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Diagnostic Rigid Urethrocystoscopy: Indications, Results and Pain Assessment

Open Journal of Urology 2020年第8期10卷 239-244页

作者： Ousmane Sow Abdoulaye Ndiath Aboubacar Traore Alioune Sarr Babacar Sine Modou Ndiaye Yassin Sayerh Cyrille Ze Ondo Amath Thiam Ndiaga Seck Ndour el hadj malick daw Ndeye Aissatou Bagayogo Yaya Sow Boubacar Fall Babacar Diao Papa Ahmed Fall Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal Urology-Andrology Department Dalal Jamm Hospital Dakar Senegal

Background: Over the last 50 years, endourology has revolutionized urological practices worldwide. This is not so in many urological centers in West Africa. Although, some centers have made progress in the level of urological services that they offer;many of such centers provide rigid urethrocystoscopy services. Rigid urethrocystoscopy is an endoscopic examination that explores the urethra, bladder and prostate in men. Aims: We report the indications, results and pain assessment of rigid urethrocystoscopy in our center. Patients and Methods: We carried out a retrospective, descriptive, monocentric study in our center between January 2016 and June 2018. The study included all patients who had a rigid urethrocystoscopy under local anaesthesia. We studied the following parameters: sex, age, indications for the examination, outcomes and the pain assessment. Results: Five hundred and forty-one patients were included. The sex-ratio was 1.49. The mean age was 49.47 ± 18.48 years (12 years and 91 years). Lower urinary tract symptoms (29%) and hematuria (28%) were the most common indications. The rigid urethrocystoscopy was normal in 26.8% of patients. Bladder tumors (21.2%) were the most frequent lesions. In men, prostate tumors were more common (21%) followed by bladder tumors (17.9%), while in women, bladder tumors (26.3%) were predominant followed by cystopathy lesions (12.4%).The mean Simple Verbal Scale (SVS) score was 1.25 in women and 2.1 in men. Conclusion: Rigid urethrocystoscopy was relatively well tolerated by our patients. Hematuria was the primary indication and the main etiologies were bladder and prostate tumors.

关键词： Rigid Urethrocystoscopy Bladder Tumors Hematuria

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Disparities in Dental Caries among Students in Senegalese Koranic School: Epidemiological Study in Daara of Koki

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Open Journal of Epidemiology 2022年第2期12卷 125-133页

作者： Serigne Ndame Dieng Amadou Dieng Mbathio Diop el hadj malick Diouf Aida Kanouté Massamba Diouf Cheikh Mbaké Lô Daouda Faye Public Health Service Institute of Dentistry and Stomatology Faculty of Medicine Pharmacy and Odonto-Stomatology Cheikh Anta Diop University Dakar Senegal Sangalkam Health District Dakar Medical Region Ministry of Health and Social Action Dakar Senegal

Background: School is a space where children are exposed to the social and psychosocial environment that can affect their health. In Senegal, the prevalence of dental caries is high in classic schools according to fragmented data, and unknown in the koranic school (Daaras). Objective: The objective is to describe the disparity of dental caries in the schoolchildren (talibes) of Daara of Koki. Method: A cross-sectional study was carried out on 400 talibes aged 7 to 12 years. Dental caries and socio-demographic data were, respectively, collected by clinical examination and questionnaire. Results: The sex ratio was 9, the mean age of 9.9 ± 1.5 years and the mean length of stay in the Daara was 2.3 ± 1.1 years. The prevalence of dental caries was 47.4%. The average mixed DFMT index was 1.1 ± 1.5. The prevalence was 51.2% among boys, 60% among eight-year-old children and 37.4% among twelve-year-old children. By length of stay, the prevalence was 52.9% at the start and 22.2% at the end with a significant downward trend (p Conclusion: The study showed an unequally distributed of caries among talibes of Koki’s Daara. She suggests that oral health promotion policies are needed in Koranic schools and must rely on koranic teachers.

关键词： Dental Caries Students Koranic School

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Association between Hyperhomocysteinemia and Microangiopathic Complications (Neuropathy and Nephropathy) in Subjects with Type 1 and Type 2 Diabetes

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Journal of Diabetes Mellitus 2023年第4期13卷 325-339页

作者： Nene Oumou Kesso Barry Soukeyna Gueye Moustapha Djité Pape Matar Kandji Michel Assane Ndour el hadj malick Ndour Demba Diedhiou Fatou Gueye-Tall Ndeye Mareme Thioune Najah Fatou Coly Dominique Doupa Maïmouna Ndour Mbaye Philomène Lopez Sall Papa Madieye Gueye Laboratory of Pharmaceutical Biochemistry University Cheikh Anta DIOP Dakar Senegal Laboratory of Biochemistry University Hospital Fann Dakar Senegal Department of Internal Medicine Abass Ndao Hospital Center Dakar Senegal Medical Biology Laboratory Diamniadio Children Hospital Dakar Senegal Department of Medical Biochemistry Saint-Louis University Saint-Louis Senegal

This prospective case-control study aimed to assess the prevalence of hyperhomocysteinemia and explore its potential correlation with microangiopathic complications, specifically nephropathy and neuropathy, in a cohort of both type 1 and type 2 diabetic patients. Conducted at the Marc Sankalé Center of Abass Ndao Hospital in Dakar from June to September 2018, the study enrolled a total of 106 diabetic patients, comprising 93 type 2 diabetics and 13 type 1 diabetics, who were matched with control subjects free from clinically detectable pathologies, based on sex and age ± 2 years. The mean age of type 1 and type 2 diabetic patients was 24.46 ± 8.41 years and 57.28 ± 11.28 years, respectively. Our findings revealed a statistically significant elevation in mean homocysteine levels among patients when compared to controls (12.63 vs. 9.88;p ely among those with type 2 diabetes. Within the hyperhomocysteinemia subgroup, 58% were male, and 42% were female. The analysis of neuropathy and nephropathy frequencies among type 2 diabetic patients, stratified by homocysteine concentrations, demonstrated a notably higher prevalence of diabetic nephropathy in patients with hyperhomocysteinemia compared to those with normohomocysteinemia (23.07% vs. 8.75%;p = 0.052). Similarly, diabetic neuropathy exhibited a significantly greater frequency in patients with hyperhomocysteinemia as opposed to normohomocysteinemia (80.76% vs. 50%;p = 0.005). Furthermore, our results established a significant positive correlation between homocysteine concentrations and both age (r = 0.402;p els (r = 0.461;p eloping neuropathy (OR = 3.5;p = 0.061) and diabetic nephropathy (OR = 6.092;p = 0.014), respectively.

关键词： Homocysteine Hyperhomocysteinemia Diabetes Mellitus Type 1 Diabetes Type 2 Diabetes Nephropathy Neuropathy

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Thermoresistant, Ethanol-Resistant and Acid-Resistant Properties of Acetic Acid Bacteria Isolated from Fermented Mango Alcohol

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Advances in Microbiology 2022年第4期12卷 177-191页

作者： Mariama Ciré Kourouma malick Mbengue Ndèye Coumba Daga Sarr Khady Sarr Coumba Touré Kane Laboratory of Applied Microbiology and Industrial Engineering (MAGI) Ecole Supérieure Polytechnique (ESP) Université Cheikh Anta Diop Dakar-Fann Senegal Université Sine Saloum el hadj Ibrahima Niass (USSEIN) Kaolack Senegal

Vinegar production is seriously affected by the sensitivity of acetic acid bacteria (AAB) to high temperature, high ethanol concentrations, and high acetic acid concentrations. The aim of this study was to investigate the thermo-ethanol-acid tolerance characters of five AAB strains (VMA1, VMA5, VMA7, VMAM, VMAO) previously isolated from fermented mango alcohol and belonging to Gluconoacetobacter genera. As result, the five AAB strains exhibited good growth and acid production at temperatures up to 45°C;they could tolerate and produce acetic acid at ethanol concentrations up to 20% (v/v). In addition, the studied strains showed growth at acetic acid concentrations up to 4.5% (w/v). Strains VMA7 and VMAO showed the highest resistance properties: they demonstrated acid production at 50°C and VMAO could even grow at 60°C;they tolerated and produced acetic acid at 25% (v/v) ethanol concentration;they showed resistance to acetic acid concentrations up to 6% (w/v). Considering all these properties, the use of these strains would seriously contribute to improving the quality of the vinegar produced and help to reduce the cooling water feeds in vinegar production especially in hot countries in the context of global warming.

关键词： Vinegar Acetic Acid Bacteria Thermotolerant Ethanol-Tolerant Acid-Tolerant

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Metastatic Prostate Cancer under Androgen Deprivation Therapy: Factors Influencing Castration Resistance

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Open Journal of Urology 2020年第7期10卷 225-232页

作者： Modou Ndiaye Ousmane Sow Babacar Sine Omar Gaye Alioune Sarr Abdoulaye Ndiath Cyrille Ze Ondo Amath Thiam Ndeye Aissatou Bagayogo Samba Thiapato Faye Ndiaga Seck Ndour Aboubacar Traore Ngor Mack Thiam el hadj malick Diaw Yaya Sow Boubacar Fall Babacar Diao Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal

Objective: To evaluate the factors predicting the time to progression to castration-resistant in metastatic prostate cancer under Androgen Deprivation Therapy (ADT) in our center. Patients and Methods: This is a retrospective, descriptive, analytical study in a single center over a period of 2 years. It has interest patients followed for metastasized prostate cancer under ADT. The parameters studied were: epidemiological, clinical, paraclinical, prostate specific antigen (PSA) nadir, time to nadir (TTN) and their link with the castration resistance. Results: The frequency of castration resistant prostate cancer was 28 patients per year. The mean age was 70.4 ± 7.9 years. An ECOG score ≥ 3 was more common as was the cT2c stage. The median of the initial total PSA was 489.6 ng/ml (203.3;1653.2). All patients had adenocarcinoma. The International Society of Urological Pathology (ISUP) 1 was more frequent. Bone metastases were more frequent. The medians of nadir, TTN and the castration resistance were 19.3 ng/ml (3.7;102.1), 5.5 months (3;9) and 11 months (6;15.3), respectively. The Eastern Cooperative Oncology Group (ECOG) score, clinical stage, metastatic site, the nadir and its TTN influenced the DSR. Age, lymph node involvement, initial total PSA and Gleason score did not influence the castration resistance. Conclusion: ADT should be initiated as soon as possible before an attack of general and/or clinical stage advanced to delay resistance. A drilling should be associated with this hormone therapy as much as possible because of its gain on resistance.

关键词： Cancer Prostate Androgen Deprivation Therapy Resistance Prognoses

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CT Scans and Delays in Diagnosis of Stroke in Senegal’s Regional Hospitals: A Multicenter Study of 655 Cases

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Open Journal of Medical Imaging 2020年第2期10卷 96-104页

作者： Hamidou Deme Nfally Badji Léra Géraud Akpo Oumou Dieng Abdoulaye Dione Diop Fallou Galass Niang Mouhamadou Hamine Toure Ibrahima Faye malick Diouf Aicha Ndichout Marie Mbengue Cherif Mohamadou Aidara Mamadou Ly Ousmane Sano Ndiaga Matar Gaye Ousmane Cissé Abdoulaye Ndoye Diop Aissata Ly Ba Sokhna Ba Diop el hadj Niang Radiology Department of the Aristide Le Dantec Hospital in Dakar Dakar Senegal Radiology Department of the CHNU de Fann in Dakar Dakar Senegal Neurology Department of the Fann University Hospital in Dakar Dakar Senegal Radiology Department of the Albert Royer Children’s Hospital of Fann in Dakar Dakar Senegal

Stroke represents the 2nd cause of mortality and 1st cause of physical disability in the adult population. In Senegal, it represents 30% of hospitalization and 2/3 of the mortality in the department of neurology in the capital city, Dakar. Objective: To specify the types of stroke and to evaluate diagnostic delays in Senegal’s regional hospitals. Materials and Methods: This was a retrospective, cross-sectional, descriptive, multicentric study for 4 years (from 2014 to 2017) including any patient presenting a clinical suspicion with a CT scan confirmation of stroke in one of the 9 regional hospitals in Senegal with a recruitment period of 6 months per hospital. CT scans were performed with a 16 slices machine in 6 hospitals, 4 slices in 2 hospitals and 2 slices in 1 hospital. We studied the types and location of strokes, the associated signs and the time from stroke onset to admission and the time from admission to CT scan. Results: 655 patients were retained including 322 men and 333 women for an M/F ratio of 0.96. The average age was 63 years (range: 7 years, 112 years). High blood pressure was noted in 59.2% of patients and diabetes in 10.7% of patients. Strokes were ischemic in 76% of cases involving the middle cerebral artery in 73% of cases and hemorrhagic in 24%, of which 80.7% were deep localized. A mass effect was noted in 7.5% of cases, an engagement in 6.9% of cases and ventricular hemorrhage in 2.7% of cases. The delay between the onset of the deficit and admission was less than 6 hours in 10.6% of patients. The time between the onset of stroke and admission to hospital was specified in 416 patients (63.5%) of the study population, it was less than 6 hours in 10.6% of patients, between 6 hours and 24 hours for 29.3% and more than 24 hours for 60.1%. Between admission and the CT scan, the time was precise in 459 patients (70%), it was less than 6 hours in 37.9%, between 6 hours and 24 hours in 43.6 % and more than

关键词： Stroke CT Scans Diagnostic Delays

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