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Effect of a Diet Rich in Interesterified, Non-Interesterified and Trans Fats on Biochemical Parameters and Oxidative Status of Balb-c Mice

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Food and Nutrition Sciences 2020年第11期11卷 1032-1052页

作者： elinete eliete de lima Luiza S. E. P. W. Castro Valdelúcia Maria A. de S. Grinevicius Josiane Hilbig Nádia S. R. S. Mota Rodrigo C. Zeferino Roberta C. da Silva Iván Jachmanián Edson Luiz da Silva Rozangela C. Pedrosa Jane Mara Block Laboratory of Fats and Oils Department of Food Science and Technology Federal University of Santa Catarina Florianópolis SC Brazil Campus Florianópolis Continente Federal Institute of Education Science and Technology of Santa Catarina Florianópolis-SC Brazil Laboratory of Experimental Biochemistry Department of Biochemistry Federal University of Santa Catarina Florianópolis SC Brazil Faculty of Pharmaceutical Sciences University of S&#227 o Paulo S&#227 o Paulo-SP Brazil Laboratory of Lipid Research Department of Family and Consumer Sciences College of Agriculture and Environmental Sciences North Carolina A & T State University NC USA department of Food Science and Technology Facultad de Química Universidad de la República Montevideo Uruguay Laboratory of Lipids Department of Clinical Analysis Federal University of Santa Catarina Florianópolis-SC Brazil

The aim of this study was to investigate the effects of different modified fats on the body weight, biochemical profile, and biomarkers of hepatic oxidative status in Balb-c mice. The animals were divided into four groups and fed for 75 days with a normolipidic (Control Group, CG) or hiperlipidic diets (40% kcal) containing a commercial interesterified fat (IFG) rich in palmitic acid (39%);a blend of non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the sn-2 position of triacylglycerols;or a partially hydrogenated vegetable oil (PHFG), source of trans fatty acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented similar results in all evaluated parameters. The serum biochemical profile and hepatic oxidative stress markers in mice of the PHFG were similar to CG, except for total cholesterol (TC) which was significantly higher (p e PHFG. The mice feed with interesterified fat (IFG) showed serum TC (p < 0.01), non-HDL-C (p < 0.05), gluco

关键词： Interesterified Fat Trans Fat Palmitic Acid Cholesterol Oxidative Stress

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