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Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats

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World Journal of Gastroenterology 2005年第18期11卷 2733-2738页

作者： Constantin Fotiadis Paraskevi Xekouki Apostolos E Papalois PantelisT Antonakis Ioannis Sfiniadakis Dimitrios Flogeras eleutheria karampela George Zografos 3~(rd) Department of Surgery Athens University Medical School Athens Greece ExperimentalResearch Unit ELPEN Pharma Athens Greece Department of Pathology Naval Hospital Athens Greece

AIM: To develop an experimental model of islet allotransplantation in diabetic rats and to determine the positive or adverse effects of MMF as a single agent. METHODS: Thirty-six male Wistar rats and 18 male Lewis rats were used as recipients and donors respectively. Diabetes was induced by the use of streptozotocin (60 mg/kg) intraperitoneally. Unpurified islets were isolated using the collagenase digestion technique and transplanted into the splenic parenchyma. The recipients were randomly assigned to one of the following three groups: group A (control group) had no immunosuppression; group B received cyclosporine (CsA) (5 mg/kg); group C receivedmycophenolate mofetil (MMF) (20 mg/kg). The animalswere killed on the 12th d. Blood and grafted tissues were obtained for laboratory and histological assessment. RESULTS: Median allograft survival was significantly higher in the two therapy groups than that in the controls (10 and 12 d for CsA and MMF respectively vs 0 d for the control group, P＜0.01). No difference in allograft survival between the CsA and MMF groups was found. However,MMF had less renal and hepatic toxicity and allowed weight ***: Monotherapy with MMF for immunosu ppression was safe in an experimental model of islet allotransplantation and was equally effective with cyclosporine, with less toxicity.

关键词：麦考酚酸吗乙酯药物治疗器官移植糖尿病小鼠动物实验

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