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Hepatoma Research 2019年第2期5卷 12-33页

作者： Paola Guerriero Farzaneh Moshiri Laura Lupini Silvia Sabbioni Massimo Negrini elisa callegari Department of Morphology Surgery and Experimental MedicineUniversity of FerraraFerrara 44121Italy Department of Molecular Medicine School of Advanced Technologies in MedicineTehran University of Medical SciencesTehran 11369Iran Department of Life Sciences and Biotechnologies University of FerraraFerrara 44121Italy

Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related deaths worldwide and despite improvement in therapeutic approaches,prognosis remains *** can be partly attributed to the fact that the majority of HCCs are diagnosed at intermediate or advanced *** of circulating biomarkers able to detect HCC at early stages could improve patients'*** present,however,alpha fetoprotein or des-g-carboxyprothrombin are unable to reliably detect HCC at early stages and better circulating biomarkers are *** tumor DNA(ctDNA)and non-coding RNAs(ncRNAs)are emerging as promising biomarkers to achieve the *** and epigenetic alterations in ctDNA allow to pinpoint tumor-specific biomarkers,reveal tumor heterogeneity,help monitor tumor evolution over time and assess therapy *** remains to be fully evaluated the possibility of detecting these biomarkers at early tumor *** ncRNAs are quantitative biomarkers with potential use in diagnostic,prognostic and predictive clinical *** may help to reveal HCC at early ***,because of heterogeneous and sometimes conflicting reported results,they still require validation and standardization of pre-analytical and analytical approaches before clinical applications could be envisaged.

关键词： Liquid biopsy hepatocellular carcinoma circulating tumor DNA non-coding RNA diagnosis prognosis therapy response

CORPORATE GROUPS UNDER ITALIAN LAW:A COMPARATIVE APPROACH AND THE BRAND-NEW"CRISIS CODE"

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Frontiers of Law in China-Selected Publications from Chinese Universities 2019年第4期14卷 533-559页

作者： Mia callegari Department of Law University of TurinTurin 10124Italy

This paper provides an overview of the evolution of the harmonization process of European law in the field of group of companies,referring to the development of a national "group of companies law" — from the company law reform to the crisis and insolvency code — with the purpose of examining the main aspects of the regulation in force,considering mainly the possible interaction with the rules on the crisis of the groups of companies introduced by the Legislative Decree No.14/2019,and with the aim of analyzing its suitability for being devoted to the prospect of harmonization across countries.

关键词： corporate groups of companies group interest liability of the parent company insolvency of a group of companies harmonization of law

Early Cardiac Catheterizations within 30 Days Post Congenital Heart Surgery in Children

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Congenital Heart Disease 2023年第1期18卷 79-95页

作者： Daniel Quandt Alessia callegari Oliver Niesse Martin Christmann Anke Meinhold Hitendu Dave Walter Knirsch Oliver Kretschmar Pediatric Heart Centre-Division of Pediatric Cardiology University Children’s Hospital ZurichZurichSwitzerland Department Neonatology and Pediatric Intensive Care University Children’s Hospital ZurichZurichSwitzerland Department of Congenital Cardiothoracic Surgery University Children’s Hospital ZurichZurichSwitzerland Children’s Research Centre ZurichSwitzerlandUniversity Children’s Hospital ZurichZurichSwitzerland University of Zurich ZurichSwitzerland

Background:This study set out to assess the indications,feasibility,safety,and outcome of early cardiac catheterizations(CC)within 30 days after congenital heart surgery(CHS)in *** and Results:This is a retrospective,single-center case review study of all CC within 30 days after CHS between 1/2010-12/2020.A total of 317(138 diagnostic,179 interventional)CC were performed in 245 patients at a median of 4 days(IQR 13)after *** median age was 3 months(IQR 6),and body weight was 5 kg(IQR 4).A total of 194(61.2%)CC were performed in patients with univentricular *** revealed significant pathologies leading to early redo-surgery in 37 patients(12%).The transcatheter interventions primarily were needed in patients after cavo-pulmonary connection(n=69%,21.8%),right ventricle to pulmonary artery conduit(n=39%,12.3%),and Norwood-I surgery(n=34%,10.7%)presenting with hypoxemia,prolonged postoperative course,and suspected arterial stenosis on *** clinical impact of an early postoperative transcatheter intervention for the following clinical course was high in most *** were nine(2.8%)major and 20(6.3%)minor intra-procedural *** factor analysis revealed no difference for the occurrence of complications for patients’age,weight,and time from initial CHS,underlying *** heart disease,or ***:Early CC within 30 days after CHS in children can be performed safely with a high diagnostic and therapeutic *** rate of complications is low,while the therapeutic consequence is relevant.

关键词： Early postoperative cardiac catheterization congenital heart surgery children

Dietary xylanase and live yeast supplementation influence intestinal bacterial populations and growth performance of piglets fed a sorghum-based diet

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Animal Nutrition 2020年第4期6卷 457-466页

作者： Gemma González-Ortiz Marco A.callegari Pete Wilcock Diego Melo-Duran Michael R.Bedford Hilário R.V.Oliveira Marcos A.A.da Silva Carlos R.Pierozan Caio A.da Silva AB Vista MarlboroughWiltshireSN84ANUnited Kingdom AKEI Animal Research Fartura18870000Brazil Servei de Nutricio i Benestar Animal(SNiBA) Department de Ciencia Animal i dels AlimentsUniversitat Autonoma de Barcelona(UAB)08193Spain Universidade Estadual Norte do Parana Bandeirantes86360000Brazil Universidade Estadual de Londrina Londrina86051990Brazil

This study was to evaluate the effect of xylanase supplementation and the addition of live yeast,Saccharomyces cerevisiae,on growth performance and intestinal microbiota in *** hundred and eighty commercial crossbred 23-d-old piglets(PIC 417)were sorted by initial BW and allocated to 3 treatments:control(CTR)diet,CTR diet supplemented with xylanase at 16,000 birch xylan units/kg(XYL)and XYL diet supplemented with live yeast(2 x 1010 CFU/g)at 1 kg/t(XYL+LY).Each treatment had 10 replicates,with 6 animals each.A sorghum-based diet and water were available ad libitum for 42 d of the *** daily gain(ADG)and average daily feed intake(ADFI)were measured from 0 to 42 d(23-to 65-d-old)and feed conversion ratio(FCR)*** the end of the study,bacterial identification through 16 S rRNA(V3 to V4)sequencing of the ileal and caecal digesta from one piglet per replicate was *** treatment effects were observed on *** offered the live yeast in addition to the xylanase had increased ADG compared with those supplemented with xylanase alone(XYL+LY ***;P=0.655).FCR was improved with XYL and XYL+LY compared with CTR(P=0.018).Clostridiaceae counts in the ileum tended to reduce by 10%with XYL and 14%with XYL+LY compared to CTR(P=0.07).XYL and XYL+LY increased the counts of Lactobacillaceae in the caecum compared with CTR(P<0.0001).Dietary supplementation of live yeast combined with xylanase improved growth performance and microbial balance of piglets during the nursery phase.

关键词： Sorghum Nursery piglet Xylanase Live yeast Growth performance Microbiota

微波MESFET_s中金属-GaAs相互作用及接触退化(续)

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电子产品可靠性与环境试验 1995年第6期13卷 19-25页

作者： ENRICO ZANONI ALESSANDRO callegari 李志国北京工业大学 Italy 100022 U.S.A

4 欧姆接触的退化源和漏欧姆接触电阻直接影响着寄生串联电阻Rs和Rd,并由此而影响器件的特征参数如Idss,gm,Po,NF等。 GaAs上的欧姆接触最常采用的是Au-Ge-Ni合金系统,因为它能提供高频、大功率应用所需的低接触电阻（0.1-0.5Ωmm）。 ... 详细信息

4 欧姆接触的退化源和漏欧姆接触电阻直接影响着寄生串联电阻Rs和Rd,并由此而影响器件的特征参数如Idss,gm,Po,NF等。 GaAs上的欧姆接触最常采用的是Au-Ge-Ni合金系统,因为它能提供高频、大功率应用所需的低接触电阻（0.1-0.5Ωmm）。表4总结了对试验样品的Au-Ge-Ni欧姆接触进行研究得出的最新结论。接触电阻的增加归因于四种效应:（1）Au对Ga的过量吸杂作用造成Ga外扩散,在接触下产生一个电阻率较高、成份失配的多缺陷区域。在最上面的Au层和Au-Ge-Ni之间加入合适的扩散阻挡层可以减少这种影响。（2）覆盖层结构会对接触产生不利影响,这可能是由于有互扩散的原因。（3）Au和Ni的内扩散会降低接触区下面半导体的掺杂浓度。（4）热退火会使NiAs（Ge）或Ni2GeAs晶相和GaAs之间的接触面积减小。

关键词：砷化镓 MESFETs 接触退化

Conventional kinesiotherapy or Pilates mat exercises,what is more efficient for abdominal weakness?A feasibility study

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Journal of Biomedical Science and Engineering 2013年第12期6卷 1171-1177页

作者： Renan Lima Monteiro Laio Braga de Oliveira Luiz Armando Vidal Ramos Mauricio Oliveira Magalhaes Marília Maniglia de Resende Bianca callegari Department of Physical Speech and Occupational TherapySchool of Medicine of University of Sao PauloSao PauloBrazil Educational Association of Amazonia—SEAMA AmapáBrazil Department of Physical Therapy and Occupational Therapy Institute of Health SciencesUniversity Federal of ParáBelémBrazil

The aim of this feasibility study was to contrast rectus abdominis (RA) muscle strength and electrical activity after two abdominal training protocols, conventional kinesiotherapy (CK) and Pilates mat exercises (PME). 13 participants were randomized to one of two groups: CK and PME, and were trained accordingly. The upper rectus abdominis (URA) and lower rectus abdominis (LRA) were independently examined and intra-group and inter-group comparison were done. Findings demonstrate a significant increase in RA strength after both protocols, relative to baseline. Significantly increased electrical activation was seen in the URA after CK. Training with PME, although as efficient as CK in strength improvement, produced decreased activation level of muscles. CK training induced an opposite result. The differences after training suggest that CK and PME training programmers may strength RA, but the neuromuscular activation strategies for that are not the same. PME can be incorporated into protocols to improve abdominals strength, and trunk stabilization.

关键词： Rectus Abdominis Pilates Mat Exercise Surface Electromyography

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地热电站汽轮机转子锻件用的马氏体不锈钢

大型铸锻件 1982年第A2期 38-42页

作者： M.Priante L.callegari 喻孝魁

对于越来越使人们感兴趣的地热能的开发利用,大部分需要采用抗腐蚀的安全可靠的材料。对此,台尔尼(Terni)公司研究和生产了化学成分为13％铬、6％镍、1.5％钼的马氏体不锈钢汽轮机转子。转子是用重达100t的钢锭锻制的。生产大钢锭时,对... 详细信息

对于越来越使人们感兴趣的地热能的开发利用,大部分需要采用抗腐蚀的安全可靠的材料。对此,台尔尼(Terni)公司研究和生产了化学成分为13％铬、6％镍、1.5％钼的马氏体不锈钢汽轮机转子。转子是用重达100t的钢锭锻制的。生产大钢锭时,对于这一类钢种特别重要的偏析现象,已作了研究并予以克服。转子锻件的优良性能已经测定,并且是特别感兴趣的。

关键词：马氏体不锈钢转子锻件地热能电站汽轮机汽轮机转子开发利用安全可靠化学成分

Barefoot and High-Heeled Gait: Changes in Muscles Activation Patterns

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Health 2014年第16期6卷 2190-2196页

作者： Nathalya Ingrid Cardoso do Nascimento Thaís Sepêda Saraiva Alex Tadeu Viana da Cruz Jr. Givago da Silva Souza Bianca callegari Institute of Health Sciences Federal University of Pará Belém Brazil Institute of Biological Sciences Federal University of Pará Belém Brazil Center for Tropical Medicine Federal University of Pará Belém Brazil

Most women like wearing high-heeled shoes for the benefit of sensuous attractiveness and self-esteem while musculoskeletal problems and gait patterns changes are often associated. The present study aimed to identify changes during the gait stance and swing phases in some lower limb muscles. In addition, abdominal muscle was included due to its importance in dynamic trunk stability, and lack of studies on the subject. Here, we found that the use of high-heeled shoes elicited not only the increasing of the electrical activity from the muscles involved in the gait cycle, but also altered the temporal sequence of their recruitment. As practical applications, these changes may be strategies to maintain stability and minimize risks of falling, but they are often associated to diseases. Women that use high-heeled shoes for prolonged time must apply specific muscle exercises to minimize its long-term effects.

关键词： Human Gait High-Heeled Shoes Lower Limb Muscles Temporal Activation Electromyography

Malignant Graves’Ophthalmopathy

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 71-74页

作者： Jose Francisco de Salles Chagas Jose Luis Braga de Aquino Maria Beatriz Nogueira Paschoal Luis Antonio Brandi Filho Fernanda Fruet Douglas Alexandre Rizzanti Pereira Fernanda Garcia callegari Thalita dos Reis Ruba Service of Head and Neck Surgery Beneficiencia Portuguesa de Sao PauloMedical SchoolCatholic University of CampinasCampinasBrazil

Introduction: One of the most common causes of hyperthyroidism is Graves’ disease. The malignant exophthalmos is a rare condition characterized by the loss of visual function that doesn’t adequately respond to various forms of treatment, requiring, in most cases, surgical correction. Objective: We report a case of conjunctival edema and protrusion of the eyeball in patients secondary to Graves’ disease, characterizing malignant ophthalmopathy and discuss their surgical treatment. Case Report: A 73-year-old male patient presenting bilateral conjunctive hyperaemia, decreased visual acuity, exophtalmos with progressive deterioration. Pulse therapy was performed without improvement and then underwent bilateral ethmoidectomy. Discussion: Late diagnosis is harmful due to the fact that malignant disease is extremely aggressive and fast, as reported in this case. Most often, the ophthalmopathy follows a relatively mild and self-limiting course, making a proper diagnosis difficult if the disease progresses. In extreme cases acute orbital decompression is indicated complementing appropriate medical treatment, which will allow herniation of orbital contents. Many orbital decompression techniques have been used in the treatment of Graves’ ophthalmopathy. The most common of these is the endoscopic sinus surgery which potentiated act in decompression of the medial wall safely and minimally invasive. In our case, open bilateral ethmoidectomy was used, due to the fact that surgeons are most experienced in this technique. Although the post-operative has been successfully submitted, no signs of recurrence were observed after fifteen days due to the evolution of Graves’ disease. Even with outpatient treatment, he walked to the total visual loss. Conclusion: We observed that the malignant ophthalmopathy is rare and aggressive;however, in spite of therapeutic resources used, it can progress to total visual loss.

关键词： Malignant Exophthalmos Ethmoidectomy Hyperthyroidism

Multicentric Cervical Paraganglioma. Rare Case of Five Locations in One Patient. Case Report and Literature Review

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 82-88页

作者： José Francisco de Sales Chagas Maria Beatriz Nogueira Pascoal José Luis Braga de Aquino Luis Antonio Brandi Filho Fernanda Fruet Douglas Alexandre Rizzanti Pereira Amilcar de Castro Matos Thalita Ruba Fernanda callegari Department of Pathology School of Medicine Catholic Uni-versity of Campinas Campinas Brazil Head and Neck Service School of Medicine Catholic University of Campinas Campinas Brazil School of Medicine Catholic University of Campinas Cam-pinas Brazil

Objective: To report a case of a multiple paraganglioma with 5 concurrent locations and also describe a complication not found in the literature, spontaneous tumor bleeding. Introduction: The paragangliomas are mostly benign and more frequent in women. Can be multiple, and these are considered as the most likely source of familial origin (30%-35%). The multicentric lesions can occur at different life stages not being necessarily simultaneous, a fact that prevents image exam research to be conclusive for tumor presence or absence. In this way the examination of the family members of patients, specially young ones, diagnosed with multicentric tumors may lead to negative results which doesn’t meant that the disease can be developed at a later time period. Therefore routine examination is not justifiable when symptoms relative to tumor presence are not present. Case report: A female patient of 32 years old complaining of tinnitus and diagnosed with five paragangliomas (jugulo-timpanic, bilateral carotid body and bilateral brachiocephalic trunk) through imaging studies. She reported suffering relatives of paragangliomas. Conclusion: The paper reports a rare case and perhaps unique in the literature, multiple paraganglioma with five locations and discusses difficult choice of treatment and complications.

关键词： Glomus Tumor Paraganglioma Glomus Jugulare Carotid Body Tumor Postoperative Complications