX 10 mg/kg for *** a 5-point Likert scale,factors that influenced the decision not to increase IFX dosing in patients with UC included:"improvement on initial dose of IFX"(mean:3.88) and "decision to move to colectomy"(3.69).Lowest mean Likert scores were:"lack of guidelines or literature regarding increased IFX dosing"(1.96) and "insurance authorization or other insurance issues"(2.34)."Insurance authorization or other insurance issues" was identified by 39% as at least somewhat of a factor(Likert score ≥ 3) in their decision not to increase the IFX *** 10 mg/kg was more commonly used for the treatment of pediatric UC among responders based in the United States(75/100) compared to non-United States responders(6/13,P = 0.047).Induction of remission was reported by 78% of all responders and 81% reported maintenance of remission with IFX 10 mg/*** responder reported one death with IFX 10 mg/***:IFX 10 mg/kg is more commonly used in the United States to treat pediatric *** and safety data are required to avoid insurance barriers for its use.

关键词： Immunosuppression Inflammatory boweldisease Ulcerative colitis Children Pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ca^(2+) signalling in cardiovascular disease:the role of the plasma membrane calcium pumps

引用

Science China(Life Sciences) 2011年第8期54卷 691-698页

作者： elizabeth J.CARTWRIGHT Delvac OCEANDY Clare AUSTIN Ludwig NEYSES Cardiovascular Medicine Research Group Manchester Academic Health Science CentreUniversity of Manchester

The plasma membrane calcium ATPases(PMCA) are a family of genes which extrude Ca2+from the cell and are involved in the maintenance of intracellular free calcium levels and/or with Ca2+signalling,depending on the cell *** the cardiovascular system,Ca2+ is not only essential for contraction and relaxation but also has a vital role as a second messenger in signal transduction pathways.A complex array of mechanisms regulate intracellular free calcium levels in the heart and vasculature and a failure in these systems to maintain normal Ca2+homeostasis has been linked to both heart failure and *** article focuses on the functions of PMCA,in particular isoform 4(PMCA4) ,in the heart and vasculature and the reported links between PMCAs and contractile function,cardiac hypertrophy,cardiac rhythm and sudden cardiac death,and blood pressure control and *** is becoming clear that this family of calcium extrusion pumps have essential roles in both cardiovascular health and disease.

关键词： plasma membrane calcium/calmodulin-dependent ATPase Ca2+ homeostasis Ca2+ signalling heart failure hypertension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physical activity,exercise,and chronic diseases:A brief review

引用

Sports Medicine and Health Science 2019年第1期1卷 3-10页

作者： elizabeth Anderson J.Larry Durstine Department of Exercise Science University of South CarolinaColumbiaSCUSA

Chronic diseases are the leading cause of death worldwide with increasing prevalence in all age groups,genders,and *** chronic disease deaths occur in middle-to low-income countries but are also a significant health problem in developed *** chronic diseases now affect children and adolescents as well as *** physically inactive is associated with increased chronic disease *** societies are being negatively impacted by the increasing prevalence of chronic disease which is directly related to rising healthcare expenditures,workforce complications regarding attendance and productivity,military personnel recruitment,and academic ***,increased physical activity(PA)and exercise are associated with reduced chronic disease *** physiologic systems in the body benefit positively from PA and exercise by primary disease prevention and secondary disease prevention/*** purpose of this brief review is to describe the significant global problem of chronic diseases for adults and children,and how PA and exercise can provide a noninvasive means for added prevention and treatment.

关键词： Chronic disease Noncommunicable diseases Obesity Diabetes Cardiovascular disease Cancer Physical activity Exercise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collective Magnetic Behavior of Graphene Nanohole Superlattices

引用

Nano Research 2008年第1期1卷 56-62页

作者： Decai Yu elizabeth MLupton Miao Liu Wei Liu Feng Liu Department of Materials Science and Engineering University of UtahSalt Lake CityUT 84112USA

We predict a new class of 2-D crystalline“bulk”magnets-the graphene nanohole(GNH)superlattices with each GNH acting like a“super”magnetic atom,using first principles *** show that such superlattices can exhibit long-range magnetic order above room temperature,with a collective magnetic behavior governed by inter-NH spin spin interactions in additional to intra-NH spin ***,magnetic semiconductors can be made by doping magnetic NHs into semiconducting NH *** possibility of engineering magnetic GNHs for storage media and spintronics applications is discussed.

关键词： Graphene magnetism spin magnetic semiconductor superlattice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of wheat debranning using laboratory equipment for ethanol production

引用

International Journal of Agricultural and Biological Engineering 2014年第6期7卷 54-66页

作者： elizabeth George Bayartoghtok Rentsen Lope G.Tabil Venkatesh Meda Department of Chemical and Biological Engineering University of SaskatchewanSaskatoonSK S7N 5A9Canada

Ethanol production from starchy cereal grains is increasing rapidly due to increasing demand for alternative *** Canada,wheat is the primary feedstock in ethanol *** improve the productivity of the ethanol plants in terms of product quality and yield,debranning of wheat grains may be *** is advantageous in two ***,bran removal increases the starch content of the feedstock,improving the fermentation efficiency of the ethanol ***,bran,a valuable co-product can be used as an animal feed *** this study,experiments to optimize the debranning process were carried out using two kinds of abrasive equipment,the Satake and the TADD(tangential abrasive dehulling device)*** samples(30 and 200 g)were debranned in the Satake mill at 1215,1412,and 1515 r/min rotational speeds,30,36,and 40 grit sizes,and 30,60,and 90 s retention times,and in the TADD mill at 900 r/min rotational speed,30,36,50,and 80 grit sizes,and 120,180,240,and 300 s retention *** addition to debranning efficiency,the starch separation efficiencies of the two mills were calculated in different debranning *** the Satake mill,the 30 g and 200 g sample size,1412 r/min and 1515 r/min rotational speeds,all grit sizes,and 60 s of retention time demonstrated the highest debranning ***,optimal results in the TADD mill were obtained with 200 g sample size,900 r/min rotational speed,50 and 80 grit sizes,and 180 s and 240 s retention ***,based on the experimental results,Satake mill provided better debranning values compared to the TADD *** starch separation efficiency values supported these results.

关键词： wheat debranning ethanol production Satake mill tangential abrasive dehulling device grit size retention time rotational speed starch separation efficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune response differences in degradable and non-degradable alloy implants

引用

Bioactive Materials 2023年第6期24卷 153-170页

作者： Taravat Khodaei elizabeth Schmitzer Abhirami P.Suresh Abhinav P.Acharya Biomedical Engineering School of Biological and Health System EngineeringArizona StateUniversityTempeAZ85281USA Biological Design Arizona State UniversityTempeAZ85281USA Chemical Engineering School for the Engineering of MatterTransportand EnergyArizona StateUniversityTempeAZ85281USA Materials Science and Engineering School for the Engineering of MatterTransportand EnergyArizona State UniversityTempeAZ85281USA Center for Immunotherapy Vaccines and VirotherapyArizona State UniversityTempeAZ85281USA

Alloy based implants have made a great impact in the clinic and in preclinical *** responses are one of the major causes of failure of these implants in the *** the immune responses toward non-degradable alloy implants are well documented,there is a poor understanding of the immune responses against degradable alloy ***,there have been several reports suggesting that degradable implants may develop substantial immune *** phenomenon needs to be further studied in detail to make the case for the degradable implants to be utilized in ***,we review these new recent reports suggesting the role of innate and potentially adaptive immune cells in inducing immune responses against degradable ***,we discussed immune responses to allergen components of non-degradable implants to give a better overview on differences in the immune response between non-degradable and degradable ***,we also provide potential areas of research that can be undertaken that may shed light on the local and global immune responses that are generated in response to degradable implants.

关键词： alloy utilized implants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of pathogens of abnormal vaginal discharges in a Nigerian tertiary hospital

引用

Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 483-485页

作者： Samue Nwadioha Julie O Egesie Henry Emejuo elizabeth Iheanacho Department of Medical Microbiology & Parasitology College of Health SciencesBenue State UniversityMakurdiNigeria Department of Haematology Jos University Teaching HospitalJosNigeria Department of Medical Microbiology & Parasitology Aminu Kano Teaching HospitalKano

Objective:To investigate the prevalence of pathogens of abnormal vaginal discharges and to improve the current syndromic management of abnormal vaginal ***:A prospective study of pathogens of abnormal vaginal discharge was carried out from December 2007 to December *** of female genital swabs were collected from Obstetrics and Gynecology Units of Aminu Kano Teaching Hospital,Kano,Nigeria,and analyzed by microscopy,culture and sensitivity test in Medical Microbiology Laboratory of Aminu Kano Teaching ***:Microorganisms were detected in 70%(1 400) of a total 2 000 female genital swabs *** species peaked with 42.0%(840),followed by Gardnerella vaginalis,a pathogen of bacteria vaginosis with 26.0%.The distribution of abnormal vaginal discharge was highest in young adults aged from 21 to 30 ***:The commonest Microorganisms of infective vaginal discharge were Candida species,followed by Gardnerella vaginalis,a pathogen of bacterial *** discharge was prevalent among young adults. We recommend prevention,early diagnosis and prompt treatment of infected female,especially among the young,sexually active group in order to reduce the menace of HIV transmission.

关键词： Genital swabs Microscopy Culture Sensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Task sharing: situation analysis about capacity and resources for management of diabetic retinopathy in Pakistan

引用

International Journal of Ophthalmology(English edition) 2019年第5期12卷 809-814页

作者： Mufarriq Shah Ayesha Noor C Alex Harper Jill elizabeth Keeffe Pakistan Institute of Community Ophthalmology Hayatabad Medical Complex Vision and Dental Care Clinic Centre for Eye Research Australia Department of OphthalmologyUniversity of Melbourneand Royal Victorian Eye and Ear Hospital LV Prasad Eye Institute

AIM: To assess the capacity and resources of eye care facilities, using the WHO Health Systems Framework, to manage diabetic retinopathy(DR) through task ***: Using purposive sampling, four participants(administrators) from four selected hospitals in two provinces in Pakistan were recruited for this cross-sectional study. A survey, to assess the capacity and resources of the selected eye care facilities for the feasibility to adopt task sharing in management of DR to prevent vision loss, was emailed to participants who were asked to complete. Responses to open-ended questions were entered into a Microsoft Excel spread sheet and inductive approach was applied for ***: All the surveyed eye care facilities offer eye care services for people with diabetes and DR. All surveyed eye care facilities have a shortage in the number of human resources across all cadres. Optometrists and mid-level eye care workers did not have active roles in DR screening and management in all four hospitals. All the hospitals surveyed did not have a computerized record management system for patients who visit ophthalmologists for eye examinations. Equipment for detection and management of DR were short in number and main users were ophthalmologists. There was no policy for population-based screening program for detection of DR in any of the surveyed ***: A system-based approach to manage DR is needed. The capacity of eye care facilities and the potential to improve access of people with diabetes to eyecare services can be enhanced through implementation of task sharing.

关键词： task sharing capacity diabetes diabetic retinopathy Pakistan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of Evolutionarily ConservedMotifs Involved in Activity and Regulation of theABA-INSENSITIVE （ABI） 4 Transcription Factor

引用

Molecular Plant 2014年第2期7卷 422-436页

作者： Josefat Gregorio Alma Fabiola Hernández-Bernal elizabeth Cordoba Patricia León Departamento de Biología Molecular de Plantas Instituto de Biotecnología Universidad Nacional Autónoma de México Av. Universidad # 2001 Col. Chamilpa Cuernavaca Morelos C.p. 62210 Mexico

In recent years, the transcription factor ABI4 has emerged as an important node of integration for externaland internal signals such as nutrient status and hormone signaling that modulates critical transitions during the growthand development of plants. For this reason, understanding the mechanism of action and regulation of this protein rep-resents an important step towards the elucidation of crosstalk mechanisms in plants. However, this understanding hasbeen hindered due to the negligible levels of this protein as a result of multiple posttranscriptional regulations. To betterunderstand the function and regulation of the ABI4 protein in this work, we performed a functional analysis of severalevolutionarily conserved motifs. Based on these conserved motifs, we identified ortholog genes of ABI4 in differentplant species. The functionality of the putative ortholog from Theobroma cacao was demonstrated in transient expres-sion assays and in complementation studies in plants. The function of the highly conserved motifs was analyzed aftertheir deletion or mutagenesis in the Arabidopsis ABI4 sequence using mesophyll protoplasts. This approach permitted usto immunologically detect the ABI4 protein and identify some of the mechanisms involved in its regulation. We identi-fied sequences required for the nuclear localization （AP2-associated motif） as well as those for transcriptional activationfunction （LRP motif）. Moreover, this approach showed that the protein stability of this transcription factor is controlledthrough protein degradation and subcellular localization and involves the AP2-associated and the PEST motifs. We dem-onstrated that the degradation of ABI4 protein through the PEST motif is mediated by the 26S proteasome in responseto changes in the sugar levels.

关键词： ABI4 posttranslational regulation transcription factor sugar signaling abscisic acid-insensitive protea-some nuclear localization signals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamics of Strigolactone Function and Shoot Branching Responses in Pisum sativum

引用

Molecular Plant 2013年第1期6卷 128-140页

作者： elizabeth A. Dun Alexandre de Saint Germain Catherine Rameau Christine A. Beveridge The University of Queensland School of Biological Sciences St Lucia QLD 4072 Australia Institut Jean-Pierre Bourgin INRA UMR1318 INRA-AgroParisTech F-78000 Versailles France

Strigolactones （SLs）, or their metabolites, were recently identified as endogenous inhibitors of shoot branch- ing. However, certain key features and dynamics of SL action remained to be physiologically characterized. Here we show that successive direct application of SL to axillary buds at every node along the stem can fully inhibit branching. The SL inhibition of early outgrowth did not require inhibitory signals from other growing buds or the shoot tip. In add- ition to this very early or initial suppression of outgrowth, we also found SL to be effective, up to a point, at moderating the continuing growth of axillary branches. The effectiveness of SL at affecting bud and branch growth correlated with the ability of SL to regulate expression of PsBRC1. PsBRC1 is a transcription factor that is expressed strongly in axillary buds and is required for SL inhibition of shoot branching. Consistent with a dynamic role of the hormone, SL inhibition of bud growth did not prevent buds from later responding to a decapitation treatment, even though SL treatment immediately after decapitation inhibits the outgrowth response. Also, as expected from the hypothesized branching control network in plants, treatment of exogenous SL caused feedback down-regulation of SL biosynthesis genes within 2 h. Altogether, these results reveal new insights into the dynamics of SL function and support the premise that SLs or SL-derived metabolites function dynamically as a shoot branching hormone and that they act directly in axillary buds.

关键词： hormonal regulation dormancy shoot branching.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：