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Linking the Paul Coverdell National Acute Stroke Program to commercial claims to establish a framework for real-world longitudinal stroke research

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Stroke & Vascular Neurology 2022年第2期7卷 114-123页

作者： elisabetta Patorno Sebastian Schneeweiss Mary G George Xin Tong Jessica M Franklin Ajinkya Pawar Helen Mogun Lidia M V R Moura Lee H Schwamm Division of Pharmacoepidemiology and Pharmacoeconomics Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBostonMassachusettsUSA Division for Heart Disease and Stroke Prevention NCCDPHPCenters for Disease Control and PreventionAtlantaGeorgiaUSA Epilepsy and Neurophysiology Division Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA Fireman Vascular Center and Stroke Division Department of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMassachusettsUSA

Background Non-interventional large-scale research on real-world patients who had a stroke requires the use of multiple data sources ensuring access to longitudinal data from large populations with clinically-detailed *** sought to establish a framework for longitudinal research on patients hospitalised with stroke by linking information-rich,deidentified inpatient data from the Paul Coverdell National Acute Stroke Program(PCNASP)to commercial and Medicare Advantage longitudinal claims *** All stroke admissions in PCNASP between 2008 and 2015 were evaluated for linkage to longitudinal claims from a commercial insurer using an algorithm based on six available common data fields(patient age,gender,admission date,discharge date,discharge diagnosis and state)and a hospital *** evaluated the linkage quality(via the percentage of unique records in the linked dataset)and the representativeness of the linked *** also described medical history,stroke severity and patterns of medication use among the PCNASP-claims linked *** The linkage produced uniqueness equal to 99.1%.We identified 5644 linked and 98896 unlinked patients who had an ischaemic stroke hospitalisation in claims *** patients were younger than unlinked(69.7 vs 72.5 years),but otherwise similar by medical history,prestroke medication use or lab *** severity was mild and most patients were discharged *** and discharge use of antihypertensive and statins in the PCNASP were greater than their use as measured by filled prescriptions in *** High-quality linkage between the PCNASP and commercial claims data is *** linkage identified differences between reported or recommended versus actual out-of-hospital medication utilisation,highlighting the importance of longitudinal data availability for research aimed to improve the care of patients who had a stroke.

关键词： linkage claims younger

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Coupling effects in QD dimers at sub-nanometer interparticle distance

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Nano Research 2020年第4期13卷 1071-1080页

作者： Carlo Nazareno Dibenedetto elisabetta Fanizza Rosaria Brescia Yuval Kolodny Sergei Remennik Annamaria Panniello Nicoletta Depalo Shira Yochelis Roberto Comparelli Angela Agostiano Maria Lucia Curri Yossi Paltiel Marinella Striccoli CNR-Istituto per i Processi Chimico-Fisici SS Bari Via Orabona 470125-BariItaly Dipartimento di Chimica Universita degli Studi di Bari Aldo MoroVia Orabona 470125-BariItaly Electron Microscopy Facility Istituto Italiano di Tecnologiavia Morego 3016163 GenovaItaly Department of Applied Physics and the Center for Nanoscience and Nanotechnology Hebrew University of JerusalemJerusalem 9190401Israel

Currently,intensive research efforts focus on the fabrication of meso-structures of assembled colloidal quantum dots(QDs)with original optical and electronic *** collective features originate from the QDs coupling,depending on the number of connected units and their ***,the development of general methodologies to assemble colloidal QD with precise stoichiometry and particle-particle spacing remains a key ***,we demonstrate that dimers of CdSe QDs,stable in solution,can be obtained by engineering QD surface chemistry,reducing the surface steric hindrance and favoring the link between two *** connection is made by using alkyl dithiols as bifunctional linkers and different chain lengths are used to tune the interparticle distance from few nm down to 0.5 *** spectroscopic investigation highlights that coupling phenomena between the QDs in dimers are strongly dependent on the interparticle distance and QD size,ultimately affecting the exciton dissociation efficiency.

关键词： quantum dots dimers surface chemistry dithiols coupling

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Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms

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World Journal of Gastroenterology 2022年第34期28卷 4943-4958页

作者： Giuseppe Iabichino Milena Di Leo Monica Arena Giovanni Giuseppe Rubis Passoni elisabetta Morandi Francesca Turpini Paolo Viaggi Carmelo Luigiano Luca De Luca Digestive Endoscopy Unit ASST Santi Paolo e CarloMilano 20144Italy Gastroenterology Section Grande Ospedale Metropolitano“Bianchi-Melacrino-Morelli”Reggio Calabria 89124Italy

Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are rare tumors derived from the neuroendocrine cell system,which that have increased in incidence and prevalence in recent *** improvements in radiological and metabolic imaging,endoscopy still plays a pivotal role in the number of *** detection,characterization,and staging are essential in management and treatment *** and lower gastrointestinal(GI)endoscopy is essential for correct localization of the primary tumor site of GI *** ultrasonography(EUS)has an important role in the imaging and tissue acquisition of pancreatic NENs and locoregional staging of GI neuroendocrine *** staging and histological diagnosis have important prognostic *** operating techniques allow the removal of small GI NENs in the early stage of mucosal or submucosal invasion of the intestinal *** EUS-guided techniques may help the surgeon locate small and deep tumors,thus avoiding formal pancreatic resections in favor of parenchymal-sparing ***,locoregional ablative treatments have been proposed in recent studies with promising results in selected patients.

关键词： Neuroendocrine neoplasms Gastrointestinal endoscopy Endoscopic resection Endoscopic ultrasound Ablative technique Tissue acquisition

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Non-invasive investigation in patients with inflammatory joint disease

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World Journal of Gastroenterology 2009年第20期15卷 2463-2468页

作者： elisabetta Dal Pont Renata D’Incà Antonino Caruso Giacomo Carlo Sturniolo Department of Surgical and Gastro-enterological Sciences University of Padova

Gut inflammation can occur in 30%-60% of patients with ***, the presence of such gut inflammation is underestimated, only 27% of patients with histological evidence of gut inflammation have intestinal symptoms, but subclinical gut inflammation is documented in two-thirds of patients with inflammatory joint *** are common genetic and immunological mechanisms behind concomitant inflammation in the joints and intestinal tract.A number of blood tests, *** sedimentation rate, orosomucoid, C-reactive protein, and white cell and platelet counts, are probably the most commonly used laboratory markers of inflammatory disease, however, these tests are difficult to interpret in arthropathies associated with gut inflammation, since any increases in their blood levels might be attributable to either the joint disease or to gut ***, it would be useful to have a marker capable of separately identifying gut *** proteins, which are indirect markers of neutrophil migration in the gut wall, and intestinal permeability, seem to be ideal for monitoring intestinal inflammation:they are easy to measure non-invasively and are specific for intestinal disease in the absence of gastrointestinal *** the traditional markers for characterizing intestinal inflammation, there are also antibodies, in all probability generated by the immune response to microbial antigens and auto-antigens, which have proved useful in establishing the diagnosis and assessing the severity of the condition, as well as the prognosis and the risk of *** short, noninvasive investigations on the gut in patients with rheumatic disease may be useful in clinical practice for a preliminary assessment of patients with suspected intestinal disease.

关键词： Biochemical markers Fecal markers Inflammatory bowel disease Intestinal permeability Serological markers Spondyloarthropathies

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Post-synthesis phase and shape evolution of CsPbBr3 colloidal nanocrystals: The role of ligands

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Nano Research 2019年第5期12卷 1155-1166页

作者： elisabetta Fanizza Francesca Cascella Davide Altamura Cinzia Giannini Annamaria Panniello Leonardo Triggiani Francesca Panzarea Nicoletta Depalo Roberto Grisorio Gian Paolo Suranna Angela Agostiano M.Lucia Curri Marinella Striccoli Dipartimento di Chimica Università degli Studi di Bari "A.Moro"Via Orabona 470126 BariItaly CNR-Istituto per i Processi Chimico Fisici S.S.BariVia Orabona470126 BariItaly CNR-Istituto di Cristallografia Via Amendola122/O70126 BariItaly yDipartimento di Ingegneria Civile Ambientaledel TerritorioEdile e di Chimica(DICATECh)Politecnico di BariVia Orabona 470125Italy CNR-NANOTEC-Istituto di Nanotecnologia Via Monteroni 73100 LecceItaly

The surface chemistry of colloidal cesium lead bromide (CsPbBr3) nanocrystals is decisive in determining the stability and the final morphology of this class of materials,characterized by ionic structure and a high defect tolerance ***,the high sensitivity of purified colloidal nanocubes of CsPbBr3 to diverse environmental condition (solvent dilution,ageing,ligands post synthetic treatment) in ambient atmosphere is investigated by means of a comprehensive morphological (electron microscopy),structural (θ/2θ X-ray diffraction (XRD) and grazing incidence wide angle scattering (GIWAXS)),and spectroscopic chemical (1H nuclear magnetic resonance (NMR),nuclear Overhauser effect spectroscopy (NOESY),absorption and emission spectroscopy) *** aging and solvent dilution contribute to modify the nanocrystal morphology,due to a modification of the ligand ***,we establish the ability of aliphatic carboxylic acids and aikyl amines ligands to induce,even in a post preparative process at room temperature,structural,morphological and spectroscopic *** post synthesis alkyl amine addition,in particular of oleyl amine and octyl amine,the highly green emitting CsPbBr3 nanocubes effectively tum into one-dimensional (1 D) thin tetragonal nanowires or lead halide deficient rhombohedral zero-dimensional (0D) Cs4PbBr6 structures with a complete loss of *** addition of an alkyl carboxylic acid,as oleic and nonanoic acid,produces the transformation of nanocubes into still emitting orthorombic two-dimensional (2D) *** acid/base equilibrium between the native and added ligands,the edsorbed/free ligands dynamic in solution and the ligand solubility in non-polar solvent contribute to render CsPbBr3 particularly sensitive to environmental and processing conditions and,therefore prone to undergo to structural,morphological and,hence spectroscopic,transformations.

关键词： lead halide perovskite nanocrystals surface chemistry ligands equilibria long term stability

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Fashion prints

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2008年

作者： elisabetta. Drudi

Title translated: 时尚图案159 p. : ill. (some col.) ; 28 cm. + 1 CD-ROM (4 3/4 in.)

ISBN: (纸本)9789054961406

Title translated: 时尚图案159 p. : ill. (some col.) ; 28 cm. + 1 CD-ROM (4 3/4 in.)

关键词： Repetitive patterns (Decorative arts) Textile printing. Textile design.

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Etiology of chronic liver diseases in the Northwest of Italy, 1998 through 2014

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World Journal of Gastroenterology 2016年第36期22卷 8187-8193页

作者： Giorgio Maria Saracco Andrea Evangelista Sharmila Fagoonee Giovannino Ciccone elisabetta Bugianesi Gian Paolo Caviglia Maria Lorena Abate Mario Rizzetto Rinaldo Pellicano Antonina Smedile Department of Oncology University of Turin10123 Turin Italy Unit of Cancer Epidemiology (CPO Piemonte) University of Turin10123 Turin Italy Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center University of Turin10126 Turin Italy Department of Medical Sciences University of Turin10123 Turin Italy Unit of Gastroenterology Molinette Hospital10123 Turin Italy

AIM To assess the etiology of chronic liver diseases(CLD) from 1998 to 2014 at the outpatient clinic of Gastroenterology of the main hospital in Northwest of Italy among those dedicated to *** A random sample of charts of patients referred to for increased liver enzymes between January 1998 and December 2006, and between January 2012 and December 2014 were reviewed. Etiology search included testing for hepatitis B virus(HBV), hepatitis C virus(HCV), autoimmune hepatitis, primary biliary cirrhosis, Wilson's disease and hereditary hemocromatosis. A risky alcohol consumption was also considered. Nonalcoholic fatty liver disease(NAFLD) was diagnosed in patients with histological and/or ultrasound evidence of steatosis/steatohepatitis, and without other causes of *** The number of patients included was 1163. Of them, 528(45%) had positivity for HCV and 85(7%) for HBV. Among the virus-free patients, 417(36%) had metabolic disorders whereas the remaining had history of alcohol abuse, less prevalent causes of CLD or concomitant conditions. In comparison to 1998-2000(41%), a reduction of HCV alone-related cases was detected during the periods 2001-2003(35%, OR = 0.75, 95%CI: 0.53-1.06), 2004-2006(33%, OR = 0.70, 95%CI: 0.50-0.97) and 2012-2014(31%, OR = 0.64, 95%CI: 0.46-0.91). On the contrary, in comparison to 1998-2000(31%), metabolic-alone disorders increased in the period 2004-2006(39%, OR = 1.37, 95%CI: 0.99-1.91) and 2012-2014(41%, OR = 1.53, 95%CI: 1.09-2.16). The other etiologies remained stable. The increase of incidence of metabolic-alone etiology during the period 2004-2006 and 2012-2014 tended to be higher in older patients(≥ 50 years) compared to younger(P = 0.058).CONCLUSION In the Northwest of Italy, during this study period, the prevalence of HCV infection decreased notably whereas that of NAFLD increased.

关键词： Chronic liver diseases Cirrhosis Hepatitis C virus Hepatitis B virus Nonalcoholic steatohepatitis

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具有非线性刚度边界的杆梁结构的动态特性分析

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振动与冲击 2022年第14期41卷 158-163,232页

作者：许文峰唐斌 BRENNAN Michael J. MANCONI elisabetta GONCALVES Paulo J.Paupitz 大连理工大学能源与动力学院辽宁大连116024 圣保罗州立大学工程学院伊利亚索泰拉15385-000 帕尔马大学工程和建筑系帕尔马43100 圣保罗州立大学工程学院巴鲁17033-360

许多工程结构中存在着非线性边界,而非线性边界会对结构振动产生一定的影响。对非线性刚度弹簧固定的杆梁结构进行了动力学特性研究。对于杆结构,分别采用了行波法和分离变量法进行分析,并通过比较得到了两种方法之间的联系。对于梁结构... 详细信息

许多工程结构中存在着非线性边界,而非线性边界会对结构振动产生一定的影响。对非线性刚度弹簧固定的杆梁结构进行了动力学特性研究。对于杆结构,分别采用了行波法和分离变量法进行分析,并通过比较得到了两种方法之间的联系。对于梁结构,分别考虑了入射传递波和入射近场波,应用谐波平衡法得到了无量纲频率、位移、反射系数及相位等参数之间的关系。最后,应用相位闭合原理与分离变量法得到了杆和梁的骨架与频响曲线。为了验证理论计算的准确性与有效性,对杆梁模型进行了有限元数值仿真。结果表明,理论解与仿真解基本吻合。

关键词：非线性边界相位闭合原理谐波平衡法骨架曲线

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Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?

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World Journal of Gastroenterology 2009年第20期15卷 2456-2462页

作者： elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese Unit of Gastroenterology Department of Medical Sciences IRCCS-CSS Hospital Laboratory of Genetic Research Department of Medical Sciences IRCCS-CSS Hospital Unit of Digestive Endoscopy Department of Medical SciencesIRCCS-CSS Hospital

The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic *** studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular *** this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over *** existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic *** far, however, IL23R is the only identified susceptibility gene shared by both IBD and *** functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Ankylosing spondlitis Sacroiliitis Spondyloarthropathy

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Fabric textures & patterns / = Fabric textures and patterns

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2008年

作者： Drudi elisabetta.

Title translated: 织物质地与图案352 p. : ill. (some col.) ; 22 cm. + 1 CD-ROM.

ISBN: (纸本)9789057681127

Title translated: 织物质地与图案352 p. : ill. (some col.) ; 22 cm. + 1 CD-ROM.

关键词： Textile fabrics.

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