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Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas

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World Journal of Clinical Cases 2016年第1期4卷 1-4页

作者： Alessandro Landi Valeria Palmarini Alessandro D'elia Nicola Marotta Maurizio Salvati Antonio Santoro Roberto Delfini Department of Neurology and Psychiatry Division of NeurosurgeryUniversity of Rome "Sapienza"

Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord *** measurements may are used to predicting the outcome of patients who have spinal cord *** tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or *** this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future.

关键词： Fiber tracking diffusion tensor imaging Surgery Magnetic resonance diffusion tensor imaging Intramedullary astrocytomas Spinal cord tumors Radiology

Extrahepatic aneurysm of the portal venous system and portal hypertension

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World Journal of Hepatology 2013年第3期5卷 149-151页

作者： Wilma Debernardi-Venon Davide Stradella Greta Ferruzzi Filippo Marchisio Chiara elia Mario Rizzetto Gastro-Hepatology Unit San Giovanni Battista Hospital University of Turin Diagnostic and Interventional Radiology Unit San Giovanni Battista Hospital University of Turin

Portal venous aneurysm (PVA) is a rare condition characterized by dilatation of the portal venous system. PVA manifestation of symptoms is varied and depends on the aneurysm size, location and related-complications, such as thrombosis. While the majority of reported cases of PVA are attributed to portal hypertension, very little is known about the condition's pathophysiology and clinical management remains a challenge. Here, we describe a 67-year-old woman who presented with complaint of dyspepsia and without a significant medical history, for whom PVA was incidentally diagnosed. The initial upper abdominal ultrasound revealed marked dilatation of the main portal vein, and subsequent contrast-enhanced computed tomography with angiography revealed a large aneurysm arising from the extrahepatic troncus portion of the portal vein, as well as gastroesophageal varices. A conservative approach using beta-blocker therapy was chosen. The patient was followed-up for 60 mo, during which time the asymptomatic status was unaltered and the PVA remained stable.

关键词： Portal vein aneurysm Portal hypertension Gastroesophageal varices Hepatic venous pressure gradient

Significance of ipsilateral breast tumor recurrence after breast conserving treatment: role of surgical removal

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Chinese Journal of Cancer Research 2013年第1期25卷 22-31页

作者： Romano Demicheli Ilaria Ardoino Federico Ambrogi Roberto Agresti elia Biganzoli Scientific Directorate IRCCS National Cancer Institute Medical Statistics and Biometry University of Milan Breast Surgery IRCCS National Cancer Institute Medical Statistics and Biometry IRCCS National Cancer Institute

Objective： To analyze the pattern over time （dynamics） of further recurrence and death after ipsilateral breast tumor recurrence （IBTR） in breast cancer patients undergoing breast conserving treatment （BCT）. Methods： A total of 338 evaluable patients experiencing IBTR were extracted from a database of 3,293 patients undergoing BCT. The hazard rates for recurrence and mortality throughout 10 years of follow-up after IBTR were assessed and were compared to the analogous estimates associated to the primary treatment. Results： In a time frame with the time origin at the surgical treatment for IBTR, the hazard rate for further recurrence displays a bimodal pattern （peaks at the second and at the sixth year）. Patients receiving mastectomy for IBTR reveal recurrence and mortality dynamics similar to that of node positive （N＋） patients receiving mastectomy as primary surgery, apart from the first two-three years, when IBTR patients do worse. If the patients with time to IBTR longer than 2.5 years are considered, differences disappear. Conclusions： The recurrence and mortality dynamics following IBTR surgical removal is similar to the corresponding dynamics following primary tumor removal. In particular, patients with time to IBTR in excess of 2.5 years behave like N＋ patients following primary tumor removal. Findings may be suitably explained by assuming that the surgical manoeuvre required by IBTR treatment is able to activate a sudden growing phase for tumor foci most of which, as suggested by the systemic model of breast cancer, would have reached the clinical level according to their own dynamics.

关键词： Breast cancer IBTR recurrence dynamics effects of surgery conservative surgery tumor homeostasis

Epithelial cell identity in hyperplastic precursors of breast cancer

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Chinese Journal of Cancer 2015年第3期34卷 121-129页

作者： Danila Coradini Patrizia Boracchi Saro Oriana elia Biganzoli Federico Ambrogi Department of Clinical Sciences and Community Health Medical StatisticsBiometry and BioinformaticsUniversity of Milan Senology Center Ambrosiana ClinicCesano Boscone

Introduction:In the adult human breast,hyperplastic enlarged lobular unit(HELU) and atypical ductal hyperplasia(ADH) are two common abnormalities that frequently coexist with ductal carcinoma in situ(DCIS).For this reason,they have been proposed as the early steps in a biological continuum toward breast ***:We investigated in silico the expression of 369 genes experimentally recognized as involved in establishing and maintaining epithelial cell identity and mammary gland remodeling,in HELUs or ADHs with respect to the corresponding patient-matched normal ***:Despite the common luminal origin,HELUs and ADHs proved to be characterized by distinct gene profiles that overlap for 5 genes *** HELUs were associated with the overexpression of progesterone receptor(PGR),ADHs were characterized by the overexpression of estrogen receptor 1(ESR1) coupled with the overexpression of some proliferation-associated ***:This unexpected finding contradicts the notion that in differentiated luminal cells the expression of estrogen receptor(ER) is dissociated from cell proliferation and suggests that the establishing of an ER-dependent signaling is able to sustain cell proliferation in an autocrine manner as an early event in tumor *** clinical evidence indicates that only a fraction of HELUs and ADHs evolve to invasive cancer,present findings warn that exposure to synthetic progestins,frequently administered as hormone-replacement therapy,and estrogens,when abnormally produced by adipose cells and persistently present in the stroma surrounding the mammary gland,may cause these hyperplastic lesions.

关键词：上皮细胞乳腺癌增生性雌激素受体孕激素受体前体细胞增殖过度表达

Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation

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Chinese Journal of Cancer 2014年第10期33卷 501-510页

The establishment and maintenance of mammary epithelial cell identity depends on the activity of a group of proteins, collectively called maintenance proteins, that act as epigenetic regulators of gene transcription through DNA methylation, histone modification, and chromatin remodeling. Increasing evidence indicates that dysregulation of these crucial proteins may disrupt epithelial cell integrity and trigger breast tumor initiation. Therefore, we explored in silico the expression pattern of a panel of 369 genes known to be involved in the establishment and maintenance of epithelial cell identity and mammary gland remodeling in cell subpopulations isolated from normal human mammary tissue and selectively enriched in their content of bipotent progenitors, committed luminal progenitors, and differentiated myoepithelial or differentiated luminal cells. The results indicated that, compared to bipotent cells, differentiated myoepithelial and luminal subpopulations were both characterized by the differential expression of 4 genes involved in cell identity maintenance: CBX6 and PCGF2, encoding proteins belonging to the Polycomb group, and SMARCD3 and SMARCE1, encoding proteins belonging to the Trithorax group. In addition to these common genes, the myoepithelial phenotype was associated with the differential expression of HDAC1, which encodes histone deacetylase 1, whereas the luminal phenotype was associated with the differential expression of SMARCA4 and HAT1, which encode a Trithorax protein and histone acetylase 1, respectively. The luminal compartment was further characterized by the overexpression of ALDH1A3 and GATA3, and the down-regulation of NOTCH4 and CCNB1, with the latter suggesting a block in cell cycle progression at the G2 phase. In contrast, myoepithelial differentiation was associated with the overexpression of MYC and the down-regulation of CCNE1, with the latter suggesting a block in cell cycle progression at the G1 phase.

关键词：基因表达差异乳腺细胞分化遗传调控乳腺上皮细胞组蛋白修饰人类表观

Assessment of Eye-hand Coordination in Italian Preschools

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Journal of Sports Science 2016年第5期4卷 311-317页

作者： Ambretti Antinea Viscione Ilaria D'elia Francesca Department of Human Philosophical and Educational Sciences University of Salerno Fisciano Salerno 84084 Italy

In 2012, the Italian Ministry of Education introduced in the Guidelines for preschool the need to evaluate one aspect of coordination related to the eye-hand relationship. Meinel＇s theoretical model provides an overview of the eye hand coordination, based on capacity to integrate anatomic-functional skills with specific and synchronic hand＇s actions. Meinel＇s model is rich of possible teaching ideas which are consistent with the Italian school system. They might also be a topical theoretical support to choose and use the motor evaluation tests in the Italian preschool, in order to evaluate the eye hand coordination and its constituent elements.

关键词： Eye-hand coordination pre-school assessment.

Adaptive immune response during hepatitis C virus infection

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World Journal of Gastroenterology 2014年第13期20卷 3418-3430页

作者： Juan Ramon Larrubia elia Moreno-Cubero Megha Uttam Lokhande Silvia Garcia-Garzon Alicia Lazaro Joaquin Miquel Cristian Perna Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University HospitalUniversity of AlcalaE-19002 GuadalajaraSpain Department of Medicine and Medical Specialities School of MedicineUniversity of AlcalaE-28801 Alcala de HenaresSpain

Hepatitis C virus(HCV)infection affects about 170 million people worldwide and it is a major cause of liver cirrhosis and hepatocellular *** is a hepatotropic non-cytopathic virus able to persist in a great percentage of infected hosts due to its ability to escape from the immune *** damage and disease progression during HCV infection are driven by both viral and host ***,adaptive immune response carries out an essential task in controllingnon-cytopathic viruses because of its ability to recognize infected cells and to destroy them by cytopathic mechanisms and to eliminate the virus by non-cytolytic *** is able to impair this response by several means such as developing escape mutations in neutralizing antibodies and in T cell receptor viral epitope recognition sites and inducing HCV-specific cytotoxic T cell anergy and *** impair HCV-specific T cell reactivity,HCV affects effector T cell regulation by modulating T helper and Treg response and by impairing the balance between positive and negative co-stimulatory molecules and between pro-and antiapoptotic *** this review,the role of adaptive immune response in controlling HCV infection and the HCV mechanisms to evade this response are reviewed.

关键词： Hepatitis C, Adaptive immune response, Hepatitis C virus-specific cytotoxic T cells, Hepatitis C virus-specific T helper cells, T regs, Hepatitis C virus escape mutations, Anergy, Apoptosis, Chemotaxis

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海上交通安全监管程序与管理技术作用的研究

海上交通安全监管程序与管理技术作用的研究

作者： MAHENGE elia HABIBU 大连海事大学

学位级别：硕士

由于人口的不断增长和全球化的不断发展,海上交通量也得以不断增加。近几十年来,由于持续不断的海上交通事故,海上安全和监视的课题受到了广泛关注。现有研究表明,海上交通的风险是由于操作和管理失误造成的。因此,该研究集中研究海上... 详细信息

由于人口的不断增长和全球化的不断发展,海上交通量也得以不断增加。近几十年来,由于持续不断的海上交通事故,海上安全和监视的课题受到了广泛关注。现有研究表明,海上交通的风险是由于操作和管理失误造成的。因此,该研究集中研究海上安全和监管方面存在的不足,旨在分析海运行业的重大安全问题,特别是在坦桑尼亚。本研究利用文献分析开展定性研究,总结出海运行业的安全问题,如工作人员对安全文化缺乏了解,不遵守规章制度,安全管理落实不到位;采用CRISP-DM模型进行海运风险评估,以辅助分析船舶交通管理。研究发现坦桑尼亚事故是由于管理上的缺陷、人为失误和缺乏先进技术造成的。研究建议,遵守法规,在海运系统中建立弹性,开展风险评估,以及在操作、通信和船舶设计方面运用高技术可以减少事故,进而有助于提升海上交通安全的整体水平。

关键词：海上交通事故安全管理人为失误监管缺点

The Use of Exergames for Adaptive Physical Activity among the Elderly

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Journal of Sports Science 2014年第1期2卷 47-52页

作者： Francesca D'elia Rodolfo Vastola Maurizio Sibilio Department of Human Philosophical and Educational Sciences University of Salerno Fisciano Salerno 84084 Italy

The research program proposed in this study promotes the development of a pilot study for the promotion of physical and motor activities for the elderly, with particular reference to the over 80 years old. The study aims to promote the practice of adapted physical activity for the elderly and proposes the design and development of specific exergames for the promotion of a healthy and active lifestyle among the elderly even when they can not do motor activities in dedicated places such as gyms or specialized centers or adequate natural environments. The project involved elderly people living in the Salerno area who can not do motor activity in a regular way due to cultural, socio-economic, environmental or personal reasons. The identification of the experimental group for the pilot study required a preliminary survey on the levels of autonomy, intellectual efficiency and motor functioning： Instrumental activities of daily living, activities of daily living, short portable mental status questionnaire, clock drawing test, geriatric depression scale （GDS-15） and the short physical performance battery were administered. A specific program of adapted physical activities was planned and realized for 8 months. The study could open interesting perspectives of research that involve interesting results also from a social point of view.

关键词： Elderly adapted physical activities exergames.