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Neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

Neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce Parra-Villamar Liliana Blancas-Espinoza elisa garcia-vences Juan Herrera-García Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla Antonio Ibarra Raúl Silva-García Unidad de Investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico Centro de Investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico Centro de Investigación del Proyecto Camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).Nevertheless, neither strategy has achieved a convincing *** purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with *** objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord *** Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate *** groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + *** months after injury, motor functional recovery was evaluated using the open field *** and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, *** number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, *** deposition was evaluated using Masson's trichrome *** combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned *** combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after *** study was approved by the National Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date November 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

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Aging Effects on Neuromuscular Activity in Karate Practitioners

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Journal of Sports Science 2015年第5期3卷 203-213页

作者： AntOnio Manue VitOria vences de Brito Mario Andr Ferreira Rodrigues Wojciech Jan Cynarski Carlos Gutiorrez garcia Sport Sciences School of Rio Maior Polytechnic Institute of Santar~m 2040-413 Rio Maior Portugal Life Quality Research Centre-CIEQV Complexo Andaluz Apartado 279 2001-904 SantarOm Portugal International Martial Arts and Combat Sports Scientific Society--IMACSSS 35-959 Rzeszow A. Towarnickiego Str. 3/17APoland Faculty of Physical Education University of RzeszEw Rzeszow 35-959 Poland Department of Physical and Sport Education Faculty of Physical and Sport Sciences University of Le6n Vegazana Campus24071-Le6n Spain

Aging leads to a general decline in body functions that affects quality of life. Sports practice is recommended as a means to attenuate the impact of the aging process. The aim of this study was to identify and analyze the neuromuscular activity and its patterns on active karate practitioners and assess the effects of the aging process. Two groups of black belt male karate practitioners, one with nine practitioners over 50 years old and the other with 21 practitioners aged between 20-30 years old performed the frontal kick mae-geri. Kinematic and electromyographic data of five muscles were collected from the right leg. Results showed two distinct periods of muscular activation in the mae-geri performance, with similar muscles activity patterns between groups. Nevertheless, some differences were found in the muscles＇ activity onset and offset, in root mean square and in inter-muscle delay and co-contraction periods. Those differences indicated that aging affects the neuromuscular activity in the mae-geri performance of the oldest karate practitioners. Nevertheless, the results showed that lifelong practice of karate can preserve the quality of the neuromuscular activity in older practitioners when they perform a kick, and this could be associated with benefits to balance control.

关键词： Aging motor control neuromuscular activity karate combat sports martial arts.

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Overexpression Of Protein P16ink4a As A Marker Of Squamous Intraepithelial Lesions Induced By High Risk Hpv Infection In Mexican Women

Overexpression Of Protein P16ink4a As A Marker Of Squamous I...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del Carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-Alfaro Amafia vences Velazquez Gloria Fernondez-Tilapa Esther Ivonne Lopez-Bayghen Ethel A garcia-Latorre Patricia Romero Neri Victor Gabriel Hernandez Chavez Marco Antonio Teron-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Clinica de Displasias ChilpancingoGuerreroMexico Departamento de Anatomia patologica Hospital de Cardiologia Centro Medico Nacional Siglo XXI del IMSSMexicoD.F Instituto Estatal de Cancerologia‘Dr Arturo Beltran Ortega’ AcapulcoGuerreroMexico

＜正＞Background:Expression of the high-risk human papillomavirus（hr-hpv）e7-gene replicating epithelial cells results in disruption of the prb-e2f complex and degradation of prb This leads to strong overexpression o...

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