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Molecular predictive markers in tumors of the gastrointestinal tract

World Journal of Gastrointestinal Oncology 2016年第11期8卷 772-785页

作者： eirini papadopoulou Vasiliki Metaxa-Mariatou Georgios Tsaousis Nikolaos Tsoulos Angeliki Tsirigoti Chrisoula Efstathiadou Angela Apessos Konstantinos Agiannitopoulos Georgia Pepe Eugenia Bourkoula George Nasioulas Department of Molecular Biology Gene Kor Medical S.A.

Gastrointestinal malignancies are among the leading causes of cancer-related deaths worldwide. Like all human malignancies they are characterized by accumulation of mutations which lead to inactivation of tumor suppressor genes or activation of oncogenes. Advances in Molecular Biology techniques have allowed for more accurate analysis of tumors' genetic profiling using new breakthrough technologies such as next generation sequencing(NGS), leading to the development of targeted therapeutical approaches based upon biomarker-selection. During the last 10 years tremendous advances in the development of targeted therapies for patients with advanced cancer have been made, thus various targeted agents, associated with predictive biomarkers, have been developed or are in development for the treatment of patients with gastrointestinal cancer patients. This review summarizes the advances in the field of molecular biomarkers in tumors of the gastrointestinal tract, with focus on the available NGS platforms that enable comprehensive tumor molecular profile analysis.

关键词：预兆的 biomarkers 指向的治疗定序的下一代胃肠的道体的变化液体活体检视

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Erectile dysfunction in chronic kidney disease:From pathophysiology to management

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World Journal of Nephrology 2015年第3期4卷 379-387页

作者： eirini papadopoulou Anna Varouktsi Antonios Lazaridis Chrysoula Boutari Michael Doumas 2nd Propaedeutic Department of Internal Medicine Aristotle University

Chronic kidney disease(CKD) is encountered in millions of people worldwide,with continuously rising incidence during the past decades,affecting their quality of life despite the increase of life expectancy in these *** of sexual function is common among men with CKD,as both conditions share common pathophysiological causes,such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease,hypertension and diabetes *** estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease ***,sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients,a fact which should raise awareness among clinicians.A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes.

关键词：慢性肾脏病患者治疗方法临床分析

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Development of Biofunctionalized Cellulose Acetate Nanoscaffolds for Heart Valve Tissue Engineering

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World Journal of Nano Science and Engineering 2016年第4期6卷 129-152页

作者： eirini Chainoglou Varvara Karagkiozaki Theodora Choli-papadopoulou Charisios Mavromanolis Argiris Laskarakis Stergios Logothetidis Nanomedicine Group Department of Physics Aristotle University of Thessaloniki Thessaloniki Greece Department of Chemistry Aristotle University of Thessaloniki Thessaloniki Greece Cardio-Thoracic Surgery Clinic General Hospital “G. PAPANIKOLAOU” Exohi Thessaloniki Greece

Currently-used mechanical and biological heart valve prostheses have a satisfactory short-term performance, but may exhibit several major drawbacks on the long-term. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. In recent years, there is a need for a heart valve prosthesis that can grow, repair and remodel. The concept of tissue engineering offers good prospects into the development of such a device. An ideal scaffold should mimic the structural and purposeful profile of materials found in the natural extracellular matrix (ECM) architecture. The goal of this study was to develop cellulose acetate scaffolds (CA) for valve tissue regeneration. After their thorough physicochemical and biological characterization, a biofunctionalization process was made to increase the cell proliferation. Especially, the surface of scaffolds was amplified with functional molecules, such as RGD peptides (Arg-Gly-Asp) and YIGSRG laminins (Tyrosine-Isoleucine-Glycine-Serine-Arginine-Glycine) which immobilized through biotin-streptavidin bond, the strongest non-covalent bond in nature. Last step was to successfully coat an aortic metallic valve with CA biofunctionallized nanoscaffolds and cultivate cells in order to create an anatomical structure comparable to the native valve. Promising results have been obtained with CA-based nanoscaffolds. We found that cells grown successfully on the biofunctionalized valve surface thereby scaffolds that resemble the native tissues, elaborated with bioactive factors such as RGD peptides and laminins not only make the valve’s surface biocompatible but also they could promote endothyliazation of cardiac valves causing an anti-coagulant effect

关键词： Heart Valve Tissue Engineering Cellulose Acetate Scaffolds Nanomaterials Polymers Atomic Force Microscopy

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