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Acceptance of COVID-19 vaccine and its related determinants in nigeria:An online survey

World Journal of Virology 2024年第4期13卷 89-110页

作者： Eyiuche D Ezigbo Seyi S Enitan Esther n Adejumo Abiodun E Durosinmi Richard Y Akele Michael O Dada Grace E Itodo Abah M Idoko Okeoghene M Edafetanure-Ibeh edwin n okafor Adedeji A Abdulsalam Oyekan I Oyedoyin Polit U Yelpoji Ogunwola O Opeyemi Ogbuji S nmesomachi Adesola O Oyekale Chisom B Onyeji Haemostasis and Thrombosis Unit Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400241Nigeria Department of Medical Laboratory Science School of Public and Allied HealthBabcock UniversityIlishan-RemoOG 121109Nigeria Department of Medical Laboratory Science State HospitalIjebu-OdeOG 120221Nigeria Department of Biomedical Science School of Applied ScienceUniversity of BrightonBrightonES BN24ATUnited Kingdom Department of Microbiology Federal Teaching Hospital LokojaLokojaKO 260006Nigeria Department of Hematology and Blood Group Serology Federal College of Veterinary and Medical Laboratory TechnologyVomPL 930101Nigeria Department of Environmental and Occupational Health Texas A and M University School of Public HealthGarlandTX 75049United States Division of Chemical Pathology Department of Medical Laboratory SciencesUniversity of NigeriaEnugu CampusEnuguEN 400102Nigeria School of Molecular Bioscience Sciences College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowSCO G128QQUnited Kingdom Department of Medical Laboratory Science State Hospital Ijebu-OdeIjebu-OdeOG 360101Nigeria Department of Medical Laboratory Science Faculty of Health Sciences and TechnologyUniversity of JosJosPL 930103Nigeria Department of Medical Laboratory Science Bola Tinubu Health and Diagnostic CenterLagosLA 100102Nigeria Department of Pathology 68 Nigerian Army Reference HospitalYabaLA 1211001Nigeria Department of Medical Laboratory Science Ladoke Akintola University of TechnologyOgbomosoOS 2111105Nigeria

BACKGROUnD Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019(COVID-19)*** the sociodemographic factors associated with vaccine acceptance among nigerians is crucial for improving vaccine *** To assess the acceptance rate of COVID-19 vaccine and its related determinants among *** An online cross-sectional survey(observational study)was conducted between February 2021 and May 2021,using a questionnaire hosted on *** invitation to take part in the poll was sent out to participants through social networking platforms.A logistic regression was used to determine which sociodemographic factors were associated with vaccine acceptance *** A total of 1800 persons responded to the survey,a larger proportion of whom were males(53.9%)and within the age group of 21-30 years(29.4%)and earned an average income of less than$500 per month(43.3%).Only 0.56%of participants had a high perceived risk of COVID-19 infection,while only 1.11%had a perceived risk of dying from *** perception rate of the COVID-19 vaccine among participants was 51.1%,while the acceptance rate was 63.9%.There was no significant association between the COVID-19 vaccine acceptance rate and related determinants assessed,particularly age(χ²=3.049,P=0.550),sex(χ²=0.102,P=0.749),average income(χ²=3.802,P=0.875),and religion(χ²=2.819,P=0.420).Participants with chronic conditions demonstrated a higher acceptance rate compared to the general *** Despite the positive perception observed and substantial vaccine acceptance rate among the study participants,more public health interventions are still needed to enhance vaccine acceptability in nigeria.

关键词： Acceptance COVID-19 Determinants Hesitancy nigerians Online survey Vaccine

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The Origin of Quarks in Quantum Gravity

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Journal of Modern Physics 2024年第8期15卷 1229-1245页

作者： edwin Eugene Klingman Cybernetic Micro Systems Inc. San Gregorio USA

A theory of quantum gravity has recently been developed by the author based on the concept that all forces converge to one at the moment of Creation. This primordial field can only interact with itself, as no other field exists, contrasting with the Standard Model of Particle Physics in which each elementary particle is an excitation in its own quantum field. The primordial field theory of quantum gravity has produced a model of a fermion with a mass gap, ½-integral spin, discrete charge, and magnetic moment. The mass gap is based on an existence theorem that is anchored in Yang-Mills, while Calabi-Yau anchors ½-integral spin, with charge and magnetic moment based on duality. Based on n-windings, this work is here extended to encompass fractional charge, with the result applied to quarks, yielding fermion mass and charge in agreement with experiment and novel size correlations and a unique quantum gravity-based ontological understanding of quarks.

关键词： Duality Calabi-Yau Topology Fermion Charge Primordial Field Self-Interaction Equations Yang-Mills Gravity Quantum Gravity Ontology of Quarks

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胰岛素对昆虫病原线虫生长发育、生殖力及致病力的影响

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中国生物防治学报 2024年第4期40卷 856-865页

作者：钱秀娟孙丹臧建成 edwin E.Lewis 甘肃农业大学植物保护学院/甘肃省农作物病虫害生物防治工程实验室西藏农牧学院植物科学学院美国爱达荷大学农业与生命科学学院昆虫学植物病理学及线虫学系

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经... 详细信息

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经卡森斯氏线虫Steinernemakraussei0657L和短尾异小杆线虫Heterorhabditisbrevicaudis0641TY侵染的大蜡螟Galleriamellonella注射不同浓度胰岛素，观测昆虫病原线虫的生活史及其对大蜡螟的致病力，以明确胰岛素对昆虫病原线虫生长发育、生殖力、致病力的影响。结果表明：胰岛素干预时间和干预浓度均可对卡森斯氏线虫0657L在寄主昆虫体内的生长发育产生影响，侵染当天（t）干预和高浓度（1:500）干预，会明显缩短其发育历期；侵染当天无论是高浓度还是低浓度的胰岛素干预，均会明显缩短短尾异小杆线虫0641TY的发育历期，且相比较卡森斯氏线虫0657L，胰岛素促进短尾异小杆线虫0641TY发育历期的效果更明显。在卡森斯氏线虫0657L侵染大蜡螟10 d后，注射低浓度的胰岛素，可显著提高其生殖力；在短尾异小杆线虫0641TY侵染大蜡螟1d后，注射低浓度的胰岛素，可显著提高其生殖力。胰岛素对卡森斯氏线虫0657L致病力有影响，在24 h内高浓度胰岛素可显著缩短寄主昆虫的死亡时间，但是侵染36 h后，各处理间差异不显著；而对短尾异小杆线虫0641TY致病力无影响。综上所述，胰岛素对卡森斯氏线虫0657L和短尾异小杆线虫0641TY的发育和生殖力均有影响，且对卡森斯氏线虫致病力有影响。

关键词：胰岛素昆虫病原线虫生长发育生殖力致病力

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RnA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen Ying Mao Guomin Zhou Bo Liao Jinsong Wu edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RnA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RnA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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Clinical and Demographic Profile of Women with Uterine Fibroids Living in Puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第9期14卷 1347-1362页

作者： edwin Y. Soto-Velázquez Alexander J. Jaramillo-Cañas Shania n. Aponte-Paris Gabriela V. Martínez-Marrero Irazu S. Guinan Gabrielle A. Rivera-Maldonado Alexandra novas Pedro L. Cruz-Rosa Idhaliz Flores-Caldera Maricarmen Colón-Diaz Department of Physiology and Pathology San Juan Bautista School of Medicine Caguas Puerto Rico United States Ponce Research Institute Ponce Health Sciences University Ponce Puerto Rico United States

Introduction: Uterine leiomyomas, or fibroids, are prevalent benign tumors affecting up to 70% of reproductive-age women in the United States, significantly impacting productivity and quality of life. Despite their commonality, the epidemiology and clinical patterns of leiomyomas in Puerto Rico remain inadequately researched. Methods: This study conducted a secondary data analysis using clinical, menstrual cycle characteristics, and demographic data from self-administered questionnaires of women undergoing diagnostic laparoscopy for endometriosis in Puerto Rico. Chi-square tests and t-tests analyzed categorical and continuous variables, respectively (p Results: Among 1,610 endometriosis cases, 312 included uterine fibroids. Prevalence estimates were 10.3% (40 years). Primiparous women averaged 22.14 years, with 40.71% having 2 - 3 pregnancies and 26.28% experiencing miscarriages. Symptoms included infertility (29.5%), dyspareunia (40.7%), severe pain (50%), and dysmenorrhea (75.6%). Comorbidities included ovarian cysts (52.2%) and abnormal uterine bleeding (37.8%). Conclusions: Advanced age, parity, and comorbidities like diabetes and hypertension were prevalent in our cohort. Understanding the epidemiological profile of women living in Puerto Rico with uterine fibroids is crucial for improving diagnostic awareness and enhancing patient care.

关键词： Uterine Fibroids Puerto Rico Epidemiology Dysmenorrhea Abnormal Uterine Bleeding

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昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

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昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of Entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPn)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPn与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPn的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPn的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPn影响及EPn的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

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胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能研究进展

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昆虫学报 2024年 1-13页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室美国爱达荷大学农学院线虫学系

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、繁殖、胁迫抗性和寿命,且均与脊椎动物的胰岛素样肽信号通路和及胰岛素样生长因子通路高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans等的胰岛素信号通路研究,作为一根探针,在生命科学研究中为人类胰岛素相关疾病研究提供试验模型,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫作为一种重要的生防因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPn与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对昆虫病原线虫的影响,必须同时关注胰岛素对寄主昆虫的影响。为了能科学系统地展开胰岛素对昆虫病原线虫的影响并进行深入探讨,本文就胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能展开综述,以期为研究胰岛素对昆虫病原线虫的影响及昆虫病原线虫的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

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Trends in gastrointestinal disease hospitalizations and outcomes during the first year of the coronavirus pandemic

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World Journal of Gastroenterology 2023年第4期29卷 744-757页

作者： Ayooluwatomiwa Deborah Adekunle Muni Rubens Mary Sedarous Tahniyat Tariq Philip n okafor Division of Internal Medicine St.Luke's HospitalChesterfieldMI 63017United States Office of Clinical Research Miami Cancer InstituteMiamiFL 33176United States Division of Internal Medicine McMaster UniversityHamilton ON L8S 4L8OntarioCanada Division of Gastroenterology Stanford University School of MedicineRedwood CityCA 94063United States Division of Gastroenterology Stanford University College of MedicineRedwood CityCA 94063United States

BACKGROUnD The impact of the coronavirus on hospitalizations for gastrointestinal(GI)disease,particularly at a population level is *** To investigate trends in hospitalizations,inpatient endoscopy resource utilization,and outcomes during the first year of the coronavirus pandemic and subsequent *** Using the California State Inpatient Database for 2018-2020,we explored year-toyear and 2020 month-to-month trends in hospitalizations,length of stay,and inpatient mortality(all-cause&viral pneumonia-specific)for common inpatient GI diagnoses including acute pancreatitis,diverticulitis,cholelithiasis,noninfectious gastroenteritis,upper and lower GI bleeding(LGIB),Clostridium difficile,viral gastroenteritis,inflammatory bowel disease,and acute *** Disease-specific hospitalizations decreased for all included conditions except nonvariceal upper GI bleeding(nVUGIB),LGIB,and ulcerative colitis(UC)(ptrendnpatient mortality was higher in 2020 vs 2019,for acute pancreatitis(P=0.029),diverticulitis(P=0.04),nVUGIB(P=0.003),and Crohn’s disease(P=0.004).In 2020,hospitalization rates were lowest in April,november,and *** was no significant corresponding increase in inpatient mortality except in UC(ptrend=0.048).Viral pneumonia and viral pneumonia complicated by respiratory failure increased(Png GI *** utilization within 24 h of admission was unchanged for GI emergencies except nVUGIB(PnCLUSIOn Our findings suggest that hospitalization rates for common GI conditions significantly declined in California during the COVID pandemic,particularly in April,november and December *** mortality was significantly higher among acute pancreatitis,diverticulitis,nVUGIB,and Crohn’s disease *** endoscopy rates were mostly comparable between 2020 and 2019.

关键词： COVID-19 Shelter-in-place Procedure utilization Outcomes Hospitalizations Gastrointestinal diseases

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Charged grain boundary transitions in ionic ceramics for energy applications

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npj Computational Materials 2019年第1期5卷 947-958页

作者： K.S.n.Vikrant R.edwin García School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA

Surfaces and interfaces in ionic ceramics play a pivotal role in defining the transport limitations in many of the existing and emerging applications in energy-related systems such as fuel cells,rechargeable batteries,as well as advanced electronics such as those found in semiconducting,ferroelectric,and piezotronic ***,a variational framework has been developed to understand the effects of the intrinsic and extrinsic ionic species and point defects on the structural and electrochemical stability of grain boundaries in polycrystalline *** theory predicts the conditions for the interfacial electrochemical and structural stability and phase transitions of charged interfaces and quantifies the properties induced by the broad region of electrochemical influence in front of a grain boundary capable of spanning anywhere from a few angtroms to entire *** demonstrate the validity of this theory for Y_(x)Zr_(1−x)O_(2−x/2),cubic yttria stabilized zirconia.

关键词： ceramics grain transitions

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Photolysis of a mixture of anthracene and benzo[a] pyrene at ultra-trace levels in natural water with disinfection purposes

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Journal of Environmental Sciences 2020年第6期32卷 79-94页

作者： Ainhoa Rubio-Clemente edwin Chica Gustavo A.Penuela Facultad de Ciencias de La Salud.Universidad Catolica de Murcia(UCAM) Murcia 30107Spain Grupo GDCOn Facultad de IngenieriaSede de Investigaciones Universitarias(SIU)Universidad de Antioquia(UdeA)Medellín 050010Colombia Facultad de Ingenieria Tecnologico de Antioquia-Institucion Universitaria(TdeA)Medellín 050034Colombia Departamento de Ingenieria Mecanica Facultad de IngenieriaUniversidad de Antioquia(UdeA)Medellín 050010Colombia

The photodegradation of anthracene(An)and benzo[a]pyrene(BaP),two priority polycyclic aromatic hydrocarbons(PAHs),was examined at ultra-trace levels in surface water to elucidate their behaviour under several irradiance values and types of *** emitting flux and the spectrum of the lamps were found to develop a crucial role in An and BaP degradation since removal efficiencies of the target contaminants higher than 99%were found after 15 min of irradiation under an ultraviolet C(UVC)irradiance of 0.63 mW/cm^2,corresponding to a fluence of 560.25 mJ/cm^*** the other hand,although ultraviolet A(UVA)lamps exhibited a higher irradiance compared to that of UVC lamps,they were not efficient for degrading the target *** removal kinetic studies corroborated these findings,being the An elimination rate in surface water higher than that in deionized water at optimal operating *** potential was also measured.A rapid microbial load inactivation,in terms of total coliforms naturally contained in the water matrix studied,was evidenced within 15 min of treatment for the fluence ***,after 24 hr in the dark,a regrowth was ***,photolysis products more toxic than the parent compounds were found,which were not removed even by extending the treatment *** this regard,it can be concluded that the individual action of UVC light for removing An and BaP with disinfection purposes is not an efficient treatment;therefore,the use of radiation in combination with other kinds of treatments is required.

关键词： Polycyclic aromatic hydrocarbon Photolysis Matrix constituent Intermediate product Disinfection Regrowth

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