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p.evalence and Risk Factors for Hep.titis Delta Virus Transmission among HBsAg p.sitive Blood Donors in Brazzaville, Congo

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Journal of Biosciences and Medicines 2021年第8期9卷 43-50页

作者： Serge O. Mokono Chaldam J. Mbani Brunel M. Angounda Boris S. Bakoua Sara R. Mbao-Bongo edwige p. louanga nanitelamio Fabien R. Niama Donatien Moukassa National Center of Blood Transfusion Brazzaville Congo Faculty of Health Sciences Marien NGOUABI University Brazzaville Congo Faculty of Science and Technology Marien NGOUABI University Brazzaville Congo

Background: Hep.titis D virus (HDV) is a defective virus that requires the p.esence of hep.titis B virus (HBV) for rep.ication. It is a major cause of severe acute and chronic hep.titis B. The objective of this study was to determine the p.evalence and risk factors of HDV in blood donors. Methods: This was a descrip.ive, cross-sectional study involving HBsAg-p.sitive blood donors covering the p.riod from July to December 2020. Testing for HDV RNA was p.rformed by conventional two-step.RT-p.R. Data were analysed using Sp.S version 22 software. Result: Of 113 HBsAg p.sitive samp.es included in the study 22 or 19.5% were HDV p.sitive. The p.evalence of HDV was higher in the age group.31 - 45 years (45.5%), in male donors (71.4%) and in donors with secondary education (50.0%). Furthermore, 55.4% belonged to the family donor category. A significant statistical difference was observed between HDV infection, tattoos, p.ercings and multip.e sexual p.rtners. Conclusion: This study shows a high p.evalence of HDV among blood donors in Brazzaville.

关键词： p.evalence HDV Blood Donors Brazzaville Risk Factors

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Serop.evalence of SARS-CoV-2 among Blood Donors in the Rep.blic of Congo

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Op.n Journal of Blood Diseases 2022年第4期12卷 124-132页

作者： Serge Oscar Mokono edwige p.ola Chancelle louanga nanitelamio Chaldam Jesp.re Mbani Aude Tabap.ka Taty Taty Nina Esther Ngoyi Née Ontsira Donatien Moukassa Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo National Blood Transfusion Centre Brazzaville Republic of Congo Faculty of Science and Technology Marien Ngouabi University Brazzaville Republic of Congo Hosp.tal and University Centre Brazzaville Republic of Congo

Corona Virus Disease 2019 (COVID-19) is a highly transmissible and p.thogenic viral infection caused by severe acute resp.ratory syndrome coronavirus 2 (SARS-CoV-2), which erup.ed in Wuhan, China, in 2019 and has sp.ead worldwide [1]. The objective of this study was to assess the serop.evalence of SARS-CoV-2 among blood donors in the Rep.blic of Congo. Method: This is an analytical and cross-sectional study that was carried out during the p.riod from July to December 2021. Biological analyses were p.rformed with the serological tests n2019 rap.d IgG/IgM from Beijing Diagreat Biotechnologies and antigen tests from Abbot using the serum for the detection of anti-SARS-Cov-2 antibodies and nasal mucus for the detection of SARS-Cov-2 antigens. Statistical analysis was p.rformed using Sp.S version 22. The Results: Out of 2553 donors recruited in our study, we observed a p.edominance of male sex with 86.1% or a ratio of 6.19, the age group.of 18 - 30 years was dominant with 45.9%, family donation rep.esented 59.2%, the dominant p.ofession was workers with 46.9% and the dominant blood group.was O Rh p.sitive with 54%. The p.evalence of anti-SRAS-CoV-2 antibodies and antigens were resp.ctively 31.4% for anti-SRAS CoV-2 IgG antibodies, 36.7% for anti-SRAS CoV-2 IgM antibodies and 2.93% for SARS-CoV-2 antigen.

关键词： Serop.evalence Blood Donors Anti IgM Antibody Anti IgG Antibody Antigen SARS-CoV-2

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Hematological and Biochemical p.ofile of Sickle Cell p.tients in Critical and Inter-Critical p.riods in Brazzaville, Rep.blic of Congo

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Op.n Journal of Blood Diseases 2021年第2期11卷 57-65页

作者： edwige p.ola louanga nanitelamio Serge Oscar Mokono Chaldam Jesp.re Mbani Olivia Galiba Atip.-Tsiba Fabien Roch Niama Etienne Mokondjimobe Donatien Moukassa Ange Antoine Abena Alexis Elira Dokekias Faculty of Health Sciences Marien NGOUABI University Brazzaville Congo National Center of Blood Transfusion Brazzaville Congo Faculty of Science and Technology Marien NGOUABI University Brazzaville Congo National Reference Center for Sickle Cell Disease Brazzaville Congo

Introduction: Sickle cell disease is a p.blic health p.oblem in the Rep.blic of Congo where the p.evalence of sickle cell trait is estimated at 1.25%. The objective of this study is to describe the variations of hemat... 详细信息

Introduction: Sickle cell disease is a public health problem in the Republic of Congo where the prevalence of sickle cell trait is estimated at 1.25%. The objective of this study is to describe the variations of hematological and biochemical parameters of hemolysis in sickle cell patients in critical and inter-critical periods. Methods: This is a descriptive cross-sectional study including sickle cell patients followed regularly at the National Reference Center for Sickle Cell Disease (CNRDr) from November 2019 to March 2020. A sample of 167 patients (sickle cell subjects in crisis and in steady state as well as control subjects) was randomly selected during the study period. The blood count was performed using a Sysmex-XN 350 automated system and the biochemical parameters were determined using the Cobas e 311 automated system. Statistical analysis was performed with SPSS version 22 software. Results: The study showed that the mean cholesterol level in controls was 4.16 ± 0.77 ul compared with 9.64 ± 4.34 ul in sickle cell crisis subjects. Hb and HCT levels were significantly higher in controls compared with sickle cell subjects in crisis. During crisis, total bilirubin, direct bilirubin, triglycerides, LDH, AST, and CRP were significantly elevated. Hematological parameters such as Hb and HCT were elevated in controls, while the mean WBC value and RET were higher in sickle cell patients in steady state. The mean values of the biochemical parameters were higher in sickle cell patients in steady state. Conclusion:p.n style="font-family:Verdana;"> Evaluation of the influence of sickle cell trait on biochemical and hem

关键词： Sickle Cell Disease Hematological p.rameters Biochemical p.rameters Critical and Inter-Critical p.riod Brazzaville

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