检索结果-南通市图书馆

Improving nutrition for the prevention of gestational diabetes:Current status and perspectives

World Journal of Diabetes 2021年第9期12卷 1494-1506页

作者： Polina V Popova Evgenii A Pustozerov Aleksandra S Tkachuk elena n grineva Institute of Endocrinology Almazov National Medical Research CentreSaint Petersburg 194156Russia Department of Faculty Therapy Saint Petersburg Pavlov State Medical UniversitySaint Petersburg 197022Russia Department of Biomedical Engineering Saint Petersburg State Electrotechnical UniversitySaint Petersburg 197341Russia

Gestational diabetes mellitus(GDM)is a common complication of pregnancy and a serious public health *** carries significant risks of short-term and longterm adverse health effects for both mothers and their *** factors,especially modifiable risk factors,must be considered to prevent GDM and its *** studies have identified several nutritional and lifestyle factors associated with the risk of *** results of intervention studies examining the effects of diet and lifestyle on the prevention of GDM are *** in the study populations,types and intensity of intervention,time frame of the intervention,and diagnostic criteria for GDM may explain the heterogeneity in the results of intervention *** review provides an overview of new diets and other factors that may help prevent *** main results of epidemiological studies assessing the risk factors for GDM,as well as the results and methodological problems of intervention studies on the prevention of GDM and their meta-analyses,are *** addition,the evidence that gene and lifestyle interactions influence the development of GDM,as well as prospects for increasing the effectiveness of interventions designed to prevent GDM,including new data on the possible uses of personalized diet therapy,are highlighted.

关键词： Gestational diabetes mellitus Risk factors nutrition Prevention Personalized medicine Postprandial glycemic response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of glucagon-like peptide 1 analogs in combination with insulin on myocardial infarct size in rats with type 2 diabetes mellitus

引用

World Journal of Diabetes 2018年第9期9卷 149-156页

作者： Vladislav A Zykov Taisiia P Tuchina Denis A Lebedev Irina B Krylova Alina Y Babenko Elvira V Kuleshova elena n grineva Alekber A Bayramov Michael M Galagudza Almazov national Medical Research Centre St-Petersburg 197341Russia Institute of Experimental Medicine St-Petersburg 197376Russia

AIM To evaluate the effects of glucagon-like peptide-1 analogs(GLP-1 a) combined with insulin on myocardial ischemiareperfusion injury in diabetic *** Type 2 diabetes mellitus(T2 DM) was induced in maleWistar rats with streptozotocin(65 mg/kg) and verified using an oral glucose tolerance test. After anesthesia, the left coronary artery was occluded for 40 min followed by 80 min reperfusion. Blood glucose level was measured during surgery. Rats were randomized into six groups as follows:(1) control rats;(2) insulin(0.1 U/kg) treated rats prior to ischemia;(3) insulin(0.1 U/kg) treated rats at reperfusion;(4) GLP-1 a(140 mg/kg) treated rats prior to ischemia;(5) GLP-1 a(140 mg/kg) treated rats at reperfusion; and(6) rats treated with GLP-1 a(140 mg/kg) prior to ischemia plus insulin(0.1 U/kg) at reperfusion. Myocardial area at risk and infarct size was measured planimetrically using Evans blue and triphenyltetrazolium chloride staining, *** There was no significant difference in the myocardial area at risk among groups. Insulin treatment before ischemia resulted in a significant increase in infarct size(34.7% ± 3.4% vs 18.6% ± 3.1% in the control rats, P nistration of insulin or GLP-1 a had no effect on infarct size. However, pre-ischemic administration of GLP-1 a reduced infarct size to 12% ± 2.2%(P nfarct size reduction was observed in the group treated with GLP-1 a prior to ischemia and insulin at reperfusion(8% ± 1.6%, P ntrol and GLP-1 a alone treated groups).COnCLUSIOn GLP-1 a pre-administration results in myocardial infarct size reduction in rats with T2 DM. These effects are maximal in rats treated with GLP-1 a pre-ischemia plus insulin at reperfusion.

关键词： Glucagon-like peptide-1 analog Insulin Myocardial ischemia-reperfusion injury Infarct size Type 2 diabetes mellitus Rats Experimental research

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：