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The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis:A Rat Model

Current Medical Science 2020年第3期40卷 556-562页

作者： Ismet Hortu Gokay Ozceltik elif karadadas Oytun Erbas Gurkan Yigitturk Murat Ulukus Department of Obstetrics and Gynecology School of MedicineEge UniversityIzmir35100Turkey Department of Stem Cell Institute of Health SciencesEge UniversityIzmir35100Turkey Department of Biochemistry School of MedicineEge UniversityIzmir35100Turkey Department of Physiology School of MedicineIstanbul Bilim UniversityIstanbul34394Turkey Department of Histology and Embryology School of MedicineMugla Sitki Kocman UniversityMugla48000Turkey

To evaluate the potential effect of Ankaferd Blood Stopper(ABS)and oxytocin(OT)in an experimental endometriosis model,18 female Sprague Dawley rats were used in this *** animals were divided randomly into three groups after surgical induction of endometriosis:group 1:control group(isotonic NaCl,1 mL/kg/day,intramuscular,n=6);group 2:OT group(OT,80 U/kg/day,intramuscular,n=6);group 3:ABS group(ABS,1.5 mL/kg/day,intraperitoneal,n=6).Each group was treated for four weeks(two times per week).Volumes of endometriotic explants were measured in biopsy samples for histopathological *** endothelial growth factor(VEGF),monocyte chemotactic protein-1(MCP-1),and tumour necrosis factor(TNF-α)levels were measured in plasma and peritoneal *** explant volumes were significantly decreased after OT administration(P<0.0001).The epithelial score was significantly decreased in both treatment groups compared to the control group(P<0.05).TUNEL immunohistochemistry showed more apoptotic changes in the endometriosis foci(gland epithelium and surrounding tissue)in the OT group than in the control group(P<0.05).The levels of VEGF,MCP-1,and TNF-αwere significantly reduced in the OT group(P<0.05),whereas no significant changes in protein levels were found in the ABS-applied *** results indicate that OT has greater potential as a therapeutic agent in experimentally induced peritoneal endometriosis,where ABS,which is a VEGF modulator,appears to act through different mechanisms to show its palliative effects on a rat model of peritoneal endometriosis.

关键词： endometriosis Ankaferd Blood Stopper oxytocin cytokines

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