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Foreword to the Special Issue on Optical Technologies in Biophysics and Medicine

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 1-2页

作者： elina a.genina Dan Zhu Valery V.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University SaratovRussia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology(HUST)Wuhan P.R.China Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

We are pleased to present the third issue of JIOHS,which focuses on optical technologies of diagnosticsand therapy,These are selected papers presented during Saratov Fall Meeting,1t International Sym-posium on Optics and Biophotonics(September 24-28,2013,Saratov,Russia)in the framework of the Workshops:"Optical Technologies in Biophysics_and Medicine,"Nanobiophotonics,"and"Internet Biophotonics."

关键词： Biophys ics photonics

Glycerol effects on optical,weight and geometrical properties of skin tissue

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 64-74页

作者： Vadim D.Genin elina a.genina Valery V.Tuchin Alexey N.Bashkatov Saratov State University(National Research University) 83Astrakhanskaya Str.Saratov 410012Russia Tomsk State University(National Research University) 36Lenina Av.Tomsk 634050Russia Institute of Precise Mechanics and Control of RAS 24Rabochaya Str.Saratov 410028Russia

Complex study of glycerol effects on the skin tissue was *** change in optical,weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex *** mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were *** results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues.

关键词： Glycerol solutions skin optical clearing collimated transmittance dehydration

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FOREWORD

Journal of Innovative Optical Health Sciences 2009年第1期2卷 I0001-I0002页

作者： elina a.genina Kirill V.Larin Valery V.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Biomedical Engineering University of Houston Houston USA Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

Special Issue Optical Technologies in the Study of Tissues and Biological Fluids We are pleased to present this special issue of JIOHS,which focuses on optical technologies in the study of tissues and biological *** selected papers were presented during Saratov Fall Meeting—XII International School for Junior Scientists and Students on Optics,Laser Physics and Biophotonics(September 23–26,2008,Saratov,Russia)in the framework of the following workshops:“Optical Technologies in Biophysics and Medicine,”“Nanostructures and Nanoparticles,”“Microscopic and Low-Coherence Methods in Biomedical Applications,”and“Internet Biophotonics.”All eight papers in this special issue are research papers.

关键词： Junior photonics Russia

Quantification of glucose and glycerol diffusion in myocardium

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 46-55页

作者： Daria K.Tuchina Alexey N.Bashkatov elina a.genina Valery V.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precise Mechanics and Control RAS Saratov 410028 Russia Optoelectronics and Measurement Techniques Laboratory P.O.Box 4500 University of Oulu FIN-90014OuluFinland

The results on determination of glucose and glycerol difusion cofficients in myocardium tissuse are *** method is based on the measurement and analysis of temporal dependence of tissue optical collimated transmittance umder action of a hyperosmotic *** temporal tissue response is related to the rate of the agent and water diffusion in a *** diffusion coefficients for tssue fAuid fluxes at glucose and glycerol application to the myocardium at 20℃ have been estimated as(4.75±3.40)×10^(-7) and(7.71±4.63)×10^(-7) cm^(2)/s,respectively.

关键词： Difusion cofficient optical clearing delhydration scattering.

COMPARATIVE TREATMENT OF ACNE VULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION

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Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： elina a.genina ALEXEY N.BASHKATOV VALERY V.TUCHIN GEORGY V.SIMONENKO VERA N.SHERSTNEVA ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 B.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

PHOTOTHERAPY OF GINGIVITIS:PILOT CLINICAL STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 437-446页

作者： elina a.genina VLADIMIR A.TITORENKO VALERY V.TUCHIN GEORGY V.SIMONENKO ALEXEY N.BASHKATOV GENNADY M.SHUB ALEXANDER V.LEPILIN ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER Saratov State University Saratov410012Russia Saratov State Medical University Saratov410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia Palomar Medical Technology Inc.Burlington MA 01803USA

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were *** microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the *** the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two *** in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized *** second(control)group used only the toothpaste and a regular *** in both groups followed their respective procedures 2 times a day(morning and evening)for 30 *** of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day *** the both groups,all indices improved in comparison with ***,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum ***,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction.

关键词： Tooth brushing methylene blue photodynamic therapy pathogenic bacteria

低合金钢、不锈钢和铝合金在氯化钠溶液中的腐蚀研究

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低合金钢、不锈钢和铝合金在氯化钠溶液中的腐蚀研究

作者： Ermolaeva elina（伊琳娜）北京化工大学

学位级别：硕士

Lab results of COVID-19 patients:Omicron vs delta variants

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World Journal of Virology 2024年第2期13卷 71-77页

作者： Dana Avraham Amir Herman Gal Shaham Arkady Shklyar elina Sulim Maria Oulianski Orthopedic Department Kaplan Medical CenterRehovot 7661041Israel Department of Medicine Lithuanian University of Health SciencesKaunas 44307Lithuania Emergency Department Kaplan Medical CenterRehovot 7661041Israel

BACKGROUND The coronavirus disease 2019(COVID-19)virus has been a world-known pan-demic since February *** variances had been established;the most common variants in Israel were omicron and *** To analyze and compare laboratory values in the"omicron"and"delta"variants of the coronavirus by conducting follow-up examinations and laboratory audits on COVID-19 patients admitted to our *** A retrospective study,two groups,50 patients in each *** examined positive for COVID-19 were divided into groups according to the common variant at the given *** reviewed demographic data and laboratory results such as complete blood count and full chemistry,including electrolytes and coagulation *** The mean age was 52%,66.53±21.7 were *** significance was found comparing laboratory results in the following disciplines:Blood count,hemo-globin,and lymphocytes(P=0.41,P=0.87,P=0.97).Omicron and delta variants have higher neutrophil counts,though they are not significantly different(P=0.38).Coagulation tests:Activated paritial thromoplastin test and international normalized ratio(P=0.72,P=0.68).We found no significance of abnormality for all *** The study compares laboratory results of blood tests between two variants of the COVID-19 virus–omicron and *** found no significance between the *** results show the need for further research with larger data as well as the need to compare all COVID-19 variants.

关键词： COVID-19 Coronavirus Omicron variant Delta variant

Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo

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Nano Research 2014年第3期7卷 325-337页

作者： Georgy Terentyuk Elizaveta Panfilova Vitaly Khanadeev Daniil Chumakov Elina.genina Alexey Bashkatov Valery Tuchin Alia Bucharskaya Galina Maslyakova Nikolai Khlebtsov Boris Khlebtsov Saratov State University 83 Astrakhanskaya Saratov 410012 Russia Institute of Biochemistry and Physiology of Plants and Microorganisms 13 pr. Entuziastov Saratov 410049 Russia Institute of Precise Mechanics and Control of RAS 24 Rabochaya Saratov 410028 Russia Ulyanovsk State University 42 Lev Tolstoy Ulyanovsk 432017 Russia Optoelectronics andMeasurement Techniques Laboratory UniversityofOulu P.O. Box4500 Oulu FIN-90014 Finland Saratov State Medical University 112 Bolshaya Kazachia Saratov 410012 Russia

Nanocomposites （NCs） consisting of a gold nanorod core and a mesoporous silica shell doped with hematoporphyrin （HP） have been fabricated in order to improve the efficiency of cancer treatment by combining photothermal and photodynamic therapies （PDT ＋ PTT） in vivo. In addition to the long-wavelength plasmon resonance near 810-830 nm, the fabricated NCs exhibited a 400-nm absorbance peak corresponding to bound HP, generated singlet oxygen under 633-nm excitation near the 632.5-nm Q-band, and produced heat under a 808-nm near-infrared （NIR） laser irradiation. These modalities were used for a combined PDT ＋ PTT treatment of large （about 3 cm3） solid tumors in vivo with a xenorafted tumor rat model. NCs were directly injected into tumors and irradiated simultaneously with 633-nm and 808-nm lasers to stimulate the combined photodynamic and photothermal activities of NCs. The efficiency of the combined therapy was evaluated by optical coherence tomography, histological analysis, and by measurements of the tumor volume growth during a 21-day period. The NC-mediated PDT led to weak changes in tissue histology and to a moderate 20% decrease in the tumor volume. In contrast, the combined PDT ＋ PTT treatment resulted in the large-area tumor necrosis and led to dramatic decrease in the tumor volume.

关键词： nanocomposites gold nanorods mesoporous silica hematoporphyrin photodynarnic andphotothermal therapy