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Repetitiveness of the oral glucose tolerance test in children and adolescents

World Journal of Clinical Pediatrics 2021年第3期10卷 29-39页

作者： eirini kostopoulou Spyridon Skiadopoulos Ioanna Partsalaki Andrea Paola Rojas Gil Bessie E Spiliotis Division of Paediatric Endocrinology and Diabetes Department of PaediatricsUniversity of Patras School of MedicinePatras 26504Greece Department of Medical Physics School of MedicineUniversity of PatrasPatras 26504Greece Department of Nursing University of PeloponneseTripolis 22100Greece

BACKGROUND Data regarding the most suitable diagnostic method for the diagnosis of glucose impairment in asymptomatic children and adolescents are ***,limited data are available on the reproducibility of the oral glucose tolerance test(OGTT)in children and adolescents who are obese(OB).AIM To investigate the usefulness of the OGTT as a screening method for glucose dysregulation in children and *** Eighty-one children and adolescents,41 females,either overweight(OW),OB or normal weight(NW)but with a strong positive family history of type 2 diabetes mellitus(T2DM),were enrolled in the present observational study from the Outpatient Clinic of Paediatric Endocrinology of the University Hospital of Patras in *** or two 3-h OGTTs were performed and glucose,insulin and Cpeptide concentrations were measured at several time points(t=0 min,t=15 min,t=30 min,t=60 min,t=90 min,t=120 min,t=180 min).RESULTS Good repetitiveness was observed in the OGTT response with regard to T2DM,while low repetitiveness was noted in the OGTT response with regard to impaired glucose tolerance(IGT)and no repetitiveness with regard to impaired fasting glucose(IFG).In addition,no concordance was observed between IFG and *** the 1st and 2nd OGTTs,no significant difference was found in the glucose concentrations between NW,OW and OB patients,whereas insulin and C-peptide concentrations were higher in OW and OB compared to NW patients at several time points during the ***,OW and OB patients showed a worsening insulin and C-peptide response during the 2nd OGTT as compared to the 1st *** In mild or moderate disorders of glucose metabolism,such as IFG and IGT,a diagnosis may not be reached using only one OGTT,and a second test or additional investigations may be *** glucose metabolism is profoundly impaired,as in T2DM,one OGTT is probably more reliable and adequate for establishing the *** weight and/or a positiv

关键词： Oral glucose tolerance test Obesity Impaired fasting glucose Impaired glucose tolerance Children Adolescents

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Infantile hemangiomas screening modalities for primary care physicians

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Pediatric Investigation 2023年第3期7卷 199-205页

作者： Stylianos Roupakias eirini kostopoulou Despoina Gkentzi Sotirios Fouzas Xenophon Sinopidis Department of Pediatric Surgery University of Patras School of MedicinePatrasGreece Department of Pediatrics University of Patras School of MedicinePatrasGreece

Infantile hemangiomas are the most common benign vascular tumors in *** present a characteristic natural history of spontaneous involution after a phase of initial proliferation.A small but significant minority demonstrates incomplete regression or complications and requires prompt *** of the evolution of infantile hemangiomas is challenging because of their morphological and behavioral *** decision between referral for treatment and observation is sometimes difficult,especially among non-expert physicians,with the risk of missing the period for optimizing outcomes in case of delayed *** aim of this review is to update our knowledge,especially of the primary care providers,regarding the ongoing difficulties of the early clinical evaluation of infantile hemangiomas,and to outline the importance of current practical scoring tools for the identification of the lesions which require expert consultation and referral.

关键词： Diagnosis Infantile hemangioma Scoring tool Screening Vascular tumor

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