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LIGHT-INDUCED FLUORESCENCE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY OF BASAL CELL CARCINOMA

Journal of Innovative Optical Health Sciences 2009年第3期2卷 261-268页

作者： ekaterina borisova ELFRIDA CARSTEA LUMINITA CRISTESCU ELMIRA PAVLOVA NIKOLAY HADJIOLOV PETRANKA TROYANOVA LATCHEZAR AVRAMOV Institute of Electronics Bulgarian Academy of Sciences 72Tsarigradsko Chaussee Blvd.1784 SofiaBulgaria National Institute for Optoelectronics Atomistilor 409077125 MagureleRomania National Oncological Center 6Plovdivsko Pole Str.1156 SofiaBulgaria

Many up-to-date optical techniques have been developed and applied recently in clinical practice for obtaining qualitatively and quantitatively new data from the investigated *** to their high sensitivity in detection of small changes,these techniques are widely used for detection of early changes in biological ***-induced fluorescence spectroscopy(LIFS)is one of the most promising techniques for early detection of cutaneous *** number of recent publications have suggested that optical coherence tomography(OCT)also has potential for non-invasive diagnosis of skin *** recent work is a part of clinical trial procedure for introduction of LIFS technique into the common medical practice in National Oncological Medical Center in Bulgaria for diagnosis of non-melanoma skin *** focus our attention here on basal cell carcinoma lesions and their specific features revealed by LIFS and OCT *** this paper we prove the efficiency of using the combined LIFS-OCT method in skin lesions studies by integrating the complimentary qualities of each particular *** LIFS measurements several excitation sources,each emitting at 365,385 and 405 nm maxima are *** associated microspectrometer detects in vivo the fluorescence signals from human *** main spectral features of the lesions and normal skin are discussed and their possible origins are *** images are used to evaluate the lesion thickness,structure and severity stage,when *** obtained results could be used to develop a more complete picture of optical properties of these widely spread skin *** the same time,our studies show that the combined LIFS-OCT method could be introduced in clinical algorithms for early tumor detection and differentiation between normal/benign/malignant skin lesions.

关键词： Cutaneous fluorescence OCT BCC images endogenous porphyrins skin cancer

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Photodynamic diagnostics of early gastric cancer:Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 64-73页

作者： Alexey Pavlov ekaterina borisova Olga Pavlova Ilana Agranovich Alexander Khorovodov Andrey Terskov Aysel Mamedova Maria Klimova Latchezar Avramov Oxana Semyachkina-Glushkovskaya Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Electronics Bulgarian Academy of Sciences Tsarigradsko Chaussee Blvd.72Sofia 1784Bulgaria

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient *** photodynamic diagnosis(PDD)of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX(5-ALA/PpIX)has been reported in several ***,the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric ***,a measure of the complexity of gastric microcirculation(multi-scale entropy,MSE)and the detrendedfluctuation analysis(DFA)were applied as additional tools to detect early gastric cancer in *** this experimental study,we used our original model of metastatic adenocarcinoma in the stomach of a *** induce a gastric tumor,we used a long-term combination(for 9 months,which is 1/2 of the life of rats)of two natural factors,such as chronic stress(overpopulation being typical for modern cities)and the daily presence of nitrites in food and drinks,which are common ingredients added to processed meat andfish to help preserve *** results clearly show that both methods,namely,PDD using 5-ALA/PpIX and complexity/correlation analysis,can detect early gastric cancer,which was confirmed by histological ***-cancerous areas in the stomach were detected as an intermediatefluorescent signal or MSE level between normal and malignant lesions of the ***,in some cases,PDD with 5-ALA/PpIX produced a false-positivefluorescence of exogenousfluorophores due to its accumulation in benign and inflammatory areas of the *** fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer,and the use of additional characteristics,e.g.,complexity measures or scaling exponents,can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

关键词： Experimental model of gastric cancer in animals highly heterogeneous adenocarcinoma photodynamic diagnosis complexity measures gastric microcirculation

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A special issue on Biophotonics in Europe

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Frontiers of Optoelectronics 2017年第3期10卷 203-210页

作者： Valery V. TUCHIN ekaterina borisova Malgorzata JEDRZEJEWSKA-SZCZERSKA Martin J. LEAHY Francesco S. PAVONE Jurgen POPP Jose POZO Research-Educational Institute of Optics and Biophotonics Samtov State University (National Research University of Russia) 410012 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk State University (National Research University of Russia) 634050 Tomsk Russia Laboratory of-Laser Diagnostics of Technical and Living Systems Instituteof Precision Mechanics and Control of RAS 410028 Saratov Russia 4 Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Institute of Electronics Bulgarian Academy of Sciences Sofia Bulgaria Faculty of Electronics Telecommunicationand Informatics Gdafisk University of Technology Poland National Biophotonics and Imaging Platform Ireland Chair of Applied Physics School of Physics National University of Ireland Galway Ireland European Laboratory for Non Linear Spectroscopy (LENS) and University of Florence Sesto Fiorentino Italy Leibniz Institute of Photonic Tectmology Jena Institute of Physical chemistry & AbbeCenter of Photonics Friedrich Schiller University Jena Germany Technology and Innovation EPIC - European Photonics Industry Consortium Netherlands

Biophotonics is an emerging multidisciplinary research area, embracing all light-based technologies applied to the life sciences and medicine [1-6]. The expression itself is the combination of the Greek syllables ＂bios＂ standing for life and ＂phos＂ standing for light. Photonics is the technical term for all methodologies and technologies utilizing photons over the whole spectrum from X-ray over the ultraviolet, visible and the infrared to the terahertz region, and its interaction with any matter. Beyond this definition, biophotonics is a scientific discipline of remarkable societal importance. As a part of photonics, it has proved to be an important enabling technology for accelerated progress in medicine and biotechnology. It can do so, because it originated at the interface of the most innovative academic disciplines of the last century, i.e., photonics, biotechnology and nanotechnologies. This field of research brings together scientists from different professions, such as physicists, biologists, pharmacists, medical doctors, etc. To work on common projects, they need to understand the ideas and the techniques of their counterparts.

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