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COVID-19 infection and liver injury:Clinical features,biomarkers,potential mechanisms,treatment,and management challenges

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World Journal of Clinical Cases 2021年第22期9卷 6178-6200页

作者： Gholam Reza Sivandzadeh Hassan Askari Ali Reza Safarpour Fardad Ejtehadi ehsan raeis-abdollahi Armaghan Vaez Lari Mohammad Foad Abazari Firoozeh Tarkesh Kamran Bagheri Lankarani Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran Department of Medical Sciences Qom Medical BranchIslamic Azad UniversityQom ***Iran Department of Physiology School of MedicineAhvaz Jundishapur University of Medical ScienceAhvaz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Health Policy Research Center Shiraz University of Medical SciencesShiraz 71348-45794Iran

It is hypothesized that liver impairment caused by coronavirus disease 2019(COVID-19)infection might play a central role in severe clinical *** injury is closely associated with severe disease and,even with antiviral drugs,have a poor prognosis in COVID-19 *** addition to the common hepatobiliary disorders caused by COVID-19,patients with pre-existing liver diseases demand special considerations during the current ***,it is vital that upon clinical presentation,patients with concurrent pre-existing liver disease associated with metabolic dysfunction and COVID-19 be managed properly to prevent liver *** monitoring and early detection of liver damage through biomarkers after hospitalization for COVID-19 is underscored in all cases,particularly in those with pre-existing metabolic liver *** purpose of this study was to determine most recent evidence regarding causality,potential risk factors,and challenges,therapeutic options,and management of COVID-19 infection in vulnerable patients with pre-existing liver *** review aims to highlight the current frontier of COVID-19 infection and liver injury and the direction of liver injury in these patients.

关键词： Liver injury COVID-19 SARS-CoV-2 Inflammation Management

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Cholangiocarcinoma and liver transplantation:What we know so far?

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World Journal of Gastrointestinal Pathophysiology 2021年第5期12卷 84-105页

作者： Ali Reza Safarpour Hassan Askari Farshid Ejtehadi Asaad Azarnezhad ehsan raeis-abdollahi Amir Tajbakhsh Mohammad Foad Abazari Firoozeh Tarkesh Alireza Shamsaeefar Ramin Niknam Gholam Reza Sivandzadeh Kamran Bagheri Lankarani Fardad Ejtehadi Department of Gastroenterohepatology Research Center Shiraz University of Medical SciencesShiraz ***Iran The Princess Alexandra Hospital HNS Trust HarlowEssex CM201QXUnited Kingdom Liver and Digestive Research Center Research Institute for Health DevelopmentKurdistan University of Medical SciencesSanandaj ***Iran Department of Basic Medical Sciences Qom Medical BranchIslamic Azad UniversityQomIran Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShiraz ***Iran Research Center for Clinical Virology Tehran University of Medical SciencesTehran ***Iran Shiraz Organ Transplant Center Shiraz University of Medical SciencesShiraz ***Iran Health Policy Research Centre Shiraz University of Medical SciencesShiraz ***Iran

Cholangiocarcinoma(CCA)is a type of cancer with increasing prevalence around the world that originates from cholangiocytes,the epithelial cells of the bile *** tumor begins insidiously and is distinguished by high grade neoplasm,poor outcome,and high risk for *** transplantation has become broadly accepted as a treatment option for *** transplantation is expected to play a crucial role as palliative and curative therapy for unresectable hilar CCA and intrahepatic *** purpose of this study was to determine which cases with CCA should be subjected to liver transplantation instead of resection,although reported post-transplant recurrence rate averages approximately 20%.This review also aims to highlight the molecular current frontiers of CCA and directions of liver transplantation for CCA.

关键词： Cholangiocarcinoma Liver transplantation Primary sclerosing cholangitis Neoadjuvant chemoradiotherapy

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