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Simultaneous integrated boost ImRT in pediatric:evaluation for two commercial treatment planning systems

The Chinese-German Journal of Clinical Oncology 2013年第1期12卷 6-14页

作者： ehab m.attalla Ismail Eldesoky Eman Eldebawy Radiotherapy&Nuclear medicine Department National Cancer Institute Cairo University Children Cancer Hospital

Objective： The aim of the work was to compare the dosimetric results that were obtained by using two treatment planning systems （TPS） Siemens KonRad version 2.2.23, Elekta XiO version 4.4 to perform a simultaneous integrated boost （SIB） for head and neck and central nervous system （CNS） cases in paediatric patients. methods： The CT scan data for five paediatric patients, with head and neck and CNS tumors, were transferred into both of the TPSs. Clinical step-and-shoot intensity-modulated radiotherapy （ImRT） treatment plans were designed using 6 mV photon beam for delivery on a Siemens Oncor Accelerator with multileaf collimator mLC （82 leaf）. Plans were optimized to achieve the same clinical objectives using the same beam energy, number and direction of beams. The analysis was based on isodose distributions, the dose volume histogram （DVH） for planning target volume （PTV） and the relevant organs at risk （OARs） as well as volume receiving 2 Gy and 5 Gy, also total number of segments, mU/segment, and the number of mU/cGy had been investigated. Treatment delivery time and conformation number were two other parameters in this study. Results： The segmentation using KonRad was more efficient, resulting in fewer segments （reduction between 13.2% and 48.3%）, fewer m Us （reduction between 10.7% and 33%） and that reflected on treatment delivery times to be shorter by up to 8 rain or 46%. In most of the cases KonRad had the highest volume receiving in excess of 2 and 5 Gy, and XiO showed the lowest. Also KonRad achieved slightly better conformality （0.76 ± 0.054） than XiO （0.73 ± 0.05） while XiO presented a higher modulation factor value （3.3 mU/cGy） than KonRad （2.4 mU/cGy）. Conclusion： The KonRad treatment planning system was found to be superior to the XiO treatment planning system. This is true for the possible increase of radiation-induced secondary malignancies as well as for the local control.

关键词： intensity-modulated radiotherapy (ImRT) KonRad simultaneous integrated boost (SIB) XiO

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Evaluating the influence of 6 mV and 15 mV photon beams on prostate intensity-modulated radiation therapy plans

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Oncology and Translational medicine 2016年第1期2卷 26-33页

作者： Reham A.El Gendy ehab m.attalla Yasser m.Elkerm Ali Alfarrash Ayadi Al mostakbl 0ncology Center AlexandriaEgypt National Cancer Institute Cairo UniversityCairoEgypt Cancer management and Research Department Medical Research InstituteAlexandria UniversityAlexandriaEgypt Faculty of Science Mansoura UniversityMansouraEgypt

Objective We aimed to determine the ef ects of low- and high-energy intensity-modulated radiation therapy （ImRT） photon beams on the target volume planning and on the critical organs in the case of prostate can-cer. methods Thirty plans were generated by using either 6 mV or 15 mV beams separately, and a combination of both 6 and 15 mV beams. Al plans were generated by using suitable planning objectives and dose con-straints, which were identical across the plans, except the beam energy. The plans were analyzed in terms of their target coverage, conformity, and homogeneity, regardless of the beam energy. Results The mean percentage values of V70 Gy for the rectal wal for the plans with 6 mV, 15 mV, and mixed-energy beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were 53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 mV, 15 mV, and mixed-en-ergy plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 mV plans was 10% larger than those for the 15 mV and mixed-energy *** These preliminary results suggest that mixed-energy ImRT plans may be advantageous with respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the organs at risk may not be clinical y relevant, in this study, ImRT plans using mixed-energy beams exhibited better OAR sparing and overal higher plan quality for deep-seated tumors.

关键词： intensity-modulated radiation therapy (ImRT) mixed-energy plans 6 mV 15 mV prostate cancer radiation treatment planning dose-volumetric analysis

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Dosimetric study comparing photon and electron beams for boosting the tumor bed in early-stage breast cancer

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The Chinese-German Journal of Clinical Oncology 2012年第12期11卷 710-715页

作者： mohamed mahmoud Soha Ahmed ehab m.attalla Hassan S.Abouelenein Shaimaa Shoier mohsen Barsoum Radiation Oncology Department National Cancer InstituteCairo University Radiation Oncology Department Children's Cancer Hospital

Objective： The aim of our study was to assess and compare the potential dosimetric advantages and drawbacks of photon beams and electron beams as a boost for the tumor bed in superficial and deep seated early-stage breast cancer. methods： We planned CTs of 10 women with early breast cancer underwent breast conservative surgery were selected. Tumor bed was defined as superficial and deep with a cut of point 4 cm, those with less than 4 cm were defined as superficial tumors representing 4 patients and those with depth of 4 cm or more were classified as deep tumors representing 6 patients. The clinical target volume （C＇I＇V） was defined as the area of architectural .distortion surrounded by surgical clips. The plan- ning target volume （PTV） was the C＇I＇V plus margin 1 cm. A dose of 10 *** 2 Gy fractions was given concurrently at the last week of treatment. Organs at risk （OARs） were heart, lungs, contra-lateral breast and a 5 mm thick skin segment of the breast surface. Dose volume histograms were defined to quantify the quality of concurrent treatment plans assessing target coverage and sparing OARs. The following treatment techniques were assessed： photon beam with 3D-conformal technique and a single electron beam. Results： For superficial tumors better coverage for CTV and P＇I＇V with good homogeneity with better CI was found for the 3D conformal radiotherapy （3DCRT） but with no significant planning objectives over electron beam. For deep tumors, the 3DCRT met the planning objectives for C＇I＇V, PTV with better coverage and fewer hot spots with better homogeneity and CI. For superficial tumors, OARs were spared by both techniques with better sparing for the electron beam where as for deep tumors also OARs were well spared by both techniques. Conclusion： Boosting the tumor bed in early- stage breast cancer with optimized photon may be preferred to electron beam for both superficial and deep tumors. The OARs dose sparing effect may allow for a potential long-term toxic

关键词： 3D conforrnal radiotherapy electron beam organs at risk

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Dosimetric evaluation using the diode measurements for total skin electron therapy technique

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The Chinese-German Journal of Clinical Oncology 2014年第7期13卷 328-331页

作者： ehab m.attalla Nashaat A.Deiab Walaa S.Abd Elgawad Radiotherapy & Nuclear medicine Department National Cancer InstituteCairo University Children Cancer Hospital CairoEgypt

Objective： The purpose of this study was to present the dosimetric study and evaluation the dose delivered to the skin tumor by using diode detector with total skin electron therapy （TSET）. methods： The total skin electron irradiation （TSEI） technique was used to treat ten patients with histological confirmed mycosis fungoides according to the Stanford staging system at the Radiotherapy Department, National Cancer Institute, Cairo University, Egypt. High dose rate electron beams with low electron energy 5 meV from a Siemens linear accelerator were used for treatment. Diodes were calibrated at TSET distance 300 cm and field size （35 × 35） cm^2. Results： The result of diodes measurements showed the dose to flat surface of the body was within ：1：10 % from the prescribed dose. Special areas of the body such as the perineum ＆ eyelid showed large deviation up to 30% variation from the prescription dose. Conclusion： The diode results of this study will be used as a quality assurance check for all new patients treated with TSET and to compare it to the prescribed dose delivered to the patients. It is recommends to evaluate the diodes measurements for all patients throughout the full treatment cycle and to identify individually the boost dose areas.

关键词： total skin electron therapy (TSET) in vivo dosimetry diode detector mycosis fungoides (mF)

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Dosimetric evaluation of a beam matching procedure

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The Chinese-German Journal of Clinical Oncology 2014年第2期13卷 89-93页

作者： ehab m.attalla H.S.Abou-Elenein Hany Ammar Ismail Eldesoky Children's Cancer Hospital National Cancer Institute Cairo University

Objective: The dosimetric characteristics for linear accelerators with the same model, and nominal energy are known to be very similar, as long as the machines are unaltered from the manufacturer's original specifications. In this preliminary study, a quantitative investigation of the similarity in the basic photon and electron dosimetry data from the Siemens Oncor linear accelerators at our hospital(Children's Cancer Hospital, Cairo, Egypt) was reported. methods: The output factor(OF), wedge factors(WF), percentage depth dose(PDD), and beam profile for the 6 and 10 mV photon beams were measured. Results: The measured output factors varied by less than about 1% for each field size. The difference between the maximum and minimum PDD values at each depth was less than about 1%. The difference between the beam flattnes and symetry was no more than 1% at all off-axis distances. For electron the results showed that the PDD, OF, and the beam profiles were matched within 1% differences. Conclusion: These results strongly suggest that it is feasible to establish one reference photon and electron dosimetry data set for the two machines and nominal energies.

关键词： beam matching dosimetric verification linear accelerator

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Bayesian and Non-Bayesian Analysis for the Sine Generalized Linear Exponential model under Progressively Censored Data

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Computer modeling in Engineering & Sciences 2024年第9期140卷 2795-2823页

作者： Naif Alotaibi A.S.Al-moisheer Ibrahim Elbatal mohammed Elgarhy ehab m.Almetwally Department of mathematics and Statistics Faculty of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Department of mathematics College of ScienceJouf UniversityP.O.Box 848Sakaka72351Saudi Arabia mathematics and Computer Science Department Faculty of ScienceBeni-Suef UniversityBeni-Suef62521Egypt Department of Basic Sciences Higher Institute of Administrative SciencesBelbeisEgypt Faculty of Business Administration Delta University for Science and TechnologyGamasa11152Egypt

This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)*** SGLE distribution utilizes the sine transformation to enhance its *** updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability *** suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique *** model includes many well-known lifespan distributions as separate *** suggested model is accompanied with a range of statistical *** model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored *** order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing *** relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models.

关键词： Sine G family generalized linear failure rate progressively censored data moments maximum likelihood estimation Bayesian estimation simulation

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Thermal performance of domed roof in air-conditioned spaces

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Energy and Built Environment 2024年第2期5卷 270-287页

作者： Ibrahim Reda Raouf N.Abdelmessih mohamed Steit ehab m.mina mechanical Power Engineering Faculty of EngineeringAin Shams University1 El-Sarayat St.Cairo 11517Egypt Architectural Engineering Faculty of EngineeringAin Shams UniversityCairoEgypt

Due to their thermal performance,domed roofs are one of the passive solutions that affect energy consumption in *** thermal performance of domed roofs has been investigated in many naturally ventilated ***,few studies have discussed their performance in conditioned ***,this study introduces a computational comparison between domed and flat roofs to investigate their impact on thermal comfort inside a conditioned *** an earlier stage,field measurements were carried out inside a Bahraini mosque to acquire its indoor air conditions during the summer period of 2021,in addition to validating the computational *** findings of this study confirm that,under mechanical cooling conditions,the flat roof offers a lower indoor temperature than the domed roof by 0.4℃and 0.1℃for open and closed doors,***,the air velocity is lower by approximately 0.01 m/s for both door *** overall PmV values of the flat roof are also lower by 0.07 and 0.01,while the PPD values are lower by 0.20,and 0.34 for open and closed doors,*** on these small differences,it can be concluded that the thermal performance of both roofing systems behaves equally in conditioned ***,the air patterns are substantially different,the overall thermal performance is *** similarity drives building designers to rethink the thermal performance of the domed roofs in air-conditioned spaces with such a hot climate,regardless of their aesthetic and acoustical behaviour.

关键词： Thermal comfort Computational fluid dynamics(CFD) Predicted mean vote(PmV)and predicted percentage dissatisfied(PPD) Domed roof Flat roof

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Identifying and validating mmP family members(mmP2,mmP9,mmP12,and mmP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC)

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Oncology Research 2024年第4期32卷 737-752页

作者： KUNLUN LI DANDAN LI BARBOD HAFEZ mOUNIR m.SALEm BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI ehab I.TAHA SAYED H.AUDA FAIQAH RAmZAN mUHAmmAD JAmIL The Second Affiliated Hospital of Harbin medical University Harbin Medical UniversityHarbinChina Department of Pharmaceutical Engineering Jiangsu Ocean UniversityLianyungangChina Department of Biological Engineering University of SalfordSalfordUK Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Animal and Poultry Production Faculty of Veterinary and Animal SciencesGomal UniversityDera Ismail KhanPakistan Department of Arid Zone Research PARC instituteDera Ismail KhanPakistan

Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and *** mmP family assumes a crucial role in tumor invasion and *** study aimed to uncover the mechanistic relevance of the mmP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular ***,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TImER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze mmP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for *** performing STRING and Cytohubba analyses of the 24 mmP gene family members,mmP2(matrix metallopeptidase 2),mmP9(matrix metallopeptidase 9),mmP12(matrix metallopeptidase 12),and mmP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree *** analyzing mmP2,mmP9,mmP12,and mmP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to *** notable effect of the up-regulated mmP2,mmP9,mmP12,and mmP16 was also documented on the overall survival(OS)of the KIRC ***,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(mmP2,mmP9,mmP12,and mmP16).In addition to this,hub genes were involved in various diverse oncogenic *** mmP gene family members(mmP2,mmP9,mmP12,and mmP16)may serve as therapeutic targets and prognostic biomarkers in KIRC.

关键词： KIRC mmP gene family Chemotherapy Overall survival

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Combining ability of Egyptian cotton(Gossypium barbadense L.)reveals genetic potential for improved yield and fiber quality

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Journal of Cotton Research 2024年第2期7卷 109-122页

作者： Abdelghany Ahmed m. El-Banna Aly A.A. Lamlom Sobhi F El-Sorady Gawhara A. Salama ehab A.A. Ren Honglei Shaibu Abdulwahab S. Yehia Waleed m.B. Crop Science Department Faculty of AgricultureDamanhour UniversityDamanhour 22516Egypt Plant Production Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Agricultural Botany Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Heilongjiang Academy of Agricultural Sciences Soybean Research InstituteHarbin 150086China Department of Agronomy Bayero University KanoKano 700001Nigeria Cotton Breeding Department Cotton Research InstituteAgriculture Research CenterGizaEgypt

Background As the most widely cultivated fiber crop,cotton production depends on hybridization to unlock the yield potential of current varieties.A deep understanding of genetic dissection is crucial for the cultivation of enhanced hybrid plants with desired traits,such as high yield and fine fiber *** this study,the general combining ability(GCA)and specific combining ability(SCA)of yield and fiber quality of nine cotton parents(six lines and three testers)and eighteen F1 crosses produced using a line×tester mating design were *** The results revealed significant effects of genotypes,parents,crosses,and interactions between parents and crosses for most of the studied ***,the effects of both additive and non-additive gene actions played a notably significant role in the inheritance of most of the yield and fiber quality *** F1 hybrids of(Giza 90×Aust)×Giza 86,Uzbekistan 1×Giza 97,and Giza 96×Giza 97 demonstrated superior performance due to their favorable integration of high yield attributes and premium fiber quality *** analysis revealed that lint yield has the highest positive direct effect on seed cotton yield,while lint percentage showed the highest negative direct effect on seed cotton *** component analysis identified specific parents and hybrids associated with higher cotton yield,fiber quality,and other agronomic *** This study provides insights into identifying potential single-and three-way cross hybrids with superior cotton yield and fiber quality characteristics,laying a foundation for future research on improving fiber quality in cotton.

关键词： Gossypium barbadense L. Combining ability Seed cotton yield Fiber quality Cluster analysis Path analysis

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Comparison of two methods for assessing leakage radiation dose around the head of the medical linear accelerators

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The Chinese-German Journal of Clinical Oncology 2013年第9期12卷 435-438页

作者： ehab m. attalla Department of Radiotherapy and Nuclear medicine National Cancer Institute Cairo University Children Cancer Hospital

Objective:The aim of this study was to measure the leakage by two methods with ion chamber and ready packs film,and to investigate the feasibility and the advantages of using two dosimetry methods for assessing leakage radiation around the head of the linear ***:measurements were performed using a 30 cm3ion chamber;the gantry at 0°,the X-ray head at 0°,the field size at between the central axis and a plane surface at a FSD of 100 as a reference,a series of concentric circles having radii of 50,75,and 100 cm with their common centre at the reference *** absorbed dose was measured at the reference point,and this would be used as the reference *** the diaphragm closed,the measurements were taken along the circumference of the three circles and at 45°***:Leakage radiations while the treatment head was in the vertical position varied between 0.016%–0.04%.With the head lying horizontally,leakage radiation was the same order magnitude and varied between 0.02%–0.07%.In the second method,the verification was accomplished by closing the collimator jaws and covering the head of the treatment unit with the ready pack *** films were marked to permit the determination of their positions on the machine after exposed and *** the diaphragm closed,and the ready packs films around the linear accelerator the beam turned on for 2500 cGy(2500 mU).The optical density of these films was measured and compared with this of the reference *** radiation varied according to the film positions and the magnitude of leakage was between 0.005%–0.075%.Conclusion:The differences between the values of the leakage radiation levels observed at different measurement points do not only reflect differences in the effective shielding thickness of the head wall,but are also related to differences in the distances between the target and the measurement *** experimental errors involved in dosimetric measurement also contribute to such d

关键词： leakage radiation acceptance testing linear accelerator ion chamber ready packs film

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