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Current perspectives on dengue episode in Malaysia

Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 386-392页

作者： ee leen pang Hwei-San Loh School of Biosciences.Faculty of Science.The University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

To Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per *** encroachment,ecological disruption and poor sanitation are all contributory factors of increased *** however arises from the fact that dengue virus inherently exists as four different *** infection is often manifested in the more severe form,such that antibody-dependent enhancement(ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of ***,increased viraemic litter and suppression of antiviral response are *** concerns are thus expressed in regards to escalating trend of hospitalisation and mortality *** Malaysia,situation is exacerbated by improper clinical management and pending vector control *** a preparedness strategy against the potential deadly dengue pandemic,the call for development of a durable and costeffective dengue vaccine against all infecting serotypes is *** though several vaccine candidates are currently being evaluated in clinical trials,uncertainties in regards to serotypes interference,incomplete protection and dose adequacy have been *** of sole reliance on outsourcing,production of local vaccine should be considered in coherent to government's efforts to combat against dengue.

关键词： Dengue Antibody-dependent enhancement Pandemic Vaccine Malaysia

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Towards development of a universal dengue vaccine-how close are we?

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 209-218页

作者： ee leen pang Hwei-San Loh School of Biosciences Faculty of ScienceThe University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

Dengue has been ranked as one of the top emerging diseases in Asia and Latin *** epidemiological data may not even reflect the true burden of disease due to underreported *** control programmes have failed to contain the disease and worst of all,no specific treatment is available at the ***,this pushes the demand for a dengue vaccine as a long-term protective *** there are numerous vaccine candidates ahead,they could be held back by different aspects in promoting vaccine *** for developing nations,logistics and cost are the major hurdles that need to be addressed in order to provide a quick yet affordable medical *** an alternative,plantbased vaccine production system is able to offer an attractive prospect given to its advantages of biocontainment warranty,low operation cost,rapid scalability and logistics *** that have embarked on this scope are laid out and reviewed in terms of the feasibility of plant system to serve as a biofactory for dengue vaccine.

关键词： Dengue vaccine Protective efficacy Developing countries Plant molecular pharming

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