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High interpretable machine learning classifier for early glaucoma diagnosis

International Journal of Ophthalmology(English edition) 2021年第3期14卷 393-398页

作者： Carlos Salvador Fernandez Escamez elena martin giral Susana Perncho martinez Nicolas Toledano Fernandez Ophthalmology Department Hospital de FuenlabradaMadrid 28942Spain Doctorate Program in Heath Sciences Universidad Rey Juan CarlosAlcorcon 28922MadnidSpain

AIM:To develop a classifier for differentiating between healthy and early stage glaucoma eyes based on peripapillary retinal nerve fiber layer(RNFL)thicknesses measured with optical coherence tomography(OCT),using machine learning algorithms with a high ***:Ninety patients with early glaucoma and 85 healthy eyes were *** glaucoma eyes showed a visual field(VF)defect with mean deviation>-6.00 d B and characteristic glaucomatous *** thickness in every quadrant,clock-hour and average thickness were used to feed machine learning *** analysis was conducted to detect and exclude *** gradient boosting algorithms were used to calculate the importance of parameters on the classifier and to check the relation between their values and its impact on the *** with the lowest importance were excluded and a weighted decision tree analysis was applied to obtain an interpretable *** under the ROC curve(AUC),accuracy and generalization ability of the model were estimated using cross validation ***:Average and 7 clock-hour RNFL thicknesses were the parameters with the highest impor *** between parameter values and impact on classification displayed a stepped pattern for average *** tree model revealed that average thickness lower than 82μm was a high predictor for early *** scores had AUC of 0.953(95%CI:0.903-0998),with an accuracy of 89%.CONCLUSION:Gradient boosting methods provide accurate and highly interpretable classifiers to discriminate between early glaucoma and healthy *** and 7-hour RNFL thicknesses have the best discriminant power.

关键词： machine learning glaucoma diagnosis optical coherence tomography

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Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz elena Barbadilla-martin Jose Guadix Jesus Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

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Measures of Relative and Absolute Convergence and Pro-poor Growth with an Illustration based on China(2010–2018)

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China & World Economy 2024年第2期32卷 1-41页

作者： elena Bárcena-martin Jacques Silber Yuan Zhang Facultad de Ciencias Económicas y Empresariales Universidad de MálagaSpain Department of Economics Bar-Ilan UniversityIsrael China Center for Economic Studies Fudan UniversityChina

Income mobility is a key issue for understanding the process of economic growth and distributional *** economists have used the concept of“pro-poor growth”to examine,with individual-level panel data,whether the poor benefit more than the rich from economic growth by tracking the extent of income mobility among different population *** is also literature in macroeconomics on the measurement of *** paper introduces population-weighted relative and absolute indices of mobility,convergence,and pro-poor growth;it also distinguishes between anonymous and nonanonymous approaches to these *** empirical analysis is based on Chinese panel data for the period 2010–*** both absolute and relative terms,income growth in China was greater for individuals with an initially lower income but only for lower income deciles in relative *** was also an overall increase in individual welfare from anonymous and nonanonymous perspectives,which was higher among younger *** welfare of the poor did not increase more than that of the *** results shed light on the evolution of income distribution in China during the past decade's rapid economic growth.

关键词： anonymous and nonanonymous approach convergence exchange and structural mobility pro-poor growth

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Current and further trajectories in designing functional materials for solid oxide electrochemical cells:A review of other reviews

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Journal of Energy Chemistry 2024年第7期94卷 302-331页

作者： Stanislav Baratov elena Filonova Anastasiya Ivanova Muhammad Bilal Hanif Muneeb Irshad Muhammad Zubair Khan martin Motola Sajid Rauf Dmitry Medvedev Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Institute of Natural Sciences and Mathematics Ural Federal University620002 EkaterinburgRussia Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova 6Mlynska Dolina84215 BratislavaSlovakia State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049ShaanxiChina Department of Physics University of Engineering and TechnologyLahore 54890Pakistan Pak-Austria Fachhochschule:Institute of Applied Sciences and Technology Mang Haripur 22621Khyber PakhtunkhwaPakistan College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518000GuangdongChina Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia

Complex oxides are an important class of materials with enormous potential for electrochemical *** on their composition and structure,such complex oxides can exhibit either a single conductivity(oxygen-ionic or protonic,or n-type,or p-type electronic)or a combination thereof gener-ating distinct dual-conducting or even triple-conducting *** properties enable their use as diverse functional materials for solid oxide fuel cells,solid oxide electrolysis cells,permeable membranes,and gas *** literature review shows that the field of solid oxide materials and related electro-chemical cells has a significant level of research engagement,with over 8,000 publications published since *** manual analysis of such a large volume of material is ***,by examining the review articles,it is possible to identify key patterns,recent achievements,prospects,and remaining *** perform such an analysis,the present article provides,for the first time,a comprehensive summary of previous review publications that have been published since 2020,with a special focus on solid oxide materials and electrochemical ***,this study provides an important reference for researchers specializing in the fields of solid state ionics,high-temperature electrochemistry,and energyconversiontechnologies.

关键词： SOFCs SOECs PCFCS Electrochemistry Energy conversion Hydrogen energy,Carbon neutrality

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System Design for the Event Horizon Imaging Experiment Using the PECMEO Concept

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空间科学学报 2019年第2期39卷 250-266页

作者： KUDRIASHOV Volodymyr martin-NEIRA Manuel BARAT Itziar martin IGLESIAS Pertonilo DAGANZO-EUSEBIO elena ALAGHA Nader VALENTA Vaclav European Space Research and Technology Centre the European Space Agency

The concept for space interferometry from Polar or Equatorial Circular Medium Earth Orbits(the PECMEO concept) is a promising way to acquire the image of the"shadow"of the event horizon of Sagittarius A*with an angular resolution of circa 5 microarcseconds. The concept is intended to decrease the size of the main reflector of the instrument to about 3 m using a precise orbit reconstruction based on Global Navigation Satellite System (GNSS) navigation, inter-satellite range and range-rate measurements, and data from the Attitude and Orbit Determination System (AODS). The paper provides the current progress on the definition of the subsystems required for the concept on the basis of simulations, radio regulations, and available technology. The paper proposes the requirement for the localization of the phase centre of the main reflector. The paper provides information about the visibility of GNSS satellites and the needed accuracies of the AODS. The paper proposes the frequency plan for the instrument and its Inter-Satellite Links (ISLs).The concepts for measurement of range and range-rate using ISLs (as well as for the data exchange at these ISLs) are presented. The block diagram of the interferometer is described and its sensitivity is estimated. The link budget for both ISLs is given as well as their critical components. The calculated measurement quality factors are given. The paper shows the expected performance of the sub-systems of the interferometer. The requirements for the localization of the main reflectors and the information about the availability of the GNSS satellites are based on the simulations results. The frequency plan is obtained according to the PECMEO concept and taking into account the radio regulations. The existing technology defines the accuracies of the AODS, both the link budgets and the fundamental measurement accuracies for ISLs, and the sensitivity of the instrument. The paper provides input information for the development of the orbit r

关键词： Instrumentation Telescope High angular resolution Interferometer Space VLBI

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Anti-cytomegalovirus antibodies and other atherosclerosis risk factors in patients with cardiovascular diseases

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Journal of Geriatric Cardiology 2007年第3期4卷 131-134页

作者： Jan Kazar elena Kovacova Viera Mongiellova martin Gajdos Jan Tomka Roman Slysko Viliam Fridrich Slovak Medical University BratislavaSlovak Republic Institute of Virology Slovak Academy of SciencesBratislavaSlovak Republic National Institute of Cardiovascular Diseases BratislavaSlovak Republic

Objective To determine anti-cytomegalovirus(CMV) antibodies along with anti-Chlamydia pneumoniae(CP) antibodies in comparison with inflammatory markers and other risk factors of atherosclerosis in patients with selected cardiovascular diseases(CVD) . Methods A total of 228 patients with coronary heart disease(CHD) and/or hyperten-sion(HT) ,and those who underwent reconstructive vascular surgery(RVS) on carotids or abdominal aorta were tested for the presence of anti-CMV IgG and IgM antibodies as well as for anti-CP IgA antibodies,C-reactive protein(CRP) ,and interleukin-6(IL-6) . Other risk factors for atherosclerosis,namely age,gender,smoking,hypercholesterolemia,and diabetes mellitus were also analyzed. Results Anti-CMV IgG antibodies were found in 204 patients sera(89.5%) ,compared with 46 positive of 68 sera in the controls(67.6%) ,whereas anti-CMV IgM antibodies were detected in 4 of 54 sera of patients tested(7.4%) ,but not in the controls. The highest proportion of positive sera with not only anti-CMV IgG antibodies(95.6.7%) ,but also anti-CP IgA antibodies(78.3%) ,IL-6(84.8%) and CRP(97.8%) ,was observed in patients with RVS. The results obtained corresponded to age,hypercholesterolemia,and diabetes. Conclusions The presence of anti-CMV antibodies together with antibodies to CP and markers of inflammation(CRP and IL-6) in our study was associated with CVD,primarily in elderly patients who underwent RVS.

关键词： cytomegalovirus chlamydia pneumoniae antibodies inflammatory factor atherosclerosis cardiovascular disease

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Epidemiological Aspects and Clinicopathological Findings in Cats Naturally Infected with Feline Leukemia Virus (FeLV) and/or Feline Immunodeficiency Virus (FIV)

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Open Journal of Veterinary Medicine 2012年第1期2卷 13-20页

作者： Victorio M. Collado Ana Domenech Guadalupe Miró Sonsoles martin elena Escolar Esperanza Gomez-Lucia Departamento Medicina y Cirugía Animal Facultad de Veterinaria Universidad Complutense Madrid Spain Departamento Sanidad Animal Facultad de Veterinaria Universidad Complutense Madrid Spain

Infections produced by feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), two of the most prevalent pathogens in cats, range from passing unnoticed to presenting a wide variety of clinical signs. Different epidemiological, clinical, hematological and virological parameters were analyzed in 78 FIV- and/or FeLV-infected cats. FeLV-infected (FeLV+) cats were considerably younger than FIV-infected (FIV+) cats, and in general were seen to have a more severe disease than FIV+ cats. Around one third of the cats presented anemia, and neutropenia was also frequently observed. Though a higher percentage of FIV+ than FeLV+ cats had altered leukocyte counts, FeLV+ cats had altered counts of both neutrophils and lymphocytes more frequently than FIV+, which usually presented only either altered neutrophils or lymphocyte counts. Virological markers were only detected in FeLV+cats, either as mono- or dual-infection, and correlated with the severity of the disease, but not in FIV+ cats. In conclusion, these results suggest that FeLV affects more blood cell types and provokes death of affected animals at a much earlier age than FIV and that the severity of the disease seemed to depend on the viral status of the cat.

关键词： FIV FeLV Epidemiology Hemogram CD4:CD8 Ratio

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Cryopreservation by Vitrification of Vitis vinifera cv. ＂Red Globe＂ Zygotic Embryos and Effect on the Expression of DNA Methyltransferase Genes

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Journal of Agricultural Science and Technology(B) 2016年第6期6卷 387-399页

作者： Heriberto Garcia-Coronado Maria-elena Baez-Flores Rosalba Troncoso-Rojas Marisela Rivera-Dominguez martin-Emesto Tiznado-Hernandez Coordinacion de Tecnologia de Alimentos de Origen Vegetal Centro de Investigacion en Alimentacion y Desarrollo A.C. (CLAD)Hermosillo Sonora CP 83304 Mexico Facultad de Ciencias Quimico Biol6gicas Universidad Autonoma de Sinaloa Culiacan Sinaloa CP 80013 Mexico Coordinacion de Ciencia de los Alimentos Centro de Investigacion en Alimentacion y Desarrollo A.C. (CLAD) HermosilloSonora CP 83304 Mexico

Mexico is a large producer of table grape （Vitis vinifera L.） and therefore it is important to develop protocols to store the grape varieties germplasm. The objective of the present work was to design a protocol for the cryopreservation by vitrification of zygotic embryos of V. vinifera cv. ＂Red Globe＂ and evaluate possible epigenetics changes. The plant vitrification solution 2 （PVS2） was utilized before the utilization of liquid nitrogen （LN）. The effect of this protocol on embryo viability was tested by the triphenyl-tetrazolium chloride solution, as well as by the in vitro development of grape embryos into plantlet. A cDNA expression library of grape zygotic embryos was created to isolate expressed sequence tags of several DNA methyltrasferases. Gene expression of domains rearranged methyltransferase type 1 （DMR1） and DNA （cytosine-5）-methyltransferase 1 （MET1-2） isozymes was analyzed by quantitative reverse transcriptase PCR. The optimal conditions for vitrification were 10 min in 50% PVS2, followed by I0 min in 100% PVS2. Under these conditions, about 30% of plantlet was obtained from embryos after cryopreservation. It was recorded a reduction in the MET1-2 gene expression, which plays a role in the maintenance of DNA methylation. It is possible to cryopreserve viable grape zygotic embryos, although the treatment seems to induce alterations in the normal DNA methylation pattern of the zygotic embryo genome.

关键词： Vitis vinifera zygotic embryo cryopreservation vitrification DNA methyltransferase.

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Successful multidisciplinary clinical approach and molecular characterization by whole transcriptome sequencing of a cardiac myxofibrosarcoma: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3018-3026页

作者： Maristella Saponara Valentina Indio Carmine Pizzi elena-Daniela Serban Milena Urbini Annalisa Astolfi Pasquale Paolisso Sofia martin Suarez Margherita Nannini Davide Pacini Valentina Agostini Ornella Leone Valentina Ambrosini Giuseppe Tarantino Stefano Fanti Fabio Niro Francesco Buia Domenico Attinà Maria Abbondanza Pantaleo Department of Specialized Experimental and Diagnostic MedicineMedical Oncology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy “Giorgio Prodi”Cancer Research Center University of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineCardiology and Transplantation UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Pathology Cardiovascular Pathology UnitSant’Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Departments of Cardiovascular Surgery and Transplantation Sant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineNuclear Medicine UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy Department of Specialized Experimental and Diagnostic MedicineRadiology UnitSant'Orsola-Malpighi HospitalUniversity of BolognaBologna 40138Italy

BACKGROUND Cardiac tumors are rare and complex *** represents the cornerstone of therapy,while the role of adjuvant treatment remains unclear and,in case of relapse or metastatic disease,the prognosis is very *** of prospective,randomized clinical trials hinders the generation of high level evidence for the optimal diagnostic workup and multimodal treatment of cardiac ***,we describe the multidisciplinary clinical management and molecular characterization of a rare case of cardiac myxofibrosarcoma in an elderly *** SUMMARY A 73-year-old woman presented signs and symptoms of acute left-sided heart *** examination revealed a large,left atrial *** suspicion of a myxoma,she underwent surgery,and symptoms were promptly *** showed a cardiac myxofibrosarcoma,a rare histotype of cardiac *** months later,disease unfortunately relapsed,and after a multidisciplinary discussion,a chemotherapy with doxorubicin and then gemcitabine was started,achieving partial radiologic and complete metabolic response,which was maintained up to 2 years and is still *** report is focused on the entire clinical path of our patient from diagnosis to follow-up,through surgery and strategies adopted at ***,due to their rarity,very little is known about the molecular landscape of ***,we also performed and described preliminary genome analysis of the tumor tissue to get further insight on mechanisms involved in tumor growth,and to possibly unveil new clinically actionable *** We report a case of cardiac myxofibrosarcoma that achieved a very good prognosis due to an integrated surgical,cardiac and oncologic treatment strategy.

关键词： Cardiac sarcoma Myxofibrosarcoma Whole transcriptome sequencing Doxorubicin Gemcitabine Case report

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The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez elena Garcia-martin Carmen martinez Julian Benito-Leon Julian Benito-Leon Jorge Millan-PascualMaria Diaz-Sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores Torrecillas Esteban Garcla-Albea Jose Francisco Plaza-Nieto Felix Javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词： associated increased sclerosis

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