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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz elena Barbadilla-martin Jose Guadix Jesus Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

Plant cell wall-mediated disease resistance:Current understanding and future perspectives

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Molecular Plant 2024年第5期17卷 699-724页

作者： Antonio Molina Lucıa Jorda Miguel Angel Torres Marina martın-Dacal Diego Jose Berlanga Patricia Fernandez-Calvo elena Gomez-Rubio Sonsoles martın-Santamarıa Centro de Biotecnología y Genómica de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departamento de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas Margarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain Misión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elements for the adaptation of plants to environmental *** walls are dynamic structures whose composition and integrity can be altered in response to environmental challenges and developmental *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during development and upon stress *** cell wall damage caused by pathogen infection,wounding,or other stresses leads to the release of wall molecules,such as carbohydrates(glycans),that function as damage-associated molecular patterns(DAMPs).DAMPs are perceived by the extracellular ectodomains(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered immunity(PTI)and disease ***,glycans released from the walls and extracellular layers of microorganisms interacting with plants are recognized as microbe-associated molecular patterns(MAMPs)by specific ECD-PRRs triggering PTI *** number of oligosaccharides DAMPs/MAMPs identified that are perceived by plants has increased in recent ***,the structural mechanisms underlying glycan recognition by plant PRRs remain ***,this knowledge is mainly focused on receptors of the LysM-PRR family,which are involved in the perception of various molecules,such as chitooligosaccharides from fungi and lipo-chitooligosaccharides(i.e.,nod/MYC factors from bacteria and mycorrhiza,respectively)that trigger differential physiological ***,additional families of plant PRRs have recently been implicated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and Malectin domains in their ECDs(LRR-MAL RKs),Catharanthus roseus RECEPTOR-LIKE KInASE 1-LIKE group(CrRLK1L)with Malectin-like domains in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall damage-associated molecular patterns DAMPs disease resistance glycans oligosaccharides pattern-triggered immunity PTl pattern recognition receptor PRRs

Myoclonus and Recurrent Cardioinhibitory Vasovagal Syncope after Abdominal Surgery in a Critical Care Setting

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World Journal of Cardiovascular Diseases 2020年第5期10卷 274-277页

作者： Ana Belén Fernández elena martín Ramsés Marrero David Viera Department of Anesthesiology and Postsurgical Intensive Care Unit Ntra Sra De Candelaria University Hospital Santa Cruz de Tenerife Spain

Letter to the

关键词： Vasovagal Reflex Syncope Cardioinhibitory Response Autonomic Failure Asystole

Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

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World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis Muñoz de nova Jorge Hernando Miguel Sampedro núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María Isabel del Olmo García Jorge Barriuso Jaume Capdevila elena martín-Pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Pathology Universidad Autónoma de MadridMadrid 28029Spain Department of nuclear Medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(anETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a nETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy neoplasm grading Treatment outcome

The strigolactone receptor D14 targets SMAX1 for degradation in response to GR24 treatment and osmotic stress

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Plant Communications 2022年第2期3卷 76-91页

作者： Qingtian Li elena Sánchez martín-Fontecha Aashima Khosla Alexandra R.F.White Sunhyun Chang Pilar Cubas David C.nelson Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521USA Plant Molecular Genetics Department Centro Nacional de Biotecnología/CSICCampus Universidad Autόnoma de MadridMadridSpain

The effects of the phytohormone strigolactone(SL)and smoke-derived karrikins(KARs)on plants are generally distinct,despite the fact that they are perceived through very similar *** homologous receptors DWARF14(D14)and KARRIKIn-InSEnSITIVE2(KAI2),together with the F-box protein MORE AXILLARY GROWTH2(MAX2),mediate SL and KAR responses,respectively,by targeting different SMAX1-LIKE(SMXL)family proteins for *** mechanisms are putatively well-insulated,with D14-MAX2 targeting SMXL6,SMXL7,and SMXL8 and KAI2-MAX2 targeting SMAX1 and SMXL2 in Arabidopsis *** evidence challenges this *** investigated whether D14 can target SMAX1 and whether this occurs *** analysis indicates that the SL analog GR24 promotes D14-SMAX1 *** D14 shows weaker interactions with SMAX1 than with SMXL2 or SMXL7,D14 mediates GR24-induced degradation of SMAX1 in *** stress triggers SMAX1 degradation,which is protective,through SL biosynthesis and signaling ***,D14-SMAX1 crosstalk may be beneficial and not simply a vestige of the evolution of the SL pathway.

关键词： phytohormone signaling proteolysis crosstalk

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西班牙中学校园欺负监测研究报告

中国青年研究 2009年第8期 20-24页

作者： Cristna del Barrio elena mart n Ignacio Montero Isabel Fern.nelez H.Ctor GutirrEz 周华珍李家灿西班牙马德里自治大学法学院

校园欺负行为是中学校园中常见的现象,它严重地影响了中学生的身心健康。本报告采用问卷调查的方式对西班牙全国300多所中学中3000名学生和300名老师进行调查。从受害者、欺负者、观察者三个视角对西班牙中学校园欺负行为进行研究,报告... 详细信息

校园欺负行为是中学校园中常见的现象,它严重地影响了中学生的身心健康。本报告采用问卷调查的方式对西班牙全国300多所中学中3000名学生和300名老师进行调查。从受害者、欺负者、观察者三个视角对西班牙中学校园欺负行为进行研究,报告认真地分析了年级、性别、数量、地点等变量与欺负的相关度。

关键词：欺负受害者欺负者观察者关系

Measures of Relative and Absolute Convergence and Pro-poor Growth with an Illustration based on China(2010–2018)

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China & World Economy 2024年第2期32卷 1-41页

作者： elena Bárcena-martin Jacques Silber Yuan Zhang Facultad de Ciencias Económicas y Empresariales Universidad de MálagaSpain Department of Economics Bar-Ilan UniversityIsrael China Center for Economic Studies Fudan UniversityChina

Income mobility is a key issue for understanding the process of economic growth and distributional *** economists have used the concept of“pro-poor growth”to examine,with individual-level panel data,whether the poor benefit more than the rich from economic growth by tracking the extent of income mobility among different population *** is also literature in macroeconomics on the measurement of *** paper introduces population-weighted relative and absolute indices of mobility,convergence,and pro-poor growth;it also distinguishes between anonymous and nonanonymous approaches to these *** empirical analysis is based on Chinese panel data for the period 2010–*** both absolute and relative terms,income growth in China was greater for individuals with an initially lower income but only for lower income deciles in relative *** was also an overall increase in individual welfare from anonymous and nonanonymous perspectives,which was higher among younger *** welfare of the poor did not increase more than that of the *** results shed light on the evolution of income distribution in China during the past decade's rapid economic growth.

关键词： anonymous and nonanonymous approach convergence exchange and structural mobility pro-poor growth

Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

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World Journal of nuclear Science and Technology 2024年第1期14卷 59-71页

作者： Sergio Hugo Sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez Kevin Said Ramírez Dávila Luis martín García Ortiz Germán Flores Cortés Luz elena Vidales Rodríguez Jesús Adrián López David Alejandro García López Laboratorio de Biología Celular y neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de MicroRnAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by PAGE-SDS and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A Light (UVA) Ultraviolet B Light (UVB) Ultraviolet C Light (UVC) Heat Shock Protein 70 (Hsp70) HaCaT

Cardiogenic shock due to left main related myocardial infarction:is revascularization enough?

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Journal of Geriatric Cardiology 2022年第2期19卷 152-157页

作者： Francisco Galván-Román elena Puerto Roberto martín-Asenjo Albert Ariza-Solé Department of Cardiology Bellvitge University Hospital.Grup de Malalties Cardiovasculars.Institut d´InvestigacióBiomèdica de Bellvitge(IDIBELL).L’Hospitalet de LlobregatBarcelonaSpain Department of Cardiology Doce de Octubre University Hospital.Instituto de Investigación Sanitaria Hospital 12 de Octubre(imas12).MadridSpain*The authors contributed equally to this manuscript

The incidence of cardiogenic shock(CS)complicating acute myocardial infarction(AMI-CS)remains between 3%and 10%and in-hospital mortality is hardly less than 30%.[1-3]In addition,the economic cost of caring for these patients is high.[4]Revascularization in the acute phase is the only measure that has demonstrated to modify the prognosis of AMI-CS.

关键词： infarction acute mortality

Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin

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Journal of Environmental Sciences 2013年第7期25卷 1408-1418页

作者： Gabriela V. Aguirre-martínez Sara Buratti elena Fabbri Angel T. DelValls M. Laura martín-Díaz Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain Andalusian Center for Marine Science and Technology (CACYTMAR) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability （LMS） has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LMS in Ruditapes philippinarum haemolymph using the neutral red retention assay （nRRA）. Clamswere exposed in laboratory conditions to caffeine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, carbamazepine and novobiocin （both at 0.1, 1, 10, 50 μg/L） for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations （p 〈 0.05）（caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L）, compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status （retention time 〈45 min）, significantlyworse than controls （96 min）（p 〈 0.05）. The predicted no environmental effect concentration （PnEC） results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. Measurement of the alteration of LMS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker.

关键词： neutral red pharmaceuticals bioassay haemolymph bivalves health status Manila clam