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Pinealectomy and Exogenous Melatonin Regulate Anxiety-Like and Depressive-Like Behaviors in Male and Female Wistar Rats

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Neuroscience & Medicine 2012年第4期3卷 394-403页

作者： el Mrabet Fatima Zahra Ouaaki Siham Mesfioui Abdelhalim el hessni aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this work was to 1) study the influence of endogenous melatonin (Mel) abolishment via pinealectomy and 2) explore exogenous Mel effect on anxiety-like and depressive-like behavior in male and female rats. Rats were shamoperated (Sh) or pinealectomized (Px) and following subgroups were selected 1) Px/NaCl (0.9%) and Sh/NaCl (0.9%) : rats injected subcutaneously, once daily for 8 weeks, with saline solution NaCl (0.9%) as vehicle;2) Px/Mel (4 mg/Kg) and Sh/Mel (4 mg/Kg): Rats similarly injected with 4 mg/Kg of Mel. All animals were housed under a photoperiod of (LD:16/8). After different treatments animals were tested in the open-field test (OFT), elevated plus maze test (EPM) to determine anxiety-like behavior, and forced swimming test (FST) to evaluate depressive-like level. Our results revealed that level of anxiety-like and depressive-like behavior are significantly higher in Px/NaCl (0.9%) when compared to Sh/NaCl (0.9%) group, suggesting that pinelectomy induced an anxiogenic and depressant effects. The Px effects would be due to the absence of endogenous Mel synthesis and release. Additionally, we clearly demonstrated that the level of anxiety-like and depressive-like behavior are higher in Px/Mel (4 mg/Kg) and Sh/Mel when compared respectively to Px/NaCl (4 mg/Kg) and Sh/NaCl groups suggesting an anxiolytic and antidepressant effects of exogenous Mel. Behavioral responses were sex dependent since the difference between females and males, especially, after melatonin administration, were statistically significant. These experiments provide evidence that pinealectomy and Mel regulated emotionally behavior in male and female rats.

关键词： Pinealectomy Melatonin Sex Dependent Anxiety Depression Behavioral Tests

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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

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Neuroscience & Medicine 2012年第2期3卷 162-173页

作者： el Mrabet Fatima Zahra Lagbouri Ibtissam Mesfioui Abdelhalim el hessni aboubakr Ouichou Ali Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Department of Biology Faculty of Sciences University Ibn Tofail Kenitra Morocco

The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.

关键词： Melatonin Sex Dependent Anxiety Depression Behavior Tests Ovariectomy Orchidectomy Sex Hormones

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Cystic pancreatic lesions,the endless dilemma

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World Journal of Gastroenterology 2021年第21期27卷 2664-2680页

作者： Hussein Hassan Okasha Abeer Awad Ahmed el-meligui Reem Ezzat Ashraf aboubakr Sameh Abouelenin Ramy el-Husseiny Ahmed Alzamzamy Department of Internal Medicine and Gastroenterology Hepatology UnitKasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of Internal Medicine and Gastroenterology Hepatology UnitAssuit UniversityAssuit 71515Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11441Egypt Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11441Egypt Department of Hepatology and Tropical Medicine National Hepatology and Tropical Medicine Research Institute(NHTMRI)Cairo 11441Egypt

Cystic pancreatic lesions involve a wide variety of pathological entities that include neoplastic and non-neoplastic *** proper diagnosis,differentiation,and staging of these cystic lesions are considered a crucial issue in planning further *** are great challenges for their diagnostic *** our time,new emerging methods for this diagnosis have been *** ultrasonography-guided fine-needle aspiration cytology with chemical and molecular analysis of cyst fluid and EUS-guided fine needlebased confocal laser endomicroscopy,through the needle microforceps biopsy,and single-operator cho-langioscopy/pancreatoscopy are promising methods that have been used in the diagnosis of cystic pancreatic *** we discuss the diagnosis of cystic pancreatic lesions and the benefits of various diagnostic models.

关键词： Pancreatic cystic lesion Endoscopic diagnosis Endoscopic ultrasonography Cyst fluid markers Endoscopic ultrasonography-guided fine needle-based confocal laser endomicroscopy Through the needle microforceps biopsy Single operator cholangioscopy/pancreatoscopy

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Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

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Pharmacology & Pharmacy 2016年第4期7卷 147-152页

作者： Seham Abo-Kora Amany el-Meleh Mohamd aboubakr Department of Pharmacology Faculty of Veterinary Medicine Benha University Toukh Egypt

The effect of tilmicosin on fetal development in pregnant female rats was investigated in this study. Forty pregnant female rats were divided into four groups (each of 10 female rats). Rats in the 1st, 2nd and 3rd groups were received tilmicosin at a dose of 20, 100, 200 mg/kg·b·wt/day orally from the 6th to 15th day of gestation respectively, while the 4th group received 0.5 ml distilled water orally for the same period of gestation and was used as control group. All the pregnant female rats were sacrificed on the 20th day of gestation and their fetuses were subjected to morphological, visceral and skeletal examinations. Tilmicosin at a dose 100, 200 mg/kg·b·wt significantly decreased the number of viable fetuses;the number of resorbed fetuses was increased, and induced retardation in growth of viable fetuses;some skeletal and visceral defects in these fetuses were observed and these effects were dose dependant. It could be concluded that tilmicosin caused some abnormalities and fetal defects, so it is recommended to avoid using pregnancy.

关键词： Tilmicosin Pregnancy Anomalies Fetus

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Modulation of Anxiolytic-Like and Antidepressant-Like Effects of Melatonin by Imipramine in Wistar Rats: Possible Interaction with Central Monoaminergic Systems

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Neuroscience & Medicine 2019年第2期10卷 118-133页

作者： Sihame Ouakki Oussama Zghari Aboubaker el hessni Abdelhalem Mesfioui Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology University Ibn Tofail Kenitra Morocco

Our current study aims to explore the interaction of melatonin (Mel) with the monoaminergic system on the pathophysiology of affective disorders in Wistar rats. We mention here that, the role of monoaminergic transmission in the pathophysiology of affective disorders in humans is demonstrated in most recent reports. In this sense, our current work aims to explore the effect of melatonin (Mel) with or without imipramine (IMP) on levels of depression and anxiety in Wistar rats and would determine the role of Mel in modulating serotonin, noradrenaline and dopamine neurotransmission. From this point, twenty-four female Wister rats were divided into 4 groups of 6 animals and received subcutaneously during 4 weeks different doses of Mel (4 mg/kg), IMP (2 mg/kg) or Mel (4 mg/kg) + IMP (2 mg/kg). Behavioral performance especially anxiety and depression is measured in the open field (OFT), elevated plus maze (EPM) and forced swim test (FST). The anxiety-like and antidepressant-like effects were observed with Mel at 4 mg/Kg and IMP at 2 mg/Kg but the potentiating effect was more observed with the two combined molecules (Mel and IMP), since locomotors activity assessed by the OFT and EPM was not affected. These effects suggest that psychopharmacological actions of Mel are due, at least in part, to its ability to potentiate the central monoaminergic transmitter effects.

关键词： Melatonin Imipramine Depression Anxiety Open Field Test elevated Plus Maze Forced Swimming Test

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Bioequivalence Study of Two Oral Doxycycline Formulations (Doxysol®and Doxymed®) in Healthy Broiler Chickens

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Pharmacology & Pharmacy 2015年第1期6卷 1-8页

作者： Ahmed M. Soliman Mohamed aboubakr Mohamed el-Hewaity Department of Pharmacology Faculty of Veterinary Medicine Cairo University Giza Egypt Department of Pharmacology Faculty of Veterinary Medicine Benha University Qaliobiya Egypt Department of Pharmacology Faculty of Veterinary Medicine University of Sadat City Minoufiya Egypt

Aims: The present study was designed to assess the comparative bio-equivalence of Doxysol® and Doxymed® in healthy broiler chickens after oral administration of both products in a dose of 20 mg doxycycline/***. Materials and Methods: Twenty broiler chickens were divided into two groups. The first group was designed to study the pharmacokinetics of Doxysol, while the 2nd group was designed to study the pharmacokinetics of Doxymed. Each broiler chickens in both groups were injected intravenously with 20 mg doxycycline/***. Blood samples were obtained from the wing vein and collected immediately before and at 5, 15, 30 minute, 1, 2, 4, 6, 8, 12 and 24 hours after a single intravenous or oral administration. Results: Doxycycline in both products obeyed a two compartments open model following I.V. injection in a dose of 20 mg/***. The disposition kinetics of Doxysol® and Doxymed® following oral administration of 20 mg doxycycline base/***. revealed that the maximum blood concentration [Cmax.] were 4.70 and 4.65 μg/ml and attained at [tmax.] of 1.30 and 1.40 hours, respectively. Doxycycline in Doxysol® and Doxymed® was eliminated with half-lives [t0.5(β)] equal to 1.98 and 2.31 hours, respectively. The mean systemic bioavailability of doxycycline in Doxysol® and Doxymed® after oral administration in healthy chickens was 92.57 and 88.21%, respectively. Conclusion: Doxymed® is bioequivalent to Doxysol® since Cmax test/Cmax reference and AUCtest/AUCreference ratios were 99% and 90%, respectively.

关键词： Bioequivalence Doxycycline Broiler Chickens Pharmacokinetics

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Conversion of L-Tryptophan into Melatonin Is the Possible Action Pathway Involved in the Effect of L-Tryptophan on Antidepressant-Related Behavior in Female Rats: Analysis of the Influence of Treatment Duration

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Journal of Behavioral and Brain Science 2013年第4期3卷 362-372页

作者： Sihame Ouakki Fatima Zahra el Mrabet Aboubaker el hessni Abdelhalem Mesfioui Paul Pévet Ali Ouichou Institute for Cellular and Integrative Neurosciences Strasbourg University Strasbourg France Laboratory of Genetics Neuroendocrinology and Biotechnology Unit of Nervous and Endocrine Physiology Faculty of Sciences Université Ibn Tofail Kenitra Morocco

The aim of this study was to determine the effect of pharmacological doses of melatonin (Mel) and L-tryptophan (L-TRP) on depression-like behavior in female rats submitted to the forced swimming test (FST) after 2, 4, 6 or 8 weeks of treatment. This will allow exploring the different mechanisms of L-TRP actions particularly that due to its conversion into Mel. For this purpose, four groups of 24 rats each were constituted;(Group 1: Control): received saline solution NaCl (0.9%), (Group 2: Mel4): received 4 mg/Kg of Mel, (Group 3: L-TRP4): received 4 mg/Kg of L-TRP and (Group 4: L-TRP20): received 20 mg/Kg of L-TRP. Animals of each group were distributed on 4 subgroups of 6 rats submitted to different time treatments. The duration of immobility (TIM) and struggling period (TST) of rats in FST were measured after 2, 4, 6 and 8 weeks of drug treatment and the effects of Mel and L-TRP were compared. Chronical administration of different doses of Mel or L-TRP failed to induce any anti-depressant activity in rats subjected to FST after 2 weeks of treatment. However, after 4 weeks, daily administration of Mel at 4 mg/Kg significantly reduced the immobility period and enhanced struggling time. After 6 weeks, Mel at 4 mg/Kg and L-TRP at 20 mg/Kg were both effective in reducing immobility and increasing struggling movement, their effects being statistically comparable. All treatments were able to significantly reduce immobility time and increase struggling duration after 8 weeks, but L-TRP at 4 mg/Kg was less potent than Mel and L-TRP at 20 g/Kg. The antidepressant-like activity of L-TRP was dose and time dependent, and that of Mel was time dependent. In conclusion, the study showed that at pharmacological doses, Mel and L-TRP have anti-depressant action, and such effect is dependent on time treatment;Mel?is more effective than L-TRP. In conclusion, L-TRP, through Mel, 5-HT or by itself could modulate aminergic neurotransmission in the different brain areas to ensure its beha

关键词： Melatonin L-Tryptophan Depression Forced Swimming Immobility Struggling Female Rats

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Evaluation of Acute Toxicity and Sedative Effects of Ethylic Extract of Thymelaea lythroidesin Wistar Rats

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Journal of Behavioral and Brain Science 2014年第3期4卷 120-128页

作者： Inssaf Berkiks Abdelhalem Mesfioui Abdrahim Kribii Ali Ouichou Bouchra Benazzouz Aboubaker el hessni Laboratoire de Génétique Neuroendocrinologie et Biotechnologie Faculté des Sciences BP 133 Kenitra Maroc Laboratoire de Procédés de Séparation Equipe de Chimie Appliquée à l’Environnement Faculté des Sciences Université Ibn Tofail Kénitra Maroc

The purpose of this study was to evaluate the acute toxicity and sedative effect of the ethylic extract of Thymelaea lythroides (Tl) on Wistar rats. The study was based on the gavage administration of the ethylic extract of Tl with different doses (i.e. 200, 400, 500 and 5000 mg/kg), where the toxicity and the sedative activity of the plant were observed and the obtained results were analyzed using the ANOVA test followed by the Bonferroni test. The main results of this study showed that the lethal dose of the ethylic extract of Tl was higher than the 5000 mg/kg dose. Moreover, when compared to the control rats, the animals treated with 5000 mg/kg of the extract exhibited significant reduction in appetite for food and water in the first week. Furthermore, results of the psychotropic test conducted during this study showed visible effects on the exploratory activity of the rats. The dose of 5000 mg/kg was also found to have a significant central nervous system effect;the locomotor activities of the animals decreased in a manner similar to those administered with Zepam as control.

关键词： T. lythroides Acute Toxicity Central Nervous System Effect Sedative

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Maternal Separation Affects Mothers’ Affective and Reproductive Behaviors as Well as Second Offspring’s Emotionality

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Journal of Behavioral and Brain Science 2013年第5期3卷 409-414页

作者： R. Bousalham B. Benazzouz A. el hessni A. Ouichou A. Mesfioui Laboratory of Genetic Neuroendocrinology and Biotechnology Faculty of Sciences Ibn Tofail University Kenitra Morocco

Daily separation of rat pups from their mothers while the preweaning period has an impact on behavior and stress response of pups. We hypothesized that maternal separation may create a depression-like state in mother rats from which we separate the rat pups and decrease their reproductive function and fertility. Also, we aimed to evaluate the transmission degree of depression and anxiety across generations. Females aged 3 months were divided in two groups of 10 rats each. After a first mating and a first parturition, we conducted maternal separation 3 h during 22 days for the experienced group while the control group mothers kept their pups. At 4 months of age, females underwent behavioral tests and a second mating. Second generation’s pups were also subjected to behavioral tests. Behavioral tests showed that mothers which experienced separation were more depressive and anxious than control ones, also they had a lower litter size. Rats pups of the second generation whose mothers experienced maternal separation also revealed behavior changes akin to depression and anxiety. Thus, maternal separation causes depressive and anxious-likestates on mother rats which experienced separation and has an impact on their litter size. Also, consequences of maternal separation seem to last throughout generations.

关键词： Maternal Separation Affective Disorder Mothers’ Rat Reproduction Offspring of Second Generation

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Affective Behavior Dysregulation Was Induced by Chronic Administration of Copper in Wistar Rats

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Neuroscience & Medicine 2019年第2期10卷 134-149页

作者： Mouloud Lamtai Sihame Ouakki Oussama Zghari Abdelhalem Mesfioui Aboubaker el hessni Ali Ouichou Unit of Nervous and Endocrine Physiology Laboratory of Genetics Neuroendocrinology and Biotechnology Faculty of Science University Ibn Tofail Kenitra Morocco

As both deficiency and excess of copper (Cu) can be harmful, dysregulation in its homeostasis has been connected with various neurological disorders. The present study was undertaken to examine whether Cu chronic administration can induce alterations of affective behavior especially anxiety and depression levels in male and female rats. Twenty-four rats, for each gender, divided in control and three test groups (n = 6), were injected intraperitoneally with saline (0.9% NaCl) or CuCl2 (0.25 mg/kg, 0.5 mg/kg and 1 mg/kg) for 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. Results demonstrated that Cu administered chronically, exerts an anxiogenic effect in rats. In the OFT, Cu decreases the TCA and NRC parameters without modifying the locomotor activity represented by the NTS parameter. With regard to EPM, Cu decreases TOA and EOA parameters without modifying the TAE parameter. A significant increase in depression-like symptoms was also exhibited by Cu treated rats (p 2 showed maximum anxiety-like and depression-like symptoms as compared to controls as well as from the other two doses indicating dose-dependent effects of chronic Cu administration. Overall, these results suggest that intoxication with Cu has potentially deleterious effects on brain as reflected in behavioral dysfunctions such as depression and anxiety.

关键词： Copper Depression-Like Anxiety-Like Rat

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