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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： elena Ambrosini Angela Lanciotti Maria Stefania Brignone Department of neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CnS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

Context-dependent role of sirtuin 2 in inflammation

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neural Regeneration Research 2025年第3期20卷 682-694页

作者： noemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado elena Puerta Department of Pharmaceutical Sciences Division of PharmacologySchool of Pharmacy and NutritionUniversity of NavarraPamplonaSpain navarra Institute for Health Research(IdiSnA) PamplonaSpain

Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(nAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has been involved in the modulation of key inflammatory signaling pathways and transcription factors by deacetylating specific targets, such as nuclear factor κB and nucleotide-binding oligomerization domain-leucine-rich-repeat and pyrin domain-containing protein 3(nLRP3). However, whether sirtuin 2-mediated pathways induce a pro-or an anti-inflammatory response remains controversial. Sirtuin 2 has been implicated in promoting inflammation in conditions such as asthma and neurodegenerative diseases, suggesting that its inhibition in these conditions could be a potential therapeutic strategy. Conversely, arthritis and type 2 diabetes mellitus studies suggest that sirtuin 2 is essential at the peripheral level and, thus, its inhibition in these pathologies would not be recommended. Overall, the precise role of sirtuin 2 in inflammation appears to be context-dependent, and further investigation is needed to determine the specific molecular mechanisms and downstream targets through which sirtuin 2 influences inflammatory processes in various tissues and pathological conditions. The present review explores the involvement of sirtuin 2 in the inflammation associated with different pathologies to elucidate whether its pharmacological modulation could serve as an effective strategy for treating this prevalent symptom across various diseases.

关键词： interferon inflammation lipopolysaccharide neuroinflammation nLRP3 nuclear factorκB sirtuin 2

The Fifth Edition of the General Catalogue of Variable Stars:experiences in the constellation Centaurus

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Research in Astronomy and Astrophysics 2018年第7期18卷 93-100页

作者： nikolay n.Samus elena n.Pastukhova Olga V.Durlevich elena V.Kazarovets Institute of Astronomy Russian Academy of Sciences Sternberg Astronomical Institute Lomonosov Moscow University

We have recently announced that the General Catalogue of Variable Stars enters the stage of its fifth, purely electronic edition （GCVS 5.1）. We have included 1408 variable stars in the constellation Centaurus in this new version, GCVS 5.1. Working on this revision, we applied current possibilities from data mining, suggested new variability types for many variable stars and found new light elements for a large number of periodic variables. This paper describes the work completed during the preparation of GCVS 5.1 for Centaurus and discusses in detail a number of the most astrophysically significant cases.

关键词： catalogs - techniques photometric - stars variables general - binaries eclipsing

Casimir Effect in Optoelectronic Devices Using Ferrofluids

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Journal of Electronic Science and Technology 2020年第1期18卷 76-82页

作者： elena n.Velichko Galina L.Klimchitskaya Elina n.nepomnyashchaya Institute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Department of Astrophysics Central Astronomical Observatoryat Pulkovo of the Russian Academy of SciencesSt.Petersburg 196140

Some of the modern electronic and optoelectronic devices exploit ferrofluids contained in narrow gaps between two material plates. When the width of the gap becomes below a micrometer, the boundary plates are subjected to the Casimir force arising from the zero-point and thermal fluctuations of the electromagnetic field. These forces should be taken into account in microdevices with the dimensions decreased to below a micrometer. In this paper, we review recently performed calculations of the attractive Casimir pressure in three-layer systems containing a ferrofluid. We also find the ferrofluidic system where the Casimir pressure is repulsive. This result is obtained in the framework of the fundamental Lifshitz theory of van der Waals and Casimir forces. The conclusion is made that enhanced repulsion due to the presence of a ferrofluid may prevent from sticking of closely spaced elements of a microdevice.

关键词： Casimir pressure ferrofluids microdevices repulsion

How can ecosystem engineer plants boost productivity in east Mediterranean drylands

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Ecological Processes 2023年第1期12卷 425-437页

作者： elena Constantinou Dimitrios Sarris Magda Psichoudaki Javier Cabello Ioannis n.Vogiatzakis Faculty of Pure&Applied Sciences Open University of Cyprus2252 NicosiaCyprus KES Research Centre 1055 NicosiaCyprus KES College 1055 NicosiaCyprus nireas-International Water Research Center University of CyprusP.O.Box 205371678 NicosiaCyprus Andalusian Center for the Assessment and Monitoring of Global Change University of Almería04120 AlmeríaSpain Department of Biology and Geology University of Almería04120 AlmeríaSpain.

Background Water availability is the key limiting factor for plant productivity in drylands covering ca.40%of Earth’s land *** such ecosystems to retain productivity and biodiversity under climatic change,it would be valu-able to identify/promote keystone plant species that(i)have developed strategies to more efficiently utilize moisture resources not easily accessible and(ii)improve moisture conditions for neighboring *** very deep-rooted Ziziphus lotus,considered an ecosystem engineer,is one such ***,it is not known which biotic traits:(a)canopy interception of moisture/rainfall,(b)hydraulic redistribution of deep ground moisture by roots,or non-biotic factors:(c)soil’s volume,and(d)organic matter content,*** activates/modulates to play such a ***,thus,selected dryland ecosystems where the plant dominates and measured for potential effects on the less deep-rooted Thymbra *** assessing impacts on ecosystem productivity,we measured the spatial aggregation of ca.3600 *** *** a proxy for soil moisture availability and its spatial variability,we conducted a 7-year-long study using thymes’nighttime *** extended up to 15 m away from *** The density of *** plants growing up to 5 m around *** *** growing 10-15 m away was found significantly increased(2.5-4.5 times),while their stem/leaf moisture was ca.10%higher at predawn compared to nightfall during the dry *** suggests that ecosystem productivity is driven by a greater soil moisture avail-ability around *** permitting more thyme daytime transpiration,in contrast to thymes growing further *** phenomenon appeared only under dry topsoil(during the dry season;becoming stronger during dry years).Morning dew/rainfall interception from the canopy or soil depth/organic matter did not show significant effects,leaving only the hydraulic lift properties of *** as the most likely driver for soil moisture avail

关键词： Plant–plant interaction Desertification Mediterranean Dryland Moisture content Deep root Ziziphus lotus Stress-gradient

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Shungite as the natural pantry of nanoscale reduced graphene oxide

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International Journal of Smart and nano Materials 2014年第1期5卷 1-16页

作者： elena F.Sheka natalia n.Rozhkova General Physics Department Peoples’Friendship University of RussiaMoscow 117198Russian Federation Institute of Geology Karelian Research Centre RASPetrozavodskRussian Federation

Shungite is presented as a natural carbon allotrope of a multilevel fractal structure that is formed by a successive aggregation of~1 nm reduced graphene oxide *** stacks of the sheets of~1.5 nm in thickness and globular composition of the stacks of~6 nm in size determine the secondary and tertiary levels of the *** of globules of tens of nanometers complete the *** theory of graphene oxide,supported by large experience gained by the modern graphene science,has led to the foundation of the suggested *** microscopic view has found a definite confirmation when analyzing the available empirical appearance of *** our knowledge,this is the first time a geological process is described at quantum level.

关键词： shungite reduced graphene oxide molecular theory

Effects of site preparation methods on soil physical properties and outplanting success of coniferous seedlings in boreal forests

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维普期刊数据库

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Journal of Forestry Research 2024年第2期35卷 70-80页

作者： Aleksey S.Ilintsev elena n.nakvasina Alexander P.Bogdanov northern Research Institute of Forestry 13 Nikitova Str.Arkhangelsk 163062Russian Federation Department of Silviculture and Forest Management Northern(Arctic)Federal University Named After M.V.LomonosovSevernoy Dviny Emb.17Arkhangelsk 163002Russian Federation

This study assessed the effect of patch scarification and mounding on the physical properties of the root layer and the success of tree planting in various types of *** study was conducted on 12 forest sites in taiga forests of the European part of Russia.A total of 54 plots were set up to assess seedling survival;root collar diameter,height,and heigh increment were measured for 240 seedlings to assess *** the rooting layer,240 soil samples were taken to determine physical *** study showed that soil treatment methods had no effect on bulk density and total porosity in Cladina ***,reduced soil moisture was noted,particularly in mounds,resulting in increased *** Myrtillus sites,there were increased bulk density,reduced soil moisture,and total porosity in the *** treatment in Polytrichum sites resulted in reduced soil moisture and increased aeration *** the Myrtillus and Polytrichum sites,patch scarification had no effects on physical *** Polytrichum sites,survival rates,heights,and heigh increments of bareroot norway spruce seedlings in mounds were higher than in patches;however,the same did not apply to *** Cladina and Myrtillus sites,there was no difference in growth for bareroot and containerised seedlings with different soil *** conditions and soil types should be considered when applying different soil treatment methods to ensure high survival rates and successful seedling growth.

关键词： Boreal forests Mechanical site preparation Patch scarification Mounding Soil properties Containerised seedlings Bareroot seedlings

Role of Electromagnetic Fluctuations in Organic Electronics

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Journal of Electronic Science and Technology 2020年第1期18卷 52-58页

作者： Vladimir M.Mostepanenko elena n.Velichko Maksim Aleksandrovich Baranov Institute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Central Astronomical Observatory at Pulkovo of Russian Academy of Sciences St.Petersburg 196140

Thin organic films find expanding applications in electronic and optoelectronic devices, biotechnology,food packing, and for many other purposes. Among other factors, the stability of films with a thickness below a micrometer is determined by the zero-point and thermal fluctuations of the electromagnetic field. These fluctuations result in the van der Waals and Casimir free energy and forces between a film and a substrate. The fluctuationinduced force may be both attractive and repulsive making the film either more or less stable, respectively. Here, we review recently obtained results for the Casimir free energy of both freestanding and deposited on the metallic and dielectric substrates peptide films. We also perform computations for the free energy of the peptide films deposited on a silica glass substrate in the region of parameters where this free energy vanishes. Possible applications of the obtained results are discussed.

关键词： Casimir free energy organic electronics peptide film