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Mapping indoor overheating and air pollution risk modification across Great Britain:A modelling study

建筑节能(中英文) 2016年第4期 128-128页

作者： Jonathon Taylor Mike Davies Anna Mavrogianni Clive Shrubsole Ian Hamilton Payel Das Benjamin Jones eleni oikonomou Phillip Biddulph 侯恩哲

Housing has long been thought to play a significant role in population exposure to environmental hazards such as high temperatures and air ***,there is sparse data describing how housing may modify heat and air pollution exposure such that housing's role in poor health and mortality from these hazards may be *** paper describes the development of individual-address level indoor overheating and air pollution risk modifiers for Great Britain,for use alongside historical weather,outdoor air pollution,population socio-economic data,and mortality data in a large-scale epidemiological investigation.A geographically-referenced housing stock database was developed using the Homes Energy Efficiency Database(HEED)and the English Housing Survey(EHS).Simulations of unique combinations of building,fabric,occupation,and environment were run using a modelling framework developed for Energy Plus8.0,estimating indoor temperature metrics,indoor/outdoor ratio of pollution from outdoor sources,and indoor air pollution from multiple indoor *** were compiled,matched back to individual properties in HEED,and mapped using Geographical Information Systems(GIS).Results indicate urban areas had higher numbers of buildings prone to overheating,reduced levels indoor air pollution from outdoor sources,and higher air pollution from indoor sources relative to rural areas,driven largely by variations in building *** results provide the first national-scale quantitative estimate of heat and indoor air pollution modification by dwellings,aggregated at levels suitable for inclusion in health analysis.

关键词： Overheating IAQ Building stock modelling Building physics

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Enhanced recovery after surgery in liver transplantation:Challenges and feasibility

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World Journal of Transplantation 2022年第7期12卷 195-203页

作者： Georgios Katsanos Konstantina-eleni Karakasi Nikolaos Antoniadis Stella Vasileiadou Athanasios Kofinas Antonios Morsi-Yeroyannis Evangelia Michailidou Ioannis Goulis Emmanouil Sinakos Olga Giouleme Ilias Marios oikonomou George Evlavis Georgios Tsakiris eleni Massa eleni Mouloudi Georgios Tsoulfas Department of Transplantation Medical SchoolAristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Intensive Care Unit National Health SystemHippokration General HospitalThessaloniki 54642Greece Fourth Department of Internal Medicine Hippokration General HospitalMedical School of Aristotle UniversityThessaloniki 54642Greece Second Propaedeutic Department of Internal Medicine Hippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece Nursing Department National Health SystemDepartment of TransplantationHippokration General HospitalThessaloniki 54642Greece

BACKGROUND Enhanced recovery after surgery(ERAS)started a revolution that changed age-old surgical stereotypical practices regarding the overall management of the surgical *** the last decade,ERAS has gained significant acceptance in the community of general surgery,in addition to several other surgical specialties,as the evidence of its advantages continues to *** of the last remaining fields,given its significant complexity and intricate nature,is liver transplantation(LT).AIM To investigate the existing efforts at implementing ERAS in *** We conducted a systematic review of the existing studies that evaluate ERAS in orthotopic LT,with a multimodal approach and focusing on measurable clinical primary endpoints,namely length of hospital *** All studies demonstrated a considerable decrease in length of hospital stay,with no readmission or negative impact of the ERAS protocol applied to the postoperative *** ERAS is a well-validated multimodal approach for almost all types of surgical procedures,and its future in selected LT patients seems promising,as the preliminary results advocate for the safety and efficacy of ERAS in the field of LT.

关键词： Enhanced recovery Enhanced recovery after surgery Recovery Liver transplantation Liver

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Effects of an active lifestyle on the physical frailty of liver transplant candidates

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World Journal of Transplantation 2022年第11期12卷 365-377页

作者： Ilias Marios oikonomou Emmanouil Sinakos Nikolaos Antoniadis Ioannis Goulis Olga Giouleme Maria Anifanti Georgios Katsanos Konstantina-eleni Karakasi Georgios Tsoulfas Evangelia Kouidi Department of Transplant Surgery Aristotle University of ThessalonikiThessaloniki 54642Greece The Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642Greece The Second Propaedeutic Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642Greece Laboratory of Sports Medicine Aristotle University of ThessalonikiThessaloniki 57001Greece

BACKGROUND Liver transplantation is the most important therapeutic intervention for end-stage liver disease(ELD).The prioritization of these patients is based on the model for end-stage liver disease(MELD),which can successfully predict short-term ***,despite its great validity and value,it cannot fully incorporate several comorbidities of liver disease,such as sarcopenia and physical frailty,variables that can sufficiently influence the survival of such ***,there is growing interest in the importance of physical frailty in regard to mortality in liver transplant candidates and recipients,as well as its role in improving their survival *** To evaluate the effects of an active lifestyle on physical frailty on liver transplant *** An observational study was performed within the facilities of the Department of Transplant Surgery of Aristotle University of *** liver transplant candidate patients from the waiting list of the department were included in the *** that were bedridden,had recent cardiovascular incidents,or had required inpatient treatment for more than 5 d in the last 6 mo were excluded from the *** following variables were evaluated:Activity level via the International Physical Activity Questionnaire(IPAQ);functional capacity via the 6-min walking test(6MWT)and cardiopulmonary exercise testing;and physical frailty via the Liver Frailty Index(LFI).RESULTS According to their responses in the IPAQ,patients were divided into the following two groups based on their activity level:Active group(A,10 patients);and sedentary group(S,10 patients).Comparing mean values of the recorded variables showed the following results:MELD(A:12.05±5.63 vs S:13.99±3.60;P>0.05);peak oxygen uptake(A:29.78±6.07 mL/kg/min vs S:18.11±3.39 mL/kg/min;P<0.001);anaerobic threshold(A:16.71±2.17 mL/kg/min vs S:13.96±1.45 mL/kg/min;P<0.01);6MWT(A:458.2±57.5 m vs S:324.7±55.8 m;P<0.001);and LFI(A:3.75±0.31 vs

关键词： Liver transplantation Frailty Six-minute walk test Cardiopulmonary exercise testing Exercise therapy Observational study

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Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions

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World Journal of Clinical Cases 2023年第17期11卷 3932-3948页

作者： Panagiotis Papamichalis Katerina G oikonomou Asimina Valsamaki Maria Xanthoudaki Periklis Katsiafylloudis Evangelia Papapostolou Apostolia-Lemonia Skoura Michail Papamichalis Marios Karvouniaris Antonios Koutras eleni Vaitsi Smaragdi Sarchosi Antonios Papadogoulas Dimitrios Papadopoulos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Department of Transfusion Medicine University Hospital of LarissaLarissa 41110ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit AHEPA University HospitalThessaloniki 54636Greece 1^(st) Department of Obstetrics and Gynecology General Hospital of Athens“ALEXANDRA”National and Kapodistrian University of AthensAthens 11528Greece Department of Anesthesiology University Hospital of LarissaLarissa 41110ThessalyGreece

Clinically,it is highly challenging to promote recovery in patients with acute liver failure(ALF)and acute-on-chronic liver failure(ACLF).Despite recent advances in understanding the underlying mechanisms of ALF and ACLF,standard medical therapy remains the primary therapeutic *** transplantation(LT)is considered the last option,and in several cases,it is the only intervention that can be ***,this intervention is limited by organ donation shortage or exclusion criteria such that not all patients in need can receive a *** option is to restore impaired liver function with artificial extracorporeal blood purification *** first such systems were developed at the end of the 20th century,providing solutions as bridging therapy,either for liver recovery or *** enhance the elimination of metabolites and substances that accumulate due to compromised liver *** addition,they aid in clearance of molecules released during acute liver decompensation,which can initiate an excessive inflammatory response in these patients causing hepatic encephalopathy,multiple-organ failure,and other complications of liver *** compared to renal replacement therapies,we have been unsuccessful in using artificial extracorporeal blood purification systems to completely replace liver function despite the outstanding technological evolution of these *** middle to high-molecular-weight and hydrophobic/protein-bound molecules remains extremely *** majority of the currently available systems include a combination of methods that cleanse different ranges and types of molecules and ***,conventional methods such as plasma exchange are being re-evaluated,and novel adsorption filters are increasingly being used for liver *** strategies are very promising for the treatment of liver ***,the best method,system,or device has not been developed yet,and its probability of

关键词： Liver failure Transplantation Blood purification Liver replacement therapy Artificial extracorporeal systems Transplant-free survival

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