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Proteomic-based evidence for adult neurogenesis in birds and mammals as indicated from cerebrospinal fluid

Neural Regeneration Research 2022年第12期17卷 2576-2581页

作者： eleni voukali Michal Vinkler Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic

Adult neurogenesis is the life-long process of neural stem cell proliferation,differentiation into neurons,migration,and incorporation into the existing neuronal *** decades of research,it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult *** fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully *** studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular *** studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in *** this review,we performed literature-based data mining in studies using liquid chromatography-tandem mass spectroscopy that analyzed cerebrospinal fluid samples from healthy adult humans(Homo sapiens);mice(Mus musculus);sheep(Ovis aries);chickens(Gallus gallus);and two parrot species,the budgerigar(Melopsittacus undulatus)and cockatiel(Nymphicus hollandicus).We identified up to 911 proteins represented in cerebrospinal fluid,involved in various pathways regulating adult ***,only 196 proteins were common across humans,mice,and *** components involved in nervous system development,cell migration,and axonal guidance were commonly evident in all species investigated so *** bioinformatic analysis revealed that the universally over-represented pathways involved L1 cell adhesion molecule protein interactions,cell-adhesion molecules,signals regulating extracellular matrix remodeling,regulation of insulin growth factor signaling,axonal guidance,programmed cell death,immune signaling,and post-translational *** of the reported proteins are part of extracellular vesicles enriched in cerebrospinal ***,the information presently available is still highly fragmentary,and far more questions persist than

关键词： adult neurogenesis birds cerebrospinal fluid chicken comparative proteomics human mammals mass spectrometry parrots

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