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Hyporheic Zone Flow Disruption from Channel Linings： Implications for the Hydrology and Geochemistry of an Urban Stream, St. Louis, Missouri, USA

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Journal of Earth Science 2016年第1期27卷 98-109页

作者： elizabeth a.hasenmueller heather k.robinson Department of Earth and Atmospheric Sciences Saint Louis University St. Louis MO 63108 USA

Cement channel linings in an urban stream in St. Louis, Missouri increase event water contributions during flooding, shorten transport times, and magnify geochemical variability on both short and seasonal timescales due to disruption of hyporheic flowpaths. Detailed analyses of water isotopes, major and trace elements, and in situ water quality data for an individual flood event reveal that baseflow contributions rise by 8% only 320 m downstream of the point where this particular channel changes from cement-lined to unlined. However, additional hydrograph separations indicate baseflow contributions are variable and can be much higher（average baseflow increase is 16%）. Stream electrical conductivity（EC） and solute concentrations in the lined reach were up to 25% lower during peak flow than in the unlined channel, indicating a greater event flow fraction. In contrast, during low flow, stream EC and solute concentrations in the lined reach were up to 30% higher due to the restricted inflow of more dilute groundwater. Over longer timescales, EC, solute concentrations, turbidity, and bacterial loads decrease downstream signifying increasing contributions of dilute baseflow. The decreased connectivity of surface waters and groundwaters along the hyporheic zone in lined channels increases the hydrologic and geochemical variability of urban streams.

关键词： stream channel linings hyporheic zone groundwater-surface water interactions,flood hydrograph urban geochemistry urban streams.

Enhanced and tunable fluorescent quantum dots within a single crystal of protein

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Nano Research 2013年第9期6卷 627-634页

作者： Hui Wei Stephen House Jiangjiexing Wu Jiong Zhang Zidong Wang Ying He elizabeth J. Gao Yigui Gao Howard robinson Wei Li Jianmin Zuo lan M. Robertson Yi Lu Department of Chemistry University of Illinois at Urbana-Champaign Illinois 61801 USA Department of Materials Science and Engineering University of Illinois at Urbana-Champaign Illinois 61801 USA Key Laboratory for Green Chemical TechnologyMOE Tianjin University Tianjin 300072 China George L. Clark X-Ray Facility and 3M Materials Laboratory University of Illinois at Urbana-Champaign Urbana Illinois 61801 USA Department of Biology Brookhaven National Laboratory Upton New York 11973 USA

The design and synthesis of bio-nano hybrid materials can not only provide new materials with novel properties, but also advance our fundamental understanding of interactions between biomolecules and their abiotic counterparts. Here, we report a new approach to achieving such a goal by growing CdS quantum dots （QDs） within single crystals of lysozyme protein. This bio-nano hybrid emitted much stronger red fluorescence than its counterpart without the crystal, and such fluorescence properties could be either enhanced or suppressed by the addition of Ag（I） or Hg（II）, respectively. The three-dimensional incorporation of CdS QDs within the lysozyme crystals was revealed by scanning transmission electron microscopy with electron tomography. More importantl~ since our approach did not disrupt the crystalline nature of the lysozyme crystals, the metal and protein interactions were able to be studied by X-ray crystallography, thus providing insight into the role of Cd（II） in the CdS QDs formation.

关键词： functionalbio-nanomaterials quantum dots protein single crystals X-ray crystallography tomography

Identification and Characterization of Hepatitis B Virus Immune Escape Mutants in Kenya

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American Journal of Molecular Biology 2023年第1期13卷 1-17页

作者： Rhoda elizabeth King James Kimotho Rosaline Macharia Faith Njoki Ndung’u Samson Muuo Nzou robinson Mugasiali Irekwa Department of Molecular Biology and Biotechnology Institute for Basic Sciences Technology and Innovation Pan African University Nairobi Kenya Department of Innovation Technology and Transfer Kenya Medical Research Institute Nairobi Kenya Department of Biochemistry University of Nairobi Nairobi Kenya Department for Microbiology Research Kenya Medical Research Institute Nairobi Kenya

Hepatitis B Virus (HBV) infections affect about 400 million people globally and cause about 1.4 million deaths annually. The virus displays high levels of genetic variations/mutations, some of which are immune escape mutants. The prevalence of HBV infection in Kenya is high at about 8%. This study aimed at identifying and characterizing HBV immune escape mutants in Kenya. From 547 HBV sequences available in Kenya in NCBI, and HBVdb databases in July 2021, 120 full sequences were retrieved. The S gene sequences at position 1-225, which included the “a” determinant region of the gene were analyzed using various bioinformatics tools such as Bioedit software, and Emboss Cons. The clinical significance was flagged from the search of peer-reviewed journals. Forty-six HBV-positive blood donor samples were obtained from the Kenya National Blood Transfusion Services without personal identifiers, DNA extracted, and sequenced targeting positions 1 to 520 of S genes. Mutations were similarly identified from seventeen sequences after cleaning and analysis. Out of 120 sequences that were extracted from databases and analyzed, 79 different mutations were identified. Fifteen of them were of clinical importance with an occurrence frequency of at least 5% were obtained. The majority (64.6%, n = 51), with S207N and A194V being most dominant, could result in immune escape and reduced HBsAg detection signals while 24.1% (n = 19) could result in immune escape/reduced HBsAg detection signals and high probability of hepatocellular carcinoma. Most likely to occur on the amino acids Alanine, Lysine, Serine, Asparagine, and Valine in decreasing order. The most dominant genotype was found to be Genotype A (N = 10), while four sequences were Genotype D. In contrast to the in-silico studies, the sequences from HBV samples from blood donors did not demonstrate the presence of S207N and A194V mutations and all the genotypes were type A1. Only two (13.3%) samples showed the same mutations of sK122R

关键词： Hepatitis B Virus Mutations Hepatitis B Surface Antigen Gene Genotype

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江苏省高血压病空间地理分布影响因素初探

中华流行病学杂志 2004年第7期25卷 637-639页

作者：陆应昶赵金扣胡晓抒王培桦武鸣覃玉 robinson elizabeth William C.Hoffman 江苏省疾病预防控制中心南京210009 Sydney University Public

目前我国高血压患病率呈持续上升趋势,已严重威胁我国居民的生命健康.为进一步了解江苏省高血压病及其区域水平上的相关危险因素具体分布,我们收集了1998～2002年期间江苏省所有开展"35岁以上居民慢性非传染性疾病"基线调查的数据,运用... 详细信息

目前我国高血压患病率呈持续上升趋势,已严重威胁我国居民的生命健康.为进一步了解江苏省高血压病及其区域水平上的相关危险因素具体分布,我们收集了1998～2002年期间江苏省所有开展"35岁以上居民慢性非传染性疾病"基线调查的数据,运用地理信息系统(GIS)中的空间分析技术,对影响高血压病空间分布的一些区域性危险因素进行了分析,并初步建立了高血压病的空间分布模型.

关键词：江苏高血压空间分布地理分布影响因素

跨学科视野下的会话研究——《谈话:会话的科学》述评

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当代语言学 2021年第4期23卷 619-627页

作者： elizabeth Stokoe 刘梦徐赳赳不详浙江师范大学法政学院浙江师范大学人文学院中国社会科学院语言研究所

1.引言《谈话:会话的科学》(Talk:The Science of Conversation,简称《谈话》)一书2018年由robinson出版社出版,作者是英国拉夫堡大学elizabeth Stokoe教授。Stokoe毕业于英国莱斯特大学,2002年入职拉夫堡大学的社会科学系,加入了世界... 详细信息

1.引言《谈话:会话的科学》(Talk:The Science of Conversation,简称《谈话》)一书2018年由robinson出版社出版,作者是英国拉夫堡大学elizabeth Stokoe教授。Stokoe毕业于英国莱斯特大学,2002年入职拉夫堡大学的社会科学系,加入了世界著名的研究团队"话语与修辞小组"(DARG),与著名的话语心理学家Derek Edwards、Jonathan Potter等人成为同事。

关键词：社会科学系研究团队拉夫堡大学英国莱斯特大学跨学科视野

江苏省脑卒中地理分布特征及其与区域危险因素的关系

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中国慢性病预防与控制 2005年第3期13卷 103-107页

作者：陆应昶赵金扣胡晓抒覃玉汪旸武鸣王培桦 robinson elizabeth WilliamC.Hoffman 江苏省疾病预防控制中心慢性病预防与控制科江苏南京210009 悉尼大学 Public Health Research Laboratories

目的利用地理信息系统(GIS)技术建立江苏省脑卒中空间预测模型。方法收集1998-2002年江苏省所有开展“35岁以上居民慢性非传染性疾病基线调查”地区的数据,以江苏省数字地图为背景,在ArcView软件的支持下,与建立的数据库关联并对各地区... 详细信息

目的利用地理信息系统(GIS)技术建立江苏省脑卒中空间预测模型。方法收集1998-2002年江苏省所有开展“35岁以上居民慢性非传染性疾病基线调查”地区的数据,以江苏省数字地图为背景,在ArcView软件的支持下,与建立的数据库关联并对各地区的脑卒中标化患病率进行反距离权重插值分析,并进一步利用区域危险因素对脑卒中分布差异进行多因素分析。结果脑卒中患病资料的空间分析预测模型显示,脑卒中和缺血性脑卒中主要分布于南京、徐州和赣榆,呈现从西北向东南逐渐减低的趋势;而出血性脑卒中主要分布于苏南的南京、苏州、无锡、镇江和徐州等城区,以南京地区最为严重,呈现为南高北低的趋势;饮酒率、1998年人均GDP、超重率、肥胖率、糖尿病患病率进入脑卒中线性回归模型,饮酒率和冠心病患病率进入出血性脑卒中空间线性回归模型,吸烟率、1998年人均GDP、超重率、肥胖率、糖尿病患病率进入缺血性脑卒中线性回归模型。结论GIS技术建立的脑卒中空间预测模型对江苏省脑卒中防治重点区域的确定以及进一步预测有一定意义。

关键词：脑卒中危险因素地理信息系统

人类生命早期暴露组(HELIX)：项目理念与设计(待续)

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环境与职业医学 2015年第1期32卷 90-95页

作者： Martine Vrijheid Rémy Slama Oliver robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux Jordi Sunyer elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiología y Salud Pública(CIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of Crete(UOC) Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT) Sensing & Control Systems S.L(.S&C) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.R.L(.HYLO) Centre for Genomic Regulation(CRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de Compostela Center of Excellence in Genomic Medicine Research King Abdulaziz University Vytauto Didziojo Universitetas(VDU)

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项... 详细信息

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画"生命早期暴露组"。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。

关键词：人类生命早期暴露设计出生队列研究儿童健康生物标志效应评估生命早期

人类生命早期暴露组(HELIX)：项目理念与设计(续完)

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环境与职业医学 2015年第2期32卷 186-190页

作者： Martine Vrijheid Rémy Slama Oliver robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent Juan R.Gonzalez Berit Granum Regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas Rosemary R.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux Jordi Sunyer elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for Research in Environmental Epidemiology(CREAL) Universitat Pompeu Fabra(UPF) CIBER Epidemiologíay Salud Pública(CIBERESP) Institut National de la Santé et de la Recherche Médicale(INSERM) Institut Albert Bonniot(U823) University of Crete(UOC) HeraklionCreteGreece Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health Research Sensing & Control Systems S.L.(S&C) Institut National de l’Environnement Industriel et des Risques(INERIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.R.L.(HYLO) RomeItaly Centre for Genomic Regulation(CRG) IMIM Hospital del Mar Research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddahKingdom of Saudi Arabia Vytauto Didziojo Universitetas(VDU) KaunusLithuania Bradford Institute for Health Research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT)

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的... 详细信息

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统（GIS）（Beelen等，2013;Eeflens等，2012）、遥感（Dadvand等，2012）和智能手机技术（deNazelle等，2013）使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。

关键词：早期暴露人类生命地理信息系统设计空气污染测量误差体力活动建筑环境