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Starch Orodispersible Film Loaded with Melatonin for Human Supplementation

Journal of Renewable Materials 2024年第7期12卷 1343-1354页

作者： Fabio Tamanini Tatiane Zucchini de Souza Creusa Sayuri Tahara Amaral Antônio JoséFelix Carvalho eliane trovatti Department of Health and Biological Sciences University of Araraquara(UNIARA)São Paulo14801-340Brazil Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloSão Paulo13563-120Brazil

An innovative pharmaceutical form for administering melatonin,based on starch orodispersibleﬁlm(ODF),was designed and *** composition of the ODF included starch as the polymer matrix,the active drug melatonin,and a ***,a natural hormone produced by the pineal gland in the brain,can be absorbed by passive diffusion across the mucous membrane,resulting in improved bioavailability when compared to conventional oral *** study shows a simple and efﬁcient method for preparing melatonin-loaded orodispersibleﬁlms with a physically stable and commercially viable matrix,suitable for use in the pharmaceutical ***ﬁlms were prepared by treating the starch with microwave irradiation,followed by plasticization with glycerol,melatonin loading and drying by solvent *** tests showed theﬁlms’robustness,with a modulus of approximately 97 MPa,indicating good handling *** uptake analysis showed fast water absorption,reaching about 150%within 2 min,indicating its fast oral disintegration *** tests in artiﬁcial saliva and dissolution studies indicated the release of the drug in min-utes,indicating the potential properties of theﬁlm for oral drug *** the best of our knowledge,there is no melatonin ODF based on starch described in the literature.

关键词： Starch orodispersibleﬁlm melatonin drug delivery

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Renewable Polymers in Biomedical Applications:From the Bench to the Market

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Journal of Renewable Materials 2024年第4期12卷 643-666页

作者： Rauany Cristina Lopes Tamires Nossa Wilton Rogério Lustri Gabriel Lombardo Maria Inés Errea eliane trovatti Department of Health and Biological Sciences University of Araraquara—UNIARAAraraquara14801-340Brazil Laboratory of Materials(LabMat)and Laboratory of Biopolymers(LaBioPol) Federal Institute of EducationScience and Technology of São Paulo Campus Itapetininga(IFSP)Itapetininga18.202‑000Brazil Instituto Tecnológico de Buenos Aires Cidade Autônoma de Buenos AiresC1437FBCArgentina Conselho Nacional de Pesquisas Científicas e Técnicas(CONICET) Cidade Autônoma de Buenos AiresC1425FQBArgentina Tecnologia YPF(Y-TEC) BerissoBuenos Aires1923Argentina

Polymers from renewable resources have been used for a long time in biomedical applications and found an irreplaceable role in some of *** uses have been increasing because of their attractive properties,contributing to the improvement of life quality,mainly in drug release systems and in regenerative *** using natural polymer,nano and microscale particles preparation,composites,blends and chemical modification strategies have been used to improve their properties for clinical *** many studies have been carried out with these natural polymers,the way to reach the market is long and only very few of them become commercially *** cellulose,bacterial cellulose,chitosan,poly(lactic acid)and starch can be found among the most studied polymers for biological applications,some with several derivatives already established in the market,and others with potential for *** this scenario this work aims to describe the properties and potential of these renewable polymers for biomedical applications,the routes from the bench to the market,and the perspectives for future developments.

关键词： Polymers renewable biomedical applications market

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Water-Based Processing of Fiberboard of Acrylic Resin Composites Reinforced With Cellulose Wood Pulp and Cellulose Nanofibrils

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Journal of Renewable Materials 2019年第5期7卷 403-413页

作者： Emanoele Maria Santos Chiromito eliane trovatti Antonio Jose Felix Carvalho Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloAv.João Dagnone110013563-120São Carlos-SP-Brazil University of Araraquara-UNIARA R.Carlos Gomes1217CEP 14801-320AraraquaraSPBrazil

Despite the great potential of cellulose wood pulp and cellulose nanofibrils as reinforcing filler in thermoplastics,its use is limited due to its tendency to form agglomerates and due to its high hydrophilic *** we describe fiberboard composites with high contents of wood pulp or cellulose nanofibrils,and a resin of poly(styrene-methyl-methacrylate-acrylic acid)used as water-based *** wood pulp and cellulose nanofibrils were used directly in the form of water *** method is based on the flocculation of the polymer emulsion followed by agglomeration of a mixture of the polymer emulsion and cellulose suspension,leading to the co-precipitation of the composite material,which can be easily separated from the water *** with acrylic polymer/cellulose fibers in the proportions of 75:25,50:50 and 25:75 wt%were *** were characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),thermogravimetric analysis(TGA),dynamic mechanical analysis(DMA)and water absorption *** analysis revealed a very good dispersion of the fibers without evidence of agglomeration,which led to superior mechanical *** results showed the effectiveness of the methodology and the potential of cellulose wood pulp and CNF as reinforcement fillers in fiberboard composites and any other high fiber-content materials.

关键词： Cellulose wood pulp cellulose nanofibrils composites acrylic resin emulsion fiberboard

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Microfibrillated Cellulose from Sugarcane Bagasse as a Biorefinery Product for Ethanol Production

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Journal of Renewable Materials 2018年第2期6卷 195-202页

作者： Rafael Grande eliane trovatti Maria Tereza B.Pimenta Antonio J.F.Carvalho University of São Paulo Av.João Dagnone 1100CEP 13563-120São CarlosSão PauloBrazil University of Araraquara(UNIARA) R.Carlos Gomes1217CEP 14801-320AraraquaraSão PauloBrazil Suzano Papel e Celulose SA Av.Lirio Correa146506460-040LimeiraSão PauloBrazil

Research involving the preparation of microfibrillated cellulose(MFC)from sugarcane bagasse is a relevant topic to the production of new nanomaterials and more accessible cellulose substrates for the production of second generation *** the transformation of cellulose into glucose,the precursor of second generation ethanol,this nanosized cellulosic substrate represents a more appropriate material for the chemical hydrolysis *** high aspect ratio of MFC improves hydrolysis,requiring mild conditions and decreasing the generation of ***,MFC was prepared from sugarcane bagasse by ultrasound *** material was oxidized with 2,2,6,6-tetramethylpiperidine-N-oxyl(TEMPO)to produce negatively charged high defibrillated *** MFC was characterized by Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),scanning electron microscopy(SEM)and viscosity measurements.

关键词： Cellulose nanofibrils substrate second generation ethanol

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