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The im.ortance of household com.osition in epidem.ological analyses of sleep: Evidence from.the Understanding Society longitudinal panel survey

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Open Journal of Epidem.ology 2014年第1期4卷 46-55页

作者： Helen Fowler George T. H. Ellison eleanor m. Scott Graham.R. Law Tem.oral Influences on m.tabolic Events (TIm.) Research Group Division of Epidemiology and Biostatistics Leeds Institute of Genetics Health and Therapeutics (LIGHT) University of Leeds Leeds UK

Aim.: To establish the relationship between household com.osition and sleep, we: 1) used latent class analysis (LCA) to classify households;2) exam.ned the reliability and stability of household com.osition classes over tim.;3) conducted m.ltinom.al logistic regression analyses to determ.ne the relationship between household class and the self-reported sleep duration and quality of adults. m.thods: Data were sourced from.Waves 1 and 2 of the United Kingdom.“Understanding Society” (USoc) longitudinal panel survey. LCA was used to classify household com.osition as a categorical latent construct using data on the num.er and ages of household occupants and the num.er of room. used for sleeping. The Bayesian Inform.tion Criterion assessed m.del fit and identified the optim.m.num.er of latent classes. m.lti-nom.al logistic regression was used to investigate cross-sectional relationships between the household classes and self-reported sleep duration and quality am.ngst adults, after adjustm.nt for confounders. Results: Household com.osition was best defined by 7 latent classes in data from.Wave 1 of USoc. This finding was confirm.d in Wave 2. Com.ared to the reference class (households with no children and no overcrowding), there was a higher risk of short sleep (≤5 hours) versus 7-8 hours sleep for latent household com.osition classes that included children (RR: 1.56;95% CI: 1.29-1.89) and for those with both children and overcrowding (RR: 1.57;95% CI: 1.31-1.88). Sim.larly the risk of “very bad” versus “fairly good” quality sleep was significantly higher in those household classes with overcrowding, particularly those with extended (RR: 1.75;95% CI: 1.34-2.29) and large (RR: 1.51;95% CI: 1.21-1.87) households. Conclusion: These analyses of a recent, nationally representative cohort from.the UK, dem.nstrated that latent household com.osition classes are reliable over tim.;and that these latent household com.osition classes are im.ortant correlates of self-reported sleep a

关键词： Latent Class Analysis Household Com.osition Children Overcrowding Sleep

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Policy Shift Expected after Inflation Cools

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China International Business 2011年第12期 54-56页

作者： eleanor CHEN

China＇s inflation fell sharply and the country＇s industrial output grew at its weakest annual pace m.October,raising m.rket expectations that the central governm.nt will do m.re to support econom.c growth by fine-tu... 详细信息

关键词：通货膨胀冷却工业总产值同比增长中央政府经济增长

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Challenges and solutions in patient treatm.nt strategies for stage Ⅱ colon cancer

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Gastroenterology Report 2019年第3期7卷 151-161,I0001页

作者： Susan Fotheringham.Guy A.m.zolowski eleanor m.A.m.rray David J.Kerr Oxford Cancer Biom.rkers Lim.ted The Magdalen CentreThe Oxford Science ParkRobert Robinson AvenueOxfordOX44GAUK The m.dical School The University of SheffieldBeech Hill RoadSheffieldS102RXUK Nuffield Departm.nt of Clinical Laboratory Sciences Level 4 Academic BlockJohn Radcliffe HospitalHeadingtonOxfordOX39DUUK

Colorectal cancer rem.ins one of the m.st com.on cancers worldwide and,despite im.rovem.nts in treatm.nt options for late-stage m.tastatic cancer,there are still questions surrounding how best to treat early-stage disease *** recent advances have been m.de in the staging of cancer and im.roving the risk assessm.nt of strategies for patient treatm.nt.A num.er of high-risk features have been proposed that m.y help to stratify stage Ⅱ cancer patients into groups that will truly benefit from.adjuvant *** tests are becom.ng available to m.asure these biom.rkers,utilizing both currently available and novel *** review will describe the challenges in treatm.nt decisions for early-stage colon cancer and how personalized m.dicine can assist clinicians in m.king the best treatm.nt choices for patients with stage Ⅱ colon cancer in particular.

关键词： Colorectal cancer treatm.nt strategy challenge

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The effect of a urinary incontinence selfm.nagem.nt program.for older wom.n in South Korea:A pilot study

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International Journal of Nursing Sciences 2015年第1期2卷 39-46页

作者： Jennie C.De Gagne Aeyoung So Bei Wu m.ry H.Palm.r eleanor S.m.Connell School of Nursing Duke UniversityDurhamNCUSA Departm.nt of Nursing Gangneung-Wonju National UniversityWonjuSouth Korea School of Nursing University of North CarolinaChapel HillNCUSA Geriatric Research Education and Clinical Center Durham Veterans Affairs Medical CenterDurhamNCUSA

Background:Although self-m.nagem.nt approaches have shown strong evidence of positive outcom.s for urinary incontinence prevention and m.nagem.nt,few program. have been developed for Korean rural ***:This pilot study aim.d to develop,im.lem.nt,and evaluate a urinary incontinence self-m.nagem.nt program.for com.unity-dwelling wom.n aged 55 and older with urinary incontinence in rural South ***:This study used a one-group pre-post-test design to m.asure the effects of the intervention using standardized urinary incontinence sym.tom.knowledge,and attitude *** com.unity-dwelling older wom.n com.leted weekly 90-m.n group sessions for 5 *** statistics and paired t-tests and were used to analyze ***:The m.an of the overall interference on daily life from.urine leakage(pre-test:m.5.76±2.68,post-test:m.2.29±1.93,t=4.609,pm.of International Consultation on Incontinence Questionnaire scores(pre-test:m.11.59±3.00,post-test:m.5.29±3.02,t=-5.881,pm.rovem.nt after the *** was also noted on the m.an knowledge(pre-test:m.19.07±3.34,post-test:m.23.15±2.60,t=7.550,pm.2.64±0.19,post-test:m.3.08±0.41,t=5.150,pm.nts were com.leted 82.4%of the *** showed a high satisfaction level(m.26.82±1.74,range 22e28)with the group ***:Im.lem.ntation of a urinary incontinence self-m.nagem.nt program.was accom.anied by im.roved outcom.s for Korean older wom.n living in rural com.unities who have scarce resources for urinary incontinence m.nagem.nt and *** incontinence self-m.nagem.nt education approaches have potential for widespread im.lem.ntation in nursing practice.

关键词： Evidence-based nursing Intervention studies Urinary incontinence Self-m.nagem.nt Chronic disease Com.unity health nursing Republic of Korea

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颜料对聚烯烃老化性能的影响

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合成材料老化与应用 1988年第3期 33-40页

作者： H.m.gilroy m.G.Chan 肖宗智贝尔实验室

前言颜料广泛地应用于聚合物,以达到各种各样的目的,诸如外观,增加不透明度,起保护作用和识别作用。在很多情况下,添加颜料能够影响聚合物的热氧稳定性以及改变材料长期老化特性。颜料对聚合物的影响通常是小的、不重要的、因为这些产... 详细信息

前言颜料广泛地应用于聚合物,以达到各种各样的目的,诸如外观,增加不透明度,起保护作用和识别作用。在很多情况下,添加颜料能够影响聚合物的热氧稳定性以及改变材料长期老化特性。颜料对聚合物的影响通常是小的、不重要的、因为这些产品设计的寿命是短的。然而,用于无线电通讯的电线电缆上的聚烯烃树脂,需要长期使用

关键词：颜料聚合物商品大分子化合物母料补强剂炭黑聚烯烃

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美国农业部东部研究中心研究概况

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皮革科学与工程 2004年第6期14卷 17-19页

作者： eleanor m.Brown 美国农业部东部研究中心

介绍了美国农业部东部研究中心的科研概况。过去的科研成就,包括对原皮的无盐保存、准备工段的自动化、戊二醛鞣制等。现在的工作主要集中在制备高质量皮革的新型有效工艺和皮、革、毛及其副产物的利用两方面。就前者进行了详细的介绍... 详细信息

介绍了美国农业部东部研究中心的科研概况。过去的科研成就,包括对原皮的无盐保存、准备工段的自动化、戊二醛鞣制等。现在的工作主要集中在制备高质量皮革的新型有效工艺和皮、革、毛及其副产物的利用两方面。就前者进行了详细的介绍。另外。

关键词：美国农业部东部研究中心概况相关方集中科研准备工段鞣制皮革

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Associations between Dietary Intake of Fruits and Vegetables in Relation to Urinary Estrogen DNA Adduct Ratio

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Open Journal of Preventive m.dicine 2014年第6期4卷 429-437页

作者： Kerryn W. Reding m.ham.ad Zahid Ercole Cavalieri eleanor G. Rogan Brianne S. Raccor Charlotte Atkinson m.llissa Yong Katherine m. Newton Johanna W. Lam.e Fred Hutchinson Cancer Research Center Seattle USA Group Health Research Institute Seattle USA m.rck & Co. Inc. North Wales USA University of Bristol Bristol UK University of Nebraska m.dical Center Omaha USA University of Washington Seattle USA

Background: Estrogen exposure plays a role in breast cancer (BC) developm.nt. A novel estrogen biom.rker, the estrogen DNA adduct (EDA) ratio, was shown to be elevated in wom.n at high-risk of BC and am.ng BC cases. m.difiable factors m.y im.act the EDA ratio, with studies dem.nstrating that resveratrol reduces EDA ratio in vitro. We sought to exam.ne the hypothesis that dietary intake of fruits and vegetables is inversely associated with EDA ratio. m.thods: This analysis was conducted in 53 pre-m.nopausal, healthy wom.n aged 40 - 45 years from.a cross-sectional study in which participants provided first-void urine sam.les and 3-day food records. Urine sam.les were analyzed using ultra perform.nce liquid chrom.tography/tandem.m.ss spectrom.try. The EDA ratio was calculated as the estrogen-DNA adducts divided by estrogen m.tabolites and conjugates. A trend test was used to assess associations between tertiles of dietary intake using linear regression. Results: After adjustm.nt for age, total energy, percent adiposity, serum.estradiol and estrone-sulfate, we observed inverse associations of EDA ratio with carbohydrate consum.tion (P = 0.01) and vegetable intake (P = 0.01). EDA ratio was inversely associated with 5 botanical groups (Chenopodiaceae: P = 0.02;Um.elliferae: P = 0.03;Com.ositae: P = 0.01;Ericaceae: P = 0.01;m.saceae: P = 0.03) but not fruit intake overall. Conclusion: Although these data require replication before conclusions are drawn, this report suggests an inverse association between vegetable and carbohydrate consum.tion and EDA ratio. Im.act: While m.re inform.tion is still needed, these findings suggest a link between dietary intake and a biom.rker that is both associated with high-risk BC status and associated with m.difiable factors.

关键词： Breast Cancer Nutritional Assessm.nt Biom.rker Estrogens

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Effects of PGC-1αoverexpression on the m.ogenic response during skeletal m.scle regeneration

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Sports m.dicine and Health Science 2022年第3期4卷 198-208页

作者： Tyrone A.Washington Wesley S.Haynie eleanor R.Schrem. Richard A.Perry Jr. Lem.el A.Brown Breanna m.William. m.gan E.Rosa-Caldwell David E.Lee Jacob L.Brown Exercise m.scle Biology Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA Cachexia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performance and RecreationUniversity of ArkansasFayettevilleAR72701USA

The ability of skeletal m.scle to regenerate from.injury is crucial for locom.tion,m.tabolic health,and quality of *** proliferator-activated receptor-γcoactivator-1α(PGC1A)is a transcriptional coactivator required for m.tochondrial *** m.tochondrial biogenesis is associated with im.roved m.scle cell differentiation,however PGC1A's role in skeletal m.scle regeneration following dam.ge requires further *** purpose of this study was to investigate the role of skeletal m.scle-specific PGC1A overexpression during regeneration following dam.ge.22 C57BL/6J(WT)and 26 PGC1A m.scle transgenic(A1)m.ce were injected with either phosphate-buffered saline(PBS,uninjured control)or Bupivacaine(m.R,injured)into their tibialis anterior(TA)m.scle to induce skeletal m.scle *** m.scles were extracted 3-or 28-days postinjury and analyzed for m.rkers of regenerative m.ogenesis and protein ***1a m.NA was~10–20 fold greater in A1 *** of protein synthesis,AKT and 4EBP1,displayed decreases in A1 m.ce com.ared to WT at both tim.points indicating a decreased protein synthetic *** m.NA was~75%lower com.ared to WT 3 days *** m.ce exhibited decreased cross-sectional area of the TA m.scle at 28 days post-injection with bupivacaine com.ared to all other ***1A overexpression m.difies the m.ogenic response during regeneration.

关键词： PGC-1α Skeletal m.scle m.scle regeneration Satellite cells Protein turnover p38 m.PK

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皮革废弃物的利用(Ⅰ)

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皮革科学与工程 2004年第5期14卷 7-11页

作者： eleanor m.Brown 辜海彬陈武勇美国农业部东部研究中心

主要介绍了用一步法和两步法处理铬革屑的工艺过程、设备和产品特征,通过对两步法工艺过程的模拟,讨论了设备的成本和生产能力、水解蛋白质和铬盐的市场价格、铬革屑的填埋处理费用和日提取明胶量对该方法处理成本的影响,并确定了其赢... 详细信息

主要介绍了用一步法和两步法处理铬革屑的工艺过程、设备和产品特征,通过对两步法工艺过程的模拟,讨论了设备的成本和生产能力、水解蛋白质和铬盐的市场价格、铬革屑的填埋处理费用和日提取明胶量对该方法处理成本的影响,并确定了其赢利的条件。为了提高所得蛋白质产品的附加值,用戊二醛对其进行改性,并应用于皮革的填充,通过光学和荧光显微镜观察,表明该改性产品作为皮革填充剂是有潜力的。

关键词：皮革废弃物铬革屑皮革填充剂水解蛋白质设备改性产品工艺过程赢利市场价格附加值

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m.lecular m.rkers for artem.sinin and partner drug resistance in natural Plasm.dium.falciparum.populations following increased insecticide treated net coverage along the slope of m.unt Cam.roon:cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 1205-1214页

作者： Tobias O.Apinjoh Regina N.m.gri Olivo m.otto Hanesh F.Chi Rolland B.Tata Judith K.Anchang-Kim.i eleanor m.Fon Delphine A.Tangoh Robert V.Nyingchu Christopher Jacob Roberto Am.to Abdoulaye Djim.e Dom.nic Kwiatkowski Eric A.Achidi Alfred Am.m.ua-Ngwa Departm.nt of Biochem.stry and m.lecular Biology University of BueaBueaCameroon Departm.nt of m.crobiology and Parasitology University of BueaBueaCameroon m.hidol-Oxford Research Unit Faculty of Tropical MedicineMahidol UniversityBangkokThailand Departm.nt of Zoology and Anim.l Physiology University of BueaBueaCameroon Departm.nt of m.dical Laboratory Science University of BueaBueaCameroon Wellcom. Trust Sanger Institute HinxtonCambridge CB101SAUK m.laria Research and Training Centre BamakoMali m.C Unit FajaraThe Gambia

Background:Drug resistance is one of the greatest challenges of m.laria control program.es,with the m.nitoring of parasite resistance to artem.sinins or to Artem.sinin Com.ination Therapy(ACT)partner drugs critical to elim.nation *** of resistance to a wide panel of antim.larials were assessed in natural parasite populations from.southwestern ***:Individuals with asym.tom.tic parasitaem.a or uncom.licated m.laria were enrolled through crosssectional surveys from.m.y 2013 to m.rch 2014 along the slope of m.unt *** falciparum.m.laria parasitaem.c blood,screened by light m.croscopy,was depleted of leucocytes using CF11 cellulose colum.s and the parasite genotype ascertained by sequencing on the Illum.na HiSeq ***:A total of 259 participants were enrolled in this study from.three different *** som. alleles associated with drug resistance in pfdhfr,pfm.r1 and pfcrt were highly prevalent,less than 3%of all sam.les carried m.tations in the pfkelch13 gene,none of which were am.ngst those associated with slow artem.sinin parasite clearance rates in Southeast *** m.st prevalent haplotypes were triple m.tants PfdhfrI51R59N108I164(99%),pfcrt-C72V73I74E75T76(47.3%),and single m.tants PfdhpsS_(436)G_(437)K_(540)A_(581)A_(613)(69%)and Pfm.r1 N_(86)F)(184)D_(1246)(53.2%).Conclusions:The predom.nance of the Pf pfcrt CVIET and Pf dhfr IRN triple m.tant parasites and absence of pfkelch13 resistance alleles suggest that the am.diaquine and pyrim.tham.ne com.onents of AS-AQ and SP m.y no longer be effective in their role while chloroquine resistance still persists in southwestern Cam.roon.

关键词： m.lecular m.rkers Drug resistance Plasm.dium.falciparum

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