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Diverse Roles of ERECTA Family Genes in Plant Development

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Journal of Integrative Plant Biology 2013年第12期55卷 1238-1250页

作者： elena D.Shpak Department of Biochemistry Cellular and Molecular BiologyUniversity of Tennessee

Multiple receptor-like kinases （RLKs） enable intercellular communication that coordinates growth and development of plant tissues. ERECTA family receptors （ERfs） are an ancient family of leucine-rich repeat RLKs that in Arabidopsis consists of three genes： ERECTA, ERL1, and ERL2. ERfs sense secreted cysteine-rich peptides from the EPF/EPFL family and transmit the signal through a MAP kinase cascade. This review discusses the functions of ERfs in stomata development, in regulation of longitudinal growth of aboveground organs, during reproductive development, and in the shoot apical meristem. In addition the role of ERECTA in plant responses to biotic and abiotic factors is examined.

关键词： Arabidopsis ERECTA leaf primordium initiation receptor-like kinase stomata vasculature.

Cross-industry standard test method developments：from manufacturing to wearable robots

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1447-1457页

作者： Roger BOSTELMAN elena MESSINA Sebti FOUFOU National Institute of Standards and Technology GaithersburgMD 20899USA Le2i Universite de BourgogneDijon 21078France College of Engineering Qatar UniversityDoha 2713Qatar

Manufacturing robotics is moving towards human-robot collaboration with light duty robots being used side by side with workers. Similarly, exoskeletons that are both passive(spring and counterbalance forces) and active(motor forces) are worn by humans and used to move body parts. Exoskeletons are also called ‘wearable robots' when they are actively controlled using a computer and integrated sensing. Safety standards now allow, through risk assessment, both manufacturing and wearable robots to be used. However, performance standards for both systems are still lacking. Ongoing research to develop standard test methods to assess the performance of manufacturing robots and emergency response robots can inspire similar test methods for exoskeletons. This paper describes recent research on performance standards for manufacturing robots as well as search and rescue robots. It also discusses how the performance of wearable robots could benefit from using the same test methods.

关键词： Wearable robot Exoskeleton Cross-industry Artifact Standards Grasping

Treat-to-target in Crohn's disease:Will transmural healing become a therapeutic endpoint?

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World Journal of Clinical Cases 2018年第12期6卷 501-513页

作者： elena Daniela Serban 2nd Department of Pediatrics "Iuliu Hatieganu" University of Medicine and PharmacyEmergency Hospital for Children

Crohn's disease(CD) represents a chronic transmural inflammatory condition of the gastrointestinal tract, which usually leads to structural damage and signific-ant disability. Deep remission--defined by both clinical and endoscopic remission, signifying mucosal healing-represents the current endpoint in the treat--to--target strategy, significantly improving patients' long--term outcomes. Transmural healing(TH) could be a more effe-ctive target, but this possibility remains unclear. This narrative review aims to critically review and summarize the available literature relating TH to long--term outcomes, being the first of its kind and to the best of the author's knowledge. A systematic literature search(from incep-tion to March 31 2018) was performed, using multiple databases, and identifying seven full--text manuscripts. In those studies, long--term favorable outcomes(≥ 52 wk) included sustained clinical remission, as well as fewer therapeutic changes, CD--related hospitalizations, and surgeries. Despite heterogeneous design and me-thodological limitations, six of the studies demonstrated that TH or intestinal healing(TH plus mucosal healing) were predictive for the aforementioned favorable out-comes. Therefore, TH may become a reasonable the-rapeutic target and be included in the concept of deep remission. Further prospective, well-designed, multicenter trials aiming to better define the role of TH in personalized therapy for CD and to determine the long-term influence of TH on bowel damage and disability are warranted.

关键词： Treat to target Cross sectional imaging Deep remission Transmural healing Intestinal healing Long-term outcomes Bowel damage Crohn’s disease

Transverse magnetoresistance peculiarities of thermoelectric Lu-doped Bi_2Te_3 compound due to strong electrical disorder

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Journal of Rare Earths 2019年第3期37卷 292-298页

作者： Oleg Ivanov Maxim Yaprintsev elena Danshina Belgorod State University Belgorod State Technological University named after V.G.Shukhov

The n-type thermoelectric Bi_(1.9)Lu_(0.1)Te_3 was prepared by microwave-solvothermal method and spark plasma sintering. The magnetic field and temperature dependences of transverse magneto resistance measured within temperature 2-200 K interval allow finding the peculiarities characteristic for strongly disordered and inhomogeneous semiconductors. The first peculiarity is due to appearance of linear-inmagnetic field contribution to the total magneto resistance reflected in a crossover from quadratic magnetoresistance at low magnetic fields to linear magneto resistance at high magnetic fields. The linear magnetoresistance can result from the Hall resistance picked up from macroscopically distorted current paths due to local variations in stoichiometry of the compound studied. The second peculiarity is that both linear magnetoresistance magnitude and crossover field are functions of carrier mobility which is in agreement with the Parish and Littlewood model developed for disordered and inhomogeneous semiconductors. An increase in the mobility due to a decrease in temperature is accompanied by an increase in the magnetoresistance magnitude and a decrease in the crossover field. Finally, the third peculiarity is related to the remarkable deviation of the total magnetoresistance measured at various temperatures from the Kohler's rule. Presence of strong inhomogeneity and disorder in the Bi_(1.9)Lu_(0.1)Te_3 structure concluded from the magnetoresistance peculiarities can be responsible for the remarkable reduction in the total thermal conductivity of this compound.

关键词： Bismuth telluride Linear positive magnetoresistance Semiconductors Thermoelectric material Carrier mobility Kohler’s rule

LYVE-1 is'on stage'now:an emerging player in dendritic cell docking to lymphatic endothelial cells

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Cellular & Molecular Immunology 2018年第7期15卷 663-665页

作者： elena Rinaldi Fulvio Baggi Neurology IV-Neuroimmunology and Neuromuscular Diseases Unit Neurological Institute‘Carlo Besta’MilanItaly

The lymphatic system consists of a network of lymph capillaries and vessels deputed to drain the interstitial fluid(containing floating macromolecules,such as nutrients,cellular debris and tissue-infiltrating pathogens)and to transport tissue-patrolling lymphocytes and dendritic cells(DCs)to draining lymph nodes(drLNs).1 Knowledge of the mechanisms associated with cellular transmigration into the lymphatic system could offer the opportunity to manipulate the immune response in a wide range of diseases,such as autoimmune diseases and cancer.2,3 In this research highlight,we discuss a recent study that sheds light on our understanding of the molecules involved in DCs docking to lymphatic endothelial cells,a critical step prior to their subsequent endothelial transmigration into lymphatic *** docking occurs through the interaction between hyaluronan(hyaluronic acid,HA)molecules on the plasma membrane and lymphatic-vessel endothelial protein(LYVE-1).

关键词： lymphatic drain floating

Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

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Bio-Design and Manufacturing 2021年第2期4卷 278-310页

作者： Francesca Corduas Dimitrios A.Lamprou elena Mancuso Nanotechnology and Integrated Bio-Engineering Centre(NIBEC) Ulster UniversityJordanstown CampusNewtownabbey BT370QBUK School of Pharmacy Queen’s University BelfastBelfast BT97BLUK

Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after *** common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of *** present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most *** prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing *** the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most *** a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh *** this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical *** aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

关键词： 3D printing Electrospinning Manufacturing technologies Biomaterials Drug delivery Surgical mesh implants

Design and optimization of supersonic turbines for detonation combustors

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Chinese Journal of Aeronautics 2022年第11期35卷 33-44页

作者： Jorge SOUSA elena COLLADO-MORATA Guillermo PANIAGUA Flemish InstituteforTechnological Research Mol 2400Belgium Commissariat à lénergie atomique et aux énergies alternatives Le Barp 33114France Mechanical Engineering Purdue UniversityWest-Lafayette IN 47906USA

Detonation-based engines offer a potential surge in efficiency for compact thermal power systems. However, these cycles require ad-hoc components adapted to the high outlet velocity from the detonation combustors. This paper presents the design methodology of turbine stages suitable for supersonic inlet conditions and provides a detailed analysis of optimized turbine geometries. A reduced-order solver examines the supersonic blade rows’ functional design space, quantifies the turbine’s non-isentropic performance, and budgets the turbine loss for different optimized leading-edge designs and chord to pitch ratios. The shock-wave interactions were identified as the predominant contributor to turbine losses, and optimal pitch-chord ratios were determined for various inlet Mach numbers. Finally, with this tool, the specific-power output for a wide range of design configurations was computed;and the metal angle that ensures flow starting and maximizes power extraction was calculated. The detailed numerical study describes the flow interactions in a supersonic turbine and offers new correlations to guide the design of future supersonic turbines.

关键词： Rotating detonation Shock waves Supersonic flow Turbines Unstarting

Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease

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Neural Regeneration Research 2022年第1期17卷 93-94页

作者： elena Tamagno Michela Guglielmotto Department of Neuroscience University of TorinoTorinoItaly(Tamagno EGuglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO)University of TorinoTorinoItaly

Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced *** risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of *** increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial ***,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关键词： Alzheimer attractive therapeutic

Statistical Structures on Metric Path Spaces

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Chinese Annals of Mathematics,Series B 2012年第6期33卷 889-902页

作者： Mircea CRASMAREANU Cristina-elena HRET CANU Faculty of Mathematics Alexandru Ioan Cuza University Faculty of Food Engineering Stefan Cel Mare University

The authors extend the notion of statistical structure from Riemannian geometry to the general framework of path spaces endowed with a nonlinear connection and a generalized *** particular cases of statistical data are *** existence and uniqueness of a nonlinear connection corresponding to these classes is *** Koszul tensors are introduced in accordance with the Riemannian *** applications,the authors treat the Finslerian (α,β)-metrics and the Beil metrics used in relativity and field theories while the support Riemannian metric is the Fisher-Rao metric of a statistical model.

关键词： Semispray Nonlinear connection Metric path space Statistical struc-ture Skewness Koszul tensors (~ ~)-metric Beil metric Rayleigh sta-tistical structure Fisher-Rao metric Statistical model