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Journal of earth Science 2020年第3期31卷 514-522页

作者： Natalia N.Ankusheva ekaterina e.palenova Svetlana N.Shanina Institute of Mineralogy South-Urals Federal Research Center of Mineralogy and GeoecologyUrals BranchRussian Academy of SciencesMiass 456317Russia Geological Department South-Urals State UniversityMiass 456300Russia Institute of Geology of the Komi Science Center Urals BranchRussian Academy of SciencesSyktyvkar 167982Russia

The P-T conditions of auriferous and barren quartz veins from Kopylovsky,Kavkaz and Krasnoye gold deposits in Proterozoic black shales of Bodaybo ore region are presented the first time in this *** inclusions trapped in auriferous quartz are aqueous Na±K-Mg chloride with salinity of 6 wt.%-8.8 wt.%*** temperatures vary from 260 to 350℃,and calculated trapping pressures are 1.2-1.6 *** fluids trapped in barren quartz have more complicated compositions with Na,K,Mg and Fe chlorides,salinity up to 13 wt.%NaCleqv,and homogenization temperatures ranging between 140 and 280℃.The volatiles in fluids are dominated by H2O,followed by CO2 with minor amounts of CH4 and *** suppose that auriferous and barren quartz veins have been formed due to the basic metamorphogenic fluid as evidenced by the close slat and gas fluid composition.

关键词： Bodaybo black shales gold deposits gold-bearing quartz barren veins fluid inclusions P-T conditions

Molecular testing for colorectal cancer:Clinical applications

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1288-1301页

作者： evgeny Imyanitov ekaterina Kuligina Department of Tumor Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Medical Genetics St.-Petersburg Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Oncology I.I.Mechnikov North-Western Medical UniversitySaint-Petersburg 191015Russia

Molecular genetic analysis is an integral part of colorectal cancer(CRC)*** choice of systemic therapy for CRC is largely based on the results of tumor molecular *** of the KRAS and NRAS gene status is mandatory for consideration of anti-epidermal growth factor receptor(eGFR)*** with the BRAF V600e substitution are characterized by aggressive behaviour,may require intensified cytotoxic regimens and benefit from combined BRAF and eGFR *** inactivation of DNA mismatch repair(MMR),or MUTYH gene,or DNA polymerase epsilon results in excessive tumor mutational burden;these CRCs are highly antigenic and therefore sensitive to immune checkpoint *** CRCs are characterized by overexpression of the HeR2 oncogene and respond to the appropriate targeted *** are CRCs with clinical signs of hereditary predisposition to this disease,which require germline genetic *** biopsy is an emerging technology that has the potential to assist CRC screening,control the efficacy of surgical intervention and guide disease *** landscape of CRC molecular diagnosis is currently undergoing profound changes due to the increasing use of next generation sequencing.

关键词： Colorectal cancer Anti-epidermal growth factor receptor therapy KRAS NRAS BRAF HeR2 Microsatellite instability MUTYH Hereditary cancer

Jasmonic Acid Oxidase 2 Hydroxylates Jasmonic Acid and Represses Basal Defense and Resistance Responses against Botrytis cinerea Infection

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Molecular Plant 2017年第9期10卷 1159-1173页

作者： ekaterina Smirnova Institut de Biologie Moléculaire des Plantes CNRS Université de Strasbourg Strasbourg France Laboratoire de Chimie Organique Synthétique Institut de Chimie Université de Strasbourg CNRS Strasbourg France

Jasmonates （JAs） orchestrate immune responses upon wound/herbivore injury or infection by necrotro- phic pathogens. elucidation of catabolic routes has revealed new complexity in jasmonate metabolism. Two integrated pathways attenuate signaling by turning over the active hormone jasmonoyl-isoleucine （JA-Ile） through w-oxidation or deconjugation, and define an indirect route forming the derivative 12OH-JA. Here, we provide evidence for a second 12OH-JA formation pathway by direct jasmonic acid （JA） oxidation. Three jasmonic acid oxidases （JAOs） of the 2-oxoglutarate dioxygenase family catalyze spe- cific oxidation of JA to 12OH-JA, and their genes are induced by wounding or infection by the fungus Botrytis cinerea. JA02 exhibits the highest basal expression, and its deficiency in jao2 mutants strongly enhanced antifungal resistance. The resistance phenotype resulted from constitutive expression of antimi- crobial markers rather than from their higher induction in infected jao2 plants and could be reversed by ectopic expression of any of the three JAOs injao2. elevated defense injao2 was dependent on the activity of JASMONATe ReSPONSe 1 （JAR1） and CORONATINe-INSeNSITIVe 1 （COI1） but was not correlated with erihanced JA-Ile accumulation. Instead, jao2 mutant lines displayed altered accumulation of several JA species in healthy and challenged plants, suggesting elevated metabolic flux through JA-Ile. Collectively, these data identify the missing enzymes hydroxylating JA and uncover an important metabolic diversion mechanism for repressing basal JA defense responses.

关键词： 2-oxoglutarate oxygenase jasmonic acid defense regulation hormone metabolism Botrytis

Removal of perfluorinated surfactants from wastewater by adsorption and ion exchange--Influence of material properties,sorption mechanism and modeling

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Journal of environmental Sciences 2017年第4期29卷 160-170页

作者： Falk Schuricht ekaterina S.Borovinskaya Wladimir Reschetilowski Institute of Industrial Chemistry Dresden University of Technology

Perfluorooctane sulfonate（PFOS） has attracted increasing concern in recent years due to its world-wide distribution, persistence, bioaccumulation and potential toxicity. The influence of sorbent properties on the adsorptive elimination of PFOS from wastewater by activated carbons, polymer adsorbents and anion exchange resins was investigated with regard to their isotherms and kinetics. The batch and column tests were combined with physicochemical characterization methods, e.g., N2 physisorption, mercury porosimetry, infrared spectroscopy, differential scanning calorimetry, titrations, as well as modeling. Sorption kinetics was successfully modelled applying the linear driving force（LDF） approach for surface diffusion after introducing a load dependency of the mass transfer coefficient β*** big difference in the initial mass transfer coefficient βs,0, when non-functionalized adsorbents and ion-exchange resins are compared, suggests that the presence of functional groups impedes the intraparticle mass transport. The more functional groups a resin possesses and the longer the alkyl moieties are the bigger is the decrease in sorption *** the selectivity for PFOS sorption is increasing when the character of the functional groups becomes more hydrophobic. Accordingly, ion exchange and hydrophobic interaction were found to be involved in the sorption processes on resins, while PFOS is only physisorptively bound to activated carbons and polymer adsorbents. In agreement with the different adsorption mechanisms, resins possess higher total sorption capacities than adsorbents. Hence, the latter ones are rendered more effective in PFOS elimination at concentrations in the low μg/L range, due to a less pronounced convex curvature of the sorption isotherm in this concentration range.

关键词： PFOS Activated carbon Anion exchange resin Sorption kinetics modeling Sorption isotherm Selectivity of sorption

Free-Standing α-MoO_(3)/Ti_(3)C_(2) MXene Hybrid electrode in Water-in-Salt electrolytes

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energy & environmental Materials 2023年第4期6卷 6-14页

作者： Mohit Saraf Christopher e.Shuck Nazgol Norouzi Kyle Matthews Alex Inman Teng Zhang ekaterina Pomerantseva Yury Gogotsi A.J.Drexel Nanomaterials Institute and Department of Materials Science and engineering Drexel UniversityPhiladelphia PA 19104USA

While transition-metal oxides such as α-MoO_(3)provide high capacity,their use is limited by modest electronic conductivity and electrochemical instability in aqueous ***-dimensional(2D)MXenes,offer metallic conductivity,but their capacitance is limited in aqueous *** of partially solvated cations into Ti_(3)C_(2)MXene from lithium-based water-in-salt(WIS)electrolytes enables charge storage at positive potentials,allowing a wider potential window and higher ***,we demonstrate that α-MoO_(3)/Ti_(3)C_(2)hybrids combine the high capacity of α-MoO_(3)and conductivity of Ti_(3)C_(2)in WIS(19.8 m LiCI)electrolyte in a wide1.8 V voltage *** voltammograms reveal multiple redox peaks from α-MoO_(3)in addition to the well-separated peaks of Ti_(3)C_(2)in the hybrid *** leads to a higher specific charge and a higher rate capability compared to a carbon and binder containing α-MoO_(3)*** results demonstrate that the addition of MXene to less conductive oxides eliminates the need for conductive carbon additives and binders,leads to a larger amount of charge stored,and increases redox capacity at higher *** addition,MXene encapsulated α-MoO_(3)showed improved electrochemical stability,which was attributed to the suppressed dissolution of α-MoO_(3).The work suggests that oxide/MXene hybrids are promising for energy storage.

关键词： free-standing electrode Ti_(3)C_(2)MXene water-in-salt electrolytes α-MoO_(3)nanobelts

The composition of acid/oil interface in acid oil emulsions

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Petroleum Science 2020年第5期17卷 1345-1355页

作者： Yulia M.Ganeeva Tatiana N.Yusupova ekaterina e.Barskaya Alina Kh.Valiullova ekaterina S.Okhotnikova Vladimir I.Morozov Lucia F.Davletshina Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientifi c CenterRussian Academy of SciencesArbuzov str.8Kazan 420088Russian Federation Gubkin Russian State University of Oil and Gas(National Research University) Leninsky Prospekt 65Moscow 119991Russian Federation

In well stimulation treatments using hydrochloric acid,undesirable water-in-oil emulsion and acid sludge may produce and then cause operational problems in oil field *** processes intensify in the presence of Fe(Ⅲ),which are from the corroded surfaces of field equipment and/or iron-bearing minerals of the oil *** order to understand the reasons of the stability of acid emulsions,acid emulsions were prepared by mixing crude oil emulsion with 15% hydrochloric acid solutions with and without Fe(Ⅲ) and then separated into free and upper(water free) and intermediate(with water) *** is assumed that the oil phase of the free and upper layers contains the compounds which do not participate in the formation of acid emulsions,and the oil phase of the intermediate layers contains components involved in the formation of oil/acid *** composition of the oil phase of each layer of the emulsions was *** is found that the asphaltenes with a high content of sulfur,oxygen and metals as well the flocculated material of protonated non-polar oil components are concentrated at the oil/acid *** addition to the above,in the presence of Fe(Ⅲ) the Fe(Ⅲ)-based complexes with polar groups of asphaltenes are formed at the acid/oil interface,contributing to the formation of armor films which enhance the emulsion stability.

关键词： Acid emulsions Ferric cations Acid/oil interface Asphaltenes Resins Waxes Oil paramagnetic particles Fe(Ⅲ)-based complexes

Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词： Lymph microcirculation Transmission digital microscopy Rat mesentery Flow cytometry Photothermal technique

Variable retention forestry in european boreal forests in Russia

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ecological Processes 2019年第1期8卷 424-434页

作者： ekaterina Shorohova Sergey Sinkevich Aleksandr Kryshen Ilkka Vanha-Majamaa Forest Research Institute of the Karelian Research Centre of the Russian Academy of Sciences Pushkinskaya str.11Petrozavodsk 185910Russia Saint-Petersburg State Forest Technical University Institutsky str.5Saint Petersburg 194021Russia Natural Resources Institute Finland(Luke)Latokartanonkaari 9FI-00790 HelsinkiFinland

We explored whether,and to what extent,variable retention(VR)forestry has been applied in european boreal forests in northwestern *** survey revealed VR since *** 1910 and the 1960s,the statistics showing how much was retained are largely ***,for example,in the 1950s,on a large scale in the Republic of Karelia,up to 200-ha-sized harvesting areas,18–33%,were retention patches with a mean growing stock of 30–40m3 ha−*** the fellings defined as“incomplete clear fellings,”which were the most common final felling type at that time,11–40%of the growing stock was *** the 1960s and the early 1990s,with more efficient harvesting and skidding techniques,conventional clear fellings with a much lower amount of retention were *** about the regeneration of harvested areas gradually led to smaller(maximum 50 ha)harvesting areas and the increase of silvicultural *** now,to ensure natural regeneration,patches of understory and 20–25 seed trees(i.e.,ca.15–25m3)per ha have been left permanently in harvesting ***-scale retention for protecting ecosystem functions and biodiversity was legislated in 1978 by preserving key biotopes up to 1000 ha in *** 2001,promoted by forest certification,the key biotopes,such as paludified forest patches,buffers around water bodies,and habitats of red-listed species,have also been retained in harvesting areas,together with a dispersed retention of different *** estimates of the amount of key biotopes are largely ***,estimates of 1–13%in harvesting areas and 23%in whole managed landscapes have been *** applied during the last century has emulated natural disturbances and created diverse uneven-aged forest structures with high amounts of diverse coarse woody *** conclude that an analysis of past and current retention practices is essential for estimating the global role of Russian *** decisions on the general direction

关键词： Biological legacies Nature conservation Biodiversity Clear felling Key biotopes Coarse woody debris,Silviculture Dispersed and aggregated retention

Basal metabolic rate in free-living tropical birds： the influence of phylogenetic, behavioral, and ecological factors

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Current Zoology 2018年第1期64卷 33-43页

作者： Andrey BUSHUeV Oleg TOLSTeNKOV ekaterina ZUBKOVA eugenia SOLOVYeVA Anvar KeRIMOV Department of Vertebrate Zoology Faculty of Biology Lomonosov Moscow State University Leninskie Gory 1/12 Moscow 119234 Russia Joint Russian-Vietnamese Tropical Research and Technological Center South Branch Street 3/2 3 10 District Ho Chi Minh City Vietnam Laboratory of experimental Parasitology Center of Parasitology A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences Leninskij prospekt 33 Moscow 119071 Russia Zoological Museum of Lomonosov Moscow State University Bolshaya Nikitskaya B Moscow 125009 Russia

The majority of our knowledge of avian energetics is based on studies of birds from temperate and high latitudes. Using the largest existing sample of wild-caught Old World tropical species, we showed that birds from Southern Vietnam had lower basal metabolic rate （BMR） than temperate species. The strongest dissimilarity between tropical and temperate species was the low scaling exponent in the allometric relation between BMR and body mass in tropical birds （the regression slope was 0.573）. The passerine migrants to temperate and high latitudes had higher BMR than tropical sedentary passerines. Body mass alone accounted for 93% of the variation in BMR （body mass ranged from 5 to 252 g）. Contrary to some other studies, we did not find evidence besides the above mentioned that phylogeny, taxonomy, behavior, or ecology have a significant influence on BMR variation among tropical birds.

关键词： allometry BMR body mass energy metabolism tropical birds.

Selection of shaped charges parameters for producing aluminum particles with velocities in the range of 2.5-16 km/s

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Defence Technology（防务技术） 2024年第8期38卷 126-135页

作者： Vladimir I.Kolpakov Sergey V.Fedorov ekaterina P.Vinogradova Irina A.Bolotina Bauman Moscow State Technical University Moscow 105005Russia

Testing rocket and space technology objects in ground conditions for resistance to the impact of meteoroids and fragments of space debris can be carried out using shaped charges. To substantiate the design parameters of shaped charges that ensure the formation of aluminum particles in a wide velocity range(from 2.5 to 16 km/s), numerical modeling of the formation process was carried out within the framework of a two-dimensional axisymmetric problem of continuum mechanics using three different computing codes to increase the reliability of the results. The calculations consider shaped charges with a diameter of 20-100 mm with aluminum liners of various shapes. It is shown that the formation of particles with velocities close to the lower limit of the considered range is ensured by gently sloping segmental liners of degressive thickness. To form higher-velocity particles with velocities over 5 km/s, it is proposed to use combined liners, the jet-forming part of which has the shape of a hemisphere of constant thickness or the shape of a semi-ellipsoid or semi-superellipsoid of rotation of degressive thickness.

关键词： Space debris Meteoric impact explosion Shaped charge High-velocity aluminum element Segmental liner Combined liner Numerical simulation