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Disease impact on the quality of life of children with inflammatory bowel disease

World Journal of Gastroenterology 2017年第6期23卷 1067-1075页

作者： Giorgos Chouliaras Daphne Margoni Konstantina Dimakou Smaragdi Fessatou Ioanna Panayiotou eleftheria roma-Giannikou First Department of Pediatrics National and Kapodistrian University of Athens'Aghia Sophia'Children’s Hospital11527 AthensGreece

AIM To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases(IBD).METHODS This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the "Aghia Sophia" Children's Hospital. Children diagnosed with Crohn's disease (CD) or ulcerative colitis (UC), who were followed as outpatients or during a hospitalization, participated, after informed consent was obtained from their legal representative. QOL was assessed by the IMPACT-III questionnaire. Demographic data and disease characteristics were also collected. Statistical analyses included parametric(Student's t-test and Pearson's r) and non-parametric(Mann-Whitney test, Fisher's test and Spearman's rho) *** Ninety-nine patients (UC: 37, 73.0% females, CD: 62, 51.6% females), aged 12.8±2.6 years were ***, as well as, sub-domain scores did not differ between UC and CD(overall score: 73.9±13.3 vs 77.5±11.2, respectively, P=0.16). In the entire sample, total score was related to physician's global assessment(PGA, patients classified as "mild/moderate" active disease had, on average, 14.8±2.7 points lower total scores compared to those "in remission", P<0.001) and age at IMPACT completion (Pearson's r=0.29, P=0.05). Disease activity assessed by the indices Pediatric Ulcerative Colitis activity index, Pediatric Crohn's disease activity index or PGA was significantly associated with all subdomains scores. Presence of extraintestinal manifestations had a negative impact on emotional and social functioning *** Disease activity is the main correlate of QOL in children with IBD, underlining the importance of achieving and sustaining clinical

关键词：煽动性的肠疾病 ulcerative 大肠炎 Crohns 疾病生活的质量 IMPACT-III 孩子

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NOD2/CARD15 , ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn’s disease

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World Journal of Gastroenterology 2010年第14期16卷 1753-1758页

作者： Maria Gazouli Ioanna Pachoula Ioanna Panayotou Gerassimos Mantzaris George Chrousos Nicholas P Anagnou eleftheria roma-Giannikou Department of Biology School of Medicine University of Athens Athens 11527 Greece Laboratory of Cell and Gene Therapy Center of Basic Research Ⅱ Foundation for Biomedical Research of the Academy of Athens (IIBEAA) Athens 11527 Greece First Department of Pediatrics "Aghia Sophia" Children's Hospital School of Medicine University of Athens Athens 11527 Greece Department of Gastroenterology Evagelismos Hospital Athens 11521 Greece

AIM: To assess whether the polymorphisms of NOD2/ CARD15 , autophagy-related 16-like 1 (ATG16L1 ), and interleukin-23 receptor (IL23R ) genes play a more critical role in the susceptibility of childhood-onset than in adult-onset Crohn’s disease (CD). METHODS: Polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 ; rs2241880 A/G of ATG16L1 , and rs11209026 (R381Q) of IL23R gene were assessed in 110 childhood-onset CD, 364 adult-onset CD, and 539 healthy individuals. Analysis of polymorphisms R702W, G908R, and 3020insC of NOD2/CARD15 genotyping was performed by allele specific polymerase chain reaction (PCR) or by PCR-restriction fragment length polymor-phism analysis. The polymorphisms rs2241880 A/G of the ATG16L1 , and rs11209026 (R381Q) of the IL23R gene in the children’s cohort were genotyped by PCR and melting curve analysis whereas adult group genotyping was performed using the Affymetrix Genome-Wide Human SNP Array 5.0 (500K). RESULTS: The 3020insC allele in NOD2/CARD15 was significantly higher in childhood than in adult-onset CD (P = 0.0067). Association with at least 1 NOD2/CARD15 variant was specific for ileal disease (with or without co- lonic involvement). Even if the frequency of G allele of the rs2241880 ATG16L1 polymorphism was increased in both paediatric and adult CD patients compared to con- trols (P = 0.017 and P = 0.001, respectively), no difference was observed between the childhood and the adult cohort. The rare Q allele of IL23R rs11209026 polymorphism was underrepresented in both paediatric and adult CD cases (P = 0.0018 and P = 0.04, respectively) and no difference was observed between the childhood and the adult cohort. The presence of the rs2241880 ATG16L1 and rs11209026 IL23R polymorphisms did not influence disease phenotype. CONCLUSION: Polymorphism 3020insC in NOD2/ CARD15 occurs statistically significantly more often in patients with childhood-onset CD than in patients with adult-onset CD. The ATG16L1 and IL23R variants are associated

关键词： Genetics Childhood-onset Inflammatory bowel disease Crohn’s disease Genetic susceptibility NOD2/CARD15 ATG16L1 IL23R Polymorphisms

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Burden of celiac disease in the Mediterranean area

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World Journal of Gastroenterology 2011年第45期17卷 4971-4978页

作者： Luigi Greco Laura Timpone Abdelhak Abkari Mona Abu-Zekry Thomas Attard Faouzi Bouguerrà Paskal Cullufi Aydan Kansu Dusanka Micetic-Turk Zrinjka Miak eleftheria roma Raanan Shamir Selma Terzic European Laboratory for Food Induced Diseases Federico Ⅱ University of Naples Hopital des Enfant Ibn Rochd de Casablanca Children's Hospital Gastrointestinal Unit Cairo University University of Malta Medical School Hopital des Enfants de Tunis Department of Gastroenterology and Hepatology University Hospital Center "Mother Teresa" Department of Pediatric Gastroenterology Ankara University Dikimevi/Mamak University Medical Centre Paediatric Department Children's Hospital Zagreb Athens University Aghia Sophia Children's Hospital Schneider Children's Medical Center of Israel Tel-Aviv University University Clinical Center Tuzla Children's Hospital

AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available conf idence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic prof iles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortality: about 600 000 celiac pat

关键词：地中海地区负担腹腔疾病医疗费用世界卫生组织死亡率总人口

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Stressful life events and psychosocial correlates of pediatric inflammatory bowel disease activity

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World Journal of Psychiatry 2016年第3期6卷 322-328页

作者： George Giannakopoulos George Chouliaras Daphne Margoni Sophia Korlou Vassiliki Hantzara Ioanna Panayotou eleftheria roma Magda Liakopoulou Dimitris C Anagnostopoulos Department of Child Psychiatry National and Kapodistrian University of AthensSchool of MedicineAghia Sophia Children’s Hospital 1st Department of Pediatrics National and Kapodistrian University of AthensSchool of MedicineAghia Sophia Children’s Hospital

AIM To investigate the association of psychiatric and psychosocial correlates with inflammatory bowel disease(IBD) activity in children and *** A total of 85 pediatric IBD patients(in remission or active state of the disease) and their parents completed a series of questionnaires and semi-structured interviews measuring life events,depression,anxiety,family dysfunction,and parent mental *** between the remission and the IBD active group and the association of any significant variable with the disease activity state were *** Parents of children being in active state of the disease reported more life events(P = 0.005) and stressful life events(P = 0.048) during the past year and more mental health symptoms(P < 0.001),while the childrenthemselves reported higher levels of anxiety symptoms(P = 0.017) compared to the remission *** the logistic regression multivariate analysis,the only predictor which had a significant positive effect on the probability of the patients being in active state was parent mental health symptoms(OR = 4.8;95%CI:1.2-25.8).CONCLUSION Life events,child anxiety and parent mental health symptoms may be important correlates of pediatric IBD activity and targets of thorough assessment and treatment.

关键词： Inflammatory bowel disease Children and adolescents Stressful events Anxiety Depression

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Nonalcoholic fatty liver disease in lean subjects:Prognosis,outcomes and management

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World Journal of Gastroenterology 2020年第42期26卷 6514-6528页

作者： Lampros Chrysavgis eleftheria Ztriva Adonis Protopapas Konstantinos Tziomalos Evangelos Cholongitas First Department of Internal Medicine Medical SchoolNational and Kapodistrian University of AthensLaiko General HospitalAthens 11527Greece First Propedeutic Department of Internal Medicine Medical SchoolAristotle University of ThessalonikiAHEPA HospitalThessaloniki 54636Greece

Nonalcoholic fatty liver disease(NAFLD)accounts for most cases of chronic liver disease worldwide,with an estimated global prevalence of approximately 25%and ranges from simple steatosis to nonalcoholic steatohepatitis and *** is strongly connected to metabolic syndrome,and for many years,fatty liver was considered to be an exclusive feature of obese ***,recent studies have highlighted the presence of NAFLD in non-obese subjects,with or without increased visceral fat or even in lean subjects without increased waist circumference.“Lean NAFLD”is a relatively new concept and there is significant scientific interest in understanding the differences in pathophysiology,prognosis and management compared with NAFLD in overweight/obese *** the present editorial,we discuss the clinical and metabolic profiles and outcomes of lean NAFLD compared with both obese NAFLD and lean healthy individuals from Asian and Western ***,we shed light to the challenging topic of management of NAFLD in lean subjects since there are no specific guidelines for this ***,we discuss open questions and issues to be addressed in the future in order to categorize NAFLD patients into lean and nonlean cohorts.

关键词： Lean nonalcoholic fatty liver disease Non-obese nonalcoholic fatty liver disease Clinical outcomes Metabolic outcomes Disease management Lifestyle interventions

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Kanban System Design for Hospital Pharmacy - Case study

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Journal of Statistical Science and Application 2017年第1期5卷 30-38页

作者： Mitka eleftheria Kimmeria Campus Xanthi 67100 Greece

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Like Lambs to the Slaughter

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成功营销 2009年第7期 64-65页

作者： eleftheria Parpis

Why‘Whopper Sacrifice’was somurderously successful?One of the biggest award winners in digitalthis year is Crispin Porter+Bogusky's'Whopper Sacrifice'campaign for

关键词：信息产业发展现状经营策略营销策略

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Sprint's Data Control

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成功营销 2009年第6期 64-65页

作者： eleftheria Parpis

It＇s been more than a decade since AI Gore bragged about inventing the ＂information superhighway,＂ and in that time the lanes havegotten crowded. Thanks to the advances in broadband and mobile technology, consumers have almost any fact or figure available at their fingertips--so much so, in fact, that wading through the deluge of data can be daunting.

关键词：信息产业发展现状消费者移动技术

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Quasi-Radial Modes of Pulsating Neutron Stars: Numerical Results for General-Relativistic Rigidly Rotating Polytropic Models

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International Journal of Astronomy and Astrophysics 2014年第3期4卷 453-463页

作者： Vassilis Geroyannis eleftheria Tzelati Department of Physics University of Patras Patras Greece

In this paper we compute general-relativistic polytropic models simulating rigidly rotating, pulsating neutron stars. These relativistic compact objects, with a radius of ~10 km and mass between ~1.4 and 3.2 solar masses, are closely related to pulsars. We emphasize on computing the change in the pulsation eigenfrequencies owing to a rigid rotation, which, in turn, is a decisive issue for studying stability of such objects. In our computations, we keep rotational perturbation terms of up to second order in the angular velocity.

关键词： General-Relativistic Polytropic Models Hartle’s Perturbation Method Neutron Stars Quasi-Radial Pulsation Modes Rigid Rotation

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Water treatment and reclamation by implementing electrochemical systems with constructed wetlands

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Environmental Science and Ecotechnology 2023年第4期16卷 88-105页

作者： Suanny Mosquera-Romero eleftheria Ntagia Diederik P.L.Rousseau Abraham Esteve-Nú~nez Antonin Prevoteau Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 653B-9000GhentBelgium ESPOL Polytechnic University Escuela Superior Politécnica del LitoralESPOLFacultad de Ciencias Naturales y MatemáticasBOX9050Ecuador Department of Green Chemistry and Technology Ghent UniversitySint-Martens-Latemlaan 2BB-8500KortrijkBelgium Centre for Advanced Process Technology for Urban Resource Recovery(CAPTURE) Frieda Saeysstraat 19000GhentBelgium UniversitéParis-Saclay INRAEPROSE92160AntonyFrance Universidad de Alcalá Department of Analytical ChemistryPhysical Chemistry and Chemical EngineeringAlcaláde HenaresSpain

Seasonal or permanent water scarcity in off-grid communities can be alleviated by recycling water in decentralized wastewater treatment ***-based solutions,such as constructed wetlands(CWs),have become popular solutions for sanitation in remote *** typical CWs can efficiently remove solids and organics to meet water reuse standards,polishing remains necessary for other parameters,such as pathogens,nutrients,and recalcitrant *** CW designs and CWs coupled with electrochemical technologies have been proposed to improve treatment *** systems(ECs)have been either implemented within the CW bed(ECin-CW)or as a stage in a sequential treatment(CW+EC).A large body of literature has focused on ECin-CW,and multiple scaled-up systems have recently been successfully implemented,primarily to remove recalcitrant ***,only a few reports have explored the opportunity to polish CW effluents in a downstream electrochemical module for the electro-oxidation of micropollutants or electro-disinfection of pathogens to meet more stringent water reuse *** paper aims to critically review the opportunities,challenges,and future research directions of the different couplings of CW with EC as a decentralized technology for water treatment and recovery.

关键词： Sanitation and reuse Disinfection Advanced oxidation Decentralized systems Electrification

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