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α-synuclein基因启动子变异性和帕金森病的协同分析

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世界核心医学期刊文摘（神经病学分册） 2006年第12期2卷 1-2页

作者： Marag.nore D. M. De Andrade M. elbaz A. 郭俊(译) Department of Neurolog. Mayo Clinic College of Medicine 200 First St SW Rochester MN 55905 United States 不详

Context:Identification and replication of susceptibility g.nes for Parkinson disease at the population level have been hampered by small studies with potential biases.α-Synuclein(SNCA)has been one of the most promising.susceptibility g.nes,but larg.-scale studies have been ***:To determine whether allele-leng.h variability in the dinucleotide repeat sequence(REP1)of the SNCA g.ne promoter is associated with Parkinson disease susceptibility,whether SNCA promoter haplotypes areassociated with Parkinson disease,and whether REP1 variability modifies ag. at ***,Setting.and Participants:We performed a collaborative analysis of individual-level data on SNCA REP1 and flanking.markers in patients with Parkinson disease and *** site recruitment,data collection,and analyses were performed between April 5,2004,and December 31,*** participating.sites of a g.obal g.netics consortium provided clinical *** was performed for SNCA REP1,-770,and-116 markers at individual sites;however,each site also provided 20 DNA samples for reg.notyping.*** Outcome Measures:Measures included estimations of Hardy-Weinberg.equilibrium in controls;a test of heterog.neity;analyses for association of sing.e variants or haplotypes;and survival analyses for ag. at ***:Of the 18 sites,11 met string.nt criteria for concordance with Hardy-Weinberg.equilibrium and low g.notyping.error *** 11 sites provided complete data for 2692 cases and 2652 *** was no heterog.neity across studies(P >.60).The SNCA REP1 alleles differed in frequency for cases and controls(P >.001).g.notypes defined by the 263 base-pair allele were associated with Parkinson disease(odds ratio,1.43;95%confidence interval,1.22-1.69;P g.obal score statistic,P <.001).Two-loci haplotypes were associated with Parkinson disease only when they included REP1 as one of the loc

关键词：基因启动子区 α-synuclein 帕金森病变异性协同基因型分析单体型频率等位基因频率

帕金森病之前的受教育水平和职业:一项人群病例对照研究

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世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 36-37页

作者： Frig.rio R. elbaz A. Sanft K.R. W.A. Rocca 张殿增 Department of Health Sciences Research Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 United States

Objective: To investig.te the association of Parkinson disease (PD) with education and occupations using.a case-control study desig.. Methods: The authors used the medical records-linkag. system of the Rochester Epidemiolog. Project to identify all subjects who developed PD in Olmsted County, MN, from 1976 throug. 1995. Each incident case was matched by ag. (±1 year) and sex to a g.neral population control. The authors collected information about education and occupations using.two independent sources of data: a review of the complete medical records in the system and a telephone interview. Occupations were coded using.the 1980 Standard Occupational Classification. Results: Subjects with 9 or more years of education were at increased risk of PD (OR = 2.0; 95%CI = 1.1 to 3.6; p = 0.02), and there was a trend of increasing.risk with increasin g.education (test for linear trend, p = 0.02; medical records data). Physicians were at sig.ificantly increased risk of PD using.both sources of occupational data. By contrast, four occupational g.oups showed a sig.ificantly decreased risk of PD using.one source of data: construction and extractive workers (e.g., miner s, oil well drillers), production workers (e.g., machine operators, fabricators), metal workers, and eng.neers. These associations with increased or decreased risk did not chang. noticeably after adjustment for education. Conclusion: Subjects with hig.er education and physicians have an increased risk of Parkinson disease (PD), while subjects with some occupations presumed to involve hig. physical activity have a decreased risk of PD.

关键词：帕金森病病例对照研究奥姆斯特德电话访谈病历回顾受教育时间罗切斯特线性趋势重体力劳动

绝经后激素治疗和脑卒中的风险:雌激素给药途径及孕激素类型的影响

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中华高血压杂志 2016年第7期24卷 684-684页

作者：刘莉叶鹏 Canonico M Carcaillon L Plu-Bureau g.Og.r E Sing.-Manoux A Tubert-Bitter P elbaz A Scarabin PY

绝经后妇女激素治疗的益处/风险并不清楚,取决于其治疗后可能发生的心血管病。有证据支持血栓风险中经皮雌激素治疗的安全性及孕激素的重要性。然而,口服和经皮雌激素治疗与脑卒中的相关性是否存在差异仍未确定。

关键词：雌激素治疗心血管病给药途径处方药品国家医疗保险去甲睾酮孕烷禁忌证信息获取条件性

Structural Role of CeO2 in the Modified Borate g.ass-Ceramics

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书写线条,绘画线条:刘海粟作品中的共鸣与协调

New Journal of g.ass and Ceramics（玻璃与陶瓷期刊） 2021年第1期

作者： Nada elbaz g.maa El-Damrawi Amr M. Abdelg.any

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亚太艺术 2017年第1期 112-118页

作者： [法]帕斯卡莱·沙扎莉-艾尔巴茨不详

对于19世纪末20世纪初的中国画家而言,艺术都带有政治色彩,它关乎如何建设一个新的中国,一个有远见的强大的中国。由此中国传统绘画(它从宋代到清代都是一门高尚的艺术,被视作文人雅士的标志、艺术中的精品,但也是出于这一原因,它成为... 详细信息

对于19世纪末20世纪初的中国画家而言,艺术都带有政治色彩,它关乎如何建设一个新的中国,一个有远见的强大的中国。由此中国传统绘画(它从宋代到清代都是一门高尚的艺术,被视作文人雅士的标志、艺术中的精品,但也是出于这一原因,它成为传统价值的承载者,让人想要消除这些价值,或者至少进行一些革新)该做些什么?

关键词：刘海粟中国传统绘画文人雅士 19世纪末20世纪初承载者共鸣线条

四维虚拟导管：二叶主动脉瓣病人主动脉内血流动力学的无创评估

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国际医学放射学杂志 2020年第1期 111-111页

作者： M.S.M. elbaz M.B. Scott A.J. Barker P. Mc Carthy C. Malaisrie J.D.Collins 崔亚东 Department of Radiolog. Northwestern University Feinberg School of Medicine

四维(4D)血流MRI能够评估先天性二叶主动脉瓣(BAV)病人的血流变化。然而,目前的分析方法很繁琐,并且未使用4D MRI的容积数据。目的探讨使用类导管数学模

关键词：流动力学 MRI 主动脉无创评估二叶主动脉瓣

Role of endoscopic ultrasound and cyst fluid tumor markers in diag.osis of pancreatic cystic lesions

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World Journal of g.strointestinal Endoscopy 2022年第6期14卷 402-415页

作者： Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mog.wer Ayman Yosry Mag.y Elserafy Eman Medhat Hanaa Khalaf Mag.y Fouad Tamer elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y William g.ada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmag. Ahmed g.lal Wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Hag.ag.Tarek Ali Abdellah Mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir Mohamed El-Nady Department of Internal Medicine and Hepatog.stroenterolog. Kasr Al-Aini HospitalsCairo UniversityKasr Al-Aini HospitalsCairo UniversityCairo 11451Egypt Department of Endemic Diseases Cairo UniversityCairo 11451Egypt Department of Tropical Medicine and g.stroenterolog. Minia UniversityMinia 61511Egypt Department of Internal Medicine Kasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of g.stroenterolog. Armed forces College of MedicineCairo 11451Egypt Endoscopy and Internal Medicine Consultant at Dr/Ahmed g.lal Endoscopy Center Alexandria 35516Egypt Department of Internal Medicine Faculty of MedicineAssuit UniversityAssuit 71111Egypt Department of g.stroenterolog. and Hepatolog. Mansoura UniversityMansoura 35511Egypt Department of g.stroenterolog. and Hepatolog. Theodor Bilharz Research InstituteCairo 11451Egypt Department of Microbiolog. and Immunolog. Faculty of Medicine for girls Al-Azhar UniversityCairo 11451Egypt Department of Internal Medicine Faculty of MedicineAin shams UniversityCairo 11451Egypt Department of Internal Medicine Bani-suef UniversityBani-suefBani-suef 62511Egypt Department of Patholog. Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Clinical Patholog. Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Environmental Medicine&Clinical Patholog. National Research CentreCairo 11451Egypt

BACKg.OUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diag.osis of these lesions are crucial to avoid unnecessary treatment of benig. lesions and missed opportunities for early treatment of potentially malig.ant *** To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antig.ns [e.g., cancer antig.n(CA)19-9, CA72-4], carcinoembryonic antig.n(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial g.owth factor A(VEg.-A), and prostag.andin E2(Pg.2)], amylase, and mucin stain in diag.osing.pancreatic cysts and differentiating.malig.ant from benig. *** This study included 76 patients diag.osed with PCLs using.different imag.ng.modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling.of different *** The mean ag. of studied patients was 47.4 ± 11.4 years, with a slig.t female predominance(59.2%). Mucin stain showed hig. statistical sig.ificance in predicting.malig.ancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and neg.tive predictive value of 93.1% and 91.49%, respectively(P g.ucose, SPINK1, amylase, and CEA levels had hig. statistical sig.ificance(P g.-A, VEg.R2, and Pg.2 did not show any statistical sig.ificance. Univariate reg.ession analysis for prediction of malig.ancy in PCLs showed a statistically sig.ificant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. Meanwhile, log.stic multivariable reg.ession analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malig.ancy in cystic pancreatic *** EUS examination of cyst morpholog. with cytopatholog.cal analysis and cyst fluid ana

关键词： Pancreatic cystic neoplasm Mucinous cystic neoplasm Intraductal papillary mucinous neoplasm Mucin stain Amylase