检索结果-南通市图书馆

High Power Laser Science and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura T.Zh.Esirkepov B.Gonzalez-Izquierdo C.D.Armstrong T.A.Pikuz S.A.Pikuz W.yan T.M.Jeong S.Singh P.Hadjisolomou O.Finke G.M.Grittani M.Nevrkla C.M.Lazzarini A.Velyhan T.Hayakawa y.Fukuda J.K.Koga M.Ishino K.Kondo y.Miyasaka A.Kon M.Nishikino y.V.Nosach D.Khikhlukha I.P.Tsygvintsev D.Kumar J.Nejdl D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama y.Kato G.Korn K.Kondo S.V.Bulanov T.Kawachi A.S.Pirozhkov eli Beamlines Facility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Science(KPSI) QSTKyotoJapan Central Laser Facility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and Transdisciplinary Research Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physics ASCR PragueCzech Republic FZU-Institute of Physics ASCR PragueCzech Republic Czech Technical University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTEQ AR YerevanArmenia

Tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a~10^(22)W/cm^(2)laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy(i.e.,around half of the short Rayleigh length)and show that several diagnostics(in particular,3ωreflection and on-axis hard X-rays)can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast(it requires 10±20 laser shots)and does not rely on the coincidence of low-power and high-power focal planes.

关键词： laser-plasma interaction precise target positioning spectroscopy ultra-high intensity X-rays

<i>Chryseobacterium indologenes</i>Bacteremia: Clinical and Microbiological Characteristics of an Emerging Infection

在线全文

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2018年第6期9卷 520-527页

作者： Danny Alon eli Karniel Iris Zohar Gideon y. Stein Medicine A Meir Medical Center Kfar Saba Israel Sackler School of Medicine Tel Aviv University Tel Aviv Israel Medicine B Meir Medical Center Kfar Saba Israel Medicine B Beilinson Hosp. Rabin Medical Center Petach Tikva Israel

Purpose: Since Chryseobacterium indologenes (C. indologenes) is a rare human pathogen, its clinical significance has not yet been fully established. C. indologenes contamination of medical devices involving fluids and of surgical implants has led to an increasing number of serious infectious reported in recent years, mainly in patients in extremes ages and an immunocompromised state. In this study, we describe the clinical and microbiological characteristics of seven adult patients with C. indologenes bacteremia treated in a tertiary medical center in Israel over a six-year period. Methods: Adult patients hospitalized in Rabin Medical Center, Israel, with a blood culture positive for C. indologenes during the period 2009-2014 were identified retrospectively and their medical records were reviewed. Results: Seven episodes of C. indologenes bacteremia in seven patients were identified during the study period. Five patients were females;the mean age was 76.8 years (41 - 92). Serious underlying conditions were present in all patients. All patients but one, presented after a recent invasive healthcare related intervention. Two patients required mechanical ventilation. Two patients died. All but one isolates were susceptible to ciprofloxacin. Conclusions: Despite our limited number of cases, to the best of our knowledge, our study serves as the largest cohort of adult patients with C. indologenes bacteremia reported in recent years.

关键词： Bacteremia Chryseobacterium indologenes Invasive Intervention

Immunopathogenesis of reactive arthritis:Role of the cytokines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Immunology 2014年第2期4卷 78-87页

作者： Ricardo Javier eli?abe María Silvia Di Genaro Division of Immunology Faculty of Chemistry Biochemistry and PharmacyNational University of San Luis Laboratory of Immunopathology Multidisciplinary Institute of Biological Investigations San Luis

Reactive arthritis （ReA）, also known as sterile postin-fectious arthritis, belongs to the group of related ar-thropathies known as spondyloarthritis （SpA）. ReA can arise 1-4 wk after a gastrointestinal or genitourinary infection, but once arthritis develops, the microorgan-ism is not found in the joint. The classical microbes as-sociated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes, and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cy-tokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-infammatory cytokines involved in the immunopathogenesis of ReA.

关键词： Reactive arthritis Cytokines Immuno-pathogenesis Infection Interleukin-17 Interleukin-12 Interleukin-23 Interleukin-6 Tumor necrosis factor-α Interleukin-10

Dynamic stabilization of plasma instability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2019年第1期7卷 17-26页

作者： S.Kawata T.Karino y.J.Gu Graduate School of Engineering Utsunomiya University Institute of Physics of the ASCR ELI-Beamlines Institute of Plasma Physics of the CAS

The paper presents a review of dynamic stabilization mechanisms for plasma instabilities. One of the dynamic stabilization mechanisms for plasma instability was proposed in the paper [Kawata, Phys. Plasmas 19, 024503(2012)],based on a perturbation phase control. In general, instabilities emerge from the perturbations. Normally the perturbation phase is unknown, and so the instability growth rate is discussed. However, if the perturbation phase is known, the instability growth can be controlled by a superimposition of perturbations imposed actively. Based on this mechanism we present the application results of the dynamic stabilization mechanism to the Rayleigh–Taylor instability(RTI) and to the filamentation instability as typical examples in this paper. On the other hand, in the paper [Boris, Comments Plasma Phys. Control. Fusion 3, 1(1977)] another mechanism was proposed to stabilize RTI, and was realized by the pulse train or the laser intensity modulation in laser inertial fusion [Betti et al., Phys. Rev. Lett. 71, 3131(1993)]. In this latter mechanism, an oscillating strong force is applied to modify the basic equation, and consequently the new stabilization window is created. Originally the latter was proposed by Kapitza. We review the two stabilization mechanisms, and present the application results of the former dynamic stabilization mechanism.

关键词： dynamic instability stabilization filamentation instability plasma instability Rayleigh-Taylor instability stabilization of instability

分布布喇格反射器晶格匹配的Pb1-xSnxTe/PbSeyTel-y激光二极管

在线全文

学校读者我要写书评

暂无评论

半导体光电 1984年第3期 45-47页

作者： eli KaPon ,何兴仁

用液相外延技术制作了分专专喇格反射器（DBR）晶格匹配Pb1-xSnxTe/PbseyTe1-y激光二极管。这些DBR激光器在8.5—38K的有限热沉温度范围内工作,在20K的闲值电流密度为～8KA/cm2。在高于三倍阈值电流的情况下仍获得单纵横工作。DBR激光... 详细信息

用液相外延技术制作了分专专喇格反射器（DBR）晶格匹配Pb1-xSnxTe/PbseyTe1-y激光二极管。这些DBR激光器在8.5—38K的有限热沉温度范围内工作,在20K的闲值电流密度为～8KA/cm2。在高于三倍阈值电流的情况下仍获得单纵横工作。DBR激光器可在775cm-1附近～6cm-1的较宽范围连续调谐。平均调谐率为0.21cm/K,远小于相应的法布里—珀罗腔（FP）激光器的调谐率2.3cm-1/K。

关键词：激光器 DBR 调谐范围热沉电流密度光激射器电子器件激光二极管半导体激光器 x)S el-y ey)T nx)T_e/P_bS Pb

Venetoclax resistance:mechanistic insights and future strategies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cancer Drug Resistance 2022年第2期5卷 380-400页

作者： Faustine Ong Kunhwa Kim Marina y.Konopleva Department of Leukemia The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

Acute myeloid leukemia(AML)is historically associated with poor prognosis,especially in older AML patients unfit for intensive *** development of Venetoclax,a potent oral BH3(BCL-2 homology domain 3)mimetic,has transformed the AML ***,the short duration of response and development of resistance remain major *** mechanisms of resistance is pivotal to devising new strategies and designing rational drug combination *** this review,we will provide a comprehensive summary of the known mechanisms of resistance to Venetoclax and discuss Venetoclax-based combination *** contributing factors to Venetoclax resistance include dependencies on alternative anti-apoptotic BCL-2 family proteins and selection of the activating kinase *** landscape governing response to Venetoclax and strategic approaches developed considering current knowledge of mechanisms of resistance will be addressed.

关键词： Venetoclax acute myeloid leukemia hypomethylating agents Azacitidine Decitabine resistance BCL2 protein human

Fast magnetic energy dissipation in relativistic plasma induced by high order laser modes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2016年第2期4卷 85-89页

作者： y.J.Gu Q.yu O.Klimo T.Zh.Esirkepov S.V.Bulanov S.Weber G.Korn Institute of Physics of the ASCR Institute of Modern Physics Fudan University FNSPE Czech Technical University in Prague Kansai Photon Science Institute Japan Atomic Energy Agency

Fast magnetic field annihilation in a collisionless plasma is induced by using TEM(1,0) laser pulse. The magnetic quadrupole structure formation, expansion and annihilation stages are demonstrated with 2.5-dimensional particle-in-cell simulations. The magnetic field energy is converted to the electric field and accelerate the particles inside the annihilation plane. A bunch of high energy electrons moving backwards is detected in the current sheet. The strong displacement current is the dominant contribution which induces the longitudinal inductive electric field.

关键词： high order laser mode laser–plasma interaction magnetic annihilation

Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第17期7卷 2119-2126页

作者： Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche Servicio de Gastroenterología Instituto de Investigaciones Médico-Biológicas de la Universidad VeracruzanaHospital Juárez de México Laboratorio de Fisiología Digestiva Instituto de Investigaciones Médico-Biológicas de la Universidad Veracruzana

AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality.

关键词： Alcoholic hepatitis Model for end-stageliver disease-Na Maddrey Mortality

灾后儿童抑郁与创伤后应激障碍症状关系的两年追踪

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科学通报 2018年第20期63卷 2071-2080页

作者：布威佐热姆.艾力程锦梁一鸣付琳刘正奎中国科学院心理健康重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

通过纵向设计,考察儿童抑郁与创伤后应激障碍(PTSD)的关系,并探究PTSD各维度与抑郁关系的差异.研究采用加州大学洛杉矶分校创伤后应激障碍反应指数(儿童修订版)和儿童抑郁量表,分别在舟曲泥石流发生后的3,15和27个月对当地的儿童(男452,... 详细信息

通过纵向设计,考察儿童抑郁与创伤后应激障碍(PTSD)的关系,并探究PTSD各维度与抑郁关系的差异.研究采用加州大学洛杉矶分校创伤后应激障碍反应指数(儿童修订版)和儿童抑郁量表,分别在舟曲泥石流发生后的3,15和27个月对当地的儿童(男452,女618)进行了3次追踪调查.结果发现,创伤早期儿童PTSD和抑郁之间存在微弱的相互预测作用,创伤后期仅抑郁对PTSD显著预测.PTSD不同维度与抑郁的关系也存在差异:T1~T3阶段,抑郁对3个维度均具有持续的预测作用;而PTSD回避维度始终对抑郁无预测作用,闯入维度在T1~T2阶段有预测作用,高警觉在T1~T3阶段持续对抑郁有预测作用.研究结果表明,抑郁与PTSD的关系是随时间变化的;PTSD不同维度与抑郁的关系也存在差异.基于研究的发现,心理干预应根据不同创伤时程侧重于不同的症状.未来研究需要比较不同时程、不同事件类型、不同性别以及不同年龄段的PTSD与抑郁的关系.

关键词：儿童创伤后应激障碍(PTSD) 抑郁追踪研究