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昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

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昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin E.LEWIS 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of Entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,EPN)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,EPN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对EPN的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对EPN的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对EPN影响及EPN的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

Scan-Based Attack on Stream Ciphers: A Case Study on eSTREAM Finalists

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Journal of Computer Science & Technology 2014年第4期29卷 646-655页

作者：邹敏辉马坤吴剀劼沙行勉 College of Computer Science Chongqing University Department of Electrical and Computer Engineering University of Illinois at Chicago Chicago IL 60607 U.S.A. IEEE Key Laboratory of Dependable Service Computing in Cyber Physical Society Chongqing UniversityMinistry of Education

Scan-based design for test （DFT） is a powerful and the most popular testing technique. However, while scan-based DFT improves test efficiency, it also leaves a side channel to the privacy information stored in the chip. This paper investigates the side channel and proposes a simple but powerful scan-based attack that can reveal the key and/or state stored in the chips that implement the state-of-the-art stream ciphers with less than 85 scan-out vectors.

关键词： scan-based attack stream cipher linear and non-linear feedback shift register scan-based design for test

等通道转角挤压对Mg-Li合金力学性能的影响概述

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稀有金属材料与工程 2022年第2期51卷 491-510页

作者： edwin Eyram Klu 江静华 Bassiouny Saleh 马爱斌 Salifu Nasiru 宋丹河海大学力学与材料学院江苏南京210098 宿迁市河海大学研究院江苏宿迁223800 亚历山大大学生产工程系埃及亚历山大21544

等通道转角挤压(ECAP)是一种高效率的大塑性变形(SPD)技术,用于生产具有优异性能的超细晶粒(UFG)材料。本文总结了经ECAP加工的各种Mg-Li合金的力学性能、加工参数的影响及其相关机理,为未来提高镁锂合金力学性能提供研究方向与支持。

关键词：镁锂合金等通道转角挤压大塑性变形力学性能微观组织

Six forests in one:Tree species diversity in the Bosque Protector Chongón Colonche,a lowland mountain range in coastal Ecuadorian

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Forest Ecosystems 2022年第6期9卷 725-733页

作者： Oswaldo Jadan David ADonoso edwin Ponce-Ramírez Franz Pucha-Cofrep Omar Cabrera Facultad de Ciencias Agropecuarias Universidad de Cuenca12 de Octubre y Diego de TapiaCuenca010107Ecuador Programa de Doctorado en Conservacion de Recursos Naturales Escuela Internacional de DoctoradoUniversidad Rey Juan CarlosMostolesMadridES-28933Spain Departamento de Biología Escuela Politecnica NacionalLadron de Guevara E11⋅253Quito170525Ecuador Geoforest S.A 12 de febrero y Av.Franklin VegaMacas140150Ecuador Grupo de Investigacion Hidrología y Climatología Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador Brandenburg University of Technology(BTU)Cottbus-Senftenberg 03044CottbusGermany Departamento de Ciencias Biologicas y Agropecuarias Universidad Tecnica Particular de LojaSan Cayetano Alto S/NLoja110101Ecuador

Tropical mountain ranges shape the structure of tree communities and promote highly diverse natural ***“Bosque Protector Chong on-Colonche”(BPCC),an 86,000-ha mountain formation situated on the coast of Ecuador,is biogeographically important for the region by connecting floristic elements of the wet Choco and the dry Tumbesian *** understanding of the factors that model tree and palm diversity and distribution in this mountain range are *** measured and identified all trees and palms(DBH≥10 cm)in 289 plots of0.2 ha,distributed throughout *** used generalized linear models to explain the relationship between forest diversity and structure and climatic variables(temperature,rain,aridity),and *** then used cluster and non-metric multidimensional scale(NMDS)analyses to search for distinct forest communities within the *** partition(varpart)was used to determine which predictor variables best explained these distinct forest communities.A species indicator analysis identified the species most likely to define these distinct forest ***,we carried out a niche modeling approach to identify the potential distribution of these forest communities within *** total,we identified 220 tree and palm species in our *** average number of species per plot was 17.8±5.8,ranging from 3 to 40 *** methods sorted the 289study plots into six different forest communities,three communities in the dry forest and three in the semi-humid Garúa *** and temperature,but not altitude or aridity,explained floristic *** results emphasize the high but little cataloged diversity in the lowland mountain rainforests of coastal Ecuador.

关键词： Chongón-Colonche Climatic variables Dry forest Forest communities Garúa forest

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内毒素导致肠源性感染发病机理的实验研究

中华整形烧伤外科杂志 1990年第3期6卷 164-166,235+244页

作者：马利马敬文肖光夏黎鳌 edwin A Deitch 第三军医大学西南医院烧伤研究所美国路易斯安娜州州立大学Shrevepor医学院

我们观察了内毒素所致肠源性感染与肠粘膜形态学改变和黄嘌呤氧化酶、黄嘌呤脱氢酶活性变化之间的相关性。结果显示,循环中的内毒素主要是损伤回肠和盲肠粘膜屏障,导致肠源性细菌感染。同时回肠和盲肠粘膜中黄嘌呤氧化酶和黄嘌呤脱氢酶... 详细信息

我们观察了内毒素所致肠源性感染与肠粘膜形态学改变和黄嘌呤氧化酶、黄嘌呤脱氢酶活性变化之间的相关性。结果显示,循环中的内毒素主要是损伤回肠和盲肠粘膜屏障,导致肠源性细菌感染。同时回肠和盲肠粘膜中黄嘌呤氧化酶和黄嘌呤脱氢酶活性显著增高,本文对此进行了讨论。

关键词：肠源性感染内毒素实验研究

Expert consensus on difficult airway assessment

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 545-566页

作者： Ming Xia Wuhua ma Mingzhang Zuo Xiaoming Deng Fushan Xue Denise Battaglini Vivek Aggarwal Giustino Varrassi Vladimir Cerny Ida Di Giacinto Rita Cataldo Daqing ma Toru Yamamoto martina Rekatsina Alessandro De Cassai Andrea Carsetti marvin G.Chang edwin Seet Daniel P.Davis Michael G.Irwin Yuguang Huang Hong Jiang Department of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Anesthesiology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Department of Anaesthesiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijingChina Department of Anesthesiology Plastic Surgery HospitalCAMS and PUMCBeijingChina Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Anesthesia and Intensive Care San Martino Policlinico HospitalIRCCS for Oncology and NeuroscienceGenoaItaly Department of Conservative Dentistry&Endodontics Jamia Millia IslamiaNew DelhiIndia Paolo Procacci Foundation RomaItaly Department of Anaesthesiology and Intensive Care Medicine University Hospital Hradec KraloveHradec KraloveCzech Republic Unit of Anesthesia and Intensive Care Mazzoni HospitalAscoli PicenoItaly Unit of Anaesthesia Intensive Care and Pain ManagementDepartment of MedicineUniversitàCampus Bio-Medico of RomeRomaItaly Division of Anaesthetics Pain Medicine&Intensive CareDepartment of Surgery&CancerFaculty of MedicineImperial College Londonand Chelsea and Westminster HospitalLondonUK Division of Dental Anesthesiology Graduate School of Medicine and Dental SciencesNiigata UniversityNiigataJapan Department of Anaesthesiology National and Kapodistrian University of AthensAthensGreece Institute of Anesthesia and Intensive Care Unit University Hospital of PaduaPaduaItaly Department of Biomedical Sciences and Public Health UniversitàPolitecnica delle MarcheAnconaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria delle MarcheAnconaItaly Department of Anesthesia Critical Careand Pain MedicineMassachusetts General HospitalBostonMAUSA Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Anaesthesia Yong Loo Lin School of Medic

Background:Identifying a potentially difficult airway is crucial both in anaesthesia in the operating room(OR)and non-operation room *** are no guidelines or expert consensus focused on the assessment of the difficult airway before,so this expert consensus is developed to provide guidance for airway assessment,making this process more standardized and accurate to reduce airway-related complications and improve ***:Seven members from the Airway management Group of the Chinese Society of Anaesthesiology(CSA)met to discuss the first draft and then this was sent to 15 international experts for review,comment,and *** Grading of Recommendations,Assessment,Development and Evaluation(GRADE)is used to determine the level of evidence and grade the strength of *** recommendations were revised through a three-round Delphi survey from ***:This expert consensus provides a comprehensive approach to airway assessment based on the medical history,physical examination,comprehensive scores,imaging,and new developments including transnasal endoscopy,virtual laryngoscopy,and 3D *** addition,this consensus also reviews some new technologies currently under development such as prediction from facial images and voice information with the aim of proposing new research directions for the assessment of difficult ***:This consensus applies to anesthesiologists,critical care,and emergency physicians refining the preoperative airway assessment and preparing an appropriate intubation strategy for patients with a potentially difficult airway.

关键词： Expert consensus difficult airway airway management

Replacement of Process Scale Chromatography by Counterflow Membrane Cascades

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Advances in Bioscience and Biotechnology 2014年第11期5卷 915-923页

作者： edwin N.Lightfoot Baris Unal Department of Chemical Engineering University of WisconsinMadisonWIUSA Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Invention and innovation, always important, become ever more so in these fast changing and competitive times. They are in addition primarily dependent upon the dynamic behavior of the human mind. Our underlying purpose here is to examine these creative processes and to provide means to make them more effective. This is a timely effort because our understanding of perception and its interpretation by the human brain is very rapidly advancing. Even experimental insights into mental activity can be determined with rapidly increasing effectiveness. The framework of our discussion is that of evolution dynamics, and the scientific bases are rapidly developing neural sciences. However the bulk of our discussion deals with a specific example: the replacement of process scale chromatography by membrane-mediated steady counterflow in downstream processing. We do this because inventive activities must depend upon intimate knowledge of the systems available.

关键词： Invention Innovation Membrane Chromatography

The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

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Cell Regeneration 2013年第1期2卷 7-17页

作者： Thomas Hill Olga Krougly Enayat Nikoopour Stacey Bellemore edwin Lee-Chan Lynette A Fouser David J Hill Bhagirath Singh Department of Microbiology and Immunology University of Western OntarioLondonONCanada Inflammation and Immunology Biotherapeutics Research and DevelopmentPfizerCambridgeMA 02140USA Department of Physiology and Pharmacology University of Western OntarioLondonONCanada Lawson Health Research Institute LondonONCanada Centre for Human Immunology University of Western OntarioLondonONCanada Robarts Research Institute University of Western OntarioLondonONCanada

Background:In Type 1 diabetes,the insulin-producingβ-cells within the pancreatic islets of Langerhans are *** showed previously that immunotherapy with Bacillus Calmette-Guerin(BCG)or complete Freund’s adjuvant(CFA)of non-obese diabetic(NOD)mice can prevent disease process and pancreaticβ-cell *** was associated with increased islet Regenerating(Reg)genes expression,and elevated IL-22-producing Th17 T-cells in the ***:We hypothesized that IL-22 was responsible for the increased Reg gene expression in the *** therefore quantified the Reg1,Reg2,and Reg3δ(INGAP)mRNA expression in isolated pre-diabetic NOD islets treated with *** measured IL-22,and IL-22 receptor(R)-αmRNA expression in the pancreas and spleen of pre-diabetic and diabetic NOD *** results showed:1)Reg1 and Reg2 mRNA abundance to be significantly increased in IL-22-treated islets in vitro;2)IL-22 mRNA expression in the pre-diabetic mouse pancreas increased with time following CFA treatment;3)a reduced expression of IL-22Rαfollowing CFA treatment;4)a down-regulation in Reg1 and Reg2 mRNA expression in the pancreas of pre-diabetic mice injected with an IL-22 neutralizing antibody;and 5)an increased isletβ-cell DNA synthesis in vitro in the presence of ***:We conclude that IL-22 may contribute to the regeneration ofβ-cells by up-regulating Regenerating Reg1 and Reg2 genes in the islets.

关键词： Adjuvant immunotherapy Interleukin-22 Regenerating(Reg)genes Beta-cell regeneration Type 1 diabetes

三七皂甙对血管平滑肌上受体操纵Ca^(2+)通道的特异性作用(英文)

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中国药理学报 1994年第5期15卷 392-398页

作者：关永源关超然贺华孙家钧 edwin E DANIEL 中山医科大学药理教研室 Department of Biomedical Sciences McMaster University Hamilton Ont L6N 3Z5 Canada

三七皂甙能明显抑制狗肠系膜动脉及大隐静脉α肾上腺素能受体触发的收缩反应及^(45)Ca内流(从0.36±0.03降至0.14±0.05μmol·g^(-1)组织湿重),但对高K^+引起的Ca^(2+)内流无影响。三七皂甙不影响Ca^(2+)释放及受体的亲和力。提示三七... 详细信息

三七皂甙能明显抑制狗肠系膜动脉及大隐静脉α肾上腺素能受体触发的收缩反应及^(45)Ca内流(从0.36±0.03降至0.14±0.05μmol·g^(-1)组织湿重),但对高K^+引起的Ca^(2+)内流无影响。三七皂甙不影响Ca^(2+)释放及受体的亲和力。提示三七皂甙具有特异性阻断受体操纵Ca^(2+)通道的特性,对电位依赖性Ca^(2+)通道无作用。

关键词：人参皂甙类血管平滑肌钙通道