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Sports Medicine and Health Science 2020年第1期2卷 7-9页

作者： Tongjian You elisa F.Ogawa Department of Exercise and Health Sciences College of Nursing and Health SciencesUniversity of Massachusetts BostonBostonMAUSA New England GRECC VA Boston Healthcare SystemBostonMAUSA

This paper provides a literature review of current studies investigating the effects of meditation and mind-body exercise on peripheral concentrations of brain-derived neurotrophic factor(BDNF),an important mediator of the neuroplasticity of the central nervous system and cognitive function.A literature search was conducted to collect currently published randomized controlled,non-randomized controlled and uncontrolled intervention *** studies were identified;and among these studies,seven were randomized controlled studies,three were non-randomized studies,and five were uncontrolled *** limited evidence tends to support that mindfulness meditation and mind-body exercise(*** and tai chi)increase circulating BDNF concentrations in healthy and diseased *** is noteworthy that these findings are based on current studies with a relatively small sample size,or without a randomized controlled *** studies are needed to identify a definite effect of meditation or mind-body exercise on BDNF and its role in improving/maintaining brain functions in various populations.

关键词： Meditation Mind-body exercise BDNF

Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn's disease, cause or epiphenomenon?

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World Journal of Gastroenterology 2014年第36期20卷 13060-13070页

作者： elisa Liverani Eleonora Scaioli Carla Cardamone Paola Dal Monte Andrea Belluzzi Gastroenterology Division Department of Medical and Surgical Sciences Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy Diagnostic and Speciality Medicine Department of Experimental Microbiology Unit Sant’Orsola-Malpighi University Hospital 40138 Bologna Italy

The origin of inflammatory bowel disease is unknown. Attempts have been made to isolate a microorganism that could explain the onset of inflammation, but no pathological agent has ever been identified. Johne’s disease is a granulomatous chronic enteritis of cattle and sheep caused by Mycobacterium avium subspecies paratuberculosis (MAP) and shows some analogies with Crohn’s disease (CD). Several studies have tried to clarify if MAP has a role in the etiology of CD. The present article provides an overview of the evidence in favor and against the “MAP-hypothesis”, analyzing the methods commonly adopted to detect MAP and the role of antimycobacterial therapy in patients with inflammatory bowel disease. Studies were identified through the electronic database, MEDLINE, and were selected based on their relevance to the objective of the review. The presence of MAP was investigated using multiple diagnostic methods for MAP detection and in different tissue samples from patients affected by CD or ulcerative colitis and in healthy controls. On the basis of their studies, several authors support a close relationship between MAP and CD. Although increasing evidence of MAP detection in CD patients is unquestionable, a clear etiological link still needs to be proven.

关键词： Mycobacterium avium paratuberculosis Crohn’ s disease Inflammatory bowel disease Johne’ s disease Mycobacterial protein tyrosine phosphatase

Risk factors for hepatocellular carcinoma recurrence after liver transplantation

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Hepatoma Research 2020年第8期6卷 46-66页

作者： Pierluigi Toniutto Ezio Fornasiere elisa Fumolo Davide Bitetto Hepatology and Liver Transplantation Unit Azienda Sanitaria Universitaria IntegrataUdine 33100Italy

Liver transplantation(LT)provides an excellent option for the long-term survival of patients with unresectable hepatocellular carcinoma(HCC)based on the Milan *** careful selection of patients,HCC may still recur after LT,which represents the most important negative predictor of post-transplant *** growing demand for LT in HCC has led to the expansion of patient selection criteria,with a resultant increase in the risk of post-transplant HCC *** tumor and host factors predict HCC *** morphological,histological,and serological characteristics of tumors in predicting HCC recurrence have been extensively ***,the type and duration of anticancer response before LT has also been considered a surrogate marker of tumor aggressiveness and is associated with the risk of *** demographic and clinical characteristics of recipients,as well as the type and duration of exposure to immunosuppressive therapy,represent the main host-related risk *** studies have attempted to describe predictive models for the risk of HCC recurrence,considering evaluable parameters both before and after *** many models have been proposed,relatively few have been externally validated on different patient *** paper aims to comprehensively summarize the available data on the predictive factors of HCC recurrence after LT,and to examine and discuss those that have been externally validated.

关键词： Liver transplantation hepatocellular carcinoma tumor recurrence risk predictive model

Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation

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Molecular Plant 2017年第6期10卷 791-804页

作者： Carlos Perea-Resa Miguel A. Rodriguez-Milla elisa Iniesto Vicente Rubio Julio Salinas Departamento de Biologia Medioambiental Centro de Investigaciones Biologicas CSIC 28040 Madrid Spain Departamento de Genetica Molecular de Plantas Centro Nacional de Biotecnologia CSIC 28049 Madrid Spain present address: Department of Molecular Biology Massachusetts General Hospital Boston MA 02214 USA Present address: Unidad de Biotecnologia Celular Instituto de Salud Garlos Ⅲ 28222 Madrid Spain

The process of cold acclimation is an important adaptive response whereby many plants from temperate regions increase their freezing tolerance after being exposed to low non-freezing temperatures. The correct development of this response relies on proper accumulation of a number of transcription factors that regulate expression patterns of cold-responsive genes. Multiple studies have revealed a variety of molecular mechanisms involved in promoting the accumulation of these transcription factors. Interestingly, however, the mechanisms implicated in controlling such accumulation to ensure their adequate levels remain largely unknown. In this work, we demonstrate that prefoldins （PFDs） control the levels of HY5, an Arabidopsis transcription factor with a key role in cold acclimation by activating anthocyanin biosynthesis, in response to low temperature. Our results show that, under cold conditions, PFDs accumulate into the nucleus through a DELLA-dependent mechanism, where they interact with HY5, triggering its ubiquitination and subsequent degradation. The degradation of HY5 would result, in turn, in anthocyanin biosynthesis attenuation, ensuring the accurate development of cold acclimation. These findings uncover an unanticipated nuclear function for PFDs in plant responses to abiotic stresses.

关键词： prefoldins cold acclimation Arabidopsis HY5 anthocyanin DELLAs

FunMod: A Cytoscape Plugin for Identifying Functional Modules in Undirected Protein–Protein Networks

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Genomics,Proteomics & Bioinformatics 2014年第4期12卷 178-186页

作者： Massimo Natale Alfredo Benso Stefano Di Carlo elisa Ficarra Department of Control and Computer Engineering Politecnico di Torino

The characterization of the interacting behaviors of complex biological systems is a primary objective in protein–protein network analysis and computational biology. In this paper we present FunMod, an innovative Cytoscape version 2.8 plugin that is able to mine undirected protein–protein networks and to infer sub-networks of interacting proteins intimately correlated with relevant biological pathways. This plugin may enable the discovery of new pathways involved in diseases. In order to describe the role of each protein within the relevant biological pathways, FunMod computes and scores three topological features of the identified sub-networks. By integrating the results from biological pathway clustering and topological network analysis, FunMod proved to be useful for the data interpretation and the generation of new hypotheses in two case studies.

关键词： Systems biology Network analysis Pathway analysis Network modules Cytoscape Budd–Chiari syndrome

Powder metallurgy with space holder for porous titanium implants:A review

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Journal of Materials Science & Technology 2021年第17期76卷 129-149页

作者： Alejandra Rodriguez-Contreras Miquel Punset JoséA.Calero Francisco Javier Gil elisa Ruperez JoséMaría Manero Biomaterials Biomechanics and Tissue Engineering Group(BBT)Department of Materials Science and EngineeringUniversitat Politecnica de Catalunya(UPC)Av.Edurad Maristany 1608019BarcelonaSpain Barcelona Research Centre in Multiscale Science and Engineering Technical University of Catalonia(UPC)Av.Eduard Maristany 10-1408019BarcelonaSpain UPC Innovation and Technology Center(CIT-UPC).Technical University of Catalonia(UPC) C.Jordi Girona 3-108034Barcelona.Spain AMES GROUP SA.Carretera Nacional 340 Pol.Ind."Les Fallulles"08620Sant Vicenc dels HortsBarcelonaSpain Bioengineering Institute for Technology Universitat Intemacional de Catalunyac/Josep Trueta s/n08195BarcelonaSpain

One of the biggest challenges in the biocompatibility of implantable metals is the prevention of the stress shielding effect,which is related to the coupling of the bone-metal mechanical *** stress shielding phenomenon provokes bone resorption and the consequent adverse effects on prosthesis ***,it can be inhibited by adapting the stiffness of the implant *** the use of titanium(Ti)porous structures is a great alternative not only to inhibit this effect but also to improve the osteointegration of orthopedic and dental implants,a brief description of the techniques used for their manufacturing and a review of the current commercialized implants produced from porous Ti assemblies are compiled in this *** powder metallurgy(PM)with space holder(SH)is a powerful technology used to produce porous Ti structures,it is here discussed its potential for the fabrication of medical devices from the perspectives of both design and *** most important parameters of the technique such as the size and shape of the initial metallic particles,the SH and binder type of materials,the compaction pressure of the green form,and in the sintering stage,the temperature,atmosphere,and time are reviewed according to the bibliography ***,the importance of the porosity and its types together with the influence of the mentioned parameters in the final porosity and,consequently,in the ultimate mechanical properties of the structure are ***,a few examples of the PM-SH application for the manufacturing of orthopedic implants are presented.

关键词： Powder metallurgy Space holder method Porous titanium structures Medical devices Stress shielding effect Porous materials permeability Interconnected porosity Porous bone substitute materials Open-cell titanium foams Sintering-dissolution technique

Suspended particulate mercury associated with tidal fluxes in a lagoon environment impacted by cinnabar mining activity(northern Adriatic Sea)

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Journal of Environmental Sciences 2018年第6期30卷 100-113页

作者： Alisè Turritto Alessandro Acquavita Annelore Bezzi Stefano Covelli Giorgio Fontolan elisa Petranich Raffaella Piani Simone Pillon Department of Mathematics and Geoscience University of Trieste Via Weiss 2 34128 Trieste Italy Co.N.I.S.Ma. Consorzio Nazionale Interuniversitario per le Scienze del Mare Piazzale Flaminio 9 00196 Rome Italy ARPA FVG Environmental Protection Agency of Friuli Venezia Giulia Via Cairoli 14 33057 Palmanova (Udine) Italy

The Isonzo River has been demonstrated to be a continuing point source of mercury（Hg）in the Gulf of Trieste although the Idrija mine was last active in 1996. The present study aims to investigate the role of the suspended particulate matter（SPM） associated with tidal fluxes to disperse particulate Hg（PHg） into the Grado coastal lagoon system. PHg concentrations（avg. 3.11 ± 2.62 μg/g, d.w.）, notwithstanding the ebb or flood tides, were significantly higher than the local sediment background（0.13 μg/g）. The relative affinity of Hg for the particulate phase in surface waters was confirmed by higher average distribution coefficient（Kd） values（5.6–6.7）. PHg contents showed the highest values in ebb tide conditions, thus suggesting their origin from the erosion of tidal flats and saltmarshes of the lagoon. When compared to river discharge, high PHg surface concentrations in flood tide are related to rainfall events occurring within the river basin. Results can be used to make an indicative assessment of the amount of Hg bound to SPM which is transported in and out of the lagoon basin following the action of tidal fluxes. A simple estimation provides a negative budget for the Grado lagoon sub-basin which loses between 0.14 and 1.16 kg of PHg during a tidal semi-cycle. This conclusion is in agreement with the evidence of morphological deterioration which has emerged from recent studies on the lagoon environment, and which testifies to a current sedimentary loss from the lagoon into the northern Adriatic Sea.

关键词： Mercury Tidal fluxes Suspended particulate matter Lagoon

Analysis of genetic relationship among Arbutus unedo L. genotypes using RAPD and SSR markers

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Journal of Forestry Research 2013年第2期24卷 227-236页

作者： Filomena Gomes Rita Costa Maria M. Ribeiro elisa Figueiredo Jorge M. Canhoto CERNAS Departamento Florestal Escola Superior Agrária Coimbra INRB Instituto Nacional de Recursos Biológicos Departamento de Recursos Naturais e Desenvolvimento Sustentável Escola Superior Agrária Centre of Functional Ecology Department of Life Sciences University of Coimbra

The strawberry tree （Arbutus unedo L.） is an underutilized, drought tolerant, fire resistant species with a south western distribution in Europe, and with ecological and putative socio-economical impact in Portugal and Mediterranean countries. Our aim was to develop an appropriate set of molecular markers to enable genetic diversity to be assessed and to fingerprint Arbutus unedo genotypes for breeding and conservation purposes in Portugal. Twenty-seven trees from a broad geographic range were screened with 20 random amplified polymorphic DNA （RAPD primers） and 11 microsatellite markers （SSR）. The RAPDs generated 124 bands, 57.3% of which were polymorphic, with an expected heterozygosity of 27%. We cross-amplified 11 SSR primers developed for Vaccinium spp., and 5 were found to be polymorphic in A. unedo, with 75% of expected heterozygosity, a number of alleles of 11.6, a null allele frequency of 7.6% and a polymorphic information content of 71%. Although the SSRs were more polymorphic and informative than the RAPDs, both markers displayed high genetic variability with the gathered data. No geographic pattern was observed in the genetic variation distribution based on both marker systems, and the lack of correlation between genetic and geographical matrices was confirmed by Mantel tests. Likely, no correlation was found between pairwise SSR and RAPD band-sharing matrices. These results and their implications on A. unedo breeding and conservation programs are discussed.

关键词： Ericaceae fingerprinting geographic pattern molecular markers strawberry tree.

Synthesis of palladium-rhodium bimetallic nanoparticles for formic acid dehydrogenation

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Journal of Energy Chemistry 2021年第1期30卷 301-309,I0010页

作者： Ilaria Barlocco Sofia Capelli elisa Zanella Xiaowei Chen Juan JDelgado Alberto Roldan Nikolaos Dimitratos Alberto Villa Dipartimento di Chimica Universitàdegli Studi di MilanoMilan I-20133Italy Departamento de Ciencia de los Materiales Ingeniería Metalúrgica y Química InorgánicaFacultad de CienciasUniversidad de CádizCampus Río San PedroPuerto Real(Cádiz)E-11510Spain School of Chemistry Cardiff UniversityMain BuildingPark PlaceCF103AT CardiffUnited Kingdom Dipartimento di Chimica Industriale e dei Materiali Alma Mater Studiorum Universitàdi BolognaViale Risorgimento 4I-40136 BolognaItaly

Herein,we report for the first time the synthesis of preformed bimetallic Pd-Rh nanoparticles with different Pd:Rh ratios(nominal molar ratio:80-20,60-40,40-60,20-80) and the corresponding Pd and Rh monometallic ones by sol immobilization using polyvinyl alcohol(PVA) as protecting agent and NaBH4 as reducing agent,using carbon nanofibers with high graphitization degree(HHT) as the desired *** synthesized catalysts were characterized by means of Transmission Electron Microscopy(TEM) and inductively coupled plasma optical emission spectroscopy(ICP-OES).TEM shows that the average particle size of the Pd-Rh nanoparticles is the range of 3-4 nm,with the presence of few large agglomerated *** bimetallic catalysts,EDX-STEM analysis of individual nanoparticles demonstrated the presence of random-alloyed nanoparticles even in all cases Rh content is lower than the nominal one(calculated Pd:Rh molar ratio:90-10,69-31,49-51,40-60).The catalytic performance of the Pd-Rh catalysts was evaluated in the liquid phase dehydrogenation of formic acid to *** was found that Pd-Rh molar ratio strongly influences the catalytic ***-rich catalysts were more active than Rh-rich ones,with the highest activity observed for Pd90:Rh10(1792 h^(-1)),whereas Pd69:Rh31(921 h^(-1)) resulted the most stable during recycling ***,Pd90:Rh10 was chosen as a representative sample for the liquid-phase hydrogenation of muconic acid using formic acid as hydrogen donor,showing good yield to adipic acid.

关键词： Palladium Rhodium Alloy Formic acid Hydrogen Muconic acid

Plastic occurrence,sources,and impacts in Antarctic environment and biota

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Water Biology and Security 2022年第2期1卷 60-71页

作者： Gabriella Caruso elisa Bergami Neelu Singh Ilaria Corsi Institute of Polar Sciences National Research CouncilMessinaItaly British Antarctic Survey Natural Environment Research CouncilHigh CrossMadingley RoadCambridgeCB30ETUK Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly Norwegian Polar Institute LongyearbyenNorway Department of Physical Earth and Environmental Sciences University of Siena53100SienaItaly

Several studies have documented that plastic pollution is affecting one of the most remote and pristine regions of our planet,*** of different size and polymeric composition have been retrieved in Antarctic sea ice,surface waters and sediments,with microplastics(mostly fibers)found both in terrestrial and marine *** evidence raises concerns about potential detrimental effects on biodiversity and ecosystem *** present review aims to report the most up-to-date knowledge on occurrence and distribution of plastic pollution in the Antarctic environment and biota including interaction with microorganisms,potential sources,and its impact on Antarctic *** understanding of plastic pollution in this polar region will help us define the human footprint in Antarctica and predict future ecological risks.

关键词： Anthropogenic impact Contamination Microplastics Southern ocean Antarctica Occurrence Sources Ecotoxicity Colonization Biosecurity